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We have an exciting opportunity to recruit a Research Assistant with a background in a life sciences laboratory environment to join the Dr. Ricardo A. Fernandes group and the newly established Protein Production Platform at the Chinese Academy of Medical Sciences Oxford Institute (COI), Nuffield Department of Medicine.

COI research focuses on developing novel immunotherapies and vaccine strategies against cancer and infectious disease. These advances are driven by fundamental discoveries in cellular, molecular, and structural biology in health and disease.

 

You will be responsible for designing, expressing, and purifying recombinant proteins from mammalian, insect, or bacterial cells, performing molecular cloning techniques, and maintaining DNA stocks for the project. You will be tasked with determining the most appropriate methodologies to test hypotheses using specialist scientific equipment in a laboratory environment and conducting biophysical, biochemical, and cellular assays to characterise the activity of synthetic proteins. You will also be responsible for managing your own tasks, projects, and administrative activities, where appropriate. This involves small-scale project management and coordinating multiple aspects of work to meet deadlines.

 

To be successful in this role, hold a BSc in biochemistry, cell biology, chemistry, biotechnology, or related scientific areas along with experience in following and adapting protocols and selecting appropriate experimental methodologies. You will have experience in laboratory support in a life science laboratory and familiarity with the underlying principles of recombinant protein expression and purification. You will be highly organized, with excellent attention to detail and the ability to manage and catalogue large quantities of samples. You will also have excellent interpersonal skills with the ability to interact equally effectively with senior academic staff, researchers, and support staff and the flexibility to work independently and as part of a team;

 

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

 

This position is offered full time on a fixed term contract for 2 years and is funded by the CAMS Core grant.

 

