. . _:N53d68f0fbc924f8099312b079f303a83 . . """We are seeking to appoint a Research Assistant, to become a key member of target-based project teams and will be working alongside experts in other technical disciplines, such as chemical biology, protein production or medicinal chemistry. Within this role, you will become proficient in several platforms and able to provide technical advice to students and colleagues within the Centre for Medicines Discovery and collaborating academic groups. The CMD is a multi-disciplinary institute, with a mission to accelerate the translation of basic science into the discovery and development of novel medicines. The CMD is made up of several teams; Structural and Functional Biology; Technologies; Drug Discovery; and Research Informatics. Together these units drive several major collaborative initiatives, involving the CMD and other academic or industrial partners, as well as their own research programmes. You will be responsible for developing cellular, biochemical and biophysical assays and optimising them for utilisation in high throughput screening campaigns and compound evaluation cascades. You will manage your own research on a number of projects and administrative activities, such as data entry into electronic lab notebooks, within guidelines provided by senior colleagues. You will be responsible for the use and management of specialist scientific equipment in a laboratory environment, such as the liquid handling equipment such as Echo robotic dispenser, plate readers (Pherastar, Hidex, FLIPR) and biophysical equipment (Biacore, Octet BLI, Prometheus, Rapid Fire MS, etc.). Other duties include gathering, analysing, and presenting scientific data from a variety of sources, and contributing to scientific reports and journal articles and the presentation of data/papers at conferences. It is essential that you hold a degree in Biochemistry, Physical Chemistry, Chemistry or Biology-related subjects, together with relevant laboratory experience. You will also have experience of establishing biochemical assays, in particular enzyme activity assays and protein-protein interactions, considering throughput, specificity and robustness of various approaches, and you will be able to manage your own research with an eye for detail and take responsibility for administrative activities such as management of lab reagent stock, lab book writing. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 1 July 2026 and is funded by the Department. Only applications received before 12 midday on 4 June 2024 will be considered. Please quote **171985** on all correspondence. """ . . . . . "telephone"@en . "Unit price specification"@en . . . . _:N4f3bd232307e48efb11bd8dc625c8aa9 . . _:N29f203cedba34da7aa97620da7805c16 "+44-1865-270708" . . . "es suborganización de"@es . "Title"@en . . "018652 87775" . . . "comment" . . . _:N29f203cedba34da7aa97620da7805c16 . . . "GBP" . . _:Ne3a831fd6b4546fb8a2fe251f577b787 "United Kingdom" . . . . . "2024-06-04T12:00:00+01:00"^^ . "Centre for Medicines Discovery" . "664" . . "email"@en . . . . . . . "homepage" . "Phoebe Astbury" . . . "Research Assistant - Protein Biochemist & Physicist" . "Nuffield Department of Clinical Medicine" . . . "Agent" . . "subOrganization of"@en . . "NDM Building" . . "unit" . . "building" . . . . . . _:N4f3bd232307e48efb11bd8dc625c8aa9 "Headington" . "depiction" . . . _:Ne3a831fd6b4546fb8a2fe251f577b787 "OX1 2JD" . . _:N29f203cedba34da7aa97620da7805c16 . . . . "Description of Research Assistant - Protein Biochemist & Physicist" . "Title"@en . . . . . "Source"@en . . . . "image" . . . . . . "text/n3" . _:N4f3bd232307e48efb11bd8dc625c8aa9 "Oxford" . . "NDM Research Building" . "sous-Organization de"@fr . . "54214395"^^ . . . _:Ne079418bc49d4e8087f7405d4880290c . "has min currency value (1..1)"@en . . "Grade 6: £32,332 - £38,205 with a discretionary range to £41,732 p.a." . . . "Centre for Medicines Discovery" . . "51.753117"^^ . . "has exact match"@en . . "2024-06-04T12:00:00+01:00"^^ . . . "OxPoints"@en . "University of Oxford" . "171985"^^ . . "application/xhtml+xml" . . . _:N4f3bd232307e48efb11bd8dc625c8aa9 "OX3 7FZ " . "32332"^^ . . _:N4f3bd232307e48efb11bd8dc625c8aa9 . "Fax"@en . _:N4f3bd232307e48efb11bd8dc625c8aa9 "Old Road Campus" . "longitude" . "text/html" . . "OpenStreetMap feature identifier" . . "Document" . "name" . "application/rdf+xml" . _:N53d68f0fbc924f8099312b079f303a83 . . "664"^^ . . "01865 287775" . "OxPoints"@en . "Address"@en . . . . _:Ne3a831fd6b4546fb8a2fe251f577b787 "Oxford" . "text/plain" . . "latitude" . . _:Ne079418bc49d4e8087f7405d4880290c "+44-1865-270000" . "Oxford, University of" . """Job title Research Assistant - Protein Biochemist & Physicist Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Medicines Discovery, NDM Research Building, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7FZ Grade and salary Grade 6: £32,332 - £38,205 with a discretionary range to £41,732 p.a. Hours Full time Contract type Permanent / Fixed-term contract until 1 July 2026 Funding is provided by the Department Reporting to Dr Oleg Fedorov, Group Leader Vacancy reference 171985 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent Visa under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - Home — Centre for Medicines Discovery (CMD) (ox.ac.uk) The role The Centre for Medicines Discovery (CMD) is a multi-disciplinary institute within the University of Oxford’s Nuffield Department of Medicine with a mission to accelerate the translation of basic science into the discovery and development of novel medicines. The CMD represents over a hundred staff split across: Structural and Functional Biology; Technologies (including proteomics, chemical biology and crystallography); Drug Discovery (including medicinal chemistry, high throughput screening and the Oxford Drug Discovery Institute); Research Informatics (data management, target informatics and computational chemistry). Together these units drive several major collaborative initiatives, involving the CMD and other academic or industrial partners, as well as their own research programmes. https://www.cmd.ox.ac.uk/ CMD mission is to de-risk novel therapeutic approaches and discover novel agents fit for further discovery investment. Consequently, we work closely with pharma and biotech companies and operate industry-style project teams to deliver our target validation and translational goals. We are seeking a Research Assistant who will play a key part in driving the translational goals of our project teams. You will become an integral part of Biophysics and Biochemistry Research Group working on drug discovery projects, employ innovative biochemical, and biophysical techniques to explore protein structure and function, to identify novel ligands for the targets of interest, and to understand the molecular pharmacology of the target proteins. Reporting to Dr Oleg Fedorov, you will gain experience in using sophisticated instruments and automated liquid handling equipment (e.g. SPR and ITC to measure binding constants, Rapid Fire Mass Spectrometry to analyse metabolites and enzymatic mechanisms) You will be a key member of target-based project teams and will be working alongside experts in other technical disciplines, such as chemical biology, protein production or medicinal chemistry. You can expect, within a short space of time, to become proficient in several platforms and able to provide technical advice to students and colleagues within the Centre for Medicines Discovery and collaborating academic groups. Responsibilities You will: • • • • • • • • • Develop cellular, biochemical and biophysical assays and optimise them for utilisation in high throughput screening campaigns and compound evaluation cascades. Manage own research on a number of projects and administrative activities, such as data entry into electronic lab notebooks, within guidelines provided by senior colleagues. Use and manage specialist scientific equipment in a laboratory environment, such as the liquid handling equipment such as Echo robotic dispenser, plate readers (Pherastar, Hidex, FLIPR) and biophysical equipment (Biacore, Octet BLI, Prometheus, Rapid Fire MS, etc.). Determine the most appropriate methodologies to test compounds and identify suitable alternatives if technical problems arise. Gather, analyse, and present scientific data from a variety of sources. Contribute to scientific reports and journal articles and the presentation of data/papers at conferences Be responsible for general laboratory management and administration, including stock control of laboratory consumables. Represent the research group at external meetings/seminars, sharing research findings with colleagues in partnering institutions, either with other members of the group or alone. Carry out any other relevant duties as may reasonably be associated with the post and which may be required from time to time. 1 • • Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Selection criteria Essential • • • • • Hold a degree in Biochemistry, Physical Chemistry, Chemistry or Biology-related subject, together with relevant laboratory experience. Experience of establishing biochemical assays, in particular enzyme activity assays and protein-protein interactions, considering throughput, specificity and robustness of various approaches. Ability to manage own research with an eye for detail and take responsibility for administrative activities such as management of lab reagent stock, lab book writing. Good team-working skills and able to collaborate effectively within a dynamic team and matrix environment. Excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings. Desirable • • • • • Experience using TR-FRET, Fluorescence polarization, BLI, SPR, ITC or mass spectrometry. Experience in handling high-throughput format plates e.g. 384-1536 well plate. Protein expression and purification. Protein crystallography. Use of liquid handling equipment. 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • Night working (11pm-6am) Regular manual handling 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement 4 The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5 """^^ . . . . . _:N4f3bd232307e48efb11bd8dc625c8aa9 "United Kingdom" . "Old Road Campus" . "54908150"^^ . . . . "university" . . . "01865287775" . . . "has max currency value (1..1)"@en . . . . "in dataset" . . . "value" . . . "License"@en . . . . "00000000"^^ . "sotto-Organization di"@it . . _:Ne3a831fd6b4546fb8a2fe251f577b787 "University of Oxford" . "Is Part Of"@en . "valid through (0..1)"@en . . 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We are seeking to appoint a Research Assistant, to become a key member of target-based project teams and will be working alongside experts in other technical disciplines, such as chemical biology, protein production or medicinal chemistry. Within this role, you will become proficient in several platforms and able to provide technical advice to students and colleagues within the Centre for Medicines Discovery and collaborating academic groups.

