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169913 Research Associate Gr 7 JD - Baker
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**Pay Scale:** STANDARD GRADE 7 **Salary ( £)**: £36,024 - £44,263 per annum **Location:** Department of Biochemistry, South Parks Road, Oxford **Contract type:** Fixed Term Contract for up to 2 years in the first instance **Hours: Full Time** (37.5 hours per week) **THIS IS A RE-ADVERTISEMENT, PREVIOUS APPLICANTS NEED NOT APPLY** **About the role** We are seeking to appoint a Postdoctoral Research Associate to join the lab of Dr Lindsay Baker and be part of MIGRATE, an interdisciplinary collaboration investigating the migration of neurons during development of the brain. This role will use cellular electron cryotomograpy (cryoET) and subvolume averaging, assisted by SPOT DNA tags (Silvester et al., Cell 2021), to understand the arrangement and assembly of guidance molecules on the surface of neuronal cells, working closely with other PDRAs in MIGRATE on advanced imaging and structural biology techniques. This full-time fixed-term post is funded by the Wellcome Trust for up to 2 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. **About you** You will hold a PhD/DPhil or be near completion of a PhD/DPhil in cell biology, structural biology, biophysics or a related discipline. You will have knowledge and experience with cryoEM sample preparation, data collection and processing and have relevant knowledge and experience with mammalian cell culture, aseptic technique and live cell fluorescence microscopy. You will have demonstrated ability to manage your time and planning your own research and associated activities. Excellent oral and written communication skills are expected including the ability to write for publication, present research proposals and represent the research group at meetings. **Application Process** You will be required to upload a supporting statement, setting out how you meet the selection criteria, curriculum vitae and the names and contact details of two referees as part of your online Only applications received before **12 noon** on **Monday 8th January 2024** can be considered. **Committed to equality and valuing diversity**
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____________________________________________________________________________ DEPARTMENT OF BIOCHEMISTRY Summary Job title Postdoctoral Research Associate in electron cryotomography of cell guidance receptors Division Medical Sciences Department Department of Biochemistry Location Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford Grade and salary Grade 7: £36,024 - £44,263 per annum Hours Full time (37.5 hours per week) Contract type Fixed Term Contract for up to 2 years in the first instance Reporting to Dr Lindsay Baker Vacancy reference 169913 Additional information You are required to submit a CV and a supporting statement with your application, outlining how you meet each of the selection criteria for the role (see below for details). Your application will not be processed if you do not include both documents. Research topic Structural mechanisms in cortical migration Principal Investigator / supervisor Dr Lindsay Baker Project web site https://migrate.web.ox.ac.uk Funding partner The funds supporting this research project are provided by the Wellcome Trust Recent publications 1. Silvester E, Vollmer B, Pražák V, Vasishtan D, Machala EA, Whittle C, Black S, Bath J, Turberfield AJ, Grünewald K, and Baker LA (2021) DNA origami signposts for identifying proteins on cell membranes by electron cryotomography. Cell. 184: 1110-1121.e16 2. 3. Del Toro D, Carrasquero-Ordaz MA, Chu A, Ruff T, Shahin M, Jackson VA, Chavent M, Berbeira-Santana M, Seyit-Bremer G, Brignani S, Kaufmann R, Lowe E, et al (2020) Structural basis of Teneurin-Latrophilin interaction in repulsive guidance of migrating neurons. Cell. 180:323 - 339.e19 Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, et al. (2022) GPC3-Unc5 receptor complex structure and role in cell migration. Cell. 185:3931-3949.e26 The role Reporting to Dr. Lindsay Baker, the Principal Investigator, the post holder will be a member of a research group primarily using cellular electron cryotomography (cryoET) and part of MIGRATE, an international, interdisciplinary collaboration investigating the migration of neurons during development of the brain. The post holder will use cellular cryoET and subvolume averaging, assisted by SPOT DNA tags (Silvester et al., Cell 2021), to understand the arrangement and assembly of guidance molecules on the surface of neuronal cells, working closely with other PDRAs in MIGRATE on advanced imaging and structural biology techniques. The post holder will also have the opportunity to help supervise and provide guidance to less experienced members of the research group, including postdocs, research assistants, technicians, and PhD and project students. Responsibilities  Manage own academic research and administrative activities, including small scale project management, to co-ordinate multiple aspects of work to meet deadlines  Adapt existing and develop new scientific techniques and experimental and computational protocols  Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate  Contribute ideas for new research projects, including for generating research income  Collaborate in the preparation of scientific reports and journal articles  Conduct cell biology, fluorescence microscopy and electron microscopy experiments, keeping excellent detailed electronic records  Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques  Represent the research group and MIGRATE team at external meetings/seminars, either with other members of the group/team or alone  Carry out collaborative projects with colleagues in partner institutions and research groups  Embed the principles of mutual respect, equality, diversity, inclusivity and sustainability in all aspects of your work; undertake training as and when asked to do so. 168709 Research Associate Gr 7 JD - Baker 2 Selection criteria Essential selection criteria 1. Hold a PhD/DPhil, or be near completion of a PhD/DPhil in cell biology, structural biology, biophysics or a related discipline. 