Nuffield Department of Clinical Neurosciences
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Description of Postdoctoral Research Scientist
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Postdoctoral Research Scientist
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comment: We have an exciting opportunity for a **Postdoctoral Research Scientist** to join us, this opportunity has arisen from The Wellcome Trust grant entitled “Brain networks underlying sleep and circadian rhythm disruption (SCRD) in mental health” awarded to a team of investigators including Professors Jason Lerch and Vladyslav Vyazovskiy, and led by Professor Stuart Peirson. This post will be based at the Wellcome Centre for Integrative Neuroimaging, Oxford. In this proposal, we will explore the role of brain networks linking SCRD and mental illness. Neuroimaging studies have suggested a common neurobiological substrate for mental illness, clustering into overlapping brain networks defined by characteristic spatial and temporal properties. This framework proposes a triple network model of psychopathology, based upon interactions between the default-mode, salience, and central executive networks. We hypothesise that these networks underpin the bidirectional relationship between SCRD and mental illness. We propose that sleep and circadian rhythms play a key role in the regulation of networks - particularly the salience network. Moreover, we predict that the effects of mental illness on the salience network explains why SCRD is commonly observed in these conditions, in turn exacerbating their severity. This bidirectional model explains why interventions that improve SCRD help ameliorate the aberrant function of these networks and can improve clinical symptoms. To test this hypothesis, we will study the role of sleep and circadian rhythms in the regulation of functional networks using animal models. Mouse models have provided fundamental insights into the mechanisms of SCRD, enabling the contribution of specific neuronal circuits and genes to sleep/circadian behaviour. We aim to explore the interactions between SCRD and functional brain networks. Specifically, we hypothesise that the salience network is regulated by both the circadian clock and sleep. We predict that SCRD w…
application closing date: 2024-12-06T12:00:00+00:00
further particulars: Job Description
comment: We have an exciting opportunity for a Postdoctoral Research Scientist to join us, this opportunity has arisen from The Wellcome Trust grant entitled “Brain networks underlying sleep and circadian rhythm disruption (SCRD) in mental health” awarded to a team of investigators including Professors Jason Lerch and Vladyslav Vyazovskiy, and led by Professor Stuart Peirson. This post will be based at the Wellcome Centre for Integrative Neuroimaging, Oxford. In this proposal, we will explore the role of brain networks linking SCRD and mental illness. Neuroimaging studies have suggested a common neurobiological substrate for mental illness, clustering into overlapping brain networks defined by characteristic spatial and temporal properties. This framework proposes a triple network model of psychopathology, based upon interactions between the default-mode, salience, and central executive networks. We hypothesise that these networks underpin the bidirectional relationship between SCRD and mental illness. We propose that sleep and circadian rhythms play a key role in the regulation of networks - particularly the salience network. Moreover, we predict that the effects of mental illness on the salience network explains why SCRD is commonly observed in these conditions, in turn exacerbating their severity. This bidirectional model explains why interventions that improve SCRD help ameliorate the aberrant function of these networks and can improve clinical symptoms. To test this hypothesis, we will study the role of sleep and circadian rhythms in the regulation of functional networks using animal models. Mouse models have provided fundamental insights into the mechanisms of SCRD, enabling the contribution of specific neuronal circuits and genes to sleep/circadian behaviour. We aim to explore the interactions between SCRD and functional brain networks. Specifically, we hypothesise that the salience network is regulated by both the circadian clock and sleep. We predict that SCRD will …
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application opening date: 2024-11-01T09:00:00+00:00
notation: 176296
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value: West Wing, Level 6, John Radcliffe Hospital, Oxford, OX3 9DU Web: www.ndcn.ox.ac.uk | Tel: +44(0)1865 234702 | Email: recruitment@ndcn.ox.ac.uk Job title Postdoctoral Research Scientist Division Medical Sciences Division Department Nuffield Department of Clinical Neurosciences (NDCN) Location Wellcome Centre for Integrative Neuroimaging, FMRIB John Radcliffe Hospital, Headington, Oxford, OX3 9DU Grade 7: £38,674 – £46,913 per annum Grade and salary A less experienced candidate may be appointed at Grade 6 (£34,982 to £40,855) per annum, with a commensurate adjustment in either the essential criteria, responsibilities or duties. Hours Full time, but part time can be negotiated Contract type Fixed-term for 24 months in the first instance Reporting to Prof. Jason Lerch Vacancy reference 176296 Additional information Your work may be split across different sites, including John Radcliffe Hospital in Headington and Biomedical Sciences Building in the South Parks Road Sciences area Research topic Preclinical Neuroscience Principal Investigator / supervisor Profs. Jason Lerch, Vladyslav Vyazovskiy, Stuart Peirson Project team Preclinical Imaging Group, Wellcome Centre for Integrative Neuroimaging Funding partner The funds supporting this research project are provided by Wellcome Trust The role This opportunity has arisen from The Wellcome Trust grant entitled “Brain networks underlying sleep and circadian rhythm disruption (SCRD) in mental health” awarded to a team of investigators including Professors Jason Lerch and Vladyslav Vyazovskiy, and led by Professor Stuart Peirson. This post will be based at the Wellcome Centre for Integrative Neuroimaging, Oxford. In this proposal, we will explore the role of brain networks linking SCRD and mental illness. Neuroimaging studies have suggested a common neurobiological substrate for mental illness, clustering into overlapping brain networks defined by characteristic spatial and temporal properties. This framework proposes a triple …

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