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"""West Wing, Level 6, John Radcliffe Hospital, Oxford, OX3 9DU Web: www.ndcn.ox.ac.uk | Tel: +44(0)1865 234702 | Email: recruitment@ndcn.ox.ac.uk Job title Research Assistant in Motor Neuron Disease Division Medical Sciences Division Department Nuffield Department of Clinical Neurosciences (NDCN) Location John Radcliffe Hospital, Headington, Oxford, OX3 9DU Grade and salary Research Grade 6: £34,982 – £40,855 per annum Hours Full time Contract type Fixed-term available from 11th March 2025 until 31st March 2027 Reporting to Professor Martin Turner and Dr Monica Passoni Vacancy reference 177925 Research topic Motor Neuron Disease Principal Investigator / supervisor Professor Martin Turner Project team The Oxford MND Centre www.ox.ac.uk/ Project web site Funding partner https://www.ndcn.ox.ac.uk/research/oxford-motor-neurondisease-centre The funds supporting this research project are provided by the NIHR-BRC, EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis (EXPERTS-ALS). The role The Oxford Motor Neuron Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS) Centre requires an enthusiastic research assistant for the opportunity to develop their expertise in Motor Neurone Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS, and the related disorder frontotemporal dementia, FTD) through their engagement with an established internationally-leading programme of neuroscience research led by Professor Martin Turner, Professor Kevin Talbot and Dr Alexander Thompson. This post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience. It requires excellent organisational skills and attention to detail. The post holder will be responsible for supporting all aspects of the Good Clinical Laboratory Practice (GCLP) laboratory set up for the measurement of trial participant blood samples that underpins a major new UK drug screening platform in MND, the ‘EXPErimental Route To Success in ALS’ (EXPERTS-ALS, www.experts-als.uk). A major rate-limiting step in therapeutic advancement for ALS is the capacity to deliver Phase 3 randomised controlled trials at pace for a growing pool of drugs. Through multiple cohort studies, blood neurofilament light chain (NfL) level has been established as an objective correlate of the individual rate of disability progression in ALS. EXPERTS-ALS is a randomised, open-label, multi-arm study that will prioritise groups of candidate drugs by their ability to lower NfL levels in relatively small groups of ALS patients over up to 6 months per drug. It involves 11 MND centres around the UK. The Sheffield CTRU has general trial management oversight. A separate ground-breaking experimental medicine programme will enable the analysis of samples generated from participants for the development of novel biomarkers. The EXPERTS-ALS platform hinges on the robust and high-throughput NfL measurement using the SIMOA HDX instrument (Quanterix) which is run by a post-doctoral scientist and this postholder. The analysis of human samples collected as part of this clinical trial must comply with the Medicines for Human Use (Clinical Trials) Regulations 2004 and will provide the primary endpoint data that will dictate the outcome of each clinical trial arm. The post holder will work alongside the post-doctoral scientist, Clinical Research Project Manager, with oversight from an independent Quality Assurance Consultant and an existing Senior Clinical Project Manager to ensure that the data generated is documented and reported in compliance with GCLP and the applicable regulatory requirements. The post offers the opportunity to become proficient in biofluid sample processing, analytical techniques such as ELISA, experience of working within a Quality Management System of a GCLP laboratory and to gain experience in neurodegeneration research as it relates to MND. As such the post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience. The post requires excellent organisational skills and attention to detail. The post-holder will join a wider vibrant team of more than 30 people in the Oxford MND Centre who are involved in a range of basic science and patient-based research, plus those involved in the clinical care of those living with MND. It is an opportunity to be closely involved in driving one of the most significant global advances in drug screening in MND and biofluid biomarker development more widely. = Responsibilities • Support the running of the EXPERTS-ALS Laboratory to GCLP standards • Support the daily operation of the SIMOA HDX instrument • Ensure all work is completed in compliance with the Quality Management System established within the laboratory • Support the maintenance of study files, ensuring all documents are version controlled and maintained according to regulatory requirements • Perform clinical trial sample analysis according to validated method • Downloading data, data processing and data management • Support the analysis and reporting of primary end point data to strict deadlines. • Arranging blood sampling packs for research participants • Biofluid sample processing, extraction, storage and maintaining sample databases. • Undertaking immunoassays and other sample analyses • Managing own research and administrative activities, within guidelines provided by senior colleagues • General laboratory management and administration, including stock control of laboratory consumables and freezer resource management • Communication with customer and scientific support when issues arise with laboratory consumables and immunoassays • Contribution to scientific reports and journal articles and the presentation of data/papers at conferences • Contribution to wider team discussions, including project planning and share findings with colleagues in other research