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Postdoctoral Research Associate in novel strategies for the synthesis of oligonucleotides
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comment: Applications are invited for a **Postdoctoral Research Associate** position to carry out research on novel methods of oligonucleotide synthesis under the supervision of Professors Ed Anderson and Tom Brown. The aim of the project is to develop new chemistry for the highly efficient synthesis of modified DNA with particular relevance to therapeutic oligonucleotides. The work will be carried out in the research groups of Professor Ed Anderson and Tom Brown, combining their expertise in synthetic and nucleic acid chemistry. The project is funded by Eli Lilley (LRAP funding scheme). _Find out more about the research and groups at:_ https://www.chem.ox.ac.uk/people/ed-anderson-0 https://www.chem.ox.ac.uk/people/tom-brown-0 Applicants must hold a PhD in Organic Chemistry or a related subject area, (or be close to completion) prior to taking up your appointment. The research requires experience in synthetic chemistry and a knowledge of nucleic acid chemistry is highly desirable but not essential. You will be expected to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. The post will be based in the Department of Chemistry, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford, OX1 3QZ. This post is available as soon as possible. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. **Certificates, references and research papers should not be provided at this stage.** The closing date for applications is 12.00 midday, **Wednesday 25th September 2024.** Interviews will be held as soon as possible thereafter. The University of Oxford and The …
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comment: Applications are invited for a Postdoctoral Research Associate position to carry out research on novel methods of oligonucleotide synthesis under the supervision of Professors Ed Anderson and Tom Brown. The aim of the project is to develop new chemistry for the highly efficient synthesis of modified DNA with particular relevance to therapeutic oligonucleotides. The work will be carried out in the research groups of Professor Ed Anderson and Tom Brown, combining their expertise in synthetic and nucleic acid chemistry. The project is funded by Eli Lilley (LRAP funding scheme). Find out more about the research and groups at: https://www.chem.ox.ac.uk/people/ed-anderson-0 https://www.chem.ox.ac.uk/people/tom-brown-0 Applicants must hold a PhD in Organic Chemistry or a related subject area, (or be close to completion) prior to taking up your appointment. The research requires experience in synthetic chemistry and a knowledge of nucleic acid chemistry is highly desirable but not essential. You will be expected to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. The post will be based in the Department of Chemistry, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford, OX1 3QZ. This post is available as soon as possible. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Certificates, references and research papers should not be provided at this stage. The closing date for applications is 12.00 midday, Wednesday 25th September 2024. Interviews will be held as soon as possible thereafter. The University of Oxford and The Department of …
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value: Job Description DEPARTMENT OF CHEMISTRY Summary Job title Postdoctoral Research Associate in novel strategies for the synthesis of oligonucleotides Division Mathematical, Physical and Life Sciences Department Department of Chemistry Location Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Physical and Theoretical Chemistry, South Parks Road, Oxford, OX1 3QZ Grade and salary Grade 7: £37,524 - £45,763 per annum (inclusive of Oxford University Weighting) Hours Full time Contract type Fixed term until 6th March 2025 in the first instance Reporting to Prof E Anderson, Prof T Brown Vacancy reference 175498 Additional information Research topic Novel strategies for the synthesis of oligonucleotides for use in therapeutic applications Principal Investigator / supervisor Prof Ed Anderson, Prof Tom Brown https://www.chem.ox.ac.uk/people/ed-anderson-0 Project team Project web site https://www.chem.ox.ac.uk/people/tom-brown-0 n/a Funding partner The funds supporting this research project are provided by the Eli Lilley LRAP scheme Recent publications Review: The role of chemistry in the success of oligonucleotides as therapeutics. Pawan Kumar and Tom Brown. Beilstein J. Org. Chem. 18, 197-199, 2022. Recent work from Brown group: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exonskipping oligonucleotides. Y. R. Baker, C. Thorpe, J. Chen, L. M. Poller, L. Cox, P. Kumar, et al. Nat. Commun. 2022 13, 4036. DOI: 10.1038/s41467-022-31636-2 The role The position requires an experienced postdoctoral researcher for a project to develop new chemistry for the highly efficient synthesis of modified DNA with particular relevance to the economic production of therapeutic oligonucleotides. A number of strategies will be explored to address current limitations in oligonucleotide assembly, which seek to improve the efficiency and sustainability of oligo synthesis. The work will be carried out in the research groups of Professor Ed…
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