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Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford
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Description of Postdoctoral Researcher in Endogenous DNA damage by Aldehydes
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We are seeking a highly motivated and talented Postdoctoral Researcher to lead a research project focusing on tissue-specific responses to DNA damage caused by endogenous aldehydes. In particular, the project will focus on how endogenous aldehydes contribute to age-related decline of various tissues. You will work directly with Professor KJ Patel and his team, and closely with other MRC Molecular Haematology Unit groups. You will also be supported by world-class core Facilities within the Institute, including advanced microscopy, FACS, transgenics, next-generation sequencing, single-cell sequencing and genome engineering. You will hold a PhD (or near to completion: thesis submitted at time of appointment) in molecular biology or related field relevant to the project. Experience in cell and molecular biology, as well as knowledge of DNA repair and genome stability are essential. This position will particularly suit a candidate with a proven record of working with mouse models of neurodegeneration and premature ageing, and with strong interest in HSC biology. This is a full-time position available for 18 months, funded by Wellcome. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is noon on Wednesday 5 February 2025.
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Postdoctoral Researcher in Endogenous DNA damage by Aldehydes
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Job Description _________________________________________________________________________ Summary Job title Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes Division Medical Sciences Division Department Radcliffe Department of Medicine Location MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford, OX3 9DS Grade and salary Grade 7: £38,674 - £46,913 per annum Hours Full time (37.5 hours per week) Contract type Fixed-term for 18 months, funded by Wellcome Reporting to Professor KJ Patel, Group Head Vacancy reference 177808 Research topic Endogenous DNA Damage by Aldehydes Principal Investigator / supervisor Professor KJ Patel Project team Patel Group Project web site https://www.imm.ox.ac.uk/research/research-groups/patel-group Funding partner The funds supporting this research project are provided by Wellcome.. Wit N et a., A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production. Science Advances. 2023 May 17 Mulderrig L, et al. Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response. Nature. 2021 Dec Recent publications Dingler FA, Wang M, et al. Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans. Mol Cell. 2020 Dec 17 Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms. Nature. 2020 Mar 04 Garaycoechea JI. et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature. 2018 Jan 03 Burgos-Barragan G. et al. Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. Nature. 2017 Aug 16 The role The Patel laboratory is seeking to recruit a highly motivated and talented Postdoctoral Researcher to lead a research project focusing on tissue-specific responses to endogenous DNA damage. This position will particularly suit a candidate with an interest in the DNA damage response and cell cycle, and with a strong track record in mouse genetics and molecular biology. You will be based in the in the Patel laboratory and will work directly with Professor KJ Patel and his team as well as with other investigators in the MRC Molecular Haematology Unit. The Patel group is a world-renowned lab researching the sources of endogenous DNA damage in blood stems and peripheral tissues. Recent studies have identified simple aldehydes such as acetaldehyde (by-product of alcohol breakdown) and formaldehyde as potent sources of endogenous DNA damage. However, little is known where these aldehydes come from, how they damage DNA and what are the consequences of this to a mammal. Responsibilities • To manage the project intellectually and technically using experience, methodical approaches, attention to detail and evaluation of the literature in DNA repair, cell cycle regulation, cellular metabolism, haematopoiesis, functional in vivo and in vitro assays and CRISPR/Cas9 technologies. This involves organizing and prioritizing work efficiently and effectively and taking personal responsibility for assigned tasks. • To carefully document experiments and write clear, updated experimental protocols and scientific techniques for existing and new laboratory methods. • To test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. • To coordinate interactions with collaborators to ensure key research experiments are completed in a timely manner. • To clearly and succinctly present research data at internal laboratory and scientific meetings and externally at conferences. • To contribute ideas for new research projects and present detailed research proposals to senior researchers. To also develop ideas for generating research income. • To continuously broaden, deepen and consolidate scientific and technical knowledge and skill through reading, scientific seminars, training opportunities and meetings. To collaborate on writing manuscripts, contributing the bulk of primary data for publication. • To work as part of a team or independently. In this regard to act as a point of reference to less experienced members of the team/laboratory, providing guidance and support. In particular, providing knowledge and problem-solving skills, where applicable. • To maintain confidentiality regarding research data when interacting with non-collaborating researchers. • To be responsible with others for the daily housekeeping of the laboratory area, ensuring good laboratory practice This job description is not intended to be exhaustive and the postholder will be expected to adopt a flexible approach to working within this multi-disciplinary group. 