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Postdoctoral Scientist - Protein Biochemistry & Structural Biology
formal organization: University of Oxford
application opening date: 2023-09-11T09:00:00+01:00
subject: research
notation: 164588
further particulars: 164588 - Postdoctoral Scientist – JD.pdf
comment: PREVIOUS APPLICANTS NEED NOT APPLY We are seeking to appoint a Postdoctoral scientist with experience in protein purification, biophysical characterization of protein ligand interactions, functional assay development as well as crystallization and structure determination of proteins. You will join the CMD Chemical Biology Group at the Target Discovery Institute, Nuffield Department of Medicine. You will be responsible for unravelling the fundamental role of novel RNA binding proteins involved in human disease. You will be developing biochemical assays and studying the interaction of low molecular weight modulators to protein interaction domains and understand the SAR (structure activity relationship) of compound classes with the goal to develop a highly selective first- in-class chemical probes. You will contribute to the scientific output by publishing high quality manuscripts and by representing the group on scientific meetings. It is essential that you hold a PhD (or near completion) in protein biochemistry and structural biology with an excellent academic track record (at least one first author publication in an expert journal). Having an extensive experience in cloning and recombinant protein purification using bacterial, insect cell and mammalian host systems is essential, and you will have a demonstrable experience in biochemical assay development using various read-outs and biophysical ligand binding methods such as isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR). Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. You must not include copies (reprints) of your original publications, all scientific outputs should be listed in standard journal reference format. This position is offered full tim…
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comment: **PREVIOUS APPLICANTS NEED NOT APPLY** We are seeking to appoint a Postdoctoral scientist with experience in protein purification, biophysical characterization of protein ligand interactions, functional assay development as well as crystallization and structure determination of proteins. You will join the CMD Chemical Biology Group at the Target Discovery Institute, Nuffield Department of Medicine. You will be responsible for unravelling the fundamental role of novel RNA binding proteins involved in human disease. You will be developing biochemical assays and studying the interaction of low molecular weight modulators to protein interaction domains and understand the SAR (structure activity relationship) of compound classes with the goal to develop a highly selective first- in-class chemical probes. You will contribute to the scientific output by publishing high quality manuscripts and by representing the group on scientific meetings. It is essential that you hold a PhD (or near completion) in protein biochemistry and structural biology with an excellent academic track record (at least one first author publication in an expert journal). Having an extensive experience in cloning and recombinant protein purification using bacterial, insect cell and mammalian host systems is essential, and you will have a demonstrable experience in biochemical assay development using various read-outs and biophysical ligand binding methods such as isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR). Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. You must not include copies (reprints) of your original publications, all scientific outputs should be listed in standard journal reference format. This position is offered full…
application closing date: 2023-10-09T12:00:00+01:00
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value: Job title Postdoctoral Scientist – Protein Biochemistry & Structural Biology Division Medical Sciences Department Nuffield Department of Medicine Location Target Discovery Institute, NDM Research Building, Old Road Campus, Heading, Oxford, OX3 7BN Grade and salary Grade 7: Salary in range £36,024- £44,263 per annum Hours Full time Contract type Fixed term contract until 30 April 2025 Reporting to Dr Kilian Huber, Principal Investigator Vacancy reference 164588 Additional information Funding provided by DBT, EUbOPEN The role The CMD Chemical Biology Group is seeking a Postdoctoral Scientist with extensive experience in protein purification, biophysical characterization of protein ligand interactions, functional assay development as well as crystallization and structure determination of proteins. Our aim is to develop highly specific and potent chemical tool molecules that can be used to study the function of key signaling proteins in cellular systems with relevance to human disease. The focus of the research project will be the structural and functional exploration of proteins involved in RNA modifications, and the design, identification and characterization of first-in-class chemical ligands. The project milestones are very ambitious and you will have to be a self-motivated, skillful scientist in order to make a strong contribution to the project. Experience in preclinical drug development would be beneficial but is not a requirement. You will have a strong academic track record and experience in protein biochemistry and structural biology. You will work in a multidisciplinary team involving industry collaborations and strong communication skills will be therefore required. Responsibilities You will:              Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines Adapt existing and develop new scientific techniques and experimental protocols …

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