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Post-doctoral Research Assistant neuronal biologist: “Biomarkers of lysosomal dysfunction in Parkinson’s disease”
comment: Full-time, Fixed-term for 2 years Applications are invited for a post-doctoral neuronal biologist to work on biomarker profiles of lysosomal dysfunction in pre-clinical models of Parkinson’s. The project, funded by the Michael J Fox Foundation and in collaboration with EndLyz, a new company within the Dementia Discovery Fund (DDF) portfolio, represents an exciting opportunity to undertake translational work at the interface between academic research and pharmaceutical target and drug discovery in an exceptional setting. The project will examine metabolomic biomarkers of endolysosomal dysfunction to better understand mechanisms of disease pathology, and to establish how the biomarker profile may change on treatment with potential therapeutic compounds. Duties include design and implementation of experiments; interpretation of data; metabolomic profiling in Parkinson’s transgenic mouse models; biochemistry, immunohistochemistry and molecular neuropathology studies in brain samples from transgenic mice; preparation of data for publication; contribute ideas for new research projects and develop ideas for generating research income; manage own academic research involving small-scale project management and act as a source of information to other members of the group. You will have excellent knowledge and practical experience of working with pre-clinical transgenic models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes. The post is available for two years to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford, OX1 3PT. Informal enquiries may b…
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comment: **Full-time, Fixed-term for 2 years** Applications are invited for a post-doctoral neuronal biologist to work on biomarker profiles of lysosomal dysfunction in pre-clinical models of Parkinson’s. The project, funded by the Michael J Fox Foundation and in collaboration with EndLyz, a new company within the Dementia Discovery Fund (DDF) portfolio, represents an exciting opportunity to undertake translational work at the interface between academic research and pharmaceutical target and drug discovery in an exceptional setting. The project will examine metabolomic biomarkers of endolysosomal dysfunction to better understand mechanisms of disease pathology, and to establish how the biomarker profile may change on treatment with potential therapeutic compounds. Duties include design and implementation of experiments; interpretation of data; metabolomic profiling in Parkinson’s transgenic mouse models; biochemistry, immunohistochemistry and molecular neuropathology studies in brain samples from transgenic mice; preparation of data for publication; contribute ideas for new research projects and develop ideas for generating research income; manage own academic research involving small-scale project management and act as a source of information to other members of the group. You will have excellent knowledge and practical experience of working with pre-clinical transgenic models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes. The post is available for two years to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford, OX1 3PT. Informal enquiries m…
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value: Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job Description and Selection Criteria Job title Post-doctoral Research Assistant neuronal biologist: “Biomarkers of lysosomal dysfunction in Parkinson’s disease” Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3PT Grade and salary Grade 7: £36,024 - £44,263 per annum Hours Full time Contract type Fixed term for 2 years Reporting to Prof Richard Wade-Martins Vacancy reference (AV23049) HRIS: 169118 Research topic Biomarkers of lysosomal dysfunction in Parkinson’s disease Principal Investigator Professor Richard Wade-Martins Project team Project web site Funding partner The Post-doctoral Research Assistant will become part of the Laboratory of Molecular Neurodegeneration, a highly active research group consisting of approximately thirty research scientists, comprising a mix of research fellows, post-doctoral research scientists, DPhil students and research assistants. Group members come from a mix of scientific and medical backgrounds, creating an exciting environment for research. This highly collaborative project offers an opportunity to undertake translation work in an exceptional academic setting. www.dpag.ox.ac.uk/opdc https://www.dpag.ox.ac.uk/research/wade-martins-group This Grade 7 post is a collaborative project funded by Michael J Fox Foundation and in collaboration with EndLyz, a new company within the Dementia Discovery Fund (DDF) portfolio. Recent publications Technical skills Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR and Wade-Martins R. (2023) Post-translational proteomics platform ide…
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