groups • Undertake other duties in the department from time to time as determined commensurate with the grade and responsibilities of this post, and any other reasonable request Selection criteria Please address each of these criteria specifically in your application statement: Essential selection criteria • Hold a first degree in a relevant discipline • Previous experience working with human biosamples • Awareness of relevant legislation around human sample banking and storage • Possess sufficient specialist knowledge of working with quality-assured biomarker assays • Demonstrate excellent team working and collaboration skills Desirable selection criteria • Specific experience of adapting and troubleshooting laboratory protocols where needed and selecting appropriate experimental methodologies • Experience with database software (e.g REDCap, Open Specimen, Microsoft Access) • Knowledge of ICH GCP and MHRA regulation of CTIMPs • Some knowledge of MND or wider neurodegenerative disorders = Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. If you have previously worked for the University we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Working with blood, human products and human tissues • Work with any substance which has any of the following pictograms on their MSDS: • Travel outside of Europe or North America on University Business About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. = For more information, please visit www.ox.ac.uk/about/organisation. Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information visit: www.medsci.ox.ac.uk The Nuffield Department of Clinical Neurosciences The Nuffield Department of Clinical Neurosciences (NDCN), led by Prof Kevin Talbot, has over 400 staff and 150 postgraduate students. NDCN has an established research and teaching portfolio with a national and international reputation for excellence. NDCN is based in high quality research and clinical facilities in the West Wing of the John Radcliffe Hospital, alongside the Department's world-class Wellcome Centre for Integrative Neuroimaging (WIN) and the Weatherall Institute of Molecular Medicine (which houses 3 of our research groups), and provides the ideal facilities to translate research from bench to bedside. In keeping with the award of NIHR Comprehensive Biomedical Research Centre status, to a partnership between Oxford University and the Oxford Radcliffe Hospitals NHS Trust, we have developed a highly integrated and interdisciplinary environment in which research, teaching, clinical training and clinical care interact. This enables us to establish new approaches to the understanding, diagnosis and treatment of brain diseases. To this end the Department fosters collaborations worldwide and warmly welcomes visiting scientists, clinical fellows and students. For more information visit: www.ndcn.ox.ac.uk The Department comprises six sections: Medical Research Council Brain Network Dynamics Unit The MRC BNDU is directed by Professor Peter Magill and is exceptionally multidisciplinary, integrating research programmes that span clinical, experimental and computational neuroscience. The Unit’s collective goal is to understand and exploit the moment-to-moment interactions between nerve cells that are critical for brain functions, with a special focus on the brain circuits underlying movement and memory. For more information visit: www.mrcbndu.ox.ac.uk Nuffield Division of Anaesthesia NDA is led by Associate Professor Andrew Farmery. The NDA is committed to the development and maintenance of internationally competitive research programmes in pain and consciousness; respiration and hypoxia; adult and neuro-intensive care; simulation and human factors training. For more information visit www.nda.ox.ac.uk Division of Clinical Neurology DCN is led by Professor David Bennett. DCN is committed to the development of research programs that improve understanding of the nervous system in health and disease. For more information visit www.dcn.ox.ac.uk The Wellcome Centre for Integrative Neuroimaging (WIN) WIN is a multi-disciplinary neuroimaging research facility led by Heidi Johansen-Berg. WIN aims to bridge the gap between laboratory neuroscience and human health, by performing multi-scale studies spanning from animal models through to human populations. It focuses on the use of Magnetic Resonance Imaging (MRI) for neuroscience research, along with related technologies such as Transcranial Magnetic Stimulation, transcranial Direct Current Stimulation, MEG and = EEG. WIN has core locations at the John Radcliffe Hospital (FMRIB), Warneford Hospital (OHBA) and University Science area (BSB). For more information visit www.win.ox.ac.uk Nuffield Laboratory of Ophthalmology NLO is led by Professor Russell Foster, who leads the Sleep & Circadian Neuroscience Institute. NLO pursues scientific and clinical research into a range of areas related to vision, the eye and circadian neuroscience. For more information visit www.nlo.ox.ac.uk Centre for the Prevention of Stroke & Dementia CPSD is led by Professor Peter Rothwell. The centre carries out research that increases understanding of the causes of cerebrovascular disease. Its aims are to improve prevention of stroke and dementia by earlier diagnosis, more reliable prognostication, and more effective use of existing preventive treatments in routine clinical practice. For more information visit www.cpsd.ox.ac.uk Working at NDCN NDCN actively promotes a healthy work life balance amongst employees through a number of family friendly policies. See https://hr.admin.ox.ac.uk/staff-benefits for further information. The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Bronze Athena SWAN award. The Department of Clinical Neurosciences holds a departmental Silver Athena award in recognition of its efforts to introduce organisational and cultural practices that promote advancement of gender equality: representation, progression and success for all. = How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • as part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly: recruitment@ndcn.