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Mathematical Modeller, Oxford-GSK Institute of Molecular and Computational Medicine
comment: A highly motivated, ambitious Mathematical Modeller is required to develop and analyse mathematical models that focus on the role of sortilin-mediated progranulin-related pathways in neurodegenerative diseases, reporting to the Oxford-GSK IMCM co-director Professor John Todd and Dr Anna Sher, Director in Quantitative Systems Pharmacology at GSK, and with oversight from the Oxford- GSK IMCM Programme Manager. This position is a unique opportunity to work in a dynamic environment at the Oxford-GSK IMCM and in close collaboration with Clinical Pharmacology and Modelling and Simulation department at GSK, one of the leading global biopharmas, who are at the forefront of the application of model-informed drug development to clinical trials. You will work closely with members of the Oxford-GSK IMCM Joint Data Team (including machine learning researchers, statistical geneticists and data managers), enabling effective use of the joint data platform. You will be responsible for the hands-on development, analysis and application of mechanistic mathematical models that will be a step towards enhanced quantitative understanding of the role of anti-sortilin pathways in increasing the progranulin (PGRN) levels and in regulating downstream pathways affecting neurodegenerative disease progression, based on available literature, in vitro imaging and clinical data. You will be tasked with performing simulation studies to understand both the neurodegenerative disease processes and anti- sortilin drug pharmacodynamics, and to contribute to generation and testing of mechanistic hypotheses, and utilisation of Virtual Patients to inform optimal clinical study design including selection of key biomarkers and optimal patient subpopulations. You will ultimately be responsible for supporting the Institute’s scientific and strategic objectives and contribute to developing the strategic direction of the Oxford-GSK IMCM. It is essential that you hold a relevant PhD/DPhil in Applied Mathematics, M…
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application closing date: 2024-03-11T12:00:00+00:00
formal organization: University of Oxford
application opening date: 2004-02-12T09:00:00+00:00
comment: A highly motivated, ambitious Mathematical Modeller is required to develop and analyse mathematical models that focus on the role of sortilin-mediated progranulin-related pathways in neurodegenerative diseases, reporting to the Oxford-GSK IMCM co-director Professor John Todd and Dr Anna Sher, Director in Quantitative Systems Pharmacology at GSK, and with oversight from the Oxford-GSK IMCM Programme Manager. This position is a unique opportunity to work in a dynamic environment at the Oxford-GSK IMCM and in close collaboration with Clinical Pharmacology and Modelling and Simulation department at GSK, one of the leading global biopharmas, who are at the forefront of the application of model-informed drug development to clinical trials. You will work closely with members of the Oxford-GSK IMCM Joint Data Team (including machine learning researchers, statistical geneticists and data managers), enabling effective use of the joint data platform. You will be responsible for the hands-on development, analysis and application of mechanistic mathematical models that will be a step towards enhanced quantitative understanding of the role of anti-sortilin pathways in increasing the progranulin (PGRN) levels and in regulating downstream pathways affecting neurodegenerative disease progression, based on available literature, in vitro imaging and clinical data. You will be tasked with performing simulation studies to understand both the neurodegenerative disease processes and anti-sortilin drug pharmacodynamics, and to contribute to generation and testing of mechanistic hypotheses, and utilisation of Virtual Patients to inform optimal clinical study design including selection of key biomarkers and optimal patient subpopulations. You will ultimately be responsible for supporting the Institute’s scientific and strategic objectives and contribute to developing the strategic direction of the Oxford-GSK IMCM. It is essential that you hold a relevant PhD/DPhil in Applied Mathematics, Mat…
spatial: Centre for Human Genetics, Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN
salary: Grade 8: £45,585 - £54,395 with a discretionary range to £59,421 per annum
further particulars: 171122 - Mathematical Modeller - JD

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value: Job title Mathematical Modeller Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN Grade 8: £45,585 - £54,395 with a discretionary range to £59,421 per annum Grade and salary Whilst this role is a Grade 8 position, we would be willing to consider less experienced candidates who might be suitable to the role with adjusted duties to then be offered as an underfill at Grade 7: £36,024– £44,263, with discretionary range to £48,350 per annum This would be discussed with applicants at interview/appointment where appropriate. Hours Contract type Reporting to Full time Fixed-term contract until 30 September 2027 Funding is provided by the GSK Professor John Todd and Dr Anna Sher (GSK), with oversight from Dr Georgina Kerr Vacancy reference 171122 Hybrid working arrangements The successful person will need to work on site for a minimum of 4 days per week Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent Visa under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us • • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - www.well.ox.ac.uk / www.imcm.ox.ac.uk Research - www.imcm.ox.ac.uk The role This post provides an exciting opportunity to join the newly established multidisciplinary Oxford-GSK Institute of Molecular & Computational Medici…
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