2. Knowledge and experience with cryoEM sample preparation, data collection and processing 3. Relevant knowledge and experience with mammalian cell culture, aseptic technique, and live cell fluorescence microscopy 4. Demonstrated ability to manage their time, planning their own research and associated activities 5. Excellent oral and written communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings Desirable selection criteria 1. Experience with cryoET or culturing primary neurons 2. Experience of independently managing a discrete area within a collaborative research project Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:  Lone Working  Work with any substance which has any of the following pictograms on their MSDS: 168709 Research Associate Gr 7 JD - Baker 3 About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Biochemistry The Department of Biochemistry in Oxford was established in 1920 and is now one of the largest in Europe. Situated in an attractive area close to the University Parks and River Cherwell, the Department is housed in the University Science Area and is currently undergoing a major expansion programme centred on the recently completed and award-winning New Biochemistry Building. The Science Area includes the Radcliffe Science Library and the Natural History Museum, and is conveniently located for easy access to the town centre and colleges. The department includes research laboratories working in the areas of Cell Biology, Development and Genetics; Chromosomal and RNA Biology; Infection and Disease Processes; Microbiology and Systems Biology; and Structural Biology and Molecular Biophysics. It is particularly well equipped with an extensive computer network, all the basic hardware essential in today's research, together with an excellent range of state-of-the-art specialist equipment. For more information please visit: http://www.bioch.ox.ac.uk/ The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Bronze Athena SWAN award. The Department of Biochemistry is strongly committed to equality and valuing diversity and we operate a flexible working policy for all staff. The Department holds a departmental Silver Athena SWAN award to recognise advancement of gender equality: representation, progression and success for all. 168709 Research Associate Gr 7 JD - Baker 4 Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. It includes 15 clinical departments and 5 non-clinical departments. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.ox.ac.uk/divisions/medical_sciences.html How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs Non-technical questions about this job should be addressed to the recruiting department directly, please email jobs@bioch.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 168709 Research Associate Gr 7 JD - Baker 5 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. The University’s Policy on Information Security Awareness The information security awareness training is compulsory for all University staff; and as part of our responsibility as a Department, ALL employees of the Department will be required to complete the online information security awareness module, which provides a combination of information, case studies and links to additional resources relating to information security. You will be expected to complete this course as part of your induction process, on your first day working in the Department of Biochemistry. This training will also need to be completed in order to successfully complete your probationary period. In order to ensure that we are compliant and up-to-date with the information security awareness training, we need to ensure that all staff members have completed the latest course, which may be accessed from the Information Security’s website by using the following link: https://www.infosec.ox.ac.uk/guidance-policy/training-and-awareness You will also be required to undertake this course on an annual basis, in order to satisfy the security awareness training requirements of the University’s Information Security Policy. 168709 Research Associate Gr 7 JD - Baker 6 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Oxford Research Staff Society (OxRSS) A society run by and for Oxford University research staff. It offers researchers a range of social and professional networking opportunities. Membership is free, and all researchers employed by Oxford University are welcome to join. Subscribe at researchstaff-subscribe@maillist.ox.ac.uk to join the mailing list to find out about upcoming events and other information for researchers, or contact the committee on committee@oxrss.ox.ac.uk. For more information, see www.ox.ac.uk/oxrss, Twitter @ResStaffOxford, and Facebook www.facebook.com/oxrss. 168709 Research Associate Gr 7 JD - Baker 7
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Description of Postdoctoral Research Associate in electron cryotomography of cell guidance receptors
Pay Scale: STANDARD GRADE 7 Salary (£): £36,024 - £44,263 per annum Location: Department of Biochemistry, South Parks Road, Oxford Contract type: Fixed Term Contract for up to 2 years in the first instance Hours: Full Time (37.5 hours per week) THIS IS A RE-ADVERTISEMENT, PREVIOUS APPLICANTS NEED NOT APPLY About the role We are seeking to appoint a Postdoctoral Research Associate to join the lab of Dr Lindsay Baker and be part of MIGRATE, an interdisciplinary collaboration investigating the migration of neurons during development of the brain. This role will use cellular electron cryotomograpy (cryoET) and subvolume averaging, assisted by SPOT DNA tags (Silvester et al., Cell 2021), to understand the arrangement and assembly of guidance molecules on the surface of neuronal cells, working closely with other PDRAs in MIGRATE on advanced imaging and structural biology techniques. This full-time fixed-term post is funded by the Wellcome Trust for up to 2 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. About you You will hold a PhD/DPhil or be near completion of a PhD/DPhil in cell biology, structural biology, biophysics or a related discipline. You will have knowledge and experience with cryoEM sample preparation, data collection and processing and have relevant knowledge and experience with mammalian cell culture, aseptic technique and live cell fluorescence microscopy. You will have demonstrated ability to manage your time and planning your own research and associated activities. Excellent oral and written communication skills are expected including the ability to write for publication, present research proposals and represent the research group at meetings. Application Process You will be required to upload a supporting statement, setting out how you meet the selection criteria, curriculum vitae and the names and contact details of two referees as part of your online Only applications received before 12 noon on Monday 8th January 2024 can be considered. Committed to equality and valuing diversity
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