177808 Job Description and Selection Criteria_Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes 2 Selection criteria Essential selection criteria • A PhD (or be close to completion - thesis submitted at time of appointment) in molecular biology or related field relevant to the project, • Experience in cell and molecular biology together with knowledge of DNA repair and genome stability. • Proven experience with advanced flow cytometry and ex vivo HSC cultures. • Proven experience in working with genetically engineered mouse models, including models of neurodegeneration and premature ageing. • Ability to independently drive, innovate (generate novel scientific ideas) and complete scientific projects. • Strong communication, organisational and time-management skills with evidence of methodical and careful approach laboratory work. • Ability to communicate results clearly and succinctly in presentations, manuscripts or grant applications, as evidenced from published work or presentations at (inter)national conferences. • Ability to work as a team member and to work independently as required. Desirable selection criteria • Valid PIL license or ability to obtain. • Demonstrable ability to establish and maintain scientific collaborations and/or strong networking record. • Experience in the supervision of students and/or junior research staff. • A proven record of working with mouse models of neurodegeneration and premature ageing, and with strong interest in HSC biology. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. If you have previously worked for the University, we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Work with allergens, e.g. laboratory animals, pollen, dust, fish or insects etc. • Work with any substance which has any of the following pictograms on their MSDS: • Travel outside of Europe or North America on University Business 177808 Job Description and Selection Criteria_Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes 3 Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory basic Disclosure and Barring Service (DBS) check due to due to working in a research environment where the postholder may have knowledge or information concerning animal research and/or other knowledge of pathogens and toxins. About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Radcliffe Department of Medicine (RDM) The Radcliffe Department of Medicine (RDM) within the Medical Sciences Division is one of the largest departments in the University of Oxford. Headed by Professor Keith Channon, RDM is a multi-disciplinary department which aims to tackle some of the world’s biggest health challenges by integrating innovative basic biology with cutting edge clinical research. The Department was formed in 2012 and comprises: • The Division of Cardiovascular Medicine (CVM) • The Investigative Medicine Division (IMD) • The Nuffield Division of Clinical Laboratory Sciences (NDCLS) • The Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) • The majority of research groups from the MRC Weatherall Institute of Molecular Medicine (WIMM) The Department has internationally renowned programmes in a range of areas, including cardiovascular sciences, diabetes and endocrinology, immunology, haematology and pathology. Our work is underpinned by excellence in molecular medicine, stem cell biology, genomics and clinical laboratory science. The Department employs in the region of 535 staff, has around 140 postgraduate research students and has an annual turnover of around £63m of which £42m is externally funded grants and contracts. RDM supports a culture that is inclusive and supportive of all members, including those with caring responsibilities and those who work flexibly for other reasons. We are proud to be a family friendly department, and are committed to creating a working environment that offers opportunities for working parents/carers to achieve their professional goals and develop their careers without having a detrimental effect on family life. To support this, we have a range of family friendly policies and practices including maternity, paternity and adoption leave, shared parental leave and unpaid parental leave, flexible/part-time working and scheduling meetings within core hours (9.30am - 2.30pm). Many of our staff work flexibly, with arrangements managed informally or formally. 177808 Job Description and Selection Criteria_Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes 4 The University of Oxford is a member of the Athena Swan Charter and holds an institutional Silver Athena Swan award. The Department of RDM holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. For more information on the Department please visit: www.rdm.ox.ac.uk Nuffield Division of Clinical Laboratory Sciences (NDCLS) Led by Professor Deborah Gill, the Nuffield Division of Clinical Laboratory Sciences brings together all of the clinical laboratory-based disciplines within the Oxford Medical School (Microbiology, Genetics, Cellular Pathology, Haematology and Clinical Biochemistry). The original Nuffield Departments date from Lord Nuffield’s original benefaction to the Oxford Medical School in 1938. As well as the teaching of Undergraduate and Clinical Medical Student courses, NDCLS has an active research programme, holding more than £5.3m per annum (£25m in total) of research grants from Research Councils and charities. For more information, please visit www.ndcls.ox.ac.uk MRC Weatherall Institute of Molecular Medicine The MRC Weatherall Institute of Molecular Medicine (MRC WIMM) at the University of Oxford was founded in 1989 by Sir David Weatherall to foster research in molecular and cell biology, with the aim of improving human health. Through our excellent basic and applied research, we have become leaders in translational medicine. Our research has resulted in improved understanding, diagnosis and treatment of a wide range of human diseases. The Institute hosts staff and students from seven different departments within the Medical Sciences Division. We bring together over 500 researchers, staff and students with a passion for translational science and who share an interest in our five core research areas: rare diseases, haematology, immunology and infection, stem cells and developmental biology and cancer biology. Our interaction with clinical departments at