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Postdoctoral Research Associate in electron cryotomography of cell guidance receptors
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comment: **Pay Scale:** STANDARD GRADE 7 **Salary ( £)**: £36,024 - £44,263 per annum **Location:** Department of Biochemistry, South Parks Road, Oxford **Contract type:** Fixed Term Contract for up to 2 years in the first instance **Hours: Full Time** (37.5 hours per week) **THIS IS A RE-ADVERTISEMENT, PREVIOUS APPLICANTS NEED NOT APPLY** **About the role** We are seeking to appoint a Postdoctoral Research Associate to join the lab of Dr Lindsay Baker and be part of MIGRATE, an interdisciplinary collaboration investigating the migration of neurons during development of the brain. This role will use cellular electron cryotomograpy (cryoET) and subvolume averaging, assisted by SPOT DNA tags (Silvester et al., Cell 2021), to understand the arrangement and assembly of guidance molecules on the surface of neuronal cells, working closely with other PDRAs in MIGRATE on advanced imaging and structural biology techniques. This full-time fixed-term post is funded by the Wellcome Trust for up to 2 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. **About you** You will hold a PhD/DPhil or be near completion of a PhD/DPhil in cell biology, structural biology, biophysics or a related discipline. You will have knowledge and experience with cryoEM sample preparation, data collection and processing and have relevant knowledge and experience with mammalian cell culture, aseptic technique and live cell fluorescence microscopy. You will have demonstrated ability to manage your time and planning your own research and associated activities. Excellent oral and written communication skills are expected including the ability to write for publication, present research proposals and represent the research group at meetings. **Application Process** You will be required to upload a supporting statement, setting out how you meet the selection criteria, curriculum vitae and th…
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further particulars: 169913 Research Associate Gr 7 JD - Baker
comment: Pay Scale: STANDARD GRADE 7 Salary (£): £36,024 - £44,263 per annum Location: Department of Biochemistry, South Parks Road, Oxford Contract type: Fixed Term Contract for up to 2 years in the first instance Hours: Full Time (37.5 hours per week) THIS IS A RE-ADVERTISEMENT, PREVIOUS APPLICANTS NEED NOT APPLY About the role We are seeking to appoint a Postdoctoral Research Associate to join the lab of Dr Lindsay Baker and be part of MIGRATE, an interdisciplinary collaboration investigating the migration of neurons during development of the brain. This role will use cellular electron cryotomograpy (cryoET) and subvolume averaging, assisted by SPOT DNA tags (Silvester et al., Cell 2021), to understand the arrangement and assembly of guidance molecules on the surface of neuronal cells, working closely with other PDRAs in MIGRATE on advanced imaging and structural biology techniques. This full-time fixed-term post is funded by the Wellcome Trust for up to 2 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. About you You will hold a PhD/DPhil or be near completion of a PhD/DPhil in cell biology, structural biology, biophysics or a related discipline. You will have knowledge and experience with cryoEM sample preparation, data collection and processing and have relevant knowledge and experience with mammalian cell culture, aseptic technique and live cell fluorescence microscopy. You will have demonstrated ability to manage your time and planning your own research and associated activities. Excellent oral and written communication skills are expected including the ability to write for publication, present research proposals and represent the research group at meetings. Application Process You will be required to upload a supporting statement, setting out how you meet the selection criteria, curriculum vitae and the names and contact details of two re…

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value: ____________________________________________________________________________ DEPARTMENT OF BIOCHEMISTRY Summary Job title Postdoctoral Research Associate in electron cryotomography of cell guidance receptors Division Medical Sciences Department Department of Biochemistry Location Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford Grade and salary Grade 7: £36,024 - £44,263 per annum Hours Full time (37.5 hours per week) Contract type Fixed Term Contract for up to 2 years in the first instance Reporting to Dr Lindsay Baker Vacancy reference 169913 Additional information You are required to submit a CV and a supporting statement with your application, outlining how you meet each of the selection criteria for the role (see below for details). Your application will not be processed if you do not include both documents. Research topic Structural mechanisms in cortical migration Principal Investigator / supervisor Dr Lindsay Baker Project web site https://migrate.web.ox.ac.uk Funding partner The funds supporting this research project are provided by the Wellcome Trust Recent publications 1. Silvester E, Vollmer B, Pražák V, Vasishtan D, Machala EA, Whittle C, Black S, Bath J, Turberfield AJ, Grünewald K, and Baker LA (2021) DNA origami signposts for identifying proteins on cell membranes by electron cryotomography. Cell. 184: 1110-1121.e16 2. 3. Del Toro D, Carrasquero-Ordaz MA, Chu A, Ruff T, Shahin M, Jackson VA, Chavent M, Berbeira-Santana M, Seyit-Bremer G, Brignani S, Kaufmann R, Lowe E, et al (2020) Structural basis of Teneurin-Latrophilin interaction in repulsive guidance of migrating neurons. Cell. 180:323 - 339.e19 Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, et al. (2022) GPC3-Unc5 receptor complex structure and role in cell migration. Cell. 185:3931-3949.e26 The role Reporting to Dr. Lindsay Baker, the Principal Investigator, the post holder …

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