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Postdoctoral Research Associate in Cell Biology/Biochemistry
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comment: There is an exciting opportunity for a Postdoctoral Research Associate in Cell Biology/Biochemistry in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) based at the Botnar Research Centre, Oxford. The laboratory of Prof. John Christianson is seeking an exceptional, enthusiastic, and motivated scientist to work on a research project investigating protein degradation mechanisms in cancer. You will join an interdisciplinary team of experimental scientists working in the fields of cell biology and myeloma drug resistance as part of the Oxford Translational Myeloma Centre. In this role, you will be biochemically and functionally characterising ubiquitin ligase complexes in the endoplasmic reticulum (ER), working with both in vitro and cell culture systems. The research project will involve a wide range of basic and advanced molecular/cellular biology and biochemical techniques, including but not limited to; cell culture, genomic manipulation (e.g. CRISPR), mass spectrometry, IP-WB, FACS, protein purification, and radiolabelling. You will have previous laboratory experience, good communication skills, and an ability to work both independently and as part of a team. You will manage your own academic research and administrative activities, while contributing to the dissemination of research group findings by authorship of manuscripts, presentations at meetings, and the group’s website. We are seeking an individual with a PhD/DPhil (or be near completion) in Cell Biology, Molecular Biology, Biochemistry or related discipline. Previous and relevant experience in ubiquitin-proteasome biology, protein quality control, or membrane protein biochemistry is essential. Experience in mass spectrometry with complex samples, ER biology, ER-stress and the UPR, or background in haematological cancer biology, is highly desirable. This is a full-time fixed term (until December 2025) appointment. The closing date for this position is 12 noon on 27/…
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value: _________________________________________________________________________ Job title Postdoctoral Research Associate in Cell Biology/Biochemistry Division Medical Sciences Division Department Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Location NDORMS, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD Grade and salary Grade 7: £36,024 - £44,263 per annum Hours Full time Contract type Fixed-term (until December 2025) Reporting to Professor John Christianson Vacancy reference 168437 Research topic Protein quality control mechanisms in cancer Principal Investigator / Dr. John C Christianson supervisor Funding partner The funds supporting this research project are provided by CRUK The role Prof. Christianson’s research group at the Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, investigates the role that protein quality control mechanisms play in cancer, with their overall aim being to identify novel points of therapeutic intervention. The research focuses primarily on mechanisms of protein degradation via the ubiquitin-proteasome system (UPS). As part of a Cancer Research UK (CRUK) funded project, the group is deciphering the molecular mechanisms of ubiquitin ligase complexes involved in degradation and their role as part of the unfolded protein response to ER stress in cancer, with a long-term goal of identifying small molecules that modulate this process. You will join an interdisciplinary team of experimental scientists from diverse backgrounds working in the fields of cell biology and myeloma drug resistance. The laboratory is part of the Oxford Translational Myeloma Centre. The Centre is a hub for myeloma research groups to collaborate and develop novel therapeutic interventions that improve patient outcome. This post will work closely with academic and industry collaborators at institutions in Oxford, the UK, and abroad to develop strategies that will elucidate mechanisms of …

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