Only applications received before 12 midday on Tuesday 27 August 2024 will be considered. Please quote 174650 on all correspondence.
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"""Job title Research Assistant Division Medical Sciences Department Nuffield Department of Medicine Location CAMS Oxford Institute, Building for Molecular Physiology, Roosevelt Drive, Oxford, OX3 7BN Grade and salary Grade 6: Salary in range £32,332 - £32,982 per annum Hours Full time Contract type Fixed-term contract for 2 years Funding is provided by the CAMS Core grant Reporting to Ricardo Fernandes, PI and Group Leader Vacancy reference 174650 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation. Therefore, the Nuffield Department of Medicine welcomes applications from international applicants who require a visa. About us What we offer     University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - www.camsoxford.ox.ac.uk Fernandes Group https://www.camsoxford.ox.ac.uk/research/groups/raf-lab https://hr.admin.ox.ac.uk/staff-benefits  An excellent contributory pension scheme  38 days annual leave  A comprehensive range of childcare services  Family leave schemes  Cycle loan scheme  Discounted bus travel and Season Ticket travel loans  Membership to a variety of social and sports clubs  A welcoming and diverse community The role Applications are invited for a Research Assistant with a background in a life sciences laboratory environment to join the Dr Ricardo A. Fernandes group and the newly established Protein Production Platform at the Chinese Academy of Medical Sciences Oxford Institute (COI). The COI is a collaboration between the Chinese Academy of Medical Sciences and the University of Oxford. Combining the strengths of both partners, the Institute aims to deliver outstanding science and help to develop innovative medicines to tackle infectious diseases and cancer. COI research focuses on developing novel immunotherapies and vaccine strategies against cancer and infectious disease. These advances are driven by fundamental discoveries in cellular, molecular and structural biology in health and disease. You will provide technical and administrative support to ensure the efficient running of the Protein Production Platform. You will have a background in biochemistry, protein science or related fields. Your primary role will be to lead the support of a platform for the design and production of custom genes, plasmids and proteins. These reagents will be validated with various structural, biophysical and biochemical approaches and shared with researchers at COI and across various Institutes. You will also be responsible for maintaining, for example, cell cultures, common buffers and stocks. Moreover, you will help place orders for reagents and consumables, maintain an updated inventory, and liaise with lab members to ensure the laboratory's smooth running. Training will be provided, and you may also be responsible for training group members. You will have the ability to organise and prioritise work efficiently, delivering results to a high standard and an agreed schedule. You will be able to demonstrate a high level of written and oral communication skills and the ability to work effectively within a team. Informal enquiries regarding this position may be submitted to Dr Ricardo A. Fernandes at: Ricardo.fernandes@ndm.ox.ac.uk Responsibilities You will:  Design, express and purify recombinant proteins from mammalian, insect or bacterial cells;  Perform biophysical, biochemical and cellular assays to characterise the activity of synthetic proteins;  Perform molecular cloning techniques and maintain pDNA stocks for the project;  Select, follow, and adapt experimental protocols;  Determine the most appropriate methodologies to test hypotheses and use specialist scientific equipment in a laboratory environment;  Manage own tasks, projects, and administrative activities, where appropriate. This involves small-scale project management and coordinating multiple aspects of work to meet deadlines;  Ensure basic principles of cell culture are met and support the routine maintenance of cells;  Share responsibility for managing stocks of frozen samples;  Share responsibility for maintaining and managing stocks of chemicals, laboratory reagents, and consumables;  Collect, analyse, and present scientific data from a variety of sources;  Contribute to discussions and share research findings with colleagues in partner institutions, and research groups;  Contribute to scientific reports and journal articles and the presentation of data/papers at conferences;  Represent the research group at external meetings/seminars, either with other members of the group or alone; 1 Education and Training   Attend appropriate scientific seminars, training opportunities and meetings within the research team, in the Centre and University. Participate in the education and training of other staff as necessary and appropriate. General Responsibilities        Act at all times in the interests of the Institute to ensure good laboratory practice. Be accountable for personal and professional conduct within the project. Undertake such other duties as may be required from time to time that are commensurate with the grade and responsibilities of this post. Ensure that work in the laboratory is conducted safely and, in particular, that work is undertaken using appropriate safety procedures and in the dedicated areas. Accord due regard to the University’s Equal Opportunities and Data Protection policies Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Selection criteria Essential            Hold a BSc in biochemistry, cell biology, chemistry, biotechnology or related scientific areas; Experience in laboratory support in a life science laboratory; Experience of following and adapting protocols and selecting appropriate experimental methodologies; Experience in the preparation of common buffers and basic laboratory techniques; Experience in molecular cloning; Familiarity with the underlying principles of recombinant protein expression and purification; Highly organised, with excellent attention to detail and the ability to manage and catalogue large quantities of samples; Ability to manage own research and administrative activities, including the ability to prioritise and manage a varied workload in order to meet deadlines; The flexibility to work independently and as part of a team; Excellent interpersonal skills with the ability to interact equally effectively with senior academic staff, researchers and support staff; Excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings; Desirable       Experience in protein expression and purification; Experience in cell culture and maintenance of cell lines; Experience manipulating gene expression in cells by CRISPR or lentiviral transduction; Experience in immunoblotting techniques; Experience in contributing to reports and articles for publication; Experience using FlowJo, Snapgene, Pymol, Chimera or equivalent software; 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:     Lone Working Regular manual handling Working with blood, human products and human tissues Work with any substance which has any of the following pictograms on their MSDS:  Travel outside of Europe or North America on University Business 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents.  http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement 4 The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5 """^^ . "text/html" . . 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COI research focuses on developing novel immunotherapies and vaccine strategies against cancer and infectious disease. These advances are driven by fundamental discoveries in cellular, molecular, and structural biology in health and disease. You will be responsible for designing, expressing, and purifying recombinant proteins from mammalian, insect, or bacterial cells, performing molecular cloning techniques, and maintaining DNA stocks for the project. You will be tasked with determining the most appropriate methodologies to test hypotheses using specialist scientific equipment in a laboratory environment and conducting biophysical, biochemical, and cellular assays to characterise the activity of synthetic proteins. You will also be responsible for managing your own tasks, projects, and administrative activities, where appropriate. This involves small-scale project management and coordinating multiple aspects of work to meet deadlines. 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