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Applications are invited for a Postdoctoral Research Associate to join a research team developing new approaches to combat antimicrobial resistance, working under the supervision of Dr Thomas Lanyon-Hogg for a period of 24 months. This project is funded by the Ineos Oxford Institute for antimicrobial research (IOI) and will be carried out in the Department of Pharmacology, the Centre for Medicines Discovery (CMD), the Sir William Dunn School of Pathology, and the IOI, all based at the University of Oxford. This is an exciting opportunity to work with world-leading researchers and contribute to the development of innovative new approaches to combat antimicrobial resistance, which is a significant area of unmet medical need globally. Find out more about the Lanyon-Hogg group’s research at: Lanyon-Hogg group Reporting to Dr Thomas Lanyon-Hogg, you will be a member of a research group with responsibility for conducting a research project to identify new molecules to combat antimicrobial resistance. You will have a discrete role as part of a collaborative and interdisciplinary research team based between the Department of Pharmacology, CMD, Dunn School of Pathology and the IOI. You will be responsible for establishing and conducting biochemical, cellular and chemical biology assays to identify and validate small-molecule ligands. You will be responsible for designing and conducting experiments, analysing data, communicating findings with the wider project team, preparing publications, and presenting results at conferences. You will also contribute to management of the TLH laboratory and provide guidance to junior members of the research group, including PhD and project students. The appointee will be expected to manage their own academic research and administrative activities with a high degree of autonomy and independence, as the project will require work in multiple collaborating departments. This will involve small-scale project management to co-ordinate multiple aspects of work for presentations, publications, and patents. The appointee will analyse scientific data from a variety of sources to develop the project, reviewing and refining working hypothesis as required. You should have experience in biochemistry, microbiology, and/or chemical biology, inhibitor screening and drug discovery, and protein construct design and cloning. You must hold (or be close to completion prior to taking up appointment) a relevant PhD/DPhil in biochemistry, microbiology, cell biology, or chemical biology, together with relevant experience. Prior experience in antibiotic drug discovery, assay automation and peptide synthesis would be an advantage. The post is available from mid-February 2025. The University of Oxford and the Department of Pharmacology are Silver Athena SWAN award holders. Applications are particularly welcome from candidates in demographic groups that are under- represented in scientific research. Candidates will be assessed solely on scientific merit, and all applications will be anonymised before shortlisting. The post is offered on a fixed-term basis for 24 months, funded by the Ineos Oxford Institute (IOI). The closing date for applications is Monday 13 January 2025.
Postdoctoral Research Assistant in Chemical/Cell Biology and Antimicrobial Resistance
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177123 TLH IoI PDRA job description Dec24
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Applications are invited for a Postdoctoral Research Associate to join a research team developing new approaches to combat antimicrobial resistance, working under the supervision of Dr Thomas Lanyon-Hogg for a period of 24 months. This project is funded by the Ineos Oxford Institute for antimicrobial research (IOI) and will be carried out in the Department of Pharmacology, the Centre for Medicines Discovery (CMD), the Sir William Dunn School of Pathology, and the IOI, all based at the University of Oxford. This is an exciting opportunity to work with world-leading researchers and contribute to the development of innovative new approaches to combat antimicrobial resistance, which is a significant area of unmet medical need globally. Find out more about the Lanyon-Hogg group’s research at: Lanyon-Hogg group Reporting to Dr Thomas Lanyon-Hogg, you will be a member of a research group with responsibility for conducting a research project to identify new molecules to combat antimicrobial resistance. You will have a discrete role as part of a collaborative and interdisciplinary research team based between the Department of Pharmacology, CMD, Dunn School of Pathology and the IOI. You will be responsible for establishing and conducting biochemical, cellular and chemical biology assays to identify and validate small-molecule ligands. You will be responsible for designing and conducting experiments, analysing data, communicating findings with the wider project team, preparing publications, and presenting results at conferences. You will also contribute to management of the TLH laboratory and provide guidance to junior members of the research group, including PhD and project students. The appointee will be expected to manage their own academic research and administrative activities with a high degree of autonomy and independence, as the project will require work in multiple collaborating departments. This will involve small-scale project management to co-ordinate multiple aspects of work for presentations, publications, and patents. The appointee will analyse scientific data from a variety of sources to develop the project, reviewing and refining working hypothesis as required. You should have experience in biochemistry, microbiology, and/or chemical biology, inhibitor screening and drug discovery, and protein construct design and cloning. You must hold (or be close to completion prior to taking up appointment) a relevant PhD/DPhil in biochemistry, microbiology, cell biology, or chemical biology, together with relevant experience. Prior experience in antibiotic drug discovery, assay automation and peptide synthesis would be an advantage. The post is available from mid-February 2025. The University of Oxford and the Department of Pharmacology are Silver Athena SWAN award holders. Applications are particularly welcome from candidates in demographic groups that are under-represented in scientific research. Candidates will be assessed solely on scientific merit, and all applications will be anonymised before shortlisting. The post is offered on a fixed-term basis for 24 months, funded by the Ineos Oxford Institute (IOI). The closing date for applications is Monday 13 January 2025.
