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"""Job Description DEPARTMENT OF CHEMISTRY Summary Job title Postdoctoral Research Associate in novel strategies for the synthesis of oligonucleotides Division Mathematical, Physical and Life Sciences Department Department of Chemistry Location Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Physical and Theoretical Chemistry, South Parks Road, Oxford, OX1 3QZ Grade and salary Grade 7: £37,524 - £45,763 per annum (inclusive of Oxford University Weighting) Hours Full time Contract type Fixed term until 6th March 2025 in the first instance Reporting to Prof E Anderson, Prof T Brown Vacancy reference 175498 Additional information Research topic Novel strategies for the synthesis of oligonucleotides for use in therapeutic applications Principal Investigator / supervisor Prof Ed Anderson, Prof Tom Brown https://www.chem.ox.ac.uk/people/ed-anderson-0 Project team Project web site https://www.chem.ox.ac.uk/people/tom-brown-0 n/a Funding partner The funds supporting this research project are provided by the Eli Lilley LRAP scheme Recent publications Review: The role of chemistry in the success of oligonucleotides as therapeutics. Pawan Kumar and Tom Brown. Beilstein J. Org. Chem. 18, 197-199, 2022. Recent work from Brown group: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exonskipping oligonucleotides. Y. R. Baker, C. Thorpe, J. Chen, L. M. Poller, L. Cox, P. Kumar, et al. Nat. Commun. 2022 13, 4036. DOI: 10.1038/s41467-022-31636-2 The role The position requires an experienced postdoctoral researcher for a project to develop new chemistry for the highly efficient synthesis of modified DNA with particular relevance to the economic production of therapeutic oligonucleotides. A number of strategies will be explored to address current limitations in oligonucleotide assembly, which seek to improve the efficiency and sustainability of oligo synthesis. The work will be carried out in the research groups of Professor Ed Anderson and Tom Brown, combining their expertise in synthetic and nucleic acid chemistry. Responsibilities 1. Manage own academic research and administrative activities, including project management, developing new experimental protocols and adapting existing methods, and multi-tasking to meet deadlines. 2. Contribute ideas to problem solve, and develop new research projects. 3. Write up results in regular scientific reports, and for publication in peer-reviewed journals. 4. Use specialist scientific equipment as required for oligonucleotide synthesis. 5. Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques 6. Represent the research group at external meetings/seminars through poster or oral presentations . 7. Maintain active collaborations with our industrial partner, Eli Lilley. 8. Assist in management of the research group, including participation in journal club meetings, research meetings, and in the day-to-day supervision of junior group members. 9. PDRAs may be required to teach, this may include lecturing, small-group teaching, and tutoring of undergraduates and graduate students. job-description-and-selection-criteria-LRAP Final.docx 2 Selection criteria Essential selection criteria 1. Hold a PhD in organic chemistry or a related area (or be close to completion), prior to taking up the appointment. 2. Have experience in synthetic chemistry 3. An extensive knowledge of practical and theoretical aspects of organic chemistry 4. Be able to demonstrate competence and success in the thesis research area (and postdoctoral work if appropriate), e.g. as judged by publications (or papers in press) in high quality peer reviewed journals. Evidence will be sought of a deep understanding of the applicant's previous fields of research and evidence of independent intellectual and practical contributions to previous research projects, as indicators that such attributes can be brought to bear on the present project. 5. Be viewed as a motivated, enthusiastic, organised self-starter; one who can work independently but equally extract the benefits of an excellent collaborative research environment. 6. Have an excellent general knowledge of related areas through reading of the literature, online database searching, and attendance at seminars and conferences. 7. Be willing to learn new techniques and apply them in an interdisciplinary research environment. Be able to keep detailed electronic laboratory records and data and report on progress at regular intervals. 8. Communicate well in English in writing and in oral and visual presentations. 9. Show an ability to work supportively in a laboratory environment, supervise and educate junior coworkers and actively participate in group journal clubs and research meetings. 