 

The CMD is a multi-disciplinary institute, with a mission to accelerate the translation of basic science into the discovery and development of novel medicines. The CMD is made up of several teams; Structural and Functional Biology; Technologies; Drug Discovery; and Research Informatics. Together these units drive several major collaborative initiatives, involving the CMD and other academic or industrial partners, as well as their own research programmes.

 

You will be responsible for developing cellular, biochemical and biophysical assays and optimising them for utilisation in high throughput screening campaigns and compound evaluation cascades. You will manage your own research on a number of projects and administrative activities, such as data entry into electronic lab notebooks, within guidelines provided by senior colleagues. You will be responsible for the use and management of specialist scientific equipment in a laboratory environment, such as the liquid handling equipment such as Echo robotic dispenser, plate readers (Pherastar, Hidex, FLIPR) and biophysical equipment (Biacore, Octet BLI, Prometheus, Rapid Fire MS, etc.). Other duties include gathering, analysing, and presenting scientific data from a variety of sources, and contributing to scientific reports and journal articles and the presentation of data/papers at conferences.

 

It is essential that you hold a degree in Biochemistry, Physical Chemistry, Chemistry or Biology-related subjects, together with relevant laboratory experience. You will also have experience of establishing biochemical assays, in particular enzyme activity assays and protein-protein interactions, considering throughput, specificity and robustness of various approaches, and you will be able to manage your own research with an eye for detail and take responsibility for administrative activities such as management of lab reagent stock, lab book writing.

 

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

 

This position is offered full time on a fixed term contract until 1 July 2026 and is funded by the Department.

 

Only applications received before 12 midday on 4 June 2024 will be considered. Please quote 171985 on all correspondence.
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