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Postdoctoral Research Assistant - Peptide loading requirements and structural analysis of HLA-E
application opening date: 2024-02-07T09:00:00+00:00
salary: Grade 7: Salary in range £36,024 - £44,263 per annum
subject: research
further particulars: 170977 - Postdoctoral Research Assistant - JD
comment: A Postdoctoral Research Scientist is required to join the Gillespie Group, at the Oxford Centre for Immuno-Oncology, Nuffield Department of Medicine. The aim of this project is to elucidate how peptides are loaded onto HLA-E and how this subsequently affects HLA-E structure and function. You will be working collaboratively alongside an existing team to support new studies centred on HLA-E, and managing your own academic research and administrative activities involving small scale project management once initial training is completed. In this role, it is important to ensure research is performed safely, legally and to the highest possible standards. You will establish and maintain a good understanding of the research field by reading key reviews and research articles, and you will collaborate in the preparation of scientific reports and journal articles (by data provision or drafting sections of text) if required. Additionally, you will act as a source of information and advice to other members of the group on scientific protocols and experimental techniques, supervising and training new staff in laboratory techniques, if required. It is essential that you hold a PhD/DPhil (or close to completion) in Biochemistry, Chemistry, Biophysics in molecular immunology. You will have prior experience working on major histocompatibility complex (MHC) proteins, and basic molecular biology techniques including PCR, cloning, mutagenesis and sequencing. It is essential you have experience in protein production using prokaryotic or eukaryotic expression platforms and purification using FPLC systems. Mass spectrometry experience (e.g. Hydrogen-Deuterium Exchange (HDX- MS) and/or MHC immunopeptideomics) is required for this role. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using exam…
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spatial: Oxford Centre for Immuno-Oncology, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ
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comment: A Postdoctoral Research Scientist is required to join the Gillespie Group, at the Oxford Centre for Immuno-Oncology, Nuffield Department of Medicine. The aim of this project is to elucidate how peptides are loaded onto HLA-E and how this subsequently affects HLA-E structure and function. You will be working collaboratively alongside an existing team to support new studies centred on HLA-E, and managing your own academic research and administrative activities involving small scale project management once initial training is completed. In this role, it is important to ensure research is performed safely, legally and to the highest possible standards. You will establish and maintain a good understanding of the research field by reading key reviews and research articles, and you will collaborate in the preparation of scientific reports and journal articles (by data provision or drafting sections of text) if required. Additionally, you will act as a source of information and advice to other members of the group on scientific protocols and experimental techniques, supervising and training new staff in laboratory techniques, if required. It is essential that you hold a PhD/DPhil (or close to completion) in Biochemistry, Chemistry, Biophysics in molecular immunology. You will have prior experience working on major histocompatibility complex (MHC) proteins, and basic molecular biology techniques including PCR, cloning, mutagenesis and sequencing. It is essential you have experience in protein production using prokaryotic or eukaryotic expression platforms and purification using FPLC systems. Mass spectrometry experience (e.g. Hydrogen-Deuterium Exchange (HDX-MS) and/or MHC immunopeptideomics) is required for this role. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examp…
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170977 - Postdoctoral Research Assistant - JD
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value: Job title Postdoctoral Research Assistant - Peptide loading requirements and structural analysis of HLA-E Division Medical Sciences Department Nuffield Department of Medicine Location Oxford Centre for Immuno-Oncology, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ Grade and salary Grade 7: Salary in range £36,024 - £44,263 per annum Hours Full time Contract type Fixed-term contract until 31 August 2028 Funding is provided by the Wellcome Trust Reporting to Geraldine Gillespie, Principle Investigator Vacancy reference 170977 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent Visa under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic HLA-E and immune function Principal Investigator / supervisor Prof Geraldine Gillespie (with Profs A McMichael and T Elliott) Funding partner The funds supporting this research project are provided by the Wellcome Trust University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk The role We are interested in therapeutic or vaccination strategies that involve the targeting of peptide epitopes restricted by HLA-E, especially in the field of cancer. The aim of this project is to elucidate how peptides are loaded onto HLA-E and how this subsequently affects HLA-E structure and function. We are seeking a highly motivated Postdoctoral Research Scientist with relevant experience in biochem…

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