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We are looking to appoint a Postdoctoral Researcher/Trial Manager to manage a Wellcome funded clinical trial “FOCUS: Function and Cognition in Early Psychosis, led by Dr Rob McCutcheon. Recently the drug xanomeline-trospium which acts via non-dopaminergic mechanisms has been shown to reduce psychotic symptoms but its effects on cognition are unclear. The FOCUS trial will investigate the effects of xanomeline-trospium on cognitive function in individuals with first episode psychosis. The post is full-time and is based in the Department of Psychiatry at the Warneford Hospital, Oxford. The post is for a fixed term (funded for 12 months) with the possibility of extension. You will have trial management responsibility for the post, including leading ethical approval process, funder reporting, supervision and monitoring of recruitment. Additionally, you will have the opportunity to develop your own research with a focus on cognitive function and treatments for psychosis, including undertaking analyses of neuroimaging measures and cognitive outcomes, the development of clinical services, the conducting of meta- analyses, and the analysis of pre-acquired clinical trial data (depending on your interests and abilities). You will have or be close to the completion of a PhD/DPhil, and have experience managing experimental medicine studies or clinical trials, including recruiting individuals with psychotic disorders to research studies. With excellent communication skills you will have the ability to use initiative to plan and organise complex activities and programmes and manage your own academic research and associated activities. Experience with programming in python, matlab and R would be desirable. You will be required to upload a covering letter/supporting statement and a CV as part of your application. The closing date for this post is 12.00 midday on 10th November 2023
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_________________________________________________________________________ Summary Job title Postdoctoral Researcher/Trial Manager: Psychosis Research Division Medical Sciences Department Psychiatry Location Warneford Hospital Grade and salary Grade 7: £36024-£44263 Hours Full time Contract type Fixed-term (funded for 12 months) Reporting to Dr Rob McCutcheon Vacancy reference 168810 Additional information The role This is an exciting opportunity to manage a Wellcome funded clinical trial “FOCUS: Function and Cognition in Early Psychosis”. Cognitive deficits are a core feature of the early phases of psychosis. All licensed pharmacological treatments for psychosis act by blocking dopaminergic neurotransmission and do not improve these deficits. Recently the drug xanomeline-trospium which acts via non-dopaminergic mechanisms has been shown to reduce psychotic symptoms but its effects on cognition are unclear. The FOCUS trial will investigate the effects of xanomeline-trospium on cognitive function in individuals with first episode psychosis. In addition to being central to the success of the FOCUS clinical trial the post holder will develop their own research with a focus on cognitive function and treatments for psychosis. The post holder will report to Dr Rob McCutcheon and join a group of researchers with wide-ranging expertise and a belief there is an opportunity to make fundamental advances in the treatment of psychotic disorders, thereby improving the outcomes for individuals with psychosis. Depending on their interests and abilities, the post holder will have the opportunity to undertake analyses of neuroimaging measures and cognitive outcomes, the development of clinical services, the conducting of metaanalyses, and the analysis of pre-acquired clinical trial data. This post will be offered on a full-time, fixed term contract for 4 years. Responsibilities • Lead the ethical application process and obtain necessary permissions associated with the study such as R&D and MHRA approval • • • • • • • • • • • Manage recruitment and appointment of other posts within the project Manage reporting to the funder, including periodic and final reports, summaries of progress, resources, and financial statements etc. Supervise and monitor recruitment across sites, developing strategies to increase recruitment rates if needed To train other individuals joining the study on the study protocol and required assessments Manage PR and promotion of the project, both internally and externally, such as organising press releases and any project-related activities and events Manage own academic research and administrative activities, Develop novel analyses of clinical/neuroimaging data Contribute ideas for new research projects and grant applications Collaborate in the preparation of research publications. Present papers at conferences or public meetings. Supervise and advise students and research assistants Selection criteria Essential selection criteria • • • Have or be close to the completion of a PhD/DPhil in a relevant subject. Experience recruiting individuals with psychotic disorders to research studies Ability to use initiative to plan and organise complex activities and programmes and manage own academic research and associated activities Previous experience of managing experimental medicine studies or clinical trials Knowledge of research governance procedures (e.g. obtaining ethical approvals) Ability to contribute ideas for new research projects and research income generation Excellent communication skills, including the ability to form rapport with difficult to engage individuals, write for publication, present research proposals and results, and represent the research group at meetings Willingness to travel to other sites when required • • • • • Desirable selection criteria • Experience with programming in python, matlab, and R . Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Work in clinical areas with direct contact with patients (NOT administrative roles) Postdoctoral Researcher: Psychosis Research 168810 2 Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory enhanced Disclosure and Barring Service check due to regulated activity involving ‘at risk’ adults About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Psychiatry The Department of Psychiatry based on the Warneford Hospital site in Oxford has an international reputation for excellence. The Head of Department is Professor Belinda Lennox. The Department has a substantial research programme, with major funding from Medical Research Council (MRC), Wellcome Trust and National Institute for Health Research (NIHR) and provides highly rated medical training in psychiatry. There are approximately 220 staff including 33 principal investigators leading research groups investigating applying a wide range of approaches from translational neuroscience, experimental medicine, epidemiology, clinical trials and health services research to developmental disorders, mood disorders, cognitive disorders and self-harm and suicide. There are strong links with other departments and institutes both within and outside Oxford: these links ensure that we can apply the best scientific methods to psychiatric and cognitive disorders. The Department has an annual turnover approaching £10 million with more than 130 research grants. For more information please visit: http://www.psych.ox.ac.uk The Department of Psychiatry holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division For more information please visit: https://www.medsci.ox.ac.uk/ How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Postdoctoral Researcher: Psychosis Research 168810 3 Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs Non-technical questions about this job should be addressed to the recruiting department directly at: vacancies@psych.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Postdoctoral Researcher: Psychosis Research 168810 4 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacypolicy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/dataprotection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Postdoctoral Researcher: Psychosis Research 168810 5 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Postdoctoral Researcher: Psychosis Research 168810 6
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We are looking to appoint a Postdoctoral Researcher/Trial Manager to manage a Wellcome funded clinical trial “FOCUS: Function and Cognition in Early Psychosis, led by Dr Rob McCutcheon. Recently the drug xanomeline-trospium which acts via non-dopaminergic mechanisms has been shown to reduce psychotic symptoms but its effects on cognition are unclear. The FOCUS trial will investigate the effects of xanomeline-trospium on cognitive function in individuals with first episode psychosis. The post is full-time and is based in the Department of Psychiatry at the Warneford Hospital, Oxford. The post is for a fixed term (funded for 12 months) with the possibility of extension. You will have trial management responsibility for the post, including leading ethical approval process, funder reporting, supervision and monitoring of recruitment. Additionally, you will have the opportunity to develop your own research with a focus on cognitive function and treatments for psychosis, including undertaking analyses of neuroimaging measures and cognitive outcomes, the development of clinical services, the conducting of meta-analyses, and the analysis of pre-acquired clinical trial data (depending on your interests and abilities). You will have or be close to the completion of a PhD/DPhil, and have experience managing experimental medicine studies or clinical trials, including recruiting individuals with psychotic disorders to research studies. With excellent communication skills you will have the ability to use initiative to plan and organise complex activities and programmes and manage your own academic research and associated activities. Experience with programming in python, matlab and R would be desirable. You will be required to upload a covering letter/supporting statement and a CV as part of your application. The closing date for this post is 12.00 midday on 10th November 2023
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