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167602_Research Technician Job Description
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Standard Grade 5: £28,759 - £33,966 per annum (with a discretionary range up to £37,099 per annum)
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**About the role** We have an exciting opportunity to join the Childhood Leukaemia Research Group in the Department of Paediatrics and Molecular Haematology Unit, WIMM as our Research Technician. You will play an important role in the contribution of our lab in understanding the developmental origins of high-risk childhood leukaemia. You will be responsible for planning and conducting your own research, and assisting other members of the group or people working on collaborative projects, as well as working within the team through great communication and organisational skills. You will be working in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. The post-holder will be well supported by an experienced multi-disciplinary research team which includes other postdoctoral researchers and DPhil students in the lab, computational biologists, clinicians, as well as members of collaborating labs. The Childhood Leukaemia Research Group under the lead of Prof Anindita Roy conducts research in developmental haematopoiesis and childhood leukaemia and has successfully characterised human prenatal B lymphopoiesis, and developed a novel model of infant leukaemia using CRISPR-Cas9 gene editing. This position is offered full-time on a fixed-term contract initially for one year with the possibility to extend provided further external funding is available. This role may meet the criteria for a UK Skilled Worker visa. **About you** You will have a Bachelor’s degree or higher, supplemented by relevant post- qualification experience in a lab-based role, with proven and demonstrable technical skills. You will possess a demonstrable interest in molecular biology. You will have highly effective verbal and written communication skills with all level of staff and an ability to operate effectively in a demanding and stimulating research environment. **Application Process** You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Anindita Roy, Associate Professor of Paediatric Haematology using the contact details below. Only online applications received before 12.00 midday on Wednesday 1 November will be considered. Interviews will be held as soon as possible thereafter.
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Department of Paediatrics, Childhood Leukaemia Research Group, Weatherall Institute of Molecular Medicine, John Radcliffe, Oxford
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_________________________________________________________________________ Job description and selection criteria Job title Research Technician Division Medical Sciences Department Paediatrics Location Weatherall Institute of Molecular Medicine, John Radcliffe, Oxford Grade and salary Grade 5: salary in the range of £28,759 - £33,966 per annum (with a discretionary range up to £37,099 per annum) Hours Full time Contract type Fixed-term for one year Reporting to Professor Anindita Roy Vacancy reference 167602 Additional Information This role may meet the criteria for a UK Skilled Worker visa Principal Investigator / Professor Anindita Roy supervisor Project team Childhood Leukaemia Research Group Project web site https://www.paediatrics.ox.ac.uk/research/paediatric-leukaemiaresearch-group Funding Partner The funds supporting this research project are provided by NIH The role A position is available for a research technician to join the Childhood Leukaemia Research Group led by Prof Anindita Roy at the University of Oxford. The group’s research explores how childhood leukaemia develops before birth, with a focus on developing novel therapies for treatment resistant infant and childhood leukaemia. Acute leukemia is the most common childhood cancer, and remains one of the leading causes of death in children under 15 years of age. Survivors of both childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) face severe, lifelong treatment-related morbidities. There is growing evidence that many childhood leukaemias start to develop before birth. A comprehensive assessment of the prenatal origins of childhood leukemia is lacking. To facilitate the development of newborn screening protocols and risk prediction models for childhood leukemia, several critical questions must be answered: 1) What subtypes and, in turn, what proportion of childhood leukemia develops in utero? 2) What is the specific cell(s) of origin in which preleukemic clones arise? And 3) Are some newborns more prone to developing leukemiainitiating lesions than others? This is an exciting opportunity for a research technician (along with a postdoctoral scientist) to work on a transatlantic collaborative project that seeks to answer these critical questions in order to gain understanding of the prenatal origins of childhood leukaemia, with a focus on the ~70% of patients with known translocation or point mutation driver events. The work will be done in close collaboration with Prof Logan Spector (UMN, USA), Prof Adam de Smith and Prof Joseph Wiemels (USC, USA); and Profs Irene Roberts and Adam Mead (WIMM, Oxford) as part of the ReCORD study. Matched cord blood and diagnostic leukaemia samples from ~250 childhood leukaemia patients in the Children’s Oncology Group (COG) Project Every Child (PEC) study will be studied. Using cutting edge genomic and transcriptomic techniques (whole genome sequencing, ddPCR), and single cell assays (cell sorting, TARGET-seq for single cell genotyping and transcriptomics), we aim to identify the presence and clonal frequency of prenatal leukaemiainitiating lesions at birth (USC), determine the cell of origin of leukaemia-initiating lesions, the transcriptomic changes from preleukemia to overt leukaemia, and whether secondary mutations arise prenatally (Oxford), and determine whether the presence and frequency of preleukemic clones correlate with known risk factors for leukaemia (UMN). The successful candidate will be involved with laboratory aspects of the project including designing and conducting experiments. The post holder will work at the MRC Weatherall Institute of Molecular Medicine (MRC WIMM), John Radcliffe Campus of University of Oxford in the laboratory of Prof Anindita Roy (in close collaboration with Prof Adam Mead). He/ she will report to Anindita Roy and will be well supported by the existing team, currently consisting of four laboratory postdocs, and four DPhil students, as well as a part-time senior scientist. The postholder will work closely with other collaborators at the MRC WIMM. Department of Paediatrics Job Description 2 Career Development: The post holder will be able to receive training in collaborating labs (e.g. Mead lab/ CCB at the WIMM) in order to benefit from interaction with researchers in diverse environments. He/she will be encouraged to attend training and research skill courses provided by the University of Oxford. The successful applicant will be expected to provide assistance to other researchers in the group, help in the preparation of scientific publications, and represent the group at public engagement events. Support will be provided for applications to PhD/DPhil programmes if the post holder wishes to do so. Responsibilities • The post-holder will receive close supervision and mentorship (from the postdoctoral researcher