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Grade 7: Salary in range £36,024 - £44,263 per annum
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A Postdoctoral Research Scientist is required to join the Gillespie Group, at the Oxford Centre for Immuno-Oncology, Nuffield Department of Medicine. The aim of this project is to elucidate how peptides are loaded onto HLA-E and how this subsequently affects HLA-E structure and function. You will be working collaboratively alongside an existing team to support new studies centred on HLA-E, and managing your own academic research and administrative activities involving small scale project management once initial training is completed. In this role, it is important to ensure research is performed safely, legally and to the highest possible standards. You will establish and maintain a good understanding of the research field by reading key reviews and research articles, and you will collaborate in the preparation of scientific reports and journal articles (by data provision or drafting sections of text) if required. Additionally, you will act as a source of information and advice to other members of the group on scientific protocols and experimental techniques, supervising and training new staff in laboratory techniques, if required. It is essential that you hold a PhD/DPhil (or close to completion) in Biochemistry, Chemistry, Biophysics in molecular immunology. You will have prior experience working on major histocompatibility complex (MHC) proteins, and basic molecular biology techniques including PCR, cloning, mutagenesis and sequencing. It is essential you have experience in protein production using prokaryotic or eukaryotic expression platforms and purification using FPLC systems. Mass spectrometry experience (e.g. Hydrogen-Deuterium Exchange (HDX- MS) and/or MHC immunopeptideomics) is required for this role. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 August 2028 and is funded by the Wellcome Trust. Only applications received before 12 midday on 13 March 2024 will be considered. Please quote **170977** on all correspondence.
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Oxford Centre for Immuno-Oncology, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ
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Job title Postdoctoral Research Assistant - Peptide loading requirements and structural analysis of HLA-E Division Medical Sciences Department Nuffield Department of Medicine Location Oxford Centre for Immuno-Oncology, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ Grade and salary Grade 7: Salary in range £36,024 - £44,263 per annum Hours Full time Contract type Fixed-term contract until 31 August 2028 Funding is provided by the Wellcome Trust Reporting to Geraldine Gillespie, Principle Investigator Vacancy reference 170977 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent Visa under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic HLA-E and immune function Principal Investigator / supervisor Prof Geraldine Gillespie (with Profs A McMichael and T Elliott) Funding partner The funds supporting this research project are provided by the Wellcome Trust University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk The role We are interested in therapeutic or vaccination strategies that involve the targeting of peptide epitopes restricted by HLA-E, especially in the field of cancer. The aim of this project is to elucidate how peptides are loaded onto HLA-E and how this subsequently affects HLA-E structure and function. We are seeking a highly motivated Postdoctoral Research Scientist with relevant experience in biochemistry, biophysics and immunology, to interrogate the unusual properties HLA-E and peptide binding to inform the biology of T cell recognition. Responsibilities You will: • • • • • • • • • • • • • Work collaboratively alongside an existing team to support new studies centred on HLA-E. Ensure research is performed safely, legally and to the highest possible standards. Manage own academic research and administrative activities involving small scale project management once initial training is completed. Carry out collaborative projects with colleagues in partner departments and institutions. Adapt existing and develop new scientific techniques and protocols as necessary. Test hypotheses and analyse scientific data from a variety of sources, refining as required. Establish and maintain a good understanding of the research field by reading key reviews and research articles. Collaborate in the preparation of scientific reports and journal articles (by data provision or drafting sections of text) if required. Contribute to the smooth running of the laboratory and shared communical duties. Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques, supervising and training new staff in laboratory techniques, if required. Contribute to wider project planning. Represent the research group at internal meetings/seminars. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. 1 Selection criteria Essential • • • • • • • • Hold a PhD/DPhil (or close to completion) in Biochemistry, Chemistry, Biophysics in molecular immunology. Prior experience working on major histocompatibility complex (MHC) proteins. Basic molecular biology techniques including PCR, cloning, mutagenesis and sequencing. Protein production using prokaryotic or eukaryotic expression platforms and purification using FPLC systems. Mass spectrometry experience (e.g. Hydrogen-Deuterium Exchange (HDX-MS) and/or MHC immunopeptideomics). Structural analysis of proteins (e.g. SEC-SAXS analysis and/or x-ray crystallography). Experience of Molecular Dynamic Simulation analysis. Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings. Desirable • • • Experience or good working knowledge of Fluorescent Anisotropy Experience in the field of Structural Bioinfomatics (e.g. using tools and resources for protein drug discovery). Experience of growing and functionally analysing T cells (e.g. using flow cytometry to analyse surface marker expression or cytokine production). 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • • • Lone Working Work in hot or cold environments Working with blood, human products and human tissues Work with any substance which has any of the following pictograms on their MSDS: 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement 4 The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
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A Postdoctoral Research Scientist is required to join the Gillespie Group, at the Oxford Centre for Immuno-Oncology, Nuffield Department of Medicine. The aim of this project is to elucidate how peptides are loaded onto HLA-E and how this subsequently affects HLA-E structure and function. You will be working collaboratively alongside an existing team to support new studies centred on HLA-E, and managing your own academic research and administrative activities involving small scale project management once initial training is completed. In this role, it is important to ensure research is performed safely, legally and to the highest possible standards. You will establish and maintain a good understanding of the research field by reading key reviews and research articles, and you will collaborate in the preparation of scientific reports and journal articles (by data provision or drafting sections of text) if required. Additionally, you will act as a source of information and advice to other members of the group on scientific protocols and experimental techniques, supervising and training new staff in laboratory techniques, if required. It is essential that you hold a PhD/DPhil (or close to completion) in Biochemistry, Chemistry, Biophysics in molecular immunology. You will have prior experience working on major histocompatibility complex (MHC) proteins, and basic molecular biology techniques including PCR, cloning, mutagenesis and sequencing. It is essential you have experience in protein production using prokaryotic or eukaryotic expression platforms and purification using FPLC systems. Mass spectrometry experience (e.g. Hydrogen-Deuterium Exchange (HDX-MS) and/or MHC immunopeptideomics) is required for this role. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 August 2028 and is funded by the Wellcome Trust. Only applications received before 12 midday on 13 March 2024 will be considered. Please quote 170977 on all correspondence.
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