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DEPARTMENT OF PHARMACOLOGY UNIVERSITY OF OXFORD Head of Department Professor Fran Platt Job description and selection criteria Job title Postdoctoral Research Assistant in Chemical/Cell Biology and Antimicrobial Resistance Division Medical Sciences Department Department of Pharmacology Location Mansfield Road, Oxford OX1 3QT Grade and salary Grade 7: £38,674 -£46,915 per annum (including £1,500 per annum Oxford Weighting) Hours Full time Contract type Fixed-term for 24 months, funded by the Ineos Oxford Institute for antimicrobial research (IOI) Reporting to Dr Thomas Lanyon-Hogg Vacancy reference 177123 Additional information This vacancy is available from mid-February 2025. Committed to equality and valuing diversity The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Silver Athena SWAN award. The Department of Pharmacology holds a departmental Silver Athena award in recognition of its efforts to introduce organisational and cultural practices that promote gender equality and create a better working environment for both men and women Applications are invited for a Postdoctoral Research Associate to join a research team developing new approaches to combat antimicrobial resistance, working under the supervision of Dr Thomas Lanyon-Hogg for a period of 24 months. This project is funded by the Ineos Oxford Institute for antimicrobial research (IOI) and will be carried out in the Department of Pharmacology, the Centre for Medicines Discovery (CMD), the Sir William Dunn School of Pathology, and the IOI, all based at the University of Oxford. This is an exciting opportunity to work with world-leading researchers and contribute to the development of innovative new approaches to combat antimicrobial resistance, which is a significant area of unmet medical need globally. Find out more about the Lanyon-Hogg group’s research at: https://www.pharm.ox.ac.uk/research/lanyon-hogg-group The Role Reporting to Dr Thomas Lanyon-Hogg, you will be a member of a research group with responsibility for conducting a research project to identify new molecules to combat antimicrobial resistance. You will have a discrete role as part of a collaborative and interdisciplinary research team based between the Department of Pharmacology, CMD, Dunn School of Pathology and the IOI. You will be responsible for establishing and conducting biochemical, cellular and chemical biology assays to identify and validate small-molecule ligands. You will be responsible for designing and conducting experiments, analysing data, communicating findings with the wider project team, preparing publications, and presenting results at conferences. You will also contribute to management of the TLH laboratory and provide guidance to junior members of the research group, including PhD and project students. The appointee will be expected to manage their own academic research and administrative activities with a high degree of autonomy and independence, as the project will require work in multiple collaborating departments. This will involve small-scale project management to coordinate multiple aspects of work for presentations, publications, and patents. The appointee will analyse scientific data from a variety of sources to develop the project, reviewing and refining working hypothesis as required. The post is available from mid-February 2025. The University of Oxford and the Department of Pharmacology are Silver Athena SWAN award holders. Applications are particularly welcome from candidates in demographic groups that are under-represented in scientific research. Candidates will be assessed solely on scientific merit, and all applications will be anonymised before shortlisting. Responsibilities • Design, establishment and execution of biochemical and cellular assays for target protein function • Use of a variety of assay modalities including, but not limited to, fluorescence and biophysical binding assays, mass spectrometry, cellular reporter and viability assays • Optimising assays for high-throughput/automation • Providing assay support for medicinal chemistry team • Management own academic research and administrative activities including small scale project management to co-ordinate multiple aspects of work and meet deadlines • Adapt existing and develop new scientific methods and experimental protocols Page 2 of 7 • Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate • Contribute ideas for new research projects; develop ideas for generating research income, and present detailed research proposals to senior researchers • Collaborate in the preparation of scientific reports and journal articles, and present findings through talks and posters; represent the research group at external meetings/seminars, either with other members of the group or alone • Act as a source of information and guidance for other junior members of the group; lead by example in maintaining a positive and inclusive research culture Pre-employment screening All offers of employment are made subject to standard pre-employment screening, as applicable to the post. If you are offered the post, you will be asked to provide proof of your right-to-work, your identity, and we will contact the referees you have nominated. You will also be asked to complete a health declaration (so that you can tell us about any health conditions or disabilities so that we can discuss appropriate adjustments with you), and a declaration of any unspent criminal convictions. We advise all applicants to read the candidate notes on the University’s pre-employment screening procedures, found at: https://www.jobs.ox.ac.uk/preemployment-checks Additional security pre-employment checks As the Department of Pharmacology is involved in research involving animals, the following additional security pre-employment checks are required for all postholders: • A satisfactory Disclosure Scotland check • University security screening (eg identity checks) Selection criteria Essential • Experience in biochemistry, microbiology, and/or chemical biology • Experience in inhibitor screening and drug discovery • Protein construct design and cloning • Hold (or be close to completion prior to taking up appointment) a relevant PhD/DPhil in biochemistry, microbiology, cell biology, or