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comment: We are seeking a Research Assistant to join Prof Matthew Wood’s Group based in the Institute of Development and Regenerative Medicine on the Old Road Campus. The Wood laboratory focuses on developing molecular therapies for disorders of the nervous system and muscle. Our objectives include understanding disease biology, identifying and validating therapeutic targets, and developing gene- based nucleic acid therapeutic platforms. The laboratory uses in vitro and animal models to evaluate these platforms and simultaneously develops advanced delivery technologies to target relevant tissues and cells, such as skeletal muscle, heart, and nervous system. The laboratory has developed novel oligonucleotide and RNA editing therapies for neuromuscular disorders, including Duchenne Muscular Dystrophy (DMD), Myotonic Dystrophy type 1 (DM1), Spinal Muscular Atrophy (SMA) and Spinal and Bulbar Muscular Atrophy (SBMA). The group has also developed extracellular vesicle nanotechnologies for targeted cell delivery and discovered delivery technologies, including peptide and antibody-based technologies. Research in the laboratory also includes studying fundamental RNA biology and developing RNA-based therapeutic agents and novel technologies for their delivery. The role requires the applicant to have a BSc or MSc degree in a relevant science subject, with relevant practical working experience in a laboratory. The applicant should have experience in oligonucleotide synthesis, and be highly motivated and have the ability to communicate effectively with others. Applicants who fulfil the majority of the criteria are encouraged to apply. This role meets the criteria for a UK Skilled Worker visa. This position is offered full-time on a fixed-term contract initially until 31 October 2025. You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of …
contact: Amarjit Bhomra
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notation: 167780
salary: Standard Grade 6: £32,332 - £38,205
further particulars: 167780_Research Assistant_JD.pdf
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comment: We are seeking a Research Assistant to join Prof Matthew Wood’s Group based in the Institute of Development and Regenerative Medicine on the Old Road Campus. The Wood laboratory focuses on developing molecular therapies for disorders of the nervous system and muscle. Our objectives include understanding disease biology, identifying and validating therapeutic targets, and developing gene-based nucleic acid therapeutic platforms. The laboratory uses in vitro and animal models to evaluate these platforms and simultaneously develops advanced delivery technologies to target relevant tissues and cells, such as skeletal muscle, heart, and nervous system. The laboratory has developed novel oligonucleotide and RNA editing therapies for neuromuscular disorders, including Duchenne Muscular Dystrophy (DMD), Myotonic Dystrophy type 1 (DM1), Spinal Muscular Atrophy (SMA) and Spinal and Bulbar Muscular Atrophy (SBMA). The group has also developed extracellular vesicle nanotechnologies for targeted cell delivery and discovered delivery technologies, including peptide and antibody-based technologies. Research in the laboratory also includes studying fundamental RNA biology and developing RNA-based therapeutic agents and novel technologies for their delivery. The role requires the applicant to have a BSc or MSc degree in a relevant science subject, with relevant practical working experience in a laboratory. The applicant should have experience in oligonucleotide synthesis, and be highly motivated and have the ability to communicate effectively with others. Applicants who fulfil the majority of the criteria are encouraged to apply. This role meets the criteria for a UK Skilled Worker visa. This position is offered full-time on a fixed-term contract initially until 31 October 2025. You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of t…
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value: _________________________________________________________________________ Job description and selection criteria Job title Research Assistant Division Medical Sciences Department Paediatrics Institute of Developmental and Regenerative Medicine (IDRM), Location Department of Paediatrics, University of Oxford Grade and salary Grade 6: £32,332 to £38,205 per annum (with a discretionary range to £41,732 per annum) Hours Full time Contract type Fixed-term until 31 October 2025 Reporting to Professor Matthew Wood Vacancy reference 167780 Additional information This role meets the criteria for a UK Skilled Worker visa Research topic Oligonucleotide therapies for neuromuscular diseases Principal Investigator / Professor Matthew Wood supervisor Project team Wood Group Project web site https://www.paediatrics.ox.ac.uk/research/wood-group Funding partner Medical Research Council and LifeArc in partnership with the Nucleic Acid Therapy Accelerator (NATA) Hub The role The NATA Delivery Research Challenge is a major and prestigious programme of funding awarded to the University from the Medical Research Council and LifeArc in partnership with the Nucleic Acid Therapy Accelerator (NATA) Hub. The promise of nucleic acid therapeutics has been demonstrated in the clinic, however their development and widespread use has been hindered by a lack of robust techniques to achieve targeted delivery to specific tissues, improve stability and facilitate uptake into cells, without compromising safety or effectiveness. The Global Oligonucleotide therapy market is currently worth $1 billion and is expected to reach $1.62 billion in 2025 provided the challenges with targeted delivery are resolved. This programme will support an international consortium working to overcome major barriers to safe and effective delivery through the development of novel technologies, platforms and resources, ultimately enabling the potential of these therapies to be fully realised in the treatment of a wide range of …

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