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Wellcome Trust Centre Clinical Vaccinology and Tropical Medicine
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Jenner Institute, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ
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Old Road Campus Research Building, Roosevelt Drive
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We have an exciting opportunity for a Research Assistant to join the vibrant team at the Jenner Institute, Nuffield Department of Medicine. This project will focus on the design, expression and testing of the next generation of malaria transmission blocking vaccines as part of the UltiMalVax project. You will participate in the research project led by Professor Sumi Biswas to develop malaria transmission-blocking vaccines and contribute to wider project planning.This position offers the chance to gain valuable knowledge and training in both vaccine design and purification, as well as the overall vaccine development pipeline the Jenner Institute is renowned for. You will be responsible (post training) for the production and purification of proteins as required by the group. You will also be responsible for overseeing the daily housekeeping of the laboratory area involved in protein vaccine production. Additionally, you will help in preparing scientific papers for publication, present the research at scientific conferences and contribute to the Jenner website. To be successful in this role, you will hold a degree in a relevant biological subject, or a related discipline together with some practical laboratory experience with biological materials. You will have excellent communication and interpersonal skills with keen attention to details. You will have ability to research complex issues and interpret and capable for working independently in a laboratory. Having experience in molecular biology techniques is highly desirable. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract for 12 months with the possibility of extension and is funded by the European Commission. Only applications received before 12 midday on Monday 20 May 2024 will be considered. Please quote **172451 **on all correspondence.
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Job title Research Assistant – Protein Purification Division Medical Sciences Department Nuffield Department of Medicine Location Jenner Institute, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ Grade and salary Grade 6: Salary in range £32,332 - £38,205 per annum Hours Full time Contract type Fixed-term contract for 12 months, with the possibility of extension Funding is provided by the European Commission Reporting to Professor Sumi Biswas, Principal Investigator and Dr David Mekhaiel, Senior Postdoctoral Scientist Vacancy reference 172451 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent Visa under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us    What we offer https://hr.admin.ox.ac.uk/staff-benefits  An excellent contributory pension scheme  38 days annual leave  A comprehensive range of childcare services  Family leave schemes  Cycle loan scheme  Discounted bus travel and Season Ticket travel loans  Membership to a variety of social and sports clubs  A welcoming and diverse community University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.jenner.ac.uk/ Research topic Preclinical Development of Transmission blocking vaccines. Principal Investigator / supervisor Professor Sumi Biswas, Group Leader, Transmission-blocking Malaria Vaccines Project team Transmission-Blocking Malaria Vaccine Biswas Group - Jenner Institute Project web site Malaria Programme: Transmission-Blocking Vaccines — The Jenner Institute Funding partner The funds supporting this research project are provided by the European Commission The role Professor Sumi Biswas’ research group at the Jenner Institute, University of Oxford, is focused on the development of malaria transmission-blocking vaccines. We are currently working on developing several virus-like-particle and nanoparticle technologies to improve antibody immunogenicity of transmission-blocking malaria vaccines, as well as understanding the mechanisms of inducing protective antibody responses. This project will focus on the design, expression and testing of the next generation of malaria transmission blocking vaccines. The work will involve cloning techniques to generate constructs encoding various protein vaccines, expressing these constructs in a variety of cell lines such as yeast, insect and mammalian, followed by their purification and pre-clinical assessment. Training will be provided for these techniques, but lab experience of any of these techniques would be advantageous. Informal enquires about this position can be addressed to David.Mekhaiel@ndm.ox.ac.uk Responsibilities You will:            Participate in the research program led by Professor Sumi Biswas to develop malaria transmission-blocking vaccines and contribute to wider project planning. Help supervise students and other members of the group, as required. Liaise and coordinate with industrial and/or academic collaborators, where required. Determine the most appropriate methodologies to gest hypotheses and adapt experimental protocols. Be responsible (post training) for the production and purification of proteins as required by the group. Operate laboratory equipment used for all aspects of immunology/vaccine development. Liaise with suppliers regarding reagent and equipment purchases required for new protein vaccine production processes. Interpret results and analyse data relating to the work undertaken and present them to Prof Biswas and other members of the transmission-blocking malaria group, as well as at lab meetings in the Jenner Institute. Be responsible for overseeing the daily housekeeping of the laboratory area involved in protein vaccine production. Contribute to the efficient running, cleanliness and tidiness of the laboratory. Be responsible with others for the biological safety of the laboratory. Communication    Communicate with Professor Sumi Biswas and other members of the group as required, ensuring that they are kept fully up to date with progress in the research project. Help prepare scientific papers for publication, present the research at scientific conferences and contribute to the Jenner website. Participate in and contribute directly to scientific discussions with other members of the research group and collaborators on Jenner Institute projects. 1  Maintain confidentiality regarding research data when interacting with non-collaborating researchers. Education and training     Attend appropriate scientific seminars, training opportunities and meetings in the Jenner Institute and University. Participate in the education and training of other staff as necessary and appropriate. Continuously broaden, deepen and consolidate technical knowledge and skill. Maintain accuracy and efficiency to a high standard. Other General Responsibilities      Act at all times in the interests of the Institute to ensure good laboratory practice. Be accountable for personal professional conduct within the project. Undertake such other duties as may be required from time to time that are commensurate with the grade and responsibilities of this post. Accord due regard to the University Equal Opportunities and Data Protection policies. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements Selection criteria Essential          Hold a degree in a relevant biological subject, or a related discipline. Some practical laboratory experience working with biological materials. An interest in vaccine design. Excellent communication, and interpersonal skills, and ability to work effectively with others. Self-motivated, technically competent, and capable of working independently in a laboratory. Keen attention to detail and able to conduct experiments to a consistently high standard. Ability to research complex issues and interpret, analyse, and present scientific data and write factual reports. Excellent organisational skills. Good documentation and computer skills (Excel, PowerPoint and Word). Desirable     Experience in molecular biology techniques. Experience in protein purification. Experience in aseptic cell culture techniques. Experience of ELISAs. 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:       Lone Working Work in hot or cold environments Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens Working with blood, human products and human tissues Work with allergens, Eg laboratory animals, pollen, dust, fish or insects etc. Work with any substance which has any of the following pictograms on their MSDS:  Regular manual handling Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks:   A satisfactory basic Disclosure and Barring Service check University security screening (eg identity checks) 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents.  http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. 4 The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
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