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_________________________________________________________________________ Job description and selection criteria Job title Postdoctoral Research Scientist in Mucosal Immunology Division Medical Sciences Department Paediatrics Location Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine & Institute of Developmental and Regenerative Medicine, Headington, Oxford Grade and salary Research Grade 7: £38,674 - £46,913 per annum (with a discretionary range to £52,539 per annum) Hours Full-time Contract type Fixed-term (2 years) Reporting to Professor Daniella Ferreira Vacancy reference 178403 Additional information Research topic Applications are to be made online, please see the advert for the closing date. This role meets the criteria for a UK Skilled Worker visa Immune responses to respiratory human challenge and vaccination Principal Investigator Professor Daniela Ferreira / supervisor Project team Controlled human infection models Project web site https://www.ovg.ox.ac.uk/ Funding partner The funds supporting this research project are provided by CEPI. The role Controlled human infection models (CHIMs) are pivotal to advance the development of vaccine as they are used for proof of concept, pathogenesis, down-selection and immunogenicity studies. Using the CHIM with Streptococcus pneumoniae (pneumococcus), the team has conducted over 30 independent clinical studies, including vaccine studies, genetic modified strains, at risk populations and co-infection studies with over 2000 participants inoculated to date. We have an exciting opportunity for a Postdoctoral Research Scientist in Mucosal Immunology to work on CHIMs with respiratory pathogens (pneumococcus, RSV, influenza) on projects funded by Horizon, Wellcome Trust and industry. Each project involves the identification of mucosal mechanisms involved in protection and susceptibility to disease, as well as vaccineinduced immune responses. The potholder will lead the development of transcriptomic analysis across several ongoing projects: NOSEVAC (Horizon EU2020 programme), Wellcome Trust research grant on lung immunity to SARS-CoV2 variants of concern and RSV-pneumococcus human challenge models. As the postholder, you will join the team of Professor Daniela Ferreira at the Oxford Vaccine Group. You will have a background in immunology and ideally prior experience working with mucosal tissue (i.e nose and/or lungs) and other human tissue, including peripheral blood mononuclear cells (PBMC). We are welcoming candidates with experience in single-cell sequencing and spatial transcriptomics. Be independent working with immunological assays including but not limited to ELISAs, ELISpot, multiparameter flow cytometry, intracellular cytokine secretion (ICS), activation-induced marker (AIM) assays. You must have a proactive and adaptable approach to work and willingness to collaborate. You will have the opportunity to interact with other members of the Oxford Vaccine Group, including Prof Sir Andrew Pollard, Prof Teresa Lambe, Ass Prof Daniel O’Connor and experts in computational biologists. You should thrive on scientific challenges associated with generating and analysing complex immunological data sets, be keen to learn, test and develop new analytical tools and methods. You must be capable of learning and working independently and be able to train junior team members. Excellent record keeping, code and data management skills and the ability to meet deadlines are essential. You will be expected to document all work thoroughly, to provide manuscript-level reporting of interim and final analyses and results, and to substantially contribute to presentation preparation, grant and manuscript writing. Responsibilities • • • • Adapt existing and develop new scientific techniques and experimental protocols to understand humoral and cellular immunity induced in the context of vaccination, natural infection and control human infection models, and generate original ideas by building on existing concepts. Manage your own academic research outputs and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines including assisting in the management of laboratory work within the group Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate Develop, establish, and pursue appropriate analytical protocols and techniques to support research, working collaboratively with team members to overcome issues. Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 2 • • Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques Keep detailed and comprehensible records of your work, preparing accurate reports that communicate results clearly and effectively to a range of stakeholders, and ensure that project members are kept up to date with progress and any difficulties encountered. • Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters at scientific conferences and contribute to the OVG website. • Develop ideas for generating research income, and present detailed research proposals to senior researchers. • Contribute ideas for new research projects • Be accountable for personal professional conduct within the project and agree to the University Equal Opportunities and Data Protection policies. • Participate in and support of the public engagement and widening access activities of the Department and the University. • Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Selection criteria Essential • • • • • • • A doctoral degree (or near completion) in a subject relevant to immunology Previous relevant experience Possess sufficient specialist knowledge in immunology to work within established research programmes. Examples of techniques where you will be proficient include ELISA, ELISpot, multiparameter flow cytometry, ICS, AIM assays and single cell/bulk/spatial transcriptomic experiments. Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings. Ability to independently plan and manage a research project, including a research budget. Previous experience of contributing to publications/presentations Ability to contribute ideas for new research projects and research income generation. Desirable • • • • Experience in controlled human infection models Experience of supervising staff Experience of working to GCP and Knowledge of Human Tissue Authority regulations Experience of independently managing a discrete area of a research project . Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 3 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. If you have previously worked for the University we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens • Working with blood, human products and human tissues • Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • Enhanced Level Screening as this role includes conducting research with access to/ knowledge of the location of certain pathogens, toxins, irradiators. • A satisfactory enhanced Disclosure and Barring Service check (Adults’ Barred list) • University security screening (e.g. identity checks) Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 4 About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. We are committed to inform and inspire external audiences worldwide through our public engagement and outreach activities. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a Gold Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 5 Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two/three referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • as part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 6 Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting https://staff.web.ox.ac.uk/recruitment-support-faqs advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 7 Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 8 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts including salary sacrifice schemes for bicycles and electric cars and other discounts. Staff can access a huge range of personal and professional development opportunities. See https://hr.admin.ox.ac.uk/staff-benefits. Employee Assistance Programme As part of our wellbeing offering staff get free access to Health Assured, a confidential employee assistance programme, available 24/7 for 365 days a year. Find out more https://staff.admin.ox.ac.uk/health-assured-eap. University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/. There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme. Family-friendly benefits We are a family-friendly employer with one of the most generous family leave schemes in the Higher Education sector (see https://hr.web.ox.ac.uk/family-leave). Our Childcare Services team provides guidance and support on childcare provision, and offers a range of high-quality childcare options at affordable prices for staff. In addition to 5 University nurseries, we partner with a number of local providers to offer in excess of 450 full time nursery places to our staff. Eligible parents are able to pay for childcare through salary sacrifice, further reducing costs. See https://childcare.admin.ox.ac.uk/. Supporting disability and health-related issues (inc menopause) We are committed to supporting members of staff with disabilities or long-term health conditions, including those experiencing negative effects of menopause. Information about the University’s Staff Disability Advisor, is at https://edu.admin.ox.ac.uk/disability-support. For information about how we support those going through menopause see https://hr.admin.ox.ac.uk/menopauseguidance. Staff networks The University has a number of staff networks including for research staff, BME staff, LGBT+ staff, disabled staff network and those going through menopause. Find out more at https://edu.admin.ox.ac.uk/networks. Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 9 The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Research staff The Researcher Hub supports all researchers on fixed-term contracts. They aim to help you settle in comfortably, make connections, grow as a person, extend your research expertise and approach your next career step with confidence. Find out more https://www.ox.ac.uk/research/support-researchers/researcher-hub. Oxford’s Research Staff Society is a collective voice for our researchers. They also organise social and professional networking activities for researchers. Find out more https://www.ox.ac.uk/research/support-researchers/connecting-other-researchers/oxfordresearch-staff-society. Department of Paediatrics, 178403, Postdoctoral Research Scientist in Mucosal Immunology – Job Description 10
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**About the role** We have an exciting opportunity to join the Oxford Vaccine Group in the Department of Paediatrics as our Postdoctoral Research Scientist in Mucosal Immunology. The successful candidate will conduct research in a dynamic and highly collaborative environment of an internationally leading research institute. They will benefit from the institute and wider university expertise in immunology and vaccinology. In this position you will lead development of transcriptomic analysis across several ongoing projects contributing to the identification of mucosal mechanisms involved in protection and susceptibility to respiratory disease as well as vaccine-induced immune responses. You will also use a broad array of T and B cell experimental approaches including ELISpot, flow cytometry, ELISA and sterile cell culture. You will work closely with both laboratory and bioinformatic teams and will be responsible for analysis and/or supervision of the data analyses. You will be expected to write publications for academic journals and raise research funds through grant applications. You will be working in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. The Oxford Vaccine Group is a passionate and active research group which conducts world-leading research into creating new and optimising existing vaccines for children and adults. Our research has led to development and licensure of the new Oxford/AstraZeneca SARS-CoV-2 vaccine, by delivering and managing global vaccine trials. We are also working on human challenge models to advance the development of vaccines and therapeutics against several infectious diseases. This position is offered full-time on a fixed-term contract initially for 2 years with the possibility to extend provided further external funding is available. **About the department** The Department of Paediatrics holds the Athena Swan Gold award (a national