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"""_________________________________________________________________________ Job description and selection criteria Job title Postdoctoral Immunologist – T-cell Specialist Division Medical Sciences Department Paediatrics Location Oxford Vaccine Group Grade and salary Grade 7: £36,024 - £44,263 per annum (with a discretionary range to £48,350 per annum) Hours Full time Contract type Fixed-term until 31 December 2025 Reporting to Professor Teresa Lambe Vacancy reference 168703 Additional information This role meets the criteria for a UK Skilled Worker visa Research topic Cellular immunity post vaccination and in hybrid immunity Principal Investigator Professor Teresa Lambe / supervisor Project team Emerging Pathogens Team Project web site https://www.ovg.ox.ac.uk/team/teresa-lambe Funding partner The funds supporting this research project are provided by the Chinese Academy of Medical Sciences. The role The Emerging Pathogens team, under the direction of Professor Teresa Lambe OBE, and as part of the Oxford Vaccine Group, combines several novel approaches and established platform technologies to maximize the development of vaccines that can prevent disease caused by outbreak pathogens. We design new vaccines and progress them through an iterative process to advance them from bench to bedside with the main focus on safe, rapid translation of efficacious vaccines; as evidenced by the Oxford/AstraZeneca ChAdOx1 nCOV19/ Vaxzevria. Prof Lambe is one of the Principal Investigators overseeing the Oxford/AstraZeneca vaccine programme. This postdoctoral scientist position will play a key role in the Emerging Pathogens Vaccine Group’s on-going work describing immunity post-vaccination and following infection, with a particular focus on mechanistic understanding of correlates of protection. It is clear that cellular immunity plays an important role protecting against severe disease post infection, particularly against COVID-19. We seek an enthusiastic postdoctoral scientist to mechanistically describe and also delineate the function of both the cellular immune response and wider immunity underpinning protection post vaccination/infection. Responsibilities You will: • • • • • • • Adapt existing and develop new scientific techniques and experimental protocols to develop assays for the assessment of T-cell response from COVID-19 vaccines and control samples and when relevant other emerging pathogens Perform assays on peripheral blood mononuclear cell (PBMC) samples and other sample types e.g. mucosal and/or fine needle aspirates from clinical trials Adapt existing and develop new scientific techniques and experimental protocols that may be used for quantification and functional analysis of T-cell responses toward SARS-CoV2 and when relevant other emerging pathogens. Participate in the delivery of detailed immunological studies such as scRNA-seq studies, detailed T cell phenotyping, with HLA typing, Multicolour Flow Cytometry and Intercellular Cytokine Staining and clonal expansion with TCR analysis. Manage your own academic research and administrative activities. This involves small scale project management related to exploring the immunity induced in the context of vaccination and infection, and to co-ordinate multiple aspects of work to meet deadlines, collaborating with external partners as needed Assist with laboratory supervision and training of new students or junior research assistants in the group Be responsible with others for the biological safety of the laboratory Analyse data relating to the work undertaken and perform any other comparable duties as may be required to ensure the efficient running of the laboratory Communication • Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate while participating in, and contributing to, scientific discussions with other members of the research group and collaborators on the project Department of Paediatrics, Postdoctoral Immunologist (T-cell Specialist), Job Description 2 • • • • • • Maintain confidentiality regarding research data when interacting with non-collaborating researchers Communicate results to Professor Lambe, and other members of the OVG team, including at lab meetings Contribute ideas for new research projects in the context of interrogating immunity and correlates of protection studies in humans Develop ideas for generating research income, and present detailed research proposals to the research team Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters Represent the research group at external meetings/seminars, either with other members of the group or alone Education and Training • • • • • Attend appropriate scientific seminars, training opportunities and meetings in the Institute and University Keep detailed and comprehensible records of your work, preparing accurate reports that communicate results clearly and effectively, and ensure that project members are kept up to date with progress and any difficulties encountered. Participate in the education and training of other staff as necessary and appropriate Once trained, the post holder's performance will continue to be monitored to ensure that the required standard of accuracy and efficiency is maintained Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Further Responsibilities • • Act at all times in the interests of the Institute to ensure good laboratory practice Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques • Ensure that work in the laboratory is conducted safely and, in particular, that work is undertaken using appropriate safety procedures and in the dedicated areas Accord due regard to the University Equal Opportunities and Data Protection policies Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year • • Department of Paediatrics, Postdoctoral Immunologist (T-cell Specialist), Job Description 3 