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**About the role** A position is available for an enthusiastic and highly motivated Staff Scientist to join the research groups led by a/Prof Carlo Rinaldi at the University of Oxford. The group explores genetic causes of neurological disorders and aim to develop therapies for these conditions with a high complementary approach, ranging from stem cell modelling to functional genomic. Information on the research activity of the lab is available at: https://www.rinaldi-lab.com/. The successful candidate will be involved with all aspects of the data analysis including design, experimental conduct, and result dissemination, acting as a source of information and advice to other members of the group techniques and protocols. The post holder will work at the newly built Institute of Developmental and Regenerative Medicine (IDRM) at the Old Road/Churchill Campus of University of Oxford in the laboratory of A/Prof Carlo Rinaldi. She/he will be well supported by the existing joint team, currently consisting of postdocs, PhD candidates, and research assistants. Career Development: The post holder will be able to receive training in collaborating labs in order to benefit from interaction with researchers in diverse environments. She/he will be encouraged to attend training and research skill courses provided by the University of Oxford. There will be opportunities for contributing to and leading grant applications if appropriate, as well as being encouraged to submit work for presentation at national and international conferences. In addition, experience gained by supervision and mentoring of junior members in the lab will be useful for career development. The successful applicant will be expected to provide guidance and assistance to other researchers in the group and students, help in the preparation of scientific publications, and represent the group at public engagement events. **About the applicant** This is a highly collaborative position, so excellent communication and interpersonal skills are essential. Applicants will need to hold a PhD or equivalent in Molecular Biology, Biochemistry, Genetics, or a related subject. She/he will need to have demonstrated ability to manage own academic research and associated activities leading to impactful publications and ideally experiencing in advanced microscopy and/or stem cell culture methods. **Application Process** You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Carlo Rinaldi at carlo.rinaldi@idrm.ox.ac.uk. Only online applications received before 12.00 midday on 25th March 2024 will be considered. Interviews will be held as soon as possible thereafter.
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_________________________________________________________________________ Job description and selection criteria Job title Staff Scientist Division Medical Sciences Department Paediatrics Location Wood Research Group, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford Grade and salary Grade 7: £36,024 - £42,263 per annum (with a discretionary range to £48,350 per annum) Hours Full time Contract type Fixed-term (24 months) Reporting to Associate Professor Carlo Rinaldi Vacancy reference 171481 Additional Information This role meets the criteria for a UK Skilled Worker visa Research topic Molecular and Translational Neuroscience Principal Investigator / Carlo Rinaldi supervisor Project team Rinaldi Lab (R-Lab) https://www.idrm.ox.ac.uk/research/neurology Project web site Funding partner https://www.rinaldi-lab.com/ The funds supporting this research project are provided by UKRI MRC The role The post holder will be a member of the Rinaldi lab (R-lab) with responsibility for carrying out a critical role in supporting the overall research objective of the lab, which are to understand the molecular mechanisms of neurological diseases and to develop treatments for these conditions. The post holder will work as a member of a multidisciplinary team and provide guidance to other members of the research group, including other postdocs, research assistants, technicians, and PhD and project students. The R-lab sits within the Institute of Developmental and Regenerative Medicine (IDRM) and has access to unique disease modelling systems (e.g. organoids), genetic therapy technology and numerous datasets of varying scales. This post offers a uniquely rich opportunity to conduct translational research, train and supervise junior lab members, and contribute to the advancement of scientific knowledge within the lab's area of focus. Responsibilities 1. Plan, design, and execute experiments independently or collaboratively with other researchers in the lab; 2. Act as a source of information and advice to other members of the group on data access and methodologies, techniques, and protocols and to document these in the laboratory information base; 3. Contribute ideas for new research projects; 4. Train and supervise junior lab members, such as students or technicians, providing guidance on experimental techniques, data analysis methods, and best practices in research. 5. Attend scientific seminars, meetings, and training, as appropriate, and represent the research group at external meetings/seminars, either with other members of the group or alone; 6. Contribute to manuscripts, presentations, and other means of disseminating results; 7. Develop ideas for generating research income, and present detailed research proposals to senior researchers. 