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_________________________________________________________________________ Job Description and Selection Criteria Job title Senior Scientific Researcher in Single-Molecule Biophysics Division Mathematical Physical and Life Sciences Department Physics Location Clarendon laboratory and Kavli institute Grade and salary Grade 9: £55,636 - £64,228 per annum Hours Full time Contract type Fixed term for 2 years with the possibility of extension subject to funding Reporting to Professor Nynke Dekker Vacancy reference 177451 Closing date – midday on 17 January31 May 2025 Additional information The role We are looking to hire an outstanding senior scientific staff member to support our group’s research, which focuses on single-molecule studies of DNA replication, chromatin replication, and chromatin organization. You will form part of the research team core and support the wider group by leading strategic and outstanding research and development in single-molecule biophysics instrumentation. This senior role offers the opportunity to develop groundbreaking instrumentation to advance research in biological physics and to develop and deploy invaluable skills in leadership and interdisciplinary collaboration, all within the vibrant scientific community of the University of Oxford. About the project In this project, you will design and implement novel forms of biophysical instrumentation (e.g. advanced optical tweezers and magnetic tweezers, single-molecule fluorescence, novel single-molecule approaches to DNA sequencing, integration with cryo-EM) with the goal of maximizing their contributions to the understanding of DNA- and chromatin replication and chromatin organization. You will propose and/or implement technical advances on single-molecule instruments and use them together with graduate students and postdocs to acquire data on DNA- and chromatin replication and chromatin organization. An aptitude in biophysical and microscopy instrumentation development and hardware-software interfacing, a willingness to acquire related relevant knowledge e.g. photophysics, cryo-EM, and an interest in guiding, coaching, and training graduate students and postdocs in their scientific and technical development, are essential. The overall goal is to provide novel ways of obtaining single-molecule biophysical insights into DNA- and chromatin replication and chromatin organization to advance these exciting fields. Responsibilities • Strategically develop novel single-molecule experiments with a focus on innovative instrumentation (e.g. development of force spectroscopy, fluorescence microscopy, integration with cryo-EM). You will design novel instruments that report on DNA- and chromatin replication and chromatin organization at the single-molecule level based on an outstanding knowledge of optics, microscopy, and hardwaresoftware interfacing. You will also develop, establish, and pursue instrumentation protocols and approaches to advance the research and maintain accurate records thereof. • Guide and supervise the scientific and technical development of graduate students and postdocs in the field of single-molecule biophysics. • Coach and train graduate students and postdocs to independence on specialist methodologies (e.g. optics, microscopy) or procedures. • Develop clear task objectives and organise accordingly, and work in a flexible but organised manner. • Produce high-quality work suitable for publication in high impact journals, write research articles at an (inter)national level for peer-reviewed journals, and present work at (inter)national conferences. • Maintain general aspects of the biophysics lab and research line(s) including safety, equipment, and budget resources. • Develop research lines and acquire research funds to further develop the impact of single-molecule techniques or experiments through (collaborative) grant applications. • Contribute to a scientifically outstanding and warmly communicative interdisciplinary team at the University of Oxford. • Advise (sub)departmental committees on scientific and management matters. • The post-holder will have the opportunity to teach. This may include lecturing, small group teaching, and tutoring of undergraduates and graduate students. Pre-employment screening All offers of employment are made subject to standard pre-employment screening, as applicable to the post. If you are offered the post, you will be asked to provide proof of your right-to-work, your identity, and we will contact the referees you have nominated. You will also be asked to complete a health declaration (so that you can tell us about any health conditions or disabilities so that we can discuss appropriate adjustments with you), and a declaration of any unspent criminal convictions. We advise all applicants to read the candidate notes on the University’s pre-employment screening procedures, found at: www.ox.ac.uk/about/jobs/preemploymentscreening/. Hazard-specific / Safety-critical duties www.admin.ox.ac.uk/personnel/recruit/preempcheck/compulsorychecks/medical 177451 - JD Senior Scientific Researcher_ND.doc Physics JD template oct 21doc 2 This job includes the following hazards or safety-critical activities which will require successful preemployment health screening through our Occupational Health Service before the successful candidate will be allowed to start work: • Lone Working • Working with category 3b or 4 lasers (laser safety class) • Work with any substance which has any of the following