the Oxford University Hospitals Foundation NHS Trust, is a vital aspect of our work. A third of our faculty are clinically qualified and many are practicing clinicians. Half our groups have productive collaborations with biotech and pharma and we collaborate extensively with researchers and clinicians across the UK and further afield. Our international collaborations in the US, China, Vietnam, Thailand, Sri Lanka, East and West Africa form a major aspect of our clinical programmes directed towards progress in global health. We also centrally provide excellent, state-of-the-art core Facilities to support our researchers and work with them to develop and apply new technologies to current scientific and clinical problems. MRC Molecular Haematology Unit At the MRC MHU we aim to understand how stem cells produce mature blood cells in a healthy context, and how this process is perturbed in common blood disorders. Our ultimate goal is to improve the prognosis of patients with inherited and acquired blood diseases. The MRC Molecular Haematology Unit (MRC MHU) was founded in 1980 and is located in the MRC Weatherall Institute of Molecular Medicine, University of Oxford, at the John Radcliffe Hospital. The Unit includes 14 research teams with over 100 scientists who share a common interest in understanding the process by which multipotential haemopoietic stem cells become committed and differentiate into the highly specialised cells found in the peripheral blood (red cells, granulocytes, lymphocytes and platelets). We also study how these processes are perturbed in acquired and inherited blood diseases such as thalassaemia, myelodysplasia and leukaemia. Our work is closely integrated with the provision of NHS service to patients with blood diseases via the clinical Department of Haematology. Several permanent members of the MRC MHU are practicing clinicians working in the University’s Department of Haematology and Paediatrics, providing the Unit with access to clinical material and ensuring that our scientific developments are rapidly translated into improved clinical care. For more information please visit: http://www.imm.ox.ac.uk/mrc-molecular-haematology-unit 177808 Job Description and Selection Criteria_Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes 5 Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application, you will be asked to provide details of three referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University, please note that: - as part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full-time post. If you are offered this post, and accepting it would take you over the equivalent of fulltime hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs Non-technical questions about this job should be addressed to the recruiting department directly – please email recruitment@imm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 177808 Job Description and Selection Criteria_Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes 6 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacypolicy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/dataprotection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 177808 Job Description and Selection Criteria_Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, flexible working options, travel discounts including salary sacrifice schemes for bicycles and electric cars and other discounts. Staff can access a huge range of personal and professional development opportunities. See https://hr.admin.ox.ac.uk/staff-benefits Employee Assistance Programme As part of our wellbeing offering staff get free access to Health Assured, a confidential employee assistance programme, available 24/7 for 365 days a year. Find out more https://staff.admin.ox.ac.uk/health-assured-eap University Club and sports facilities Membership of the University Club is free for University staff. It offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits We are a family-friendly employer with one of the most generous family leave schemes in the Higher Education sector (see https://hr.web.ox.ac.uk/family-leave). Our Childcare Services team provides guidance and support on childcare provision, and offers a range of high-quality childcare options at affordable prices for staff. In addition to 5 University nurseries, we partner with a number of local providers to offer in excess of 450 full time nursery places to our staff. Eligible parents are able to pay for childcare through salary sacrifice, further reducing costs. See https://childcare.admin.ox.ac.uk/. Supporting disability and health-related issues (inc menopause) We are committed to supporting members of staff with disabilities or long-term health conditions, including those experiencing negative effects of menopause. Information about the University’s Staff Disability Advisor, is at https://edu.admin.ox.ac.uk/disability-support. For information about how we support those going through menopause see https://hr.admin.ox.ac.uk/menopause-guidance Staff networks The University has a number of staff networks including for research staff, BME staff, LGBT+ staff, disabled staff network and those going through menopause. Find out more at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Research staff The Researcher Hub supports all researchers on fixed-term contracts. They aim to help you settle in comfortably, make connections, grow as a person, extend your research expertise and approach your next career step with confidence. Find out more https://www.ox.ac.uk/research/support-researchers/researcher-hub Oxford’s Research Staff Society is a collective voice for our researchers. They also organise social and professional networking activities for researchers. Find out more https://www.ox.ac.uk/research/supportresearchers/connecting-other-researchers/oxford-research-staff-society 177808 Job Description and Selection Criteria_Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes 8
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Research Grade 7: £38,674 - £46,913 per annum
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Clinical Laboratory Sciences, Nuffield Division of
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