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Postdoctoral Scientist: Biochemistry/biophysics of protein-RNA condensates
comment: Are you an early career researcher with an interest in neurodegeneration and the central nervous system? We have an exciting opportunity for a Postdoctoral Research Scientist to join the newly established Hallegger Group in the Oxford-GSK Institute for Molecular & Computational Medicine (IMCM), at the Nuffield Department of Medicine. The Hallegger Lab is an inclusive environment with a focus on positive and proactive mentorship, teamwork, and scientific creativity. The Hallegger lab addresses the question of what proteomics and transcriptomics changes are linked to the earliest stages in neurodegeneration. In this role, you will undertake multidisciplinary approaches to discover and validate proteomic changes associated with changes in the condensation behaviour of TDP-43, an RNA-binding protein central to Motor Neuron Disease (MND) and ALS (Amyotrophic lateral sclerosis). As a protein biochemist with biophysical experience, you will be responsible for performing protein purification and phase separation experiments, and generating proteomic data of co-condensates formed by TDP-43. You will undertake cellular and biochemical assays on these co-condensates using molecular biology, proteomics techniques and microscopy, and utilise RNAseq and iCLIP RNA-sequencing approaches to look at gene expression and regulation changes to identify proteins/pathways linked to the condensation behaviour of RNA binding proteins. Other responsibilities will include managing own academic research and administrative activities, including small scale project management, co-ordinate multiple aspects of work to meet deadlines, and carrying out data analysis and interpretation of datasets (with support from local specialist proteomics, bioinformatics and imaging teams). You will have, or be close to the completion of, a PhD/DPhil in a relevant area of protein biochemistry or biophysical science, and you will be experienced in general molecular biology techniques (immunoprecipitation, immunob…
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value: Job title Postdoctoral Research Scientist – Biochemistry/biophysics of protein-RNA condensates Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN Grade and salary Grade 7: Salary in range £38,674 - £46,913 per annum (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata). Hours Full time Contract type Fixed-term contract for 36 months Funding is provided by GSK Reporting to Dr. Martina Hallegger, IMCM Fellow and Georgina Kerr, IMCM Programme Manager Vacancy reference 176287 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic The condensation-dependent protein and RNA interactome of TDP-43 Principal Investigator / supervisor Dr. Martina Hallegger, IMCM Fellow Project team Institute of Molecular and Computational Medicine (IMCM) University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.chg.ox.ac.uk/ Project web site https://www.chg.ox.ac.uk/ https://www.imcm.ox.ac.uk/about/team/martina-hallegger-1 Funding partner The funds supporting this research project are provided by the IMCM. https://www.sciencedirect.com/science/article/pii/S0092867421008771 Recent publications https://www.biorxiv.org/content/10.1101/2021.08.27.457890v1 http…

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