Selection criteria Essential • • • • • • • • Hold a relevant PhD/DPhil (or close to completion) in a relevant biological sciences subject A keen interest in immunology of infectious diseases Possess sufficient specialist knowledge in the discipline to design, plan, execute, analyse and present data from wet laboratory immunology experiments using human tissue within our established research programme. Examples of techniques where you will be proficient include ELISA, ELISpot, multiparameter flow cytometry, ICS, AIM assays and single cell/bulk/spatial transcriptomic experiments. Ability to manage own academic research by delivering high-calibre analytical outputs and a high degree of ambition and self-motivation Ability to interpret scientific data, analyse and research complex issues and write factual reports A methodical and careful approach to working in the laboratory Excellent organisational and interpersonal skills including the ability to work closely with others as part of a team, while taking personal responsibility for assigned tasks, and manage multiple projects simultaneously Excellent communication skills, including the ability to present data and represent research objectives at meetings Desirable • • • • Prior experience working to GLP, GCP or equivalent Experience in human immunology/vaccine evaluation Experience in delineation of detailed immunological profiling of cellular immune responses including complex phenotypic profiling, antigenic mapping and clonal analysis Experience in scRNA-Seq analysis . Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Department of Paediatrics, Postdoctoral Immunologist (T-cell Specialist), Job Description 4 Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Working with infectious pathogens (hazard group 2/3) • Working with blood, human products and human tissues • Work with allergens, e.g. laboratory animals, pollen, dust, fish or insects etc. • Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • Enhanced Level Screening as this role includes conducting research involving animals (or working closely with such research). • A satisfactory basic Disclosure and Barring Service check due to the nature of this position. • University security screening (e.g. identity checks) Department of Paediatrics, Postdoctoral Immunologist (T-cell Specialist), Job Description 5 About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Oxford Vaccine Group The Oxford Vaccine Group (OVG) is led by Andrew J Pollard, Professor of Paediatric Infection and Immunity. Staff re based within a purpose-built centre on the Churchill Hospital site and form part of the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM). The aim of OVG is to co-ordinate expertise in the study of microbial diseases and the immune response to microbes, in order to facilitate research on the development and implementation of vaccines. This may include new, improved or combined vaccines for the adult and paediatric population. More information about OVG may be found at the website: http://www.ovg.ox.ac.uk Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. We are committed to Department of Paediatrics, Postdoctoral Immunologist (T-cell Specialist), Job Description 6 inform and inspire external audiences worldwide through our public engagement and outreach activities. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ Department of Paediatrics, Postdoctoral Immunologist (T-cell Specialist), Job Description 7 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting https://staff.web.ox.ac.uk/recruitment-support-faqs advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 8 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 9 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 10 """^^ . . _:N7dc0175d6e224abca2f9f6a59756fea2 . 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This is an exciting opportunity for an experienced and driven individual to join the Emerging Pathogens team under the direction of Professor Teresa Lambe. The postholder will also be part of the Oxford Vaccine Group which is a multi-disciplinary team working across all aspects of vaccine research – this group led the rapid clinical development of vaccines against COVID-19 in the pandemic.

 

The Emerging Pathogens team designs new vaccines and progresses them from bench to bedside.  The successful candidate will be an an enthusiastic postdoctoral scientist who will will play a key role in the Emerging Pathogens Vaccine Group’s on-going work describing immunity post-vaccination and following infection, with a particular focus on mechanistic understanding of correlates of protection.  The postholder should have a relevant PhD (or near completion) and a keen interest in immunology of infectious diseases.  You will be able to design, plan, execute, analyse and present data from wet laboratory immunology experiments using human tissue and be proficient in techniques such as ELISA, ELISpot, multiparameter flow cytometry, ICS, AIM assays and also ideally single cell/bulk/spatial transcriptomic experiments.

 

You must have a high degree of ambition and self-motivation and happy to work in a multi-functional team while managing multiple projects simultaneously.

 

This position is offered full-time on a fixed-term contract until 31 December 2025 with the possibility to extend provided further external funding is available.

 

This role meets the criteria for a UK Skilled Worker visa.

 

To discuss the post in more detail, please contact Teresa Lambe, the Professor of Vaccinology & Immunology, using the contact details below.

 

You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement.

 

Only online applications received before 12.00 midday on Tuesday 21 November 2023 will be considered. Interviews will be held as soon as possible thereafter.
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