sede principale
OxPoints
locality
extended address
License
Format
Title
ha sede
valid through (0..1)
street address
Department of Paediatrics, Wood Research Group, Institute of Developmental & Regenerative Medicine IDRM, Oxford
postal code
a un site
has exact match
**About the role** We are seeking candidates with either extensive technical experience in molecular biology and tissue culture techniques or a strong willingness to learn and become developers of new therapies, with the potential to transition into a DPhil position based on job performance. The role requires applicants to hold a degree in a relevant scientific subject (BSc, MSc, MD). The successful candidate will join Prof. Matthew Woods' Group at the Institute of Development and Regenerative Medicine on the Old Road Campus. The laboratory has developed novel oligonucleotide therapies for muscle disorders, including Duchenne Muscular Dystrophy (DMD) and Myotonic Dystrophy type 1 (DM1), which are currently being tested in clinical trials. Additionally, the group has developed peptide and antibody-based delivery platforms for targeted cell delivery and has discovered new delivery technologies. The position is offered on a full-time basis for a 1-year fixed-term contract, funded by the CureHeart project. CureHeart is a £30m global award funded by the British Heart Foundation. This award is one of the largest non-commercial grants ever awarded and provides a “once in a generation opportunity” to offer hope to patients and families affected by these deadly diseases. The award aims to develop revolutionary and precise technologies to silence the faulty genes responsible for these conditions. The team includes world-leading scientists from Oxford, Harvard, and other highly prestigious institutions. **Application Process** You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Amarjit Bhomra, Lab Manager using the details below. Only online applications received before 12.00 midday on Tuesday 4 June 2024 will be considered.
subOrganization of
Unit price specification
Is Part Of
Fax
_________________________________________________________________________ Job description and selection criteria Job title Research Assistant Division Medical Sciences Department Paediatrics Location Wood Research Group, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford Grade and salary Grade 6: £32,332 - £38,205 per annum (with a discretionary range to £41,732 per annum) Hours Full time Contract type Fixed-term (12 months) Reporting to Professor Matthew Wood (Professor of Neuroscience) Vacancy reference 172687 Additional information Applications are to be made online, please see the advert for the closing date. The role CureHeart is a £30m global award funded by the British Heart Foundation. This award is one of the largest non-commercial grants ever given and presents a "once in a generation opportunity" to provide hope for patients and families affected by these deadly diseases. The award aims to develop the first cures for inherited heart muscle diseases by pioneering revolutionary and precise technologies to silence the faulty genes responsible for these conditions. The team consists of world-leading scientists from Oxford, Harvard, and other highly prestigious institutions. Overview of the role The successful candidate for this position will join Professor Matthew Wood's research group and collaborate with a postdoctoral research fellow on developing therapies for heritable cardiomyopathies. Specifically, the appointee will be responsible for testing novel compounds in patient-derived cells in the context of the CureHeart grant. The aim of the grant is to develop therapeutics for heritable cardiomyopathies by designing and screening drugs against a variety of targets in cardiomyocytes. The ideal candidate is expected to be dynamic, highly motivated, and capable of collecting and analysing data independently, as well as adapting existing protocols while developing new ones. Additionally, the candidate will collaborate in the preparation of scientific reports. The role requires the applicant to hold a degree in a relevant scientific subject (BSc, MSc, MD). The candidate should have either extensive technical experience in molecular biology and tissue culture techniques with a track record of high productivity or be a fast learner, ready to transition into a DPhil position based on their performance during the job. The post holder will be based at the Institute of Developmental and Regenerative Medicine (IDRM), Department of Paediatrics at the University of Oxford, UK. The Wood laboratory focuses on developing molecular therapies for disorders of the nervous system and muscle. Our objectives include understanding disease biology, identifying and validating therapeutic targets, and developing gene-based nucleic acid therapeutic platforms. The laboratory has state-of-the-art nucleic acid chemistry and synthesis platforms, and uses in vitro and animal models to evaluate these platforms. The laboratory simultaneously develops advanced delivery technologies to target relevant tissues and cells, such as skeletal muscle, heart, and the nervous system. The laboratory has developed novel oligonucleotide and RNA editing therapies for neuromuscular disorders, including Duchenne Muscular Dystrophy (DMD), Spinal Muscular Atrophy (SMA), Spinal Bulbar Muscular Atrophy (SBMA), and Myotonic Dystrophy type 1 (DM1), currently being tested in clinical trials. The group has also developed extracellular vesicle nanotechnologies for targeted cell delivery and discovered delivery technologies, including peptide- and antibody-based technologies. Research in the laboratory also includes studying fundamental RNA biology and developing RNA-based therapeutic agents and novel technologies for their delivery. Responsibilities Overall, the job responsibilities require the candidate to be self-motivated, capable of working independently, and as part of a team. Effective communication