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Postdoctoral Researcher in genetic disorders of chromatin function
salary: Salary in range £36,024 - £40,521 per annum
application closing date: 2024-09-13T12:00:00+01:00
further particulars: 174376 - Postdoctoral Researcher in genetic disorders - JD
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comment: We have an exciting opportunity to recruit a Postdoctoral Researcher in genetic disorders of chromatin function to join Dr Robert Beagrie’s Lab at the Centre for Human Genetics, Nuffield Department of Medicine. This project will involve investigating the consequences of mutations in Nipbl. Nipbl is responsible for loading the cohesin complex onto chromatin and therefore has a major role in establishing proper 3D chromatin folding. The project aims to characterize the transcriptional, epigenetic, and 3D-chromatin consequences of Nipbl disruption using animal models and cell lines. You will do this by applying advanced techniques including single-cell RNA-seq, single-cell ATAC-seq, and Genome Architecture Mapping (GAM). You will be responsible for contributing to the research group’s goal of understanding how mutations in chromatin-organizing genes cause disease by conducting laboratory experiments to test hypotheses, reviewing and refining working hypotheses as appropriate, contributing ideas for new research projects, and developing ideas for generating research income. You will be tasked with keeping detailed, accurate, and comprehensible electronic records of experimental and computational work and communicating progress and difficulties in the research project to Dr. Beagrie and the wider research group. Finally, you will also be responsible for managing your own academic research and administrative activities, including small-scale project management and coordinating multiple aspects of work to meet deadlines. To be successful in this role, you will hold a PhD/DPhil (or be close to completion) in biology, biochemistry, genetics, bioinformatics, or another related subject, along with strong experience in chromatin organization, gene regulation or congenital disease. You will have the ability to demonstrate a clear interest in learning how to generate Genome Architecture Mapping data and integrate it with single-cell and/or spatial transcriptomics data. You will a…
subject: research
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comment: We have an exciting opportunity to recruit a Postdoctoral Researcher in genetic disorders of chromatin function to join Dr Robert Beagrie’s Lab at the Centre for Human Genetics, Nuffield Department of Medicine. This project will involve investigating the consequences of mutations in _Nipbl_. Nipbl is responsible for loading the cohesin complex onto chromatin and therefore has a major role in establishing proper 3D chromatin folding. The project aims to characterize the transcriptional, epigenetic, and 3D-chromatin consequences of Nipbl disruption using animal models and cell lines. You will do this by applying advanced techniques including single-cell RNA-seq, single-cell ATAC-seq, and Genome Architecture Mapping (GAM). You will be responsible for contributing to the research group’s goal of understanding how mutations in chromatin-organizing genes cause disease by conducting laboratory experiments to test hypotheses, reviewing and refining working hypotheses as appropriate, contributing ideas for new research projects, and developing ideas for generating research income. You will be tasked with keeping detailed, accurate, and comprehensible electronic records of experimental and computational work and communicating progress and difficulties in the research project to Dr. Beagrie and the wider research group. Finally, you will also be responsible for managing your own academic research and administrative activities, including small-scale project management and coordinating multiple aspects of work to meet deadlines. To be successful in this role, you will hold a PhD/DPhil (or be close to completion) in biology, biochemistry, genetics, bioinformatics, or another related subject, along with strong experience in chromatin organization, gene regulation or congenital disease. You will have the ability to demonstrate a clear interest in learning how to generate Genome Architecture Mapping data and integrate it with single-cell and/or spatial transcriptomics data. You will…
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contact: Margarita Monroy
type: Vacancy
organization part: Wellcome Trust Centre for Human Genetics

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value: Job title Postdoctoral Researcher in genetic disorders of chromatin function Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Roosevelt Drive, Old Road Campus, Oxford, OX3 7BN Grade and salary Grade 7: Salary in range £36,024 - £40,521 per annum Hours Full time (part time hours considered, at minimum of 60% FTE) Contract type Fixed-term contract for 2 years Funding is provided by Wellcome Reporting to Robert Beagrie, Sir Henry Dale Fellow Vacancy reference 174376 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent Visa under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us • • • University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - www.chg.ox.ac.uk What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic Congenital defects caused by mutations in Nipbl, a component of the cohesin complex Principal Investigator / supervisor Dr Robert Beagrie, Sir Henry Dale Fellow Project team Beagrie Group Project web site beagrielab.com and groups/beagrie-group Funding partner The funds supporting this research project are provided by Wellcome www.well.ox.ac.uk/research/research- Beagrie, R. A. et al. Complex multi-enhancer contacts captured by genome architecture mapping. Nature 543, 519–524 (2017). Key publications Chea, S. et al. Gastrulation-stage gene expression in Nipbl+/− mouse embryos foreshadows the development of …

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