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Description of Research Assistant: Public and Patient Involvement (PPI) in Psychosis
We are looking to appoint a Research Assistant to join the Early Psychosis Research Group, led by Professor Belinda Lennox. You will be supporting the involvement of people with lived experience of psychosis Early Psychosis multi-arm, multi-stage (MAMS) platform trial (PUMA), which aims to develop and build a trial platform for early psychosis over the next 24 months, with a trial protocol that will then be ready to be delivered. The postholder will also provide some support to the FOCUS and Sleeping Better clinical trials which also focus on early psychosis. The post is based in the Department of Psychiatry at the Warneford Hospital, Oxford and is full-time. The post is for a fixed term (funded for 27 months). You will support the involvement of people with lived experience, and contribute to the research work of the PUMA, FOCUS, and Sleeping Better research studies. This will include supporting the new Oxford Psychosis Patient Advisory Group, carrying out qualitative interviews and work to look at the “acceptability” of the interventions being offered. You will have an undergraduate degree or MSc in a relevant subject area (experimental psychology, medical sciences, biomedical science,) along with an interest in Public and Patient Involvement in research. With relevant research experience and a publication record you should have expertise in writing up research reports for stakeholders. Experience of research in early psychosis would be desirable as would experience of working with multidisciplinary teams and stakeholders with different backgrounds. For more information please contact Dr Thomas Kabir, thomas.kabir@psych.ox.ac.uk or Dr Ksenija Yeeles, ksenija.yeeles@psych.ox.ac.uk You will be required to upload a covering letter/supporting statement and a CV as part of your application The closing date for this post is 12.00 midday on 26 November 2024.
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We are looking to appoint a Research Assistant to join the Early Psychosis Research Group, led by Professor Belinda Lennox. You will be supporting the involvement of people with lived experience of psychosis Early **P** sychosis m **u** lti-arm, **m** ulti-stage (MAMS) pl **a** tform trial (PUMA), which aims to develop and build a trial platform for early psychosis over the next 24 months, with a trial protocol that will then be ready to be delivered. The postholder will also provide some support to the FOCUS and Sleeping Better clinical trials which also focus on early psychosis. The post is based in the Department of Psychiatry at the Warneford Hospital, Oxford and is full-time. The post is for a fixed term (funded for 27 months). You will support the involvement of people with lived experience, and contribute to the research work of the PUMA, FOCUS, and Sleeping Better research studies. This will include supporting the new Oxford Psychosis Patient Advisory Group, carrying out qualitative interviews and work to look at the “acceptability” of the interventions being offered. You will have an undergraduate degree or MSc in a relevant subject area (experimental psychology, medical sciences, biomedical science,) along with an interest in Public and Patient Involvement in research. With relevant research experience and a publication record you should have expertise in writing up research reports for stakeholders. Experience of research in early psychosis would be desirable as would experience of working with multidisciplinary teams and stakeholders with different backgrounds. For more information please contact Dr Thomas Kabir, thomas.kabir@psych.ox.ac.uk or Dr Ksenija Yeeles, ksenija.yeeles@psych.ox.ac.uk You will be required to upload a covering letter/supporting statement and a CV as part of your application The closing date for this post is 12.00 midday on 26 November 2024.
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_________________________________________________________________________ Summary Job title Research Assistant: Public and Patient Involvement (PPI) in Psychosis Division Medical Sciences Department Psychiatry Location Warneford Hospital Grade and salary Grade 6 £34,982 - £40,855 per annum Hours Full time Contract type Fixed-term (funded for 27 months) Reporting to Belinda Lennox (Principal Investigator) and Ksenija Yeeles (Senior Project Manager) and Thomas Kabir (PUMA Patient and carer engagement working group chair) Vacancy reference 175979 Additional information Research topic Early Psychosis Multi-arm, multi-stage platform trial (PUMA), Sleeping Better, and FOCUS trials Principal Investigator / supervisor Professor Belinda Lennox Project team Early Psychosis Research Group (EPRG) and the Oxford Cognitive Approaches to Psychosis (O-CAP). Project web site https://www.psych.ox.ac.uk/research/early-psychosis/puma Funding partner The funds supporting these research projects are provided by the Wellcome Trust Recent publications Background Psychotic disorders such as schizophrenia are recognized as a global health burden but with limited therapeutic advance for half a century. Some people with early psychotic disorders recover completely, but the outcomes for too many are bleak: even when symptoms are controlled, cognition and functional outcomes can remain suboptimal and many people relapse. Clinical practice still relies on drugs that are difficult to tolerate and worsen some aspects of the syndrome such as cognition. Resistance to treatment is high and drugs have little or no effect in around a quarter of people and can tolerate the necessary blood monitoring and side effects. After two decades with no therapeutic advance, reappraisal of existing, and repurposed compounds is required. The Multi-arm, multi-stage (MAMS) platform trials approach will set up a framework to accelerate therapeutic progress in the treatment of early psychosis, in parallel with harnessing the investigative power of randomised designs as experiments to illuminate mechanisms. A large-scale platform trial of mechanistically diverse treatments has the potential to dramatically accelerate our treatment of psychosis with the added achievable goal of a stratified approach to treatment. We have received funding from the Wellcome Trust to set up a MAMS platform trial in early psychosis. This is an exciting opportunity to join the team and work on this project from inception. The post holder will join a thriving and highly collaborative research collaboration and will have significant intellectual and practical input into shaping this project for the long-term future. We have also received funding for two other studies from