10. Be willing to play a role in keeping the laboratory running by assuming a share of group responsibilities. Desirable selection criteria 1. Have an interest in Nucleic Acid Chemistry and its applications in therapeutics 2. Experience in oligonucleotide chemistry 3. Experience in biophysical studies on nucleic acids Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks job-description-and-selection-criteria-LRAP Final.docx 3 Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:  Work with any substance which has any of the following pictograms on their MSDS: About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Chemistry The mission of Oxford Chemistry is to advance the global understanding of chemistry and to use that knowledge to address major challenges for society. Oxford Chemistry maintains world-class strengths in fundamental research, including the training of outstanding young scientists, whilst being an outward-looking department engaging with other disciplines, industry, public services, government and the general public. We are a large department within the University’s Mathematical, Physical and Life Sciences Division with over 70 research groups and 900 researchers including 400 graduate research students. Our MChem degree takes 180 students a year and features the distinctive tutorials of Oxford, an innovative three-year programme of practical teaching within our state-of-the-art teaching laboratory, and a 4th year focused on research based within one of our research groups. 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Our eight research themes and business engagements showcase the breadth and depth of our research across the chemical sciences. job-description-and-selection-criteria-LRAP Final.docx 4 We are committed to providing an inclusive and supportive work and study environment for all our staff and students based on core values of respect, equality and collaboration. We have held an Athena SWAN silver award since 2015 reflecting our commitment to improving gender equality within our discipline. Oxford Chemistry is accommodated within five buildings in the University’s science area, including a modern RIBA award-winning dedicated research facility and a state-of-the-art practical teaching laboratory. 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The Department has an active Equality, Diversity and Inclusion (EDI) committee and since 2015 we have held an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices which promote gender equality and create a better working environment for all. We promote family-friendly policies and support flexible working arrangements where possible. For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Mathematical, Physical and Life Sciences Division The academic administration of the University is conducted through four divisions (Humanities, Social Sciences, Mathematical, Physical and Life Sciences, and Medical Sciences). 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If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs Non-technical questions about this job should be addressed to the recruiting department directly at recuitment@chem.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacypolicy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/dataprotection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. 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See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. job-description-and-selection-criteria-LRAP Final.docx 7 """^^ . . "Physical and Theoretical Chemistry Laboratory" . . _:N20cd391279134b548e152ea547daad21 "University of Oxford" . "based near" . "ptchem"^^ . . . "Document" . . . "email"@en . . "preferred label"@en . 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The research requires experience in synthetic chemistry and a knowledge of nucleic acid chemistry is highly desirable but not essential. You will be expected to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. The post will be based in the Department of Chemistry, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford, OX1 3QZ. This post is available as soon as possible. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your application. 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Applications are invited for a Postdoctoral Research Associate position to carry out research on novel methods of oligonucleotide synthesis under the supervision of Professors Ed Anderson and Tom Brown.  The aim of the project is to develop new chemistry for the highly efficient synthesis of modified DNA with particular relevance to therapeutic oligonucleotides. The work will be carried out in the research groups of Professor Ed Anderson and Tom Brown, combining their expertise in synthetic and nucleic acid chemistry. The project is funded by Eli Lilley (LRAP funding scheme).

 

Find out more about the research and groups at: 



 

Applicants must hold a PhD in Organic Chemistry or a related subject area, (or be close to completion) prior to taking up your appointment.  The research requires experience in synthetic chemistry and a knowledge of nucleic acid chemistry is highly desirable but not essential. You will be expected to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines.

 

The post will be based in the Department of Chemistry, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford, OX1 3QZ. This post is available as soon as possible.

 

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your application.  Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Certificates, references and research papers should not be provided at this stage.

 

The closing date for applications is 12.00 midday, Wednesday 25th September 2024. Interviews will be held as soon as possible thereafter.

 

The University of Oxford and The Department of Chemistry are Silver Athena SWAN holders.  Applications are particularly welcome from women and black and ethnic minority candidates, who are under-represented in Chemistry research posts in Oxford.
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