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comment: We are seeking an enthusiastic Postdoctoral Research Assistant to work within a vibrant research team headed by Professor David Hodson at the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) on studies related to type 1 diabetes (https://www.rdm.ox.ac.uk/people/david-hodson). The postholder will contribute to a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, which is led by Oxford together with partners at the University of Birmingham and FMP Leibniz Berlin. The overarching aims of the Grand Challenge are to: 1) Produce better functioning stem cell-derived beta cells to ensure long-lasting insulin-independence in people living with type 1 diabetes (T1D) 2) Precision deliver therapy to the pancreatic beta cell surface that can fend off immune attack in the early stages of T1D 3) Coax alpha cells, which survive immune destruction during T1D, to convert into insulin-positive cells to provide a new supply of beta cells without the need for transplantation. To allow this, we will target two surface receptors, which are highly expressed by alpha cells and beta cells. The major goal is to help improve stem cell-derived beta cell survival and function, allow immunotherapy to work better for longer with fewer side effects, and provide more evidence that endogenous beta cells can be regenerated, together making beta cell replacement a possibility for more people living with T1D. Although full training will be given in a variety of techniques, the person appointed will be expected to work independently on most tasks or in collaboration with the support of colleagues. Methods will include cell culture, stem cell-derived beta cell generation, hormone assays, sequencing, cloning and optical imaging. The position would suit a cell biologist with experience of imaging, molecular genetics and cell culture. A background in diabetes or metabolism is desirable. The position, funded by a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, and is offered as a…
formal organization: University of Oxford
organization part: Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM)
type: Vacancy
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application closing date: 2024-06-19T12:00:00+01:00
further particulars: 173446 JD - Postdoctoral Research Assistant
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comment: We are seeking an enthusiastic Postdoctoral Research Assistant to work within a vibrant research team headed by Professor David Hodson at the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) on studies related to type 1 diabetes (https://www.rdm.ox.ac.uk/people/david-hodson). The postholder will contribute to a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, which is led by Oxford together with partners at the University of Birmingham and FMP Leibniz Berlin. The overarching aims of the Grand Challenge are to: 1) Produce better functioning stem cell-derived beta cells to ensure long- lasting insulin-independence in people living with type 1 diabetes (T1D) 2) Precision deliver therapy to the pancreatic beta cell surface that can fend off immune attack in the early stages of T1D 3) Coax alpha cells, which survive immune destruction during T1D, to convert into insulin-positive cells to provide a new supply of beta cells without the need for transplantation. To allow this, we will target two surface receptors, which are highly expressed by alpha cells and beta cells. The major goal is to help improve stem cell-derived beta cell survival and function, allow immunotherapy to work better for longer with fewer side effects, and provide more evidence that endogenous beta cells can be regenerated, together making beta cell replacement a possibility for more people living with T1D. Although full training will be given in a variety of techniques, the person appointed will be expected to work independently on most tasks or in collaboration with the support of colleagues. Methods will include cell culture, stem cell-derived beta cell generation, hormone assays, sequencing, cloning and optical imaging. The position would suit a cell biologist with experience of imaging, molecular genetics and cell culture. A background in diabetes or metabolism is desirable. The position, funded by a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, and is offered as …

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173446 JD - Postdoctoral Research Assistant
value: Oxford Centre for Diabetes, Endocrinology and Metabolism Job Description Summary Job title Post-doctoral Research Assistant Division Medical Sciences Division Department Radcliffe Department of Medicine (RDM) - Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) Location OCDEM, Churchill Hospital, Headington, Oxford, OX3 7LE Grade and salary Grade 7: £36,024 - £44,263 per annum Hours Full- time Fixed-term for 2 years Contract type Reporting to Professor David Hodson Vacancy reference 173446 Additional information Interviews will be held on the week commencing 24th June 2024 Research topic Type 1 diabetes Principal Investigator / supervisor Professor David Hodson Project team Project web site https://www.rdm.ox.ac.uk/people/david-hodson Funding partner The funds supporting this research project are provided by the “Steve Morgan Foundation Type 1 Diabetes Grand Challenge” by Diabetes UK and Steve Morgan Foundation. Recent publications doi: 10.1021/jacsau.2c00130 10.1038/s41467-022-35716-1 ERC JD PDRA1_DJH.docx 1 doi: 10.1172/jci.insight.140288 doi: 10.1038/s41467-020-20632-z 10.1016/j.celrep.2020.107761 doi: 10.1038/s41467-020-14309-w The role The successful applicant will join Prof. David Hodson’s research group at the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. The lab has recently been awarded Steve Morgan Foundation Type 1 Diabetes Grand Challenge funding, together with partners at the University of Birmingham (Dr Ildem Akerman) and FMP Leibniz Berlin (Dr Johannes Broichhagen). The overarching aims of our Grand Challenge are to: 1) produce better functioning stem cell-derived beta cells to ensure long-lasting insulin-independence following transplantation into people living with T1D; 2) precision deliver therapy to the pancreatic beta cell surface that can fend off immune attack in the early stages of T1D; and 3) coax alpha cells, which survive immune destruction during T1D, to convert into insulin-positive cells to…
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