the Wellcome Trust. Both are clinical trials and focus on people with psychosis. The first is called Sleeping Better. The second study is a five-year study called FOCUS. One of the aims of the FOCUS study is to investigate a new antipsychotic medication called KarXT. The projects Early Psychosis multi-arm, multi-stage platform trial (PUMA) The MAMS approach was pioneered in the highly successful STAMPEDE (Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy) trial framework in different stages of prostate cancer. Following the STAMPEDE’s the MAMS design was implemented in other disease areas including neurodegenerative diseases such as both motor neurone disease (MND) and progressive multiple sclerosis (MSSMART trial), an expanded MAMS platform in MS (the OCTOPUS trial and Parkinson’s disease, (ACT-PD). In each of these disorders the MAMS trial will provide the single trial platform for all patients and clinical services across the UK, dramatically accelerating the treatment evaluation pipeline. An adaptive trial design platform like MAMS resolves many of the problems built into traditional trial design, helping to create a faster, cheaper and far more efficient process of testing new potential treatments. This includes greatly reduced time and costs of the addition of every new treatment arm, which will be therefore more attractive options for charity, government or commercial organisations to support. The Early Psychosis multi-arm, multi-stage platform trial (PUMA) project will develop and build a MAMS trial platform for early psychosis over the next thirty months, with a trial protocol that will then be ready to be delivered. It will develop a priority list of treatments to be included in the trial platform using systematic and comprehensive process. The trial will begin with drug treatments, but the platform can evolve to include psychological and digital interventions, including family, carer, and employment support, all of which are recognised as important treatments in early psychosis. Patients and carers will be centrally involved at every stage. Participants can be eligible for any of the arms, they do not have to be eligible for all. This inclusivity is especially important for psychosis research where strict eligibility criteria are barriers. Our ambition is that this MAMS trial will dramatically change that situation, making research available to most people with early psychosis. This will give patients and carers more choice and control over entry into trials, currently this is often not the case. Research Assistant: Public and Patient Involvement (PPI) in Psychosis 175979 2 Our team is a global, multidisciplinary consortium, including mental health clinicians, researchers, methodologists, statisticians, and people with lived experience of psychosis. Sleeping Better In Sleeping Better, a new talking therapy will be given to help people to sleep better. The hope is that if people sleep better than their mental health will be better as well. This study is a randomised control trial with 1158 participants. The study is taking place in sites across England and is led by Prof Daniel Freeman and Dr Felicity Waite in the Oxford Cognitive Approaches to Psychosis group in the Oxford Department of Experimental Psychology. FOCUS: Function & Cognition in Early Psychosis The FOCUS study is a five-year study which is funded by the Wellcome Trust. One of the aims of the study is to look at a new antipsychotic medication called KarXT. This medication targets muscarinic receptors unlike any other antipsychotic medication currently in use. Excitingly, there are some signs that KarXT may help people with cognitive problems. No other antipsychotic currently seems to help people with cognitive problems. The FOCUS study has three parts: 1. We will give KarXT to people with psychosis to see if it does help people with cognitive problems. 2. We will look at three other studies that are all studying different interventions for psychosis. These include a study of cannabidiol, memantine, and immunotherapy. This part of FOCUS will look at if these interventions help people with psychosis and how exactly they might work. In the final part of the study we will be carrying out interviews and focus groups with people with lived experience of psychosis to better understand how ‘acceptable’ people find KarXT as a medication, and how we can we better understand cognitive problems from a lived experience perspective. The study is led by Assoc Prof Rob McCutcheon and Prof Belinda Lennox in the Department of Psychiatry. The role The role will mainly be focused on the PUMA project. The post holder will be a key member of the PUMA team, supporting all aspects of PUMA, but in particular the work of the lived experience working group. The post holder will support the involvement of people with lived experience of psychosis in all aspects of PUMA. This will involve producing background briefing papers for working groups, helping to organise and minute meetings, and contributing to the research work of the PUMA study. The post holder will regularly liaise with PUMA project Working Group chairs and ensure regular communication of emerging information with these groups. This will include frequent regular meetings and communication with different stakeholders, working groups and their members, other project researchers, the project manager and PUMA Management Group. The post holder with also provide some support to involving people with lived experience of psychosis in the FOCUS and Sleeping Better studies. This will principally involve supporting the new Oxford Psychosis Patient Advisory Group alongside others. There is additionally scope to be involved in the research work of these two studies. This involves focus groups, qualitative interviews, and work to look at the ‘acceptability’ of the interventions being offered in both studies. Responsibilities ● ● ● Manage own academic work and administrative activities. This involves PUMA working group level project management and co-ordination of multiple aspects of work to meet deadlines Support the involvement of people with lived experience in the PUMA, FOCUS, and Sleeping Better research studies including supporting the new Oxford Psychosis Patient Advisory Group Contribute to the research work of the PUMA, Sleeping Better, and FOCUS studies. Research Assistant: Public and Patient Involvement (PPI) in Psychosis 175979 3 ● ● ● ● ● Contribute to discussions and grants reflecting the overall aims and objectives of the Early Psychosis Research Group(EPRG) and O-CAP research groups Contribute to the production of scientific reports and publications for high profile journals Attend scientific seminars, meetings and to contribute to