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comment: **Full time, Fixed-term until 01 December 2027 ** **About us:** At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment. **Overview of the role:** We are seeking a Postdoctoral Research Scientist (PDRS) to join the Swietach group. The ideal candidate will be an experienced cancer scientists with an interest and track record in metabolism. In this role, you will be responsible for undertaking research on metabolic heterogeneity in pancreatic cancer, implementing innovative assays to understand dynamic changes in metabolic profile, and how these affect cancer growth. The aim of the project is to unravel new vulnerabilities that could be targeted therapeutically. This post is available from 02 December 2024 until 01 December 2027. **Key responsibilities:** * Manage academic research activities and associated project management, co-ordinate multiple aspects of work to meet deadlines * Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate * Receive training to innovate scientific techniques * Use specialist scientific equipment in a laboratory environment * Engage in the collaborative opportunity between the host departments * Undertake the research plan on cell lines, including a series of animal experiments, with a view of seeking translational opportunities for future work. * Contribute ideas for new research projects, develop ideas for generating research income. * Collaborate in the preparation of scientific reports and journal articles and present papers and posters * Act as a source of i…
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comment: Full time, Fixed-term until 01 December 2027 About us: At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment. Overview of the role: We are seeking a Postdoctoral Research Scientist (PDRS) to join the Swietach group. The ideal candidate will be an experienced cancer scientists with an interest and track record in metabolism. In this role, you will be responsible for undertaking research on metabolic heterogeneity in pancreatic cancer, implementing innovative assays to understand dynamic changes in metabolic profile, and how these affect cancer growth. The aim of the project is to unravel new vulnerabilities that could be targeted therapeutically. This post is available from 02 December 2024 until 01 December 2027. Key responsibilities: Manage academic research activities and associated project management, co-ordinate multiple aspects of work to meet deadlines Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate Receive training to innovate scientific techniques Use specialist scientific equipment in a laboratory environment Engage in the collaborative opportunity between the host departments Undertake the research plan on cell lines, including a series of animal experiments, with a view of seeking translational opportunities for future work. Contribute ideas for new research projects, develop ideas for generating research income. Collaborate in the preparation of scientific reports and journal articles and present papers and posters Act as a source of information and advice to other memb…
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further particulars: Postdoctoral Research Scientist_JD_Swietach

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value: Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022, 2023 and 2024 Job description and Selection Criteria Job title Postdoctoral Research Scientist Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Sherrington Building, Parks Road, Oxford, OX1 3PT Grade and salary Grade 7: £36,024-39,347 per annum Hours Full time Contract type Fixed-term until 01 December 2027. Position available from 02 December 2024. Reporting to Professor Pawel Swietach Vacancy reference AV24043 / HRIS:174845 Research topic Mechanisms of metabolic heterogeneity in pancreatic cancer Principal Investigator / supervisor Pawel Swietach Project team Swietach Group Project web site https://www.dpag.ox.ac.uk/research/swietach-group Funding partner Recent publications The funds supporting this research project are provided by the Medical Research Council (UKRI) 1. Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance. Michl J, White B, Monterisi S, Bodmer WF, Swietach P. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2319055121. doi: 10.1073/pnas.2319055121 2. Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells. Blaszczak W, White B, Monterisi S, Swietach P. Cell Rep. 2024 Jan 23;43(1):113612. doi: 10.1016/j.celrep.2023.113612. 3. How protons pave the way to aggressive cancers. Swietach P, Boedtkjer E, Pedersen SF. Nat Rev Cancer. 2023 Dec;23(12):825841. doi: 10.1038/s41568-023-00628-9 4. Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2. Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P. Cell Rep. 2023 Jun 27;42(6):112601. doi: 10.1016/j.celrep.2023.112601 5. CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival…
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