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About the role We have an exciting opportunity to join the Berrens group in the Department of Paediatrics as our Senior Research Associate. You will play an important role in the contribution of understanding the role of Transposable element in cell fate decision. You will be responsible for developing and running a project to develop novel tools to address the role of locus-specific transposable element expression using mouse embryonic stem cells with advanced CRISPR based targeting technologies. You will be working in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. The Berrens group under the lead of Rebecca Berrens conducts research in Transposable elements and successfully developed a novel single cell long read RNA-sequencing method to study Transposable elements in cell fate choices. This position is offered full-time on a fixed-term contract initially for August 2024 for 8 years with the possibility to extend provided further external funding is available. About you You will have a Hold a DPhil Degree in Biochemistry, Molecular Biology or Genetics, supplemented by relevant post-qualification with experience in molecular and cellular biology focusing on gene regulation and epigenetics. You will possess research skills with the ability to manage your own project and extensive supervision skills to support the Berrens lab and their DPhil students. You will have highly effective verbal and written communication skills with all level of staff staff and an ability to operate effectively in a demanding research environment. Application Process You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Rebecca Berrens the Senior Research Associate job using the contact details below. Only online applications received before 12.00 midday on 20/02/2024 will be considered. Interviews will be held as soon as possible thereafter.
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_________________________________________________________________________ Job description and selection criteria Job title Senior Research Associate Division Medical Sciences Department Paediatrics Location Department of Paediatrics, Berrens Group, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford Grade and salary Grade 8: £45,585 - £54,395 per annum Hours Full time Contract type Fixed Term (8 Years) Reporting to Dr Rebecca Berrens (Principal Investigator) Vacancy reference 170538 Research topic Transposable elements in development Principal Investigator / Rebecca Berrens supervisor Project team Berrens lab Project web site https://www.paediatrics.ox.ac.uk/research/transposon-group Funding partner The funds supporting this research project are provided by Wellcome Trust The role Applications are invited for a senior research associate post, to join a team working with Dr. Rebecca Berrens at the newly established Institute, IDRM, Oxford. The post holder reports to the principal investigator Rebecca Berrens and is a member of a research group with responsibility for the provision of research support for understanding the role of transposable elements in cell fate choices. The post holder provides advice and guidance to research students where appropriate. We are looking for a talented and enthusiastic researcher to join our team and to work to develop and adapt technologies like single-cell long read transcriptomics and genome-editing approaches. The postholder will work on mouse embryonic stem cells as well as models of cellular differentiation and will be involved in the continued effort of adapting these state-of-the-art technologies to interrogate the role of Transposable elements in cell fate decision. The post is ideally suited for a candidate with an interest in working at the interface of Epigenetics, stem cell biology, developmental biology and regenerative medicine. Responsibilities • • • • • • • • • • • • • • • Develop research questions within a specific context, conduct individual research, analysing detailed and complex qualitative and/or quantitative data from a variety of sources, and generate original ideas by building on existing concepts Develop, establish, and pursue appropriate analytical protocols and techniques to support research Advise and supervise laboratory staff on a day-to-day basis Regularly write research articles at a national level for peer-reviewed journals, book chapters, and reviews. Present papers at national conferences, and lead seminars to disseminate research findings Agree clear task objectives, organise, and delegate work to other members of the team and coach other members of the group on specialist methodologies or procedures Manage own area of a larger research budget Share responsibility for shaping the research group’s plans and the writing of group-funding applications for new research projects Carry out collaborative projects with colleagues in partner institutions, and research groups Use scientific equipment in a laboratory environment Identify, define and plan new projects which contribute to the overall aims of studies Conduct detailed analysis of datasets Develop novel methodologies for analysis and data collection in collaboration with members of the research team Identify and troubleshoot technical or scientific problems, working collaboratively with database experts and scientific programmers Attend scientific seminars, meetings and to contribute to presentations or other means of disseminating results as appropriate Represent the research group at external meetings/seminars, either with other members of the group or alone Department of Paediatrics, Senior Research Associate, Job Description 2 Selection criteria Essential • • • • • • • • • • • Hold a relevant Ph.D/D.Phil with post-qualification research experience in molecular and cellular biology Strong publication record and familiarity with the existing literature and research in the field of stem cells, epigenetics and gene regulation. Possess sufficient specialist knowledge in the discipline to develop research projects and methodologies with in-depth knowledge in cell biology with focus on mammalian cell culture including mouse embryonic stem cells, trophoblast stem cells, and fibroblasts as well as ability to differentiate mouse embryonic stem cells into neuronal precursor cell and embryoid bodies. Possess extensive knowledge of conventional gene targeting strategies as well as CRISPR-Cas9 technology to generate knockout, knock-in and degron cell lines. Familiarity with Tet-ON, Cre recombinase and degron systems including advanced characterisation of clones by western blot, qPCR and