gender equality charter) acknowledging the innovative policies and practices developed across the department. We encourage staff to develop their skills by offering all staff ten paid days of professional development each year and have a policy where staff can apply to receive funding for further training. In addition to the University of Oxford wellbeing resources, the Department of Paediatrics sponsors weekly exercise classes such as yoga and bootcamp sessions as well as a choir. For staff on work visas, we also offer financial assistance towards visa renewal fees. These activities are designed to promote physical and mental wellbeing among staff members. Please visit our website to find out more about the Department. **About you** The successful candidate will hold a PhD in immunology or a related immunological subject and have specialist knowledge to independently develop research questions and conduct research on immunity induced in the context of vaccination, natural infection and controlled human infection models. The successful candidate will ideally have experience assessing immunity to respiratory pathogens (e.g pneumococcus, Influenza, RSV, SARS-CoV2 and others). Examples of techniques where you will be proficient include ELISA, ELISpot, multiparameter flow cytometry, ICS, AIM assays and single cell/bulk/spatial transcriptomic experiments. Applicants will have excellent interpersonal skills and capacity to work collaboratively and a strong publication record. All essential and desirable selection criteria are listed in the Job Description attached to this advert. **Application Process** You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Daniela Ferreira the Professor of Vaccinology using the contact details below. **Only online applications received before 12.00 midday on 9th April will be considered. Interviews will be held as soon as possible thereafter.** The Department of Paediatrics offers an Interview Expense Reimbursement Policy in its efforts towards equality, diversity and inclusion. Should you be invited to interview, we will share further information about the policy at that stage.
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About the role We have an exciting opportunity to join the Oxford Vaccine Group in the Department of Paediatrics as our Postdoctoral Research Scientist in Mucosal Immunology. The successful candidate will conduct research in a dynamic and highly collaborative environment of an internationally leading research institute. They will benefit from the institute and wider university expertise in immunology and vaccinology. In this position you will lead development of transcriptomic analysis across several ongoing projects contributing to the identification of mucosal mechanisms involved in protection and susceptibility to respiratory disease as well as vaccine-induced immune responses. You will also use a broad array of T and B cell experimental approaches including ELISpot, flow cytometry, ELISA and sterile cell culture. You will work closely with both laboratory and bioinformatic teams and will be responsible for analysis and/or supervision of the data analyses. You will be expected to write publications for academic journals and raise research funds through grant applications. You will be working in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. The Oxford Vaccine Group is a passionate and active research group which conducts world-leading research into creating new and optimising existing vaccines for children and adults. Our research has led to development and licensure of the new Oxford/AstraZeneca SARS-CoV-2 vaccine, by delivering and managing global vaccine trials. We are also working on human challenge models to advance the development of vaccines and therapeutics against several infectious diseases. This position is offered full-time on a fixed-term contract initially for 2 years with the possibility to extend provided further external funding is available. About the department The Department of Paediatrics holds the Athena Swan Gold award (a national gender equality charter) acknowledging the innovative policies and practices developed across the department. We encourage staff to develop their skills by offering all staff ten paid days of professional development each year and have a policy where staff can apply to receive funding for further training. In addition to the University of Oxford wellbeing resources, the Department of Paediatrics sponsors weekly exercise classes such as yoga and bootcamp sessions as well as a choir. For staff on work visas, we also offer financial assistance towards visa renewal fees. These activities are designed to promote physical and mental wellbeing among staff members. Please visit our website to find out more about the Department. About you The successful candidate will hold a PhD in immunology or a related immunological subject and have specialist knowledge to independently develop research questions and conduct research on immunity induced in the context of vaccination, natural infection and controlled human infection models. The successful candidate will ideally have experience assessing immunity to respiratory pathogens (e.g pneumococcus, Influenza, RSV, SARS-CoV2 and others). Examples of techniques where you will be proficient include ELISA, ELISpot, multiparameter flow cytometry, ICS, AIM assays and single cell/bulk/spatial transcriptomic experiments. Applicants will have excellent interpersonal skills and capacity to work collaboratively and a strong publication record. All essential and desirable selection criteria are listed in the Job Description attached to this advert. Application Process You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Daniela Ferreira the Professor of Vaccinology using the contact details below. Only online applications received before 12.00 midday on 9th April will be considered. Interviews will be held as soon as possible thereafter. The Department of Paediatrics offers an Interview Expense Reimbursement Policy in its efforts towards equality, diversity and inclusion. Should you be invited to interview, we will share further information about the policy at that stage.
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