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Description of Postdoctoral Research Associate in Solute Carrier structural biology/Drug Design
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Postdoctoral Research Associate in Solute Carrier structural biology/Drug Design
comment: Pay Scale: STANDARD GRADE 7 Salary (£): £39,347 - £40,521 per annum Location: Department of Biochemistry, South Parks Road, Oxford Contract type: Fixed Term Hours: Full-time About the role We are seeking to appoint a Postdoctoral Research Associate to join Prof Simon Newstead’s lab in collaboration with Prof Philip Biggin (Oxford Biochemistry) and Prof Chris Schofield (Oxford Chemistry) to develop a computational pipeline to help design antibiotics with improved uptake into humans. This builds on a substantial body of work already performed by this team using a combination of advanced structural biology, computational techniques, and chemical synthesis. The aim of this post is to establish the mechanistic rules for proton coupling in Peptide Transporters and explore the development of inhibitors and modulators. This full-time fixed-term post is funded by the BBSRC for up to 3 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. What We Offer Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel loans The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work. About you The successful applicant will work closely with the computational scientist employed in Prof Biggin’s lab to develop a computational pipeline for improving antibiotic transport. Chemical synthesis support will be provided by colleagues in Prof Schofield’s laboratory. The PDRA will therefore be expected to work very closely with PDRAs in our collaborator laboratories. You will pos…
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comment: **Pay Scale:** STANDARD GRADE 7 **Salary ( £)**: £39,347 - £40,521 per annum **Location:** Department of Biochemistry, South Parks Road, Oxford **Contract type:** Fixed Term **Hours:** Full-time **About the role** We are seeking to appoint a Postdoctoral Research Associate to join Prof Simon Newstead’s lab in collaboration with Prof Philip Biggin (Oxford Biochemistry) and Prof Chris Schofield (Oxford Chemistry) to develop a computational pipeline to help design antibiotics with improved uptake into humans. This builds on a substantial body of work already performed by this team using a combination of advanced structural biology, computational techniques, and chemical synthesis. The aim of this post is to establish the mechanistic rules for proton coupling in Peptide Transporters and explore the development of inhibitors and modulators. This full-time fixed-term post is funded by the BBSRC for up to 3 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. **What We Offer** Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel loans The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work. **About you** The successful applicant will work closely with the computational scientist employed in Prof Biggin’s lab to develop a computational pipeline for improving antibiotic transport. Chemical synthesis support will be provided by colleagues in Prof Schofield’s laboratory. The PDRA will therefore be expected to work very closely with PDRAs in our collab…
salary: Standard Grade 7: £36,024 - £44,263 per annum
application opening date: 2024-07-09T09:00:00+01:00
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further particulars: 173981 Research Associate Gr 7 JD - Newstead Biggin.pdf
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173981 Research Associate Gr 7 JD - Newstead Biggin.pdf
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value: Summary Job title Postdoctoral Research Associate in Solute Carrier structural biology/Drug Design Division Medical Sciences Department Department of Biochemistry Location Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford Grade and salary Grade 7: £39,347 - £40,521 per annum Hours Full Time (37.5 hours per week) Contract type Fixed Term Contract for up to 3 years in the first instance Reporting to Professor Simon Newstead Vacancy reference 173981 Additional information You are required to submit a 2-page CV and a supporting statement (of no more than 2 pages with 11 pt font) with your application, outlining how you meet each of the selection criteria for the role (see below for details). Your application will not be processed if you do not include both documents. No other documentation is required – please do not submit copies of published works with your application. Research topic Using cryo-EM and Biochemistry to understand drug recognition and transport in the SLC15 family of peptide transporters Principal Investigator / supervisor Prof Simon Newstead Project team Simon Newstead in collaboration with Prof Philip Biggin (Biochemistry, Oxford) and Prof Chris Schofield (Chemistry, Oxford) Project web site https://www.bioch.ox.ac.uk/research/newstead Funding partner The funds supporting this research project are provided by the BBSRC Recent publications 1 Lichtinger, S. M. & Biggin, P. C. Tackling hysteresis in conformational sampling: How to be forgetful with MEMENTO. J. 2 3 Chem. Theory Comput. 19, 3705-3720 (2023). https://doi.org:10.1021/acs.jctc.3c00140 Lichtinger, S. M., Parker, J. L., Newstead, N. & Biggin, P. C. The mechanism of mammalian proton-coupled peptide transporters. bioRxiv, 2024.2002.2004.578827 (2024). https://doi.org:10.1101/2024.02.04.578827 Parker, J. L. et al. Cryo-EM structure of PepT2 reveals structural basis for proton coupled peptide transport in mammals. Sci. Adv. 7, eabh3355 (2021). The role We are seeking to appoint a Postdoct…

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