pictograms on their MSDS: • Travel outside of Europe or North America on University Business Selection criteria • • • • • • • • • • A successfully completed Ph.D. degree in biophysics or optical physics. Practical experience and scientific maturity in the above areas. International visibility and high-quality publication record in the above areas. Strong aptitude and interest in biophysical instrumentation and microscopy, and willingness to acquire related knowledge e.g. photophysics, cryo-EM. Professional experience with force spectroscopy (e.g. optical tweezers, magnetic tweezers, or atomic force microscopy) or single-molecule fluorescence methodologies. Strong skills in hardware-software interfacing and demonstrable ability to interface and collaborate with experts in programming. An independent, well-organized, and reliable work style. Track record of obtaining scientific funding. Leadership ability to guide, coach, and train graduate students and postdocs in the context of an interdisciplinary team. Excellent interpersonal communication skills and a strong interest in the broader field of biophysics that will contribute to the interactive lab culture. About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spinouts, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Physics 177451 - JD Senior Scientific Researcher_ND.doc Physics JD template oct 21doc 3 Oxford Physics is one of the largest and most eminent departments in Europe – pursuing forefront research alongside training the next generation of leaders in Physics. With an academic staff of over one hundred our activities range from fundamental particles to the furthest reaches of the universe to manipulating matter on an atomic scale. Oxford physicists are probing new ways to harness solar energy, modelling the Earth's atmosphere to predict the future climate, exploring computation on the quantum scale and executing calculations that reveal the fundamental structure of space and time. Sub-department The post-holder will be based in the Condensed Matter Physics sub-department, which is one of the six sub-departments that together make up the Department of Physics; these are Astrophysics, Atomic and Laser Physics, Atmospheric, Oceanic and Planetary Physics, Condensed Matter Physics, Particle Physics and Theoretical Physics, with a seventh function (Central Physics) providing administrative and technical support to these sub-departments. Members of all sub-departments take part in research, teaching and matters such as examinations, discussion of syllabi, lectures and liaison with undergraduates and postgraduate students. For more information please visit: http://www2.physics.ox.ac.uk/ Mathematical, Physical & Life Sciences Division The Mathematical, Physical and Life Sciences (MPLS) Division is one of the four academic divisions of the University of Oxford. The MPLS Division's 10 departments and 3 interdisciplinary units span the full spectrum of the mathematical, computational, physical, engineering and life sciences, and undertake both fundamental research and cutting-edge applied work. Our research addresses major societal and technological challenges and is increasingly focused on key interdisciplinary issues. We collaborate closely with colleagues in Oxford across the medical sciences, social sciences and humanities, and with other universities, research organisations and industrial partners across the globe in pursuit of innovative research geared to address critical and fundamental scientific questions. For more information please visit: http://www.mpls.ox.ac.uk/ The Kavli Institute for Nanoscience Discovery (Kavli INsD) Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, OX1 3QU https://kavlinano.ox.ac.uk / info@kavlinano.ox.ac.uk “Where the physical sciences are brought into the cell” Leading scientific discovery into the most basic unit of life - the cell - the Kavli Institute for Nanoscience Discovery (Kavli INsD) is located at the heart of Oxford University’s science area and was inaugurated in March 2021. With over 30 faculty and 450 research staff and graduate students, world leading teams collaborate from multiple departments (biochemistry, cell biology, chemistry, physics, physiology, psychiatry, clinical neurosciences and engineering) to contribute to global health. By bringing multiple disciplines together under the same roof to advance scientific research the Kavli INsD creates an environment that encourages the cross-pollination of ideas and inter-disciplinary cooperation. 177451 - JD Senior Scientific Researcher_ND.doc Physics JD template oct 21doc 4 The Institute comes together to work on global health challenges and benefits from the close proximity of the scientific departments as well as advanced imaging facilities and state-of-the-art-instrumentation. As the first Director of Kavli INsD Professor Dame Carol Robinson and the research teams are creating a culture that is both bold and respectful. Learn more about Oxford University’s Kavli Institute for Nanoscience Discovery at https://kavlinano.ox.ac.uk The University of Oxford’s, Kavli Institute for Nanoscience Discovery is the U.S based Kavli Foundation’s 20th institute. The foundation, established in the year 2000 by Fred Kavli, has a mission “to advance science for the benefit of humanity”. Research institutes in the fields of nanoscience, astrophysics, neuroscience, and theoretical physics have been endowed by the foundation which also supports programs that strengthen the connection between science and society. Learn more about the Kavli Foundation at kavlifoundation.org Athena Swan Charter The Department of Physics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of three referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical https://staff.web.ox.ac.uk/recruitment-support-faqs troubleshooting 177451 - JD Senior Scientific Researcher_ND.doc Physics JD template oct 21doc 5 advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly recruitment@physics.