on the project and the PI), but be expected to manage their own academic research and administrative activities, within guidelines provided by senior colleagues • Contribute to discussions and share research findings with colleagues in partner institutions, and research groups • Responsible for managing a scientific process and maintaining quality control • Process samples, monitor results and re-run experiments where necessary • Maintain a database, run reports and interpret results • Write up experimental results which would occasionally contribute to small sections (methodology, tables) of publications • Write and review basic operating procedures, and maintain excellent laboratory and data records • Maintain equipment, including washing, sterilisation and disposal, perform quality checks and contribute to the general cleanliness and upkeep of the laboratory space • Keep up to date with and advise on matters relating to Good Laboratory Practice (GLP), Health and Safety, COSHH sheets and other regulations relevant to the post, including compliance with Human Tissue Authority (HTA). • Update and discuss results and project development with the Group Leader and other members of the team • Carry out collaborative projects with colleagues in partner institutions, and research groups • We would encourage active contribution to the development of public engagement resources and activities Department of Paediatrics Job Description 3 Selection criteria Essential 1. Experience of working laboratory environment 2. Educated to at least Bachelor’s degree qualification in science 3. Possess sufficient specialist knowledge in the discipline to work within established research programmes 4. Ability to manage own research and administrative activities 5. Excellent communication skills, including the ability to write text that can be published 6. Experience of following and adapting protocols and selecting appropriate experimental methodologies Desirable 1. Previous laboratory experience as a Research Technician 2. Experience of contributing to reports and articles for publication 3. Experience in one or more of the core molecular biology techniques for the project (molecular biology, multicolour flow cytometry and cell sorting) Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service , and the offer of employment will be subject a successful outcome of this assessment. Department of Paediatrics Job Description 4 The hazards or safety-critical duties involved are as follows: • Working with blood, human products and human tissues • Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory Disclosure and Barring Service check due to access to sensitive personal information • A satisfactory Horus Enhanced Level Screening (ELS) background check due to laboratory access • University security screening (e.g. identity checks) About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Childhood Leukaemia Research Group The Childhood Leukaemia Research Group is led by Anindita Roy, Associate Professor of Paediatric Haematology. The focus of research in this group is to study prenatal B lymphopoiesis in order to understand the origins of childhood leukaemia, in particular infant acute lymphoblastic leukaemia (ALL). The group sits within the Department of Paediatrics at the University of Oxford. The lab is based at the Weatherall Institute of Molecular Medicine in the John Radcliffe Hospital. Department of Paediatrics Job Description 5 The group provide a unique research environment, which integrates normal developmental haematopoiesis and leukaemia research using basic science as well as clinical context. The group collaborates with experts from the WIMM (I Roberts, T Milne, A Mead, B Psaila, S Thongjuea), as well as clinicians (J Bartram, P Ancliff and A Fielding, London; A Moorman, Newcastle; J Bond, Ireland; V Saha, India) to conduct high quality research in this field. More information about the Childhood Leukaemia Research Group may be found at the website: https://www.paediatrics.ox.ac.uk/research/paediatric-leukaemia-research-group MRC Weatherall Institute of Molecular Medicine The MRC Weatherall Institute of Molecular Medicine fosters research in molecular and cell biology with direct application to the study of human disease. Housing around four hundred scientists, we are proud to be at the forefront of an exciting research field impacting on our understanding and treatment of diseases ranging from Cancer to AIDS. The Institute was founded by Professor David Weatherall in 1989. The three main sponsors of research in the Institute are the University of Oxford, The Medical Research Council and Cancer Research UK. Significant funding also comes from the Wellcome Trust and other medical research charities. For more information please visit: http://www.imm.ox.ac.uk/home Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360 + staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Department of Paediatrics Job Description 6 Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ Department of Paediatrics Job Description 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Department of Paediatrics Job Description 8
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John Radcliffe West Wing and Children's Hospital
About the role We have an exciting opportunity to join the Childhood Leukaemia Research Group in the Department of Paediatrics and Molecular Haematology Unit, WIMM as our Research Technician. You will play an important role in the contribution of our lab in understanding the developmental origins of high-risk childhood leukaemia. You will be responsible for planning and conducting your own research, and assisting other members of the group or people working on collaborative projects, as well as working within the team through great communication and organisational skills. You will be working in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. The post-holder will be well supported by an experienced multi-disciplinary research team which includes other postdoctoral researchers and DPhil students in the lab, computational biologists, clinicians, as well as members of collaborating labs. The Childhood Leukaemia Research Group under the lead of Prof Anindita Roy conducts research in developmental haematopoiesis and childhood leukaemia and has successfully characterised human prenatal B lymphopoiesis, and developed a novel model of infant leukaemia using CRISPR-Cas9 gene editing. This position is offered full-time on a fixed-term contract initially for one year with the possibility to extend provided further external funding is available. This role may meet the criteria for a UK Skilled Worker visa. About you You will have a Bachelor’s degree or higher, supplemented by relevant post-qualification experience in a lab-based role, with proven and demonstrable technical skills. You will possess a demonstrable interest in molecular biology. You will have highly effective verbal and written communication skills with all level of staff and an ability to operate effectively in a demanding and stimulating research environment. Application Process You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Anindita Roy, Associate Professor of Paediatric Haematology using the contact details below. Only online applications received before 12.00 midday on Wednesday 1 November will be considered. Interviews will be held as soon as possible thereafter.
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Level 2, Children's Hospital, Headley Way