8. Managing your own research and admin activities. Department of Paediatrics, Postdoctoral Research Associate 2 Selection criteria Essential • Hold a PhD (or equivalent) in Molecular Biology, Biochemistry, Genetics, or a related subject; • Experience with independent planning, designing, and executing experiments or studies; • Demonstrable experience, ability, and practical success in molecular biology, biochemistry, and/or genetics, including experience of contributing to publications and presentations; • Ability to manage own academic research and associated activities; • Ability to collaborate with colleagues and advise other researchers both in-person and remotely; • Ability to contribute ideas for new research projects and research income generation; • Demonstrable ability to organise and prioritise work efficiently whilst delivering results to the required standard and to an agreed schedule; • Excellent communication skills, including the ability to write for publications, design and generate figures reflecting data analyses, present research proposals and results, and represent the research group at meetings. • Manage own administration and research activities Desirable • Experience with advanced microscopy (e.g. confocal, FRET, super-resolution microscopy); • Experience with induced pluripotent stem cell culture methods. . Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. . If you have previously worked for the University we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Department of Paediatrics, Postdoctoral Research Associate 3 Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • University security screening (e.g. identity checks) About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. The Rinaldi Lab The Rinaldi Group, led by A/Prof Carlo Rinaldi, works on understanding mechanism of disease for rare neurological condition, with the goal to develop gene therapy treatments for these conditions. Research activities include: • • • • • Culture of iPS cells and differentiation into motor neurons and skeletal muscle Development of organoid systems to model the neuromuscular unit Assessing the role of enhancers to genetic disorders Developing therapies for genetic disorders, including antisense oligonucleotides (ASOs) and CRISPR-based approaches Development of live imaging tools to assess transcription dynamics Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global Department of Paediatrics, Postdoctoral Research Associate 4 scale, building a paediatric network in the medical science community. We are committed to inform and inspire external audiences worldwide through our public engagement and outreach activities. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ Department of Paediatrics, Postdoctoral Research Associate 5 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert and recruitment@paediatrics.ox.ac.uk if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting https://staff.web.ox.ac.uk/recruitment-support-faqs advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 6 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Oxford Research Staff Society (OxRSS) A society run by and for Oxford University research staff. It offers researchers a range of social and professional networking opportunities. Membership is free, and all researchers employed by Oxford University are welcome to join. Subscribe at researchstaff-subscribe@maillist.ox.ac.uk to join the mailing list to find out about upcoming events and other information for researchers, or contact the committee on committee@oxrss.ox.ac.uk. For more information, see www.ox.ac.uk/oxrss, Twitter/ X @ResStaffOxford, and Facebook www.facebook.com/oxrss. 8
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Grade 7: £36,024 - £42,263 per annum (with a discretionary range to £48,350 per annum)
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Department of Paediatrics, Wood Research Group, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford
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About the role A position is available for an enthusiastic and highly motivated Staff Scientist to join the research groups led by a/Prof Carlo Rinaldi at the University of Oxford. The group explores genetic causes of neurological disorders and aim to develop therapies for these conditions with a high complementary approach, ranging from stem cell modelling to functional genomic. Information on the research activity of the lab is available at: https://www.rinaldi-lab.com/. The successful candidate will be involved with all aspects of the data analysis including design, experimental conduct, and result dissemination, acting as a source of information and advice to other members of the group techniques and protocols. The post holder will work at the newly built Institute of Developmental and Regenerative Medicine (IDRM) at the Old Road/Churchill Campus of University of Oxford in the laboratory of A/Prof Carlo Rinaldi. She/he will be well supported by the existing joint team, currently consisting of postdocs, PhD candidates, and research assistants. Career Development: The post holder will be able to receive training in collaborating labs in order to benefit from interaction with researchers in diverse environments. She/he will be encouraged to attend training and research skill courses provided by the University of Oxford. There will be opportunities for contributing to and leading grant applications if appropriate, as well as being encouraged to submit work for presentation at national and international conferences. In addition, experience gained by supervision and mentoring of junior members in the lab will be useful for career development. The successful applicant will be expected to provide guidance and assistance to other researchers in the group and students, help in the preparation of scientific publications, and represent the group at public engagement events. About the applicant This is a highly collaborative position, so excellent communication and interpersonal skills are essential. Applicants will need to hold a PhD or equivalent in Molecular Biology, Biochemistry, Genetics, or a related subject. She/he will need to have demonstrated ability to manage own academic research and associated activities leading to impactful publications and ideally experiencing in advanced microscopy and/or stem cell culture methods. Application Process You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Carlo Rinaldi at carlo.rinaldi@idrm.ox.ac.uk. Only online applications received before 12.00 midday on 25th March 2024 will be considered. Interviews will be held as soon as possible thereafter.