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Research Technician and Laboratory Manager
application opening date: 2023-09-08T09:00:00+01:00
salary: Standard Grade 6: £32,332 - £38,205
organization part: Department of Biochemistry
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spatial: Department of Biochemistry, South Parks Road, Oxford
application closing date: 2023-10-06T12:00:00+01:00
comment: Pay Scale: STANDARD GRADE 6 Salary (£): £32,332 to £38,205 per annum Location: Department of Biochemistry, South Parks Road, Oxford Contract type: Fixed Term Contract up to 6th June 2025 Hours: Full Time (37.5 hours per week) THIS IS A RE-ADVERTISEMENT, PREVIOUS APPLICANTS NEED NOT APPLY About the role We are seeking to appoint a Research Technician and Laboratory Manager to join the lab of Prof Nick Lakin. The research team investigates the molecular basis of DNA repair and how this contributes to maintenance of genome integrity. Our specific interests are in deciphering the role of poly-ADP-ribose polymerases (PARPs) in the detection and signalling of DNA damage and how this promotes DNA repair. We have significant expertise in studying these processes in human cells and model organisms. The Research Technician will manage our eukaryotic cell culture library and other lab stocks in addition to providing experimental support to a variety of projects. Tasks will involve cell-based assays for DNA repair, using genome editing technologies to generate cell lines and recombinant DNA technology. The Research Technician will also act as laboratory manager for the research group, proactively maintaining stocks, equipment and facilities, health and safety protocols, and creating an effective working environment. This full-time fixed-term post is funded by the Medical Research Council up to 6th June 2025 in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. About you You will hold a BSc Degree in an area of molecular and cell biology, genetics or biochemistry. You should have experience of mammalian cell culture, including clonal cell line generation and recombinant protein expression using mammalian expression systems. You will also have experience of employing cell-based assays to assess mechanisms of cell function. Experience in manipulating gene expressi…
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further particulars: Research Technician & Lab Manager Gr 6 JD - Lakin
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comment: **Pay Scale:** STANDARD GRADE 6 **Salary ( £)**: £32,332 to £38,205 per annum **Location: **Department of Biochemistry, South Parks Road, Oxford **Contract type: **Fixed Term Contract up to 6th June 2025 **Hours:** Full Time (37.5 hours per week) **THIS IS A RE-ADVERTISEMENT, PREVIOUS APPLICANTS NEED NOT APPLY** **About the role** We are seeking to appoint a Research Technician and Laboratory Manager to join the lab of Prof Nick Lakin. The research team investigates the molecular basis of DNA repair and how this contributes to maintenance of genome integrity. Our specific interests are in deciphering the role of poly-ADP-ribose polymerases (PARPs) in the detection and signalling of DNA damage and how this promotes DNA repair. We have significant expertise in studying these processes in human cells and model organisms. The Research Technician will manage our eukaryotic cell culture library and other lab stocks in addition to providing experimental support to a variety of projects. Tasks will involve cell-based assays for DNA repair, using genome editing technologies to generate cell lines and recombinant DNA technology. The Research Technician will also act as laboratory manager for the research group, proactively maintaining stocks, equipment and facilities, health and safety protocols, and creating an effective working environment. This full-time fixed-term post is funded by the Medical Research Council up to 6th June 2025 in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. **About you** You will hold a BSc Degree in an area of molecular and cell biology, genetics or biochemistry. You should have experience of mammalian cell culture, including clonal cell line generation and recombinant protein expression using mammalian expression systems. You will also have experience of employing cell- based assays to assess mechanisms of cell function. Experi…

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value: _________________________________________________________________________ DEPARTMENT OF BIOCHEMISTRY Job Description Job title Research Technician and Laboratory Manager Division Medical Sciences Division Department Department of Biochemistry Location Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU Grade and salary Grade 6: £32,332 - £38,205 per annum Hours Full-time (37.5 hours per week) Contract type Fixed Term Contract up to 6th June 2025 Reporting to Professor Nick Lakin Vacancy reference 168026 Additional information You are required to submit a CV and a supporting statement with your application, outlining how you meet each of the selection criteria for the role (see below for details). Your application will not be processed if you do not include both documents Research topic The role of PARPs in DNA repair and genome stability Principal Investigator / supervisor Professor Nick Lakin Project team Lakin Lab Project web site https://www.bioch.ox.ac.uk/research/lakin Funding partner Medical Research Council Recent publications Sharma A.B., Ramlee M.K., Kosmin J., Higgs M.R., Wolstenholme A., Ronson G.E, Jones D., Ebner D., Shamkhi N.F., Sims D., Wijnhoven P.W.G., Forment J., Gibbs-Seymour I. and Lakin N.D. (2023). C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption. Nature Communications. 14:5003; doi: 10.1038/s41467-023-40779-9. Richards F., Llorca-Cardenosa M.J., Langton J., Buch-Larsen S.C., Shamki N.F., Sharma A.B., Nielsen M.L. and Lakin N.D. (2023). Regulation of Rad52-dependent replication fork recovery through serine ADPribosylation of PolD3. Nature Communications. 14:4310; doi: 10.1038/s41467-023-40071-w. Brustel J., Muramoto T., Fumimoto K., Ellins J., Pears C.J. and Lakin N.D. (2022). Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones. Nature Communications. 13:185. DOI: 10.1038/s41467-021-27867-4. Ronson G.E.…

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