Laboratory Technician

The Nuffield Department of Women’s & Reproductive Health is seeking to appoint
a Laboratory Technician to join Professor Jo Poulton’s group.





This post is closely allied to the diagnostic service of the NHS funded HSS
for Rare Mitochondrial Disorders Service for Adults and Children (Oxford
branch). Diagnosing mitochondrial DNA (mtDNA) depletion syndrome is frequently
difficult and can be supported by characterising mtDNA depletion in primary
fibroblast cultures. Ours is the only national service offering such
characterisation. At present we use standard fluorescence microscopy, but we
are in the process of automating this using high content imaging (Operetta,
Perkin Elmer). We aim to validate these tests for diagnosis. Similarly, we use
related methods to support the diagnosis of defects in mitochondrial dynamics
(fission and fusion). Our method is able to quantify mitophagy (a type of
mitochondrial recycling) and we would ideally like to develop this as a
biomarker for mitochondrial disease. We thus need an experienced team member
to provide technical and administrative support, and to ensure the smooth
running of the laboratory.





You will have experience of working in a laboratory environment and with
hazardous chemicals. You will be educated to at least A-level, or with an
equivalent qualification in science. You will be able to troubleshoot problems
with experiments and arrive at an appropriate solution. You will also have a
strong attention to detail, with the ability to organise samples and record
results in a clear and organised fashion. IT skills, good organisational
skills as well as knowledge of health and safety regulations in a laboratory
environment are also essential in this role.





This position is part-time (7.5 hours per week) and fixed-term until 31st
March 2026 . Applications for flexible working arrangements are welcomed and
will be considered in line with business needs.





You will be required to upload a CV and Supporting Statement as part of your
online application. Click here for information and advice on writing an
effective Supporting Statement.





The closing date for applications is 12.00 noon on Monday 15th July 2024.
Interviews are expected to take place on Tuesday 30th July 2024.