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Salary in range £45,585-£54,395 pa. We would be willing to consider less experienced candidates who might be suitable to the role with adjusted duties to then be offered as an underfill at Grade 7: £36024 – £44,263, with discretionary range to £48,350 pa
Wellcome Trust Centre Clinical Vaccinology and Tropical Medicine
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Job title Senior Postdoctoral Immunologist Division Medical Sciences Department Nuffield Department of Medicine Location Jenner Institute, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ Grade 8: salary in range £45,585 - £54,395 per annum Grade and salary Hours Contract type Whilst this role is a Grade 8 position, we would be willing to consider less experienced candidates who might be suitable to the role with adjusted duties to then be offered as an under fill at Grade 7: £36024 – £44,263, with discretionary range to £48,350 per annum Full time Fixed-term contract for 2 years, with possibility of extension Funding is provided by the Wellcome and Medical Research Council Reporting to Adam Ritchie, Senior Vaccine Programme Manager Vacancy reference 172286 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent Visa under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - www.jenner.ac.uk Research topic Vaccine Immunology Principal Investigator / supervisor Associate Professor Sandy Douglas Project team EBV and rabies vaccine development Funding partner The funds supporting this research project are provided by the Wellcome Recent publications https://www.jenner.ac.uk/team/alexander-sandy-douglas https://www.jenner.ac.uk/research/infectious-diseases/rabies-vaccineprogramme https://www.jenner.ac.uk/research/infectious-diseases/ebv 1 The role We are seeking to appoint a Senior Immunologist to take a leading role in the development and evaluation of novel experimental medicine and vaccine approaches targeting Epstein Barr virus (EBV) and rabies. EBV is ubiquitous but causes cancers resulting in more than 100,000 deaths each year globally. It also is increasingly thought to play a role in the causation of autoimmune / inflammatory diseases, including multiple sclerosis. There is currently no licensed vaccine. Rabies causes around 60,000 deaths per year globally, mostly in Africa and Asia. Although there are vaccines available, they are currently considered too expensive for mass pre-exposure use. You will lead the immunology work of the group. This will be primarily focused on clinical trial immunology, but also includes experimental medicine and pre-clinical development of vaccine candidates. This will be focused on EBV and rabies, but may develop in other areas depending on the evolution of research programmes within the Douglas group. Commensurate with its seniority, the role will also include mentoring and supervision of graduate students and less experienced staff. We are working with a novel rabies vaccine, ChAdOx2 RabG, which is currently the subject of two clinical trials, with a third being planned. The EBV vaccine programme is at the pre-clinical stage of development, with clinical trials expected to commence in the next 1-2 years. There are associated early-stage programme also looking at shedding of EBV by carriers, as well as the development of monoclonal antibodies. The Jenner Institute is a global leader in vaccine development and provides an outstanding academic environment. The post will provide exposure to a spectrum of vaccine development activity, encompassing multiple target organisms and spanning from pre-clinical discovery to Phase III clinical efficacy trials. This post would be particularly suited to you if you have an interest in vaccine immunology and seeing academic research translated into better health outcomes. Informal enquires about this post can be addressed to: adam.ritchie@ndm.ox.ac.uk. Responsibilities You will: • • Lead immunological studies, experimental medicine, and vaccine development work targeting EBV and rabies, plus other disease areas that develop within the team. This will include: o Develop research questions; o Testing, reviewing and refining working hypotheses; o Experimental design, execution, analysis and reports; o Adapting existing scientific techniques and develop new techniques and protocols; o Undertaking research using clinical samples; o Ensuring quality assurance and regulatory compliance relating to human research samples and data integrity; o Collaborating with clinical and non-clinical partners at Oxford and other institutions. Supervise and develop other members of the team, including Research Assistants, DPhil students, and Masters students. This will include: o Agreeing on clear task objectives, organising, and delegating work to other members of the team; o Coaching other members of the group on specialist methodologies and protocols. 2 • • • • • Contribute to other research areas within the group, including the development and testing of other vaccines and immunological studies. Regularly write research articles of internationally-leading quality for peer-reviewed journals. Present papers at international conferences, and lead seminars to disseminate research findings. Raise research funds through grant applications, and manage your own area of a larger research budget. Share responsibility for shaping the research group’s plans and the writing of group-funding applications for new research projects. Represent the group through: • • • • Liaising with funders, regulatory bodies, and other stakeholders. Representing the group at external and internal meetings/committees advising on scientific and management matters. Participating in and supporting the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertaking mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Selection criteria Essential • • • • • • • • Hold a relevant PhD/DPhil with post-qualification research experience in biological or medical sciences. Ability to independently plan and manage research projects. Experience of antibody/B cell immunology, clinical research immunology, experimental medicine, and/or vaccine research. Ability to manage and ensure quality assurance of clinical trial data and human research samples, with strong attention to detail. Skills in problem-solving and critical thinking. Excellent interpersonal and management skills, with experience of collaborative research projects and supervising staff and/or students. Strong publication record and familiarity with the existing literature and research in the fields of vaccine development, antibodies, experimental medicine, and/or virology. Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings. Desirable • • • • • Experience of isolation and characterisation of novel monoclonal antibodies, molecular biology, virology, Good Clinical Practice (GCP), and/or the use of animal models. Experience of managing and analysing large datasets using packages such as R, Stata, Python or similar. Experience making grant applications. Working on clinical trials and/or clinical trial samples; Experience managing a research budget. 3 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • • • Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens Working with blood, human products and human tissues Work with allergens, Eg laboratory animals, pollen, dust, fish or insects etc. Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment This job includes duties that will require additional security pre-employment checks: • • A satisfactory basic Disclosure and Barring Service check University security screening (eg identity checks) 4 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement 5 The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 6
We have the exciting opportunity to recruit a Senior Postdoctoral Immunologist to join our research team here at Jenner Institute, Nuffield Department of Medicine. The Jenner Institute is a global leader in vaccine development and provides an outstanding academic environment. The post will provide exposure to a spectrum of vaccine development activity, encompassing multiple target organisms and spanning from pre-clinical discovery to Phase III clinical efficacy trials. As Senior Immunologist, you will take a leading role in the development and evaluation of novel experimental medicine and vaccine approaches targeting Epstein Barr virus (EBV) and rabies. You will lead the immunology work of the group. This will be primarily focused on clinical trial immunology, but also includes experimental medicine and pre-clinical development of vaccine candidates. This will also be focused on EBV and rabies, but may develop in other areas depending on the development of research programmes within the Douglas group. You will be responsible for leading immunological studies, experimental medicine, and vaccine development work targeting EBV and rabies, plus other disease areas that develop within the team. You will be tasked with supervising and developing other members of the team, including research assistants, DPhil students, and Masters students. You will be contributing to other research areas within the group, including the development and testing of other vaccines and immunological studies. Finally, you will also be responsible for regularly writing research articles of internationally-leading quality for peer-reviewed journals, presenting papers at international conferences, and leading seminars to disseminate research findings. It is essential that you hold a relevant PhD/DPhil with post-qualification research experience in biological or medical sciences. You will have experience of antibody/B cell immunology, clinical research immunology, experimental medicine, and/or vaccine research. You will also have the ability to independently plan and manage research projects as well as the ability to manage and ensure quality assurance of clinical trial data and human research samples. Experience of isolation and characterisation of novel monoclonal antibodies, molecular biology, virology, Good Clinical Practice (GCP), and/or the use of animal models is highly desirable, as is experience of managing and analysing large datasets. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is initially offered full time on a fixed term contract for 2 years in the first instance and is funded by the Wellcome and Medical Research Council. Only applications received before 12 midday on Friday 17 May 2024 will be considered. Please quote **172286** on all correspondence.
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We have the exciting opportunity to recruit a Senior Postdoctoral Immunologist to join our research team here at Jenner Institute, Nuffield Department of Medicine. The Jenner Institute is a global leader in vaccine development and provides an outstanding academic environment. The post will provide exposure to a spectrum of vaccine development activity, encompassing multiple target organisms and spanning from pre-clinical discovery to Phase III clinical efficacy trials. As Senior Immunologist, you will take a leading role in the development and evaluation of novel experimental medicine and vaccine approaches targeting Epstein Barr virus (EBV) and rabies. You will lead the immunology work of the group. This will be primarily focused on clinical trial immunology, but also includes experimental medicine and pre-clinical development of vaccine candidates. This will also be focused on EBV and rabies, but may develop in other areas depending on the development of research programmes within the Douglas group. You will be responsible for leading immunological studies, experimental medicine, and vaccine development work targeting EBV and rabies, plus other disease areas that develop within the team. You will be tasked with supervising and developing other members of the team, including research assistants, DPhil students, and Masters students. You will be contributing to other research areas within the group, including the development and testing of other vaccines and immunological studies. Finally, you will also be responsible for regularly writing research articles of internationally-leading quality for peer-reviewed journals, presenting papers at international conferences, and leading seminars to disseminate research findings. It is essential that you hold a relevant PhD/DPhil with post-qualification research experience in biological or medical sciences. You will have experience of antibody/B cell immunology, clinical research immunology, experimental medicine, and/or vaccine research. You will also have the ability to independently plan and manage research projects as well as the ability to manage and ensure quality assurance of clinical trial data and human research samples. Experience of isolation and characterisation of novel monoclonal antibodies, molecular biology, virology, Good Clinical Practice (GCP), and/or the use of animal models is highly desirable, as is experience of managing and analysing large datasets. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is initially offered full time on a fixed term contract for 2 years in the first instance and is funded by the Wellcome and Medical Research Council. Only applications received before 12 midday on Friday 17 May 2024 will be considered. Please quote 172286 on all correspondence.
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