chemical biology, together with relevant experience • Possess sufficient specialist knowledge in the discipline to work independently within established research programmes • Ability to manage own academic research and associated activities • Experience mentoring less-experienced scientists in a biochemistry/microbiology laboratory environment • Previous experience of contributing to publications/presentations • Excellent interdisciplinary communication skills, including the ability to write for publication, present results, and represent the research group at meetings • Ability to contribute ideas for new research projects and research income generation Desirable • Experience in Page 3 of 7 • • • • Experience in assay automation Experience in peptide synthesis Experience of working as part of an interdisciplinary research team Experience of independently managing a discrete area of a research project Department of Pharmacology Top of the QS World University Rankings for Pharmacy and Pharmacology 2019-2021 The Department of Pharmacology is based in the University’s science area in the centre of Oxford. The Department houses around 220 researchers, postgraduate students and support staff, and has excellent facilities. The members of the Department, associated staff and visiting scientists are all engaged in the investigation of basic questions concerning the interaction of chemical substances with biological systems. Research in the Department is focused on medicinal chemistry, cell signalling, cardiovascular pharmacology, ion channel and molecular pharmacology and neuropharmacology. In many of these areas the Department plays a leading role in the international pharmacological community. The research of the Department has consistently been given a very high ranking in the Government’s assessments of research in Universities and was rated first in the UK, within Biological Sciences, in terms of quality (ie greatest volume of 4* work) and volume (the power ranking) in the recent Research Excellence Framework (REF) exercise.. For more information please visit: www.pharm.ox.ac.uk Medical Sciences Division The Medical Sciences Division is an internationally recognised centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. It includes 15 clinical departments and 5 non-clinical departments. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit www.medsci.ox.ac.uk About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. Income from external research contracts in 2016/17 exceeded £564m and we rank first in the UK for Page 4 of 7 university spin-outs, with more than 130 companies created to date. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information please visit www.ox.ac.uk/about/organisation How to apply Before submitting an application, you may find it helpful to read the ‘Tips on applying for a job at the University of Oxford’ document, at https://www.jobs.ox.ac.uk/how-to-apply If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of two referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename All applications must be received by midday on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) Should you experience any difficulties using the online application system, please email recruitment.support@admin.ox.ac.uk. Further help and support is available from www.ox.ac.uk/about_the_university/jobs/support/. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Page 5 of 7 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: www.admin.ox.ac.uk/councilsec/compliance/gdpr/privacynotices/job/. The University’s Policy on Data Protection is available at: www.admin.ox.ac.uk/councilsec/compliance/gdpr/universitypolicyondataprotection/. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for all academic posts and some academic-related posts. From 1 October 2017, the University has adopted an EJRA of 30 September before the 69th birthday for all academic and academic-related staff in posts at grade 8 and above. The justification for this is explained at: www.admin.ox.ac.uk/personnel/end/retirement/acrelretire8+/. For existing employees, any employment beyond the retirement age is subject to approval through the procedures: www.admin.ox.ac.uk/personnel/end/retirement/acrelretire8+/. There is no normal or fixed age at which staff in posts at grades 1–7 have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Work-life balance and family-friendly policies at the University of Oxford The University aims to support all employees with parental or caring responsibilities to ensure that they are able to balance work and family life. This website (http://www.admin.ox.ac.uk/eop/parentsandcarersinformation/) provides a hub of information for all parents and carers, with links to university policies, procedures and guidance, as well as details of the facilities and benefits offered to mothers, fathers and guardians of children. In addition, the website highlights university policies, as well as external sources of guidance. You are advised to read the university policies in full; and to see respective guidance on the Personnel Services website for full details. Views expressed on external websites are not necessarily endorsed by the University of Oxford. Page 6 of 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See www.admin.ox.ac.uk/personnel/staffinfo/benefits. University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and www.sport.ox.ac.uk/oxford-university-sports-facilities. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See www.welcome.ox.ac.uk. There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See www.admin.ox.ac.uk/personnel/permits/reimburse&loanscheme/. Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to My Family Care, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See www.admin.ox.ac.uk/personnel/staffinfo/benefits/family/mfc/. Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see www.admin.ox.ac.uk/childcare/. Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see www.admin.ox.ac.uk/eop/disab/staff. Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at www.admin.ox.ac.uk/eop/inpractice/networks/. The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Page 7 of 7
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Department of Pharmacology, Mansfield Road, Oxford OX1 3QT