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. = Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. = Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, flexible working options, travel discounts including salary sacrifice schemes for bicycles and electric cars and other discounts. Staff can access a huge range of personal and professional development opportunities. See https://hr.admin.ox.ac.uk/staff-benefits Employee Assistance Programme As part of our wellbeing offering staff get free access to Health Assured, a confidential employee assistance programme, available 24/7 for 365 days a year. Find out more at https://staff.admin.ox.ac.uk/health-assured-eap University Club and sports facilities Membership of the University Club is free for University staff. It offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits We are a family-friendly employer with one of the most generous family leave schemes in the Higher Education sector (see https://hr.web.ox.ac.uk/family-leave). Our Childcare Services team provides guidance and support on childcare provision, and offers a range of high-quality childcare options at affordable prices for staff. In addition to 5 University nurseries, we partner with a number of local providers to offer in excess of 450 full time nursery places to our staff. Eligible parents are able to pay for childcare through salary sacrifice, further reducing costs. See https://childcare.admin.ox.ac.uk/. Supporting disability and health-related issues (inc menopause) We are committed to supporting members of staff with disabilities or long-term health conditions, including those experiencing negative effects of menopause. Information about the University’s Staff Disability Advisor, is at https://edu.admin.ox.ac.uk/disability-support. For information about how we support those going through menopause see https://hr.admin.ox.ac.uk/menopause-guidance Staff networks The University has a number of staff networks including for research staff, BME staff, LGBT+ staff, disabled staff network and those going through menopause. Find out more at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Research staff The Researcher Hub supports all researchers on fixed-term contracts. They aim to help you settle in comfortably, make connections, grow as a person, extend your research expertise and approach your next career step with confidence. Find out more at https://www.ox.ac.uk/research/supportresearchers/researcher-hub Oxford’s Research Staff Society is a collective voice for our researchers. They also organise social and professional networking activities for researchers. Find out more at https://www.ox.ac.uk/research/supportresearchers/connecting-other-researchers/oxford-research-staff-society = """^^ . """The Oxford Motor Neuron Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS) Centre requires an enthusiastic research assistant for the opportunity to develop their expertise in Motor Neurone Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS, and the related disorder frontotemporal dementia, FTD) through their engagement with an established internationally-leading programme of neuroscience research led by Professor Martin Turner, Professor Kevin Talbot and Dr Alexander Thompson. This post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience. It requires excellent organisational skills and attention to detail. The post holder will be responsible for supporting all aspects of the Good Clinical Laboratory Practice (GCLP) laboratory set up for the measurement of trial participant blood samples that underpins a major new UK drug screening platform in MND, the ‘EXPErimental Route To Success in ALS’ (EXPERTS-ALS, www.experts-als.uk). A major rate-limiting step in therapeutic advancement for ALS is the capacity to deliver Phase 3 randomised controlled trials at pace for a growing pool of drugs. Through multiple cohort studies, blood neurofilament light chain (NfL) level has been established as an objective correlate of the individual rate of disability progression in ALS. EXPERTS-ALS is a randomised, open-label, multi-arm study that will prioritise groups of candidate drugs by their ability to lower NfL levels in relatively small groups of ALS patients over up to 6 months per drug. It involves 11 MND centres around the UK. The Sheffield CTRU has general trial management oversight. A separate ground-breaking experimental medicine programme will enable the analysis of samples generated from participants for the development of novel biomarkers. The EXPERTS-ALS platform hinges on the robust and high-throughput NfL measurement using the SIMOA HDX instrument (Quanterix) which is run by a postdoctoral scientist alongside this post holder. The analysis of human samples collected as part of this clinical trial must comply with the Medicines for Human Use (Clinical Trials) Regulations 2004 and will provide the primary endpoint data that will dictate the outcome of each clinical trial arm. 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The Oxford Motor Neuron Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS) Centre requires an enthusiastic research assistant for the opportunity to develop their expertise in Motor Neurone Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS, and the related disorder frontotemporal dementia, FTD) through their engagement with an established internationally-leading programme of neuroscience research led by Professor Martin Turner, Professor Kevin Talbot and Dr Alexander Thompson.