PCR. Advanced expertise in molecular biology ranging from a range of cloning techniques (i.e restriction enzyme cloning, ligation independent cloning to Gibson assembly) to next generation sequencing library preparation for RNA-seq, calibrated native ChIP-seq and CUT&RUN experiments. Experience in imaging using RNA-FISH, live cell imaging as well as Fluorescence Recovery After Photobleaching (FRAP) assays. Expertise in data analysis from alignment to filtering to plotting in R and linux command lines, with focus on next generation sequencing data such as ChIP-seq, RNA-seq experiments. Ability to independently plan and manage a research project including a research budget Ability to communicate data from the group and represent the group at national and international meetings in oral or poster presentations alone or as part of a team to foster and develop novel collaborations and broaden the reach of the groups research quest Ability to supervise students of different levels and to support them in their projects. Ability to support the development of new research projects and raise research funds through supporting grant applications Desirable • • • Experience of supervising staff with focus on DPhil and Master students Experience in running and organising a seminar series Experience of managing a research budget and contributing to grant proposals Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. . If you have previously worked for the University we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that Department of Paediatrics, Senior Research Associate, Job Description 3 you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Lone Working • Work in hot or cold environments • Regular manual handling • Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory basic Disclosure and Barring Service check due to working with highly sensitive data. • University security screening (e.g. identity checks) About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Paediatrics, Senior Research Associate, Job Description 4 Berrens Group The Berrens group is interested in the functional role of transposable elements in cell fate decision during early development and in cellular regeneration. The role of transposable elements (TEs) in gene regulation during cell fate decision has largely remained elusive. Most TEs have lost their ability to insert additional copies into new genomic locations, however TEs make up 50% of the mammalian genome and harbour regulatory elements that can affect gene expression. Consequently, TEs are kept transcriptionally silent in most somatic cells by epigenetic modifications (Berrens et al., Cell Stem Cell, 2017). But these modifications are lifted during cell fate decision, hence TEs are expressed. Despite progress in our understanding of TE expression, a systematic analysis of the role of locus-specific TE expression during cell fate decision has yet to be performed. Moreover, potential patterns of altered TE expression in disease states are yet to be investigated. We aim to interrogate the role of transposable elements in cell fate decision by combining CELLO-seq (Berrens et al., Nature Biotechnology, 2022) - our novel single cell long read sequencing technology - with state-of-the-art gene editing technologies. Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. We are committed to inform and inspire external audiences worldwide through our public engagement and outreach activities. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ Department of Paediatrics, Senior Research Associate, Job Description 5 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert and recruitment@paediatrics.ox.ac.uk if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical https://staff.web.ox.ac.uk/recruitment-support-faqs troubleshooting advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 6 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Oxford Research Staff Society (OxRSS) A society run by and for Oxford University research staff. It offers researchers a range of social and professional networking opportunities. Membership is free, and all researchers employed by Oxford University are welcome to join. Subscribe at researchstaff-subscribe@maillist.ox.ac.uk to join the mailing list to find out about upcoming events and other information for researchers, or contact the committee on committee@oxrss.ox.ac.uk. For more information, see www.ox.ac.uk/oxrss, Twitter/ X @ResStaffOxford, and Facebook www.facebook.com/oxrss. 8
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NTriples description of Senior Postdoctoral Research Associate
**About the role** We have an exciting opportunity to join the Berrens group in the Department of Paediatrics as our Senior Research Associate. You will play an important role in the contribution of understanding the role of Transposable element in cell fate decision. You will be responsible for developing and running a project to develop novel tools to address the role of locus-specific transposable element expression using mouse embryonic stem cells with advanced CRISPR based targeting technologies. You will be working in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. The Berrens group under the lead of Rebecca Berrens conducts research in Transposable elements and successfully developed a novel single cell long read RNA-sequencing method to study Transposable elements in cell fate choices. This position is offered full-time on a fixed-term contract initially for August 2024 for 8 years with the possibility to extend provided further external funding is available. **About you** You will have a Hold a DPhil Degree in Biochemistry, Molecular Biology or Genetics, supplemented by relevant post-qualification with experience in molecular and cellular biology focusing on gene regulation and epigenetics. You will possess research skills with the ability to manage your own project and extensive supervision skills to support the Berrens lab and their DPhil students. You will have highly effective verbal and written communication skills with all level of staff staff and an ability to operate effectively in a demanding research environment. **Application Process** You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Rebecca Berrens the Senior Research Associate job using the contact details below. Only online applications received before 12.00 midday on 20/02/2024 will be considered. Interviews will be held as soon as possible thereafter.
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Standard Grade 8: 45,585 - 54,395 per annum
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