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Pre-employment screening Please note that the appointment of the successful candidate will be subject to standard pre-employment screening, as applicable to the post. This will include right-to-work, proof of identity and references. We advise all applicants to read the candidate notes on the University’s pre-employment screening procedures, found at: www.ox.ac.uk/about/jobs/preemploymentscreening/. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 177451 - JD Senior Scientific Researcher_ND.doc Physics JD template oct 21doc 6 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 177451 - JD Senior Scientific Researcher_ND.doc Physics JD template oct 21doc 7
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Notation3 description of Senior Scientific Researcher in Single-Molecule Biophysics
We are looking to hire an outstanding senior scientific staff member to support our group’s research, which focuses on studying DNA and chromatin replication at the single-molecule level. You will form part of the research team core and support the wider group by leading outstanding research and development in single-molecule biophysics. About the project In this project, you will design and implement novel forms of biophysical instrumentation (e.g. advanced optical tweezers and magnetic tweezers, single-molecule fluorescence, novel single-molecule approaches to DNA sequencing, integration with cryo-EM) with the goal of maximizing their contributions to the understanding of DNA replication and/or chromatin organization. You will propose and/or implement technical advances on single-molecule instruments and use them together with graduate students and postdocs to acquire data on DNA replication and/or chromatin organization. An aptitude in instrumentation development and quantitative biophysics, a willingness to acquire relevant knowledge into the photophysics of fluorescent labels, and an interest in guiding, coaching, and training graduate students and postdocs in their scientific and technical development, are essential. The overall goal is to provide novel and sound single-molecule biophysical insights into DNA replication and/or chromatin organization to advance these exciting fields. Requirements For this innovative, interdisciplinary project, we are looking a (bio)physicist, with: • A successfully completed Ph.D. degree in biophysics or optical physics. • Practical experience and scientific maturity in the above areas. • Strong aptitude and interest in biophysical instrumentation and microscopy, and willingness to acquire related knowledge e.g. photophysics. • Professional experience with force spectroscopy (e.g. optical tweezers, magnetic tweezers, or atomic force microscopy) or single-molecule fluorescence methodologies. • Strong skills in hardware-software interfacing and demonstrable ability to interface and collaborate with experts in programming. • An independent, well-organized, and reliable work style. • Track record of obtaining scientific funding. • Leadership ability to guide, coach, and train graduate students and postdocs in the context of an interdisciplinary team. • Excellent interpersonal communication skills and a strong interest in the broader field of biophysics that will contribute to the interactive lab culture. We look for friendly and driven colleagues to enrich our team. UK visa costs and NHS surcharge fees will be covered. We would like to welcome our new colleague by the summer or fall of 2025. Who are we? The Nynke Dekker Lab ( https://nynkedekkerlab.web.ox.ac.uk) is a highly successful single-molecule biophysics research lab based in the Department of Physics and the Kavli Institute of Nanoscience Discovery at the University of Oxford. The lab focuses its studies on understanding DNA replication and chromatin organization from a quantitative perspective both in vitro and in vivo. The lab employs state-of-the-art biophysical techniques (e.g. advanced single-molecule fluorescence microscopy, optical and magnetic tweezers) together with in-house molecular biology and biochemistry, all housed in a brand-new building with high quality laboratory spaces. Studying the dynamics of DNA replication and chromatin organization at the single-molecule level requires broad and integrated expertise; as such, we employ outstanding international scientists trained in biophysics, biochemistry, and cell biology who work together enthusiastically as a multidisciplinary team. You will be part of this group and will interact actively with current members. Information and application If you're excited about contributing to innovative biophysical research and collaborating with a talented team, we’d love to hear from you! For more information about these positions, or to apply, please contact Prof. Nynke Dekker, e-mail: nynke.dekker@physics.ox.ac.uk Applications should include a motivated cover letter of application, a detailed CV, and the names and contact information of three references, with the final deadline for applications being 12 noon on 31 May, 2025.
