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value: Job Description _________________________________________________________________________ Summary Job title Computational Biologist in Single Cell Genomics Division Medical Sciences Department Radcliffe Department of Medicine Location MRC Weatherall Institute of Molecular Medicine, MRC WIMM Centre for Computational Biology, John Radcliffe Hospital, Headington, Oxford, OX3 9DS. Grade and salary Grade 7: £38,674 - £46,913 per annum Hours Full time (37.5 hours per week) Contract type Fixed-term until 31 March 2026, funded by the Wellcome Trust Reporting to Professor David Sims Vacancy reference 176481 The role Professor David Sims (MRC WIMM Centre for Computational Biology) and Professor Stephen Goodwin (Centre for Neural Circuits and Behaviour (CNCB) ) have secured funding to investigate the regulation of gene expression that underlies the specification of cell fate in the brain of the fruit fly, Drosophila melanogaster. The computational biologist will lead the analysis of single-cell RNAseq and ATACseq profiles from hundreds of thousands of neurons, representing the entire fly midbrain, from flies at different developmental stages. They will work closely with experimental collaborators within the CNCB to answer important questions in neuroscience; investigating how the transcriptomes of individual cells change over the course of development, and how sexspecific neuronal identity emerge from transcriptional programmes. Responsibilities • Conduct detailed analysis of large biomedical datasets, tailoring analytical tools and pipelines appropriate to the scientific question; • Identify and troubleshoot technical or scientific problems, working collaboratively with other members of the team; • Contribute to discussions planning the overall aims and objectives of the research; • Contribute to the production of scientific reports and publications for high profile journals, including taking leadership in publications on novel aspects of bioinformatics; • Act as a source of …
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spatial: Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, MRC WIMM Centre for Computational Biology, John Radcliffe Hospital, Headington, Oxford
salary: Research Grade 7: £38,674 - £46,913 per annum
comment: At the MRC WIMM Centre for Computational Biology (CCB), we work alongside scientists and clinicians to realise the potential of ‘big data’ in biology by exploiting complex information to make discoveries that benefit human health. The CCB encompasses an international team of over 40 computational biologists, working closely with 500 lab-based scientists and clinicians. As part of a Wellcome Trust Collaborative award, applications are invited for a highly motivated individual to lead the analysis of single-cell gene expression and open chromatin profiling data, investigating transcriptional regulation during Drosophila Melanogaster brain development. You will work closely with experimental collaborators within the Centre for Neural Circuits and Behaviour to answer important questions in developmental neuroscience. You will lead the analysis of single-cell RNAseq & ATACseq profiles from hundreds of thousands of neurons, representing the entire fruit fly midbrain, from flies across development stages, to build a map of neuronal development and understand how sex-specific neuronal identity emerges from transcriptional programmes. With a PhD or MSc in a quantitative discipline (e.g. bioinformatics, computational biology, physics, statistics, engineering or mathematics), you will have experience of working in a Linux environment and be proficient in Python and R. Excellent interpersonal and communication skills, with the ability to convey concepts to other scientists in different fields of research are essential. Experience in analysis of single cell gene expression data is highly desirable. The position is available fixed-term until 31st March 2026, funded by the Wellcome Trust. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is noon on 2 December 2024. Interviews will be held in December 2024.
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further particulars: 176481_Job Description and Selection Criteria_Computational Biologist in Single Cell GenomicsFINAL.pdf
comment: At the MRC WIMM Centre for Computational Biology (CCB), we work alongside scientists and clinicians to realise the potential of ‘big data’ in biology by exploiting complex information to make discoveries that benefit human health. The CCB encompasses an international team of over 40 computational biologists, working closely with 500 lab-based scientists and clinicians. As part of a Wellcome Trust Collaborative award, applications are invited for a highly motivated individual to lead the analysis of single-cell gene expression and open chromatin profiling data, investigating transcriptional regulation during Drosophila Melanogaster brain development. You will work closely with experimental collaborators within the Centre for Neural Circuits and Behaviour to answer important questions in developmental neuroscience. You will lead the analysis of single-cell RNAseq & ATACseq profiles from hundreds of thousands of neurons, representing the entire fruit fly midbrain, from flies across development stages, to build a map of neuronal development and understand how sex-specific neuronal identity emerges from transcriptional programmes. With a PhD or MSc in a quantitative discipline (e.g. bioinformatics, computational biology, physics, statistics, engineering or mathematics), you will have experience of working in a Linux environment and be proficient in Python and R. Excellent interpersonal and communication skills, with the ability to convey concepts to other scientists in different fields of research are essential. Experience in analysis of single cell gene expression data is highly desirable. The position is available fixed-term until 31st March 2026, funded by the Wellcome Trust. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. **The closing date for this position is noon on 2 December 2024. ** **Interviews will be held in December 2024. **
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application closing date: 2024-12-02T12:00:00+00:00
contact: HR Administrator
application opening date: 2024-11-11T12:30:00+00:00

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