Applications are invited for a postdoctoral position in proteomics of the DNA damage response, funded by Cancer Research UK. The post-holder will use a novel systematic approach involving a combination of bioinformatics and cutting-edge proteomics techniques to identify functional peptide motifs and post-translational modifications that mediate crucial protein-protein interactions in the DNA damage response. Successful completion of the project will provide new insights into the underlying mechanisms that control DNA repair. This interdisciplinary project will be a close collaboration between the Blackford lab at the University of Oxford’s Department of Oncology, and the Kessler lab in the Target Discovery Institute, Nuffield Department of Medicine. The postholder will therefore have the opportunity to work in both labs and acquire a diverse and competitive skill set as the project evolves.

This role is offered on a full-time basis and is fixed term for 3 year in the first instance.

 

You should possess (or be nearing completion of) a PhD/DPhil in a relevant field such as biology, chemistry, or physics. Essential experience includes proficiency in proteomics approaches like immunoprecipitation, pulldowns, and sample preparation for mass spectrometry analysis, as well as familiarity with proteomics data workflows. A keen attention to detail, high motivation, and excellent communication skills, including writing for publication and presenting research, are crucial. Ideally, you'll have a background in areas like DNA damage response or chromosome biology and experience in techniques like mammalian cell culture, plasmid design, and high-resolution microscopy. Experience with mass spectrometers, especially orbitrap or advanced TOF, is a plus. Having a first author paper published in a reputable journal or a manuscript under review would be advantageous.

 

If you would like to discuss this role please contact Prof. Andrew Blackford on  andrew.blackford@imm.ox.ac.uk  

 

You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae and the names and contact details of two referees as part of your online application.

 

The closing date for applications is 12.00 noon on 24th October 2023.