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Postdoctoral Research Scientist in Pre-clinical MRI Methods
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application opening date: 2024-01-15T09:00:00+00:00
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organization part: Nuffield Department of Clinical Neurosciences
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comment: We are looking for a **Postdoctoral Research Scientist in Pre-clinical MRI Methods** to join the MRI Physics group at the Wellcome Centre for Integrative Neuroimaging (WIN, formerly FMRIB), NDCN. We have recently launched a research programme aiming to translate population imaging studies like the UK Biobank into the broader environment of basic and clinical neuroscience. We are now seeking someone to lead the pre-clincial (rodent) arm of this research programme. The postholder will use rodent models to identify and interpret the cellular features that drive MRI signals. We will perform measurements in mice to identify the biological sources of MR-visible cellular “compartments”. For this, we will use sophisticated multi-dimensional quantitative MRI techniques alongside the acquisition of multiple histological immunostains in rodent tissue samples. These experiments, which aim to confer neurobiological meaning to the identified compartments, will be done in a range of mouse models with specific alterations to cellular features of interest (e.g., myelin). These experiments will align to and be integrated with similar human experiments from our broader research programme. This will enable us: (i) to provide biophysically informed methods for “harmonising” human data in the UK Biobank to new settings, (ii) to precisely prediction how microstructural alterations alter MRI signals, and (iii) to design imaging protocols that are maximally sensitive to specific pathology. The post holder will be expected to take an independent and proactive role in managing the research process, maintaining and setting up collaborations, and generating new research and grant opportunities. They will be responsible for supervising students and research assistants, both in relation to the postholder’s research project and related projects. The successful candidate will hold a PhD/DPhil in Engineering, Physics or related subject. They will also have experience with MRI experimental techniques…
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spatial: Nuffield Department of Clinical Neurosciences (NDCN), WIN@FMRIB, John Radcliffe Hospital, Oxford, OX3 9DU
comment: We are looking for a Postdoctoral Research Scientist in Pre-clinical MRI Methods to join the MRI Physics group at the Wellcome Centre for Integrative Neuroimaging (WIN, formerly FMRIB), NDCN. We have recently launched a research programme aiming to translate population imaging studies like the UK Biobank into the broader environment of basic and clinical neuroscience. We are now seeking someone to lead the pre-clincial (rodent) arm of this research programme. The postholder will use rodent models to identify and interpret the cellular features that drive MRI signals. We will perform measurements in mice to identify the biological sources of MR-visible cellular “compartments”. For this, we will use sophisticated multi-dimensional quantitative MRI techniques alongside the acquisition of multiple histological immunostains in rodent tissue samples. These experiments, which aim to confer neurobiological meaning to the identified compartments, will be done in a range of mouse models with specific alterations to cellular features of interest (e.g., myelin). These experiments will align to and be integrated with similar human experiments from our broader research programme. This will enable us: (i) to provide biophysically informed methods for “harmonising” human data in the UK Biobank to new settings, (ii) to precisely prediction how microstructural alterations alter MRI signals, and (iii) to design imaging protocols that are maximally sensitive to specific pathology. The post holder will be expected to take an independent and proactive role in managing the research process, maintaining and setting up collaborations, and generating new research and grant opportunities. They will be responsible for supervising students and research assistants, both in relation to the postholder’s research project and related projects. The successful candidate will hold a PhD/DPhil in Engineering, Physics or related subject. They will also have experience with MRI experimental techniques for…

Job Description
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value: West Wing, Level 6, John Radcliffe Hospital, Oxford, OX3 9DU Web: www.ndcn.ox.ac.uk | Tel: +44(0)1865 234702 | Email: recruitment@ndcn.ox.ac.uk Job title Postdoctoral Research Scientist in Pre-clinical MRI Methods Division Medical Sciences Division Department Nuffield Department of Clinical Neurosciences (NDCN) Location WIN@FMRIB, John Radcliffe Hospital, Oxford, OX3 9DU Grade 8: £45,585 - £54,395 per annum Grade and salary A less experienced candidate may be appointed at Grade 7 (£36,024 – £44,263 per annum), with a commensurate adjustment in either the essential criteria, responsibilities or duties. Hours Full time Contract type Fixed term for 3 years Reporting to Prof. Karla Miller Vacancy reference 170423 Research topic Quantitative MRI and histology in rodent brain Principal Investigator / supervisor Prof. Karla Miller Project team WIN Physics Group Lab website (research and members): https://www.win.ox.ac.uk/research/physics-research Project web site Funding partner Lab handbook (ethos and commitment): https://www.win.ox.ac.uk/files/research-groups/physics-group-labhandbook.pdf The funds supporting this research project are provided by the Wellcome Trust MRI-Histology: Recent publications Howard…Jbabdi*, Miller* (2023). The BigMac dataset: An open resource combining multi-contrast MRI an microscopy in the macaque brain. Nature Communications, 14:4320. Huszar… Miller*, Jenkinson* (2023). Tensor Image Registration Library: Deformable registration of stand-alone histology images to whole-brain post-mortem MRI data. NeuroImage, 265:119792. Smart et al (2023). An optimised tissue processing and para n embedding protocols for mouse brains following ex vivo MR. In press, STAR Protocols. Kor …Miller*, Howard* (2022). An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons. NeuroImage, 264:119726. Tendler…Jbabdi*,Mars*,Miller* (2022). The Digital Brain Bank, an open access platform for post-mortem datas…

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