skills are essential for collaborating with colleagues: • Independently manage research and daily tasks within the guidelines provided by senior colleagues. • Test the efficacy and safety of potential oligonucleotide therapies in cells derived from patients with heritable cardiomyopathies. • Independently collect and analyse data with guidance and support from senior colleagues. • Acquire new techniques and skills as required and contribute to project planning as part of the wider team. Department of Paediatrics Research Assistant Job Description 2 • Contribute to the preparation of scientific reports and journal articles, and provide material for the presentation of papers and posters at conferences. • Ensure laboratory work is conducted safely and in compliance with relevant health and safety policies and procedures, without compromising personal safety or that of others who may be affected. Selection criteria Essential • Possess the focus to work full-time solely on the project goal, accelerating the development of an oligonucleotide drug for testing in a clinical trial. • Hold a degree in a relevant scientific subject (BSc, MSc, MD). • Demonstrate a track record of being a fast learner with the potential to transition into a DPhil position based on job performance, or have substantial experience in a wide range of analytical tools and techniques in molecular biology and tissue culture of relevance to the project. • Have excellent communication skills, with the ability to work both independently and collaboratively as part of a team. Desirable • An understanding of cardiac muscle diseases, including their underlying pathophysiology and enthusiasm to work on the development of treatments for these disorders. • Knowledge of oligonucleotides oligonucleotides. • Demonstrate experience with molecular biology techniques and tissue culture. • Have experience in independently managing a discrete area of a research project. and previous experience with working with . Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Department of Paediatrics Research Assistant Job Description 3 Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Work with allergens, e.g. laboratory animals, pollen, dust, fish or insects etc. • Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • Enhanced Level Screening as this role includes conducting research involving animals (or working closely with such research); with access to/ knowledge of the location of certain pathogens, toxins, irradiators. • A satisfactory basic Disclosure and Barring Service check due to the nature of this position which include working with highly sensitive data. • University security screening (e.g. identity checks) About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Department of Paediatrics Research Assistant Job Description 4 Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. We are committed to inform and inspire external audiences worldwide through our public engagement and outreach activities. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ Department of Paediatrics Research Assistant Job Description 5 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting https://staff.web.ox.ac.uk/recruitment-support-faqs advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Department of Paediatrics Research Assistant Job Description 6 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Department of Paediatrics Research Assistant Job Description 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Department of Paediatrics Research Assistant Job Description 8
alternative label
Source
Past vacancies at the University of Oxford
NTriples description of Research Assistant
About the role We are seeking candidates with either extensive technical experience in molecular biology and tissue culture techniques or a strong willingness to learn and become developers of new therapies, with the potential to transition into a DPhil position based on job performance. The role requires applicants to hold a degree in a relevant scientific subject (BSc, MSc, MD). The successful candidate will join Prof. Matthew Woods' Group at the Institute of Development and Regenerative Medicine on the Old Road Campus. The laboratory has developed novel oligonucleotide therapies for muscle disorders, including Duchenne Muscular Dystrophy (DMD) and Myotonic Dystrophy type 1 (DM1), which are currently being tested in clinical trials. Additionally, the group has developed peptide and antibody-based delivery platforms for targeted cell delivery and has discovered new delivery technologies. The position is offered on a full-time basis for a 1-year fixed-term contract, funded by the CureHeart project. CureHeart is a £30m global award funded by the British Heart Foundation. This award is one of the largest non-commercial grants ever awarded and provides a “once in a generation opportunity” to offer hope to patients and families affected by these deadly diseases. The award aims to develop revolutionary and precise technologies to silence the faulty genes responsible for these conditions. The team includes world-leading scientists from Oxford, Harvard, and other highly prestigious institutions. Application Process You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Amarjit Bhomra, Lab Manager using the details below. Only online applications received before 12.00 midday on Tuesday 4 June 2024 will be considered.
address
tiene sede en
Standard Grade 6: 32,332 - £38,205 per annum (with a discretionary range to £41,732 per annum)
notation
WTC Clinical Vaccinology and Tropical Medicine
preferred label
Wellcome Trust Centre Clinical Vaccinology and Tropical Medicine
has site
Notation3 description of Research Assistant
tiene sede principal en
es suborganización de
primary Site
Subject
sous-Organization de
site principal
RDF/XML description of Research Assistant
Voice
country name
sotto-Organization di
Turtle description of Research Assistant
email
telephone
Address