presentations or other means of disseminating results as appropriate Represent the research groups at external meetings/seminars, either with other members of the group or alone Act as a source of information and advice to other members of the group Selection criteria Essential selection criteria • • • • • • • • • • Hold a first degree or MSc in a relevant subject area (experimental psychology, medical sciences, biomedical science) Have an interest in Public and Patient Involvement (PPI) in research Relevant research experience and a publication record Excellent organisational skills including the ability to organise and minute meetings An understanding of evidence synthesis Familiarity in reading and extracting data from published and unpublished records. Expertise in writing up research reports for different stakeholders Excellent writing, IT and communication skills Fluent (written and spoken) in English Experience of following and adapting methodologies Desirable selection criteria ● ● ● ● ● Have or be close to completion of a MSc or PhD in a relevant subject area (experimental psychology, medical sciences, biomedical science,) Experience of research in early psychosis Experience of working with multidisciplinary teams and stakeholders with different backgrounds Ability to work under time pressure and meet deadlines Familiarity with the issues facing people with lived experience of psychosis Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Work in clinical areas with direct contact with patients (NOT administrative roles) Research Assistant: Public and Patient Involvement (PPI) in Psychosis 175979 4 Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory enhanced Disclosure and Barring Service check due to regulated activity involving ‘at risk’ adults About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Psychiatry The Department of Psychiatry based on the Warneford Hospital site in Oxford has an international reputation for excellence. The Head of Department is Professor Belinda Lennox. The Department has a substantial research programme, with major funding from Medical Research Council (MRC), Wellcome Trust and National Institute for Health Research (NIHR) and provides highly rated medical training in psychiatry. There are approximately 250 staff including 41 principal investigators leading research groups investigating applying a wide range of approaches from translational neuroscience, experimental medicine, epidemiology, clinical trials and health services research to developmental disorders, mood disorders, cognitive disorders and self-harm and suicide. There are strong links with other departments and institutes both within and outside Oxford: these links ensure that we can apply the best scientific methods to psychiatric and cognitive disorders. The Department has an annual turnover of over £10 million with more than 130 research grants. For more information please visit: http://www.psych.ox.ac.uk The Department of Psychiatry holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division For more information please visit: https://www.medsci.ox.ac.uk/ Research Assistant: Public and Patient Involvement (PPI) in Psychosis 175979 5 How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: - as part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of fulltime hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs Non-technical questions about this job should be addressed to the recruiting department directly at: vacancies@psych.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Research Assistant: Public and Patient Involvement (PPI) in Psychosis 175979 6 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacypolicy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/dataprotection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Research Assistant: Public and Patient Involvement (PPI) in Psychosis 175979 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, flexible working options, travel discounts including salary sacrifice schemes for bicycles and electric cars and other discounts. Staff can access a huge range of personal and professional development opportunities. See https://hr.admin.ox.ac.uk/staff-benefits Employee Assistance Programme As part of our wellbeing offering staff get free access to Health Assured, a confidential employee assistance programme, available 24/7 for 365 days a year. Find out more https://staff.admin.ox.ac.uk/health-assured-eap University Club and sports facilities Membership of the University Club is free for University staff. It offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits We are a family-friendly employer with one of the most generous family leave schemes in the Higher Education sector (see https://hr.web.ox.ac.uk/family-leave). Our Childcare Services team provides guidance and support on childcare provision, and offers a range of high-quality childcare options at affordable prices for staff. In addition to 5 University nurseries, we partner with a number of local providers to offer in excess of 450 full time nursery places to our staff. Eligible parents are able to pay for childcare through salary sacrifice, further reducing costs. See https://childcare.admin.ox.ac.uk/. Supporting disability and health-related issues (inc menopause) We are committed to supporting members of staff with disabilities or long-term health conditions, including those experiencing negative effects of menopause. Information about the University’s Staff Disability Advisor, is at https://edu.admin.ox.ac.uk/disability-support. For information about how we support those going through menopause see https://hr.admin.ox.ac.uk/menopause-guidance Staff networks The University has a number of staff networks including for research staff, BME staff, LGBT+ staff, disabled staff network and those going through menopause. Find out more at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Research staff The Researcher Hub supports all researchers on fixed-term contracts. They aim to help you settle in comfortably, make connections, grow as a person, extend your research expertise and approach your next career step with confidence. Find out more https://www.ox.ac.uk/research/support-researchers/researcher-hub Oxford’s Research Staff Society is a collective voice for our researchers. They also organise social and professional networking activities for researchers. Find out more https://www.ox.ac.uk/research/supportresearchers/connecting-other-researchers/oxford-research-staff-society Research Assistant: Public and Patient Involvement (PPI) in Psychosis 175979 8
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Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX
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