 

This post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience. It requires excellent organisational skills and attention to detail.

 

The post holder will be responsible for supporting all aspects of the Good Clinical Laboratory Practice (GCLP) laboratory set up for the measurement of trial participant blood samples that underpins a major new UK drug screening platform in MND, the ‘EXPErimental Route To Success in ALS’ (EXPERTS-ALS, www.experts-als.uk).

 

A major rate-limiting step in therapeutic advancement for ALS is the capacity to deliver Phase 3 randomised controlled trials at pace for a growing pool of drugs. Through multiple cohort studies, blood neurofilament light chain (NfL) level has been established as an objective correlate of the individual rate of disability progression in ALS.

 

EXPERTS-ALS is a randomised, open-label, multi-arm study that will prioritise groups of candidate drugs by their ability to lower NfL levels in relatively small groups of ALS patients over up to 6 months per drug. It involves 11 MND centres around the UK. The Sheffield CTRU has general trial management oversight. A separate ground-breaking experimental medicine programme will enable the analysis of samples generated from participants for the development of novel biomarkers.

 

The EXPERTS-ALS platform hinges on the robust and high-throughput NfL measurement using the SIMOA HDX instrument (Quanterix) which is run by a postdoctoral scientist alongside this post holder. The analysis of human samples collected as part of this clinical trial must comply with the Medicines for Human Use (Clinical Trials) Regulations 2004 and will provide the primary endpoint data that will dictate the outcome of each clinical trial arm. The post holder will work alongside the post-doctoral scientist, Clinical Research Project Manager, with oversight from an independent Quality Assurance Consultant and an existing Senior Clinical Project Manager to ensure that the data generated is documented and reported in compliance with GCLP and the applicable regulatory requirements.

 

The post offers the opportunity to become proficient in biofluid sample processing, analytical techniques such as ELISA, experience of working within a Quality Management System of a GCLP laboratory and to gain experience in neurodegeneration research as it relates to MND. As such the post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience. The post requires excellent organisational skills and attention to detail.

 

The post-holder will join a wider vibrant team of more than 30 people in the Oxford MND Centre who are involved in a range of basic science and patient-based research, plus those involved in the clinical care of those living with MND. It is an opportunity to be closely involved in driving one of the most significant global advances in drug screening in MND and biofluid biomarker development more widely.

 

Please see the below 'Job Description' for further details on the responsibilities and selection criteria, as well as further information about the university and how to apply.

 

The post is full time for a fixed term available from 11th March 2025 until 31st March 2027.

 

Only applications received before 12.00 midday on Friday 14th February 2025 will be considered.

 

Interviews will be held as soon as possible thereafter. 

 
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