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167279_Postdoctoral Researcher_Paediatrics_JD.pdf
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_________________________________________________________________________ Job description and selection criteria Job title Postdoctoral Researcher Division Medical Sciences Department Paediatrics Location Oxford Vaccine Group, CCVTM, Churchill Hospital, Oxford Grade and salary Grade 7: £36,024 - £44,263 per annum (with a discretionary range to £48,350 per annum) Hours Full time Contract type Fixed-term for three years Reporting to Andrew Pollard Vacancy reference 167279 Additional information This role meets the criteria for a UK Skilled Worker visa The role The Oxford Vaccine Group directed by Professor Sir Andrew Pollard led the rapid clinical development of vaccines against COVID-19 in the pandemic and has made major contributions to knowledge supporting the development of vaccines, understanding of infectious diseases and influencing national and global policy on immunisation over three decades. This is an exciting opportunity for an enthusiastic and self-motivated scientist with an interest in bacterial pathogens to work on a range of possible projects. Previous laboratory experience in immunological assays, good organizational and communication skills, and the ability to work as part of a team are essential. The ability to manage the day-to-day running of a research project including troubleshooting and a capacity to deliver high quality research outputs, alone or as part of a team, is essential for this role. Enteric Bacteria Enteric fever is a major threat to children in LMICs, with critical research conducted by the OVG team in the UK and across Asia and Africa leading to the deployment of 50 million doses of a first generation vaccine in the past two years. The postholder will work on an exciting programme in which human challenge models for paratyphoid are being used to test new vaccines to protect against enteric fever, a serious bacterial infection of children in low and middle income countries (LMICs) caused by Salmonella species. The new programme focuses on paratyphoid infection in a combination vaccine that could replace the one already deployed. The laboratory research studies will include immunology and microbiology, and coordination of the critical laboratory the endpoints that will define whether these new vaccines will protect children and save lives. Some of the work will require category 3 level work and training will be provided. Other projects in the portfolio include studies of invasive non-typhoidal Salmonella vaccines and evaluation of a new human challenge model against Clostridium difficile. Immunology will include ELISA, EliSpot, systems serology and flow cytometry. Yersinia pestis Yersinia pestis is the cause of plague, a bacterial infection causing increase numbers of outbreaks in Africa, China, Russia, USA with the highest number of reported cases in recent years in Madagascar. This was the cause of the black death in the Middle Ages, which killed up to 50% of the human population. The postholder will work on a programme to develop a new vaccine for plague through design and preclinical experiments and evaluation of human phase I clinical trials. The research will include antigen identification and testing, in vivo studies, and laboratory immunology to evaluate immune responses to the vaccine. Responsibilities • Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines • Adapt existing and develop new scientific techniques and experimental protocols • Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate • Contribute ideas for new research projects • Develop ideas for generating research income, and present detailed research proposals to senior researchers • Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters • Use specialist scientific equipment in a laboratory environment Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 2 • Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques • Represent the research group at external meetings/seminars, either with other members of the group or alone • Carry out collaborative projects with colleagues in partner institutions, and research groups Selection criteria Essential • Hold a relevant PhD/DPhil (or near completion), together with relevant experience • Possess sufficient specialist knowledge in the discipline to work within established research programmes • Ability to manage own academic research and associated activities • Previous experience of contributing to publications/presentations • Ability to contribute ideas for new research projects and research income generation • Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings Desirable • Experience of independently managing a discrete area of a research project • Experience of actively collaborating in the development of research articles for publication Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 3 Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens • Working with blood, human products and human tissues • Work with allergens, e.g. laboratory animals, pollen, dust, fish or insects etc. • Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • Enhanced Level Screening as this role includes conducting research involving animals (or working closely with such research); with access to/ knowledge of the location of certain pathogens, toxins, irradiators. • A satisfactory basic Disclosure and Barring Service check due to the nature of this position • University security screening (e.g. identity checks) Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 4 About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 5 Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 6 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting https://staff.web.ox.ac.uk/recruitment-support-faqs advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 7 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 8 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Department of Paediatrics Postdoctoral Researcher (Grade 7) Job Description 9
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Department of Paediatrics, Oxford Vaccine Group, CCVTM, Churchill Hospital, Oxford
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WTC Clinical Vaccinology and Tropical Medicine
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The Oxford Vaccine Group directed by Professor Sir Andrew Pollard is a multi- disciplinary team working across all aspects of vaccine research with the aim to improve human health. The group led the rapid clinical development of vaccines against COVID-19 in the pandemic and has made major contributions to knowledge supporting the development of vaccines such as meningitis, pneumococcus, typhoid and Ebola, understanding of infectious diseases, and influencing national and global policy on immunisation over 3 decades. This is an exciting opportunity for a postdoctoral researcher to work alongside world renowned scientists at the Oxford Vaccine Group in a team led by Professor Sir Andrew Pollard. The successful candidate will take responsibility for an exciting programme of work which aims to accelerate the development of a new vaccine against _Salmonella_ Paratyphi using a human challenge model to measure the efficacy of the vaccine in humans, assess immune response to the vaccine and identify correlates of protection against Salmonella infections. Other projects in the team are evaluation of vaccines against non-typhoidal Salmonella infection and evaluation of immunity against _Clostridium difficile._ The postholder should have a PhD, with some relevant research experience, sufficient knowledge of translational research and/or clinical research and of immunological methods and techniques to work within established research programmes. You must be an enthusiastic and self-motivated scientist with the ability to manage the day-to-day running of a research project including troubleshooting and a capacity to deliver high quality research outputs. This position is offered full-time on a fixed-term contract initially for three years with the possibility to extend provided further external funding is available. This role meets the criteria for a UK Skilled Worker visa. You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Professor Pollard, using the contact details below. Only online applications received before 12.00 midday on Tuesday 24 October 2023 will be considered. Interviews will be held as soon as possible thereafter.
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Notation3 description of Postdoctoral Researcher
The Oxford Vaccine Group directed by Professor Sir Andrew Pollard is a multi-disciplinary team working across all aspects of vaccine research with the aim to improve human health. The group led the rapid clinical development of vaccines against COVID-19 in the pandemic and has made major contributions to knowledge supporting the development of vaccines such as meningitis, pneumococcus, typhoid and Ebola, understanding of infectious diseases, and influencing national and global policy on immunisation over 3 decades. This is an exciting opportunity for a postdoctoral researcher to work alongside world renowned scientists at the Oxford Vaccine Group in a team led by Professor Sir Andrew Pollard. The successful candidate will take responsibility for an exciting programme of work which aims to accelerate the development of a new vaccine against Salmonella Paratyphi using a human challenge model to measure the efficacy of the vaccine in humans, assess immune response to the vaccine and identify correlates of protection against Salmonella infections. Other projects in the team are evaluation of vaccines against non-typhoidal Salmonella infection and evaluation of immunity against Clostridium difficile. The postholder should have a PhD, with some relevant research experience, sufficient knowledge of translational research and/or clinical research and of immunological methods and techniques to work within established research programmes. You must be an enthusiastic and self-motivated scientist with the ability to manage the day-to-day running of a research project including troubleshooting and a capacity to deliver high quality research outputs. This position is offered full-time on a fixed-term contract initially for three years with the possibility to extend provided further external funding is available. This role meets the criteria for a UK Skilled Worker visa. You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Professor Pollard, using the contact details below. Only online applications received before 12.00 midday on Tuesday 24 October 2023 will be considered. Interviews will be held as soon as possible thereafter.
NTriples description of Postdoctoral Researcher
Grade 7: £36,024 - £44,263 per annum (with a discretionary range to £48,350 per annum)
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