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We are looking to hire an outstanding senior scientific staff member to support our group’s research, which focuses on studying DNA and chromatin replication at the single-molecule level. You will form part of the research team core and support the wider group by leading outstanding research and development in single-molecule biophysics. **About the project** In this project, you will design and implement novel forms of biophysical instrumentation (e.g. advanced optical tweezers and magnetic tweezers, single- molecule fluorescence, novel single-molecule approaches to DNA sequencing, integration with cryo-EM) with the goal of maximizing their contributions to the understanding of DNA replication and/or chromatin organization. You will propose and/or implement technical advances on single-molecule instruments and use them together with graduate students and postdocs to acquire data on DNA replication and/or chromatin organization. An aptitude in instrumentation development and quantitative biophysics, a willingness to acquire relevant knowledge into the photophysics of fluorescent labels, and an interest in guiding, coaching, and training graduate students and postdocs in their scientific and technical development, are essential. The overall goal is to provide novel and sound single-molecule biophysical insights into DNA replication and/or chromatin organization to advance these exciting fields. **Requirements** For this innovative, interdisciplinary project, we are looking a (bio)physicist, with: • A successfully completed Ph.D. degree in biophysics or optical physics. • Practical experience and scientific maturity in the above areas. • Strong aptitude and interest in biophysical instrumentation and microscopy, and willingness to acquire related knowledge e.g. photophysics. • Professional experience with force spectroscopy (e.g. optical tweezers, magnetic tweezers, or atomic force microscopy) or single-molecule fluorescence methodologies. • Strong skills in hardware-software interfacing and demonstrable ability to interface and collaborate with experts in programming. • An independent, well-organized, and reliable work style. • Track record of obtaining scientific funding. • Leadership ability to guide, coach, and train graduate students and postdocs in the context of an interdisciplinary team. • Excellent interpersonal communication skills and a strong interest in the broader field of biophysics that will contribute to the interactive lab culture. We look for friendly and driven colleagues to enrich our team. UK visa costs and NHS surcharge fees will be covered. **We would like to welcome our new colleague by the summer or fall of 2025. ** **Who are we?** **The Nynke Dekker Lab** ( https://nynkedekkerlab.web.ox.ac.uk) is a highly successful single-molecule biophysics research lab based in the Department of Physics and the Kavli Institute of Nanoscience Discovery at the University of Oxford. The lab focuses its studies on understanding DNA replication and chromatin organization from a quantitative perspective both _in vitro_ and _in vivo_. The lab employs state-of-the-art biophysical techniques (e.g. advanced single-molecule fluorescence microscopy, optical and magnetic tweezers) together with in-house molecular biology and biochemistry, all housed in a brand-new building with high quality laboratory spaces. Studying the dynamics of DNA replication and chromatin organization at the single-molecule level requires broad and integrated expertise; as such, we employ outstanding international scientists trained in biophysics, biochemistry, and cell biology who work together enthusiastically as a multidisciplinary team. You will be part of this group and will interact actively with current members. **Information and application** If you're excited about contributing to innovative biophysical research and collaborating with a talented team, we’d love to hear from you! For more information about these positions, or to apply, please contact Prof. Nynke Dekker, e-mail: nynke.dekker@physics.ox.ac.uk Applications should include a motivated cover letter of application, a detailed CV, and the names and contact information of three references, with the final deadline for applications being 12 noon on **31 May** **, 2025**.
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