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Postdoctoral Researcher in Endogenous DNA damage by Aldehydes
further particulars: 177808 JD Postdoctoral Researcher in Endogenous DNA damage by Aldehydes 20250115 FINAL.pdf
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comment: We are seeking a highly motivated and talented Postdoctoral Researcher to lead a research project focusing on tissue-specific responses to DNA damage caused by endogenous aldehydes. In particular, the project will focus on how endogenous aldehydes contribute to age-related decline of various tissues. You will work directly with Professor KJ Patel and his team, and closely with other MRC Molecular Haematology Unit groups. You will also be supported by world-class core Facilities within the Institute, including advanced microscopy, FACS, transgenics, next-generation sequencing, single-cell sequencing and genome engineering. You will hold a PhD (or near to completion: thesis submitted at time of appointment) in molecular biology or related field relevant to the project. Experience in cell and molecular biology, as well as knowledge of DNA repair and genome stability are essential. This position will particularly suit a candidate with a proven record of working with mouse models of neurodegeneration and premature ageing, and with strong interest in HSC biology. This is a full-time position available for 18 months, funded by Wellcome. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is noon on Wednesday 5 February 2025.
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application opening date: 2025-01-22T11:00:00+00:00
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177808 JD Postdoctoral Researcher in Endogenous DNA damage by Aldehydes 20250115 FINAL.pdf
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value: Job Description _________________________________________________________________________ Summary Job title Postdoctoral Researcher in Endogenous DNA Damage by Aldehydes Division Medical Sciences Division Department Radcliffe Department of Medicine Location MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford, OX3 9DS Grade and salary Grade 7: £38,674 - £46,913 per annum Hours Full time (37.5 hours per week) Contract type Fixed-term for 18 months, funded by Wellcome Reporting to Professor KJ Patel, Group Head Vacancy reference 177808 Research topic Endogenous DNA Damage by Aldehydes Principal Investigator / supervisor Professor KJ Patel Project team Patel Group Project web site https://www.imm.ox.ac.uk/research/research-groups/patel-group Funding partner The funds supporting this research project are provided by Wellcome.. Wit N et a., A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production. Science Advances. 2023 May 17 Mulderrig L, et al. Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response. Nature. 2021 Dec Recent publications Dingler FA, Wang M, et al. Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans. Mol Cell. 2020 Dec 17 Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms. Nature. 2020 Mar 04 Garaycoechea JI. et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature. 2018 Jan 03 Burgos-Barragan G. et al. Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. Nature. 2017 Aug 16 The role The Patel laboratory is seeking to recruit a highly motivated and talented Postdoctoral Researcher to lead a research project focusing on tissue-specific responses to endogenous DNA damage. This position will particularly suit a candidate with an interest in the DNA damage response and cell cycle, and with a stro…

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