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Postdoctoral Research Associate in Translational Biology
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comment: We are seeking to appoint a highly qualified and dedicated Postdoctoral Research Associate in Translational Biology to join our research team at Oxford Translational Myeloma Centre which is based at Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), Oxford As a Postdoctoral Research Associate in Translational Biology you will lead laboratory experiments and the computational analysis and interpretation of data with the goal of discovering biological pathways, patterns and genes that are responsible for the drivers of drug response or resistance in multiple myeloma. You will specifically interrogate multiple Myeloma cell lines and immune cells for studying the mechanism of action of epigenetic therapy in Multiple Myeloma. In partnership with industrial and academic collaborators you will analyse patient derived genomic, immune, pharmacokinetic and pharmacodynamic data to build hypothesis and test them in laboratory models. You will contribute ideas for new research projects, collaborate in the preparation of scientific reports and journal articles and act as a source of information and advice to other members of the group. You will hold a PhD/DPhil (or near completion) in a biomedical discipline with direct relevance to molecular techniques and assays together with experience to undertake cell based analysis of drug activities. Ability to develop novel assays for testing compounds and their mechanisms based on genetics, OMICs and other assays is essential for success in this project. We are looking for a candidate who would be able to deliver high quality research outputs, as demonstrated by a strong publication record in high profile scientific journals. Familiarity with the existing literature and research in the field of Myeloma or cancer biology together with passion for problem-solving desirable but not essential. Experience in drug related research, strong publication track record and experience of p…
spatial: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD
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value: Job Description _________________________________________________________________________ Summary Job title Postdoctoral Research Associate in Translational Biology Division Medical Sciences Division Department Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Location Botnar Research Centre, Windmill Road, Oxford, OX3 7LD Grade and salary Grade 7: £37,524-£45,763 per annum Hours Full time Contract type Fixed-term (2 years) Reporting to Prof Anjan Thakurta Vacancy reference 175149 Research topic Understanding mechanisms of epigenetic Multiple Myeloma therapies Principal Investigator / supervisor Prof Anjan Thakurta Project team OTMC Translational group Funding partner The funds supporting this research project are provided by OTMC The role You will lead the computational analysis and interpretation of single cell and imaging datasets with the goal of discovering the cells, inter-cellular signalling circuits, biological pathways, patterns and genes that are responsible for causing disease and therapeutic response in multiple myeloma. You will develop bioinformatic tools for implementing long-read sequencing and single cell data. To do so you will work closely with a team of clinicians and experimental scientists. Responsibilities Key responsibilities – generic • • • • • • • • • • Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines Adapt existing and develop new scientific techniques and experimental protocols Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate Contribute ideas for new research projects Develop ideas for generating research income, and present detailed research proposals to senior researchers Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters Use specialist scientific equi…

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