Jenner Institute, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ
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Wellcome Trust Centre Clinical Vaccinology and Tropical Medicine
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175848 - Postdoctoral Researcher Assistant - JD
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We have an exciting opportunity to recruit a highly motivated Postdoctoral Research Assistant to join the research program focused on developing vaccines against arthropod-borne pathogens within the Jenner Institute, Nuffield Department of Medicine. You will be reporting to Dr. César López-Camacho, Group leader and Jenner Investigator, working on the molecular design of genetic-based vaccines for Dengue virus, with a focus on mRNA and viral- vectored technologies. You will be responsible for managing your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will be tasked with conducting rigorous scientific research to the highest standards of the field. The role will require you to independently research published material and keep up to date with relevant literature. You will be tasked with testing hypotheses and analysing scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. As the Postdoctoral Research Assistant, it is essential you hold a relevant PhD/DPhil (or close to completion) in Biochemistry, Molecular Biology, or a related field. It is essential you have hands-on experience with in vitro transcription, mRNA handling, and mRNA analytics and hands-on experience in flavivirus and expertise in Lipid Nanoparticle (LNP) formulations. You will also be able to contribute ideas for new research projects and research income generation. Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings are essential for this role. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 January 2026 and is funded by the Calleva Foundation. You may also benefit from being associated with the Calleva Centre for Evolution and Human Science at Magdalen College, providing access to a vibrant academic community. Only applications received before 12 midday on Monday 6 January 2025 will be considered. Please quote **175848** on all correspondence.
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Nuffield Department of Clinical Medicine
Job title Postdoctoral Research Assistant Division Medical Sciences Department Nuffield Department of Medicine Location Jenner Institute, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ Grade and salary Research Grade 7: Salary in range £38,674 - £45,628 per annum (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata). Hours Full time Contract type Fixed-term contract until 31st January 2026. Funding is provided by the Calleva Foundation Reporting to Dr. César López-Camacho, Group Leader and Jenner Investigator Vacancy reference 175848 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship or may be eligible under UK Visas and Immigration legislation. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - www.jenner.ac.uk The role We are seeking to appoint a highly motivated Postdoctoral Research Assistant to join the research program focused on developing vaccines against arthropod-borne pathogens, encompassing a broad range of viral and parasitic infectious diseases. This position will be reporting to Dr. César LópezCamacho, Group leader and Jenner Investigator. You will work on the molecular design of genetic-based vaccines for Dengue virus, with a focus on mRNA and viral-vectored technologies. You will contribute to the early stages of pre-clinical vaccine development, exploring the immunogenicity of these vaccine candidates, and assisting in their transition to clinical trials. Additionally, you will provide guidance and supervision to less experienced members of the research group, including research assistants, technicians, and PhD and project students. Responsibilities You will: • • • • • • • • • • • • • • • • Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. Conduct rigorous scientific research to the highest standards of the field. Independently research published material and keep up to date with relevant literature. Adapt existing and develop new scientific techniques and experimental protocols. Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will be contributing ideas for new research projects and research income generation. Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters. Use specialist scientific equipment in a laboratory environment. Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques. Carry out collaborative projects with colleagues in partner institutions and research groups. Provide statistical analysis of data and contribute to the overall planning of studies and identify and troubleshoot technical or scientific problems. Attend scientific seminars, meetings and training, as required by the group leader. Contribute and collaborate to manuscript preparation, presentations and other means of disseminating results. Ensure that work in the laboratory is conducted safely, making appropriate use of the dedicated research areas and safety procedures. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. 1 Selection criteria Essential • • • • • • • • • • • • Hold a PhD/DPhil (or close to completion) in Biochemistry, Molecular Biology, or a related field. Proven and relevant wet-lab experience in mRNA biology and mRNA synthesis. Hands-on experience with in vitro transcription, mRNA handling, and mRNA analytics. Hands-on experience in flavivirus Knowledge in Lipid Nanoparticle (LNP) formulations. Experience in molecular cloning techniques. Proficiency in antigen expression using various expression platforms. Solid understanding of innate and adaptive immunology. Ability to independently manage academic research and related activities. Demonstrable experience in scientific writing with at least one first-author publication. Ability to contribute ideas for new research projects and research income generation. Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings. Desirable • • • • Experience with complex molecular biology assays is highly preferred (e.g., CRISPR/Cas9, RNA interference (RNAi), Next-Generation Sequencing (NGS), and ChIP-seq. Experience in both viral and non-viral nucleic acid formulation and delivery methods. Proficiency in analytical approaches for studying nucleic acids. Experience working with pre-clinical animal models. 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • • • • • Lone Working Work in hot or cold environments Regular manual handling Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens Work with allergens, Eg laboratory animals, pollen, dust, fish or insects etc. Work with any substance which has any of the following pictograms on their MSDS: • Travel outside of Europe or North America on University Business Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • • A satisfactory basic Disclosure and Barring Service check University security screening (eg identity checks) 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy 4 Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
We have an exciting opportunity to recruit a highly motivated Postdoctoral Research Assistant to join the research program focused on developing vaccines against arthropod-borne pathogens within the Jenner Institute, Nuffield Department of Medicine. You will be reporting to Dr. César López-Camacho, Group leader and Jenner Investigator, working on the molecular design of genetic-based vaccines for Dengue virus, with a focus on mRNA and viral-vectored technologies. You will be responsible for managing your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will be tasked with conducting rigorous scientific research to the highest standards of the field. The role will require you to independently research published material and keep up to date with relevant literature. You will be tasked with testing hypotheses and analysing scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. As the Postdoctoral Research Assistant, it is essential you hold a relevant PhD/DPhil (or close to completion) in Biochemistry, Molecular Biology, or a related field. It is essential you have hands-on experience with in vitro transcription, mRNA handling, and mRNA analytics and hands-on experience in flavivirus and expertise in Lipid Nanoparticle (LNP) formulations. You will also be able to contribute ideas for new research projects and research income generation. Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings are essential for this role. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 January 2026 and is funded by the Calleva Foundation. You may also benefit from being associated with the Calleva Centre for Evolution and Human Science at Magdalen College, providing access to a vibrant academic community. Only applications received before 12 midday on Monday 6 January 2025 will be considered. Please quote 175848 on all correspondence.
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Research Grade 7: Research Grade 7: Salary in range £38,674 - £45,628 per annum (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata).
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