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Postdoctoral Research Associate: Neurophysiologist
comment: We are seeking a neuroscientist with a strong background in visual and/or circadian biology to work as part of the Sleep and Circadian Neuroscience Institute (SCNi) within the Nuffield Department of Clinical Neurosciences (NDCN). The research interests of the SCNi are to: (A) Understand the neural mechanisms that generate and regulate sleep and circadian biology (B) Define the mechanistic links between sleep/circadian rhythm disruption and disorders of the central nervous system and © Apply this knowledge for the development of evidence-based clinical interventions. The successful candidate will be responsible for leading a specific research project entitled ‘ ** _Investigating the multiple roles of cryptochromes in animal magnetoreception_** ’ which will be based within the SCNi. They will work closely with Prof Stuart Peirson ( https://www.ndcn.ox.ac.uk/team/stuart- peirson) and Mark Hankins ( https://www.ndcn.ox.ac.uk/team/mark-hankins). This project is part of a Wellcome Discovery Award, in collaboration with the University of Leicester (Profs Ezio Rosato, Bambos Kyriacou), Manchester (Prof Richard Baines) and the National Physics Laboratory (Dr Alex Jones). Many species, including humans, are reported to be magnetosensitive. Indeed, some animals navigate using the weak magnetic field (MF) of Earth. Others do not, but there are accounts of MF effects and the concern that exposure to low frequency MFs may affect health. Whether the same or different mechanisms may be involved, is currently unknown. One mechanism has acquired experimental prominence. Cryptochromes (CRYs), best known for their role in circadian rhythmicity, may mediate magnetosensitivity via a photochemical quantum reaction involving CRY-bound flavin adenine dinucleotide (FAD) and a chain of tryptophan residues within CRY that generate a radical pair (RP). Unexpectedly, we have demonstrated that the CRY C-terminal (CRY-CT), without the canonical FAD binding site or tryptophan chain, elicits behavio…
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application closing date: 2025-03-28T12:00:00+00:00
spatial: Nuffield Department of Clinical Neurosciences (NDCN), Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU, Lab based work onsite, but hybrid working possible
comment: We are seeking a neuroscientist with a strong background in visual and/or circadian biology to work as part of the Sleep and Circadian Neuroscience Institute (SCNi) within the Nuffield Department of Clinical Neurosciences (NDCN). The research interests of the SCNi are to: (A) Understand the neural mechanisms that generate and regulate sleep and circadian biology (B) Define the mechanistic links between sleep/circadian rhythm disruption and disorders of the central nervous system and © Apply this knowledge for the development of evidence-based clinical interventions. The successful candidate will be responsible for leading a specific research project entitled ‘Investigating the multiple roles of cryptochromes in animal magnetoreception’ which will be based within the SCNi. They will work closely with Prof Stuart Peirson ( https://www.ndcn.ox.ac.uk/team/stuart-peirson) and Mark Hankins ( https://www.ndcn.ox.ac.uk/team/mark-hankins). This project is part of a Wellcome Discovery Award, in collaboration with the University of Leicester (Profs Ezio Rosato, Bambos Kyriacou), Manchester (Prof Richard Baines) and the National Physics Laboratory (Dr Alex Jones). Many species, including humans, are reported to be magnetosensitive. Indeed, some animals navigate using the weak magnetic field (MF) of Earth. Others do not, but there are accounts of MF effects and the concern that exposure to low frequency MFs may affect health. Whether the same or different mechanisms may be involved, is currently unknown. One mechanism has acquired experimental prominence. Cryptochromes (CRYs), best known for their role in circadian rhythmicity, may mediate magnetosensitivity via a photochemical quantum reaction involving CRY-bound flavin adenine dinucleotide (FAD) and a chain of tryptophan residues within CRY that generate a radical pair (RP). Unexpectedly, we have demonstrated that the CRY C-terminal (CRY-CT), without the canonical FAD binding site or tryptophan chain, elicits behavioural and c…
formal organization: University of Oxford
subject: research
organization part: Nuffield Department of Clinical Neurosciences
application opening date: 2025-02-27T12:15:00+00:00
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value: West Wing, Level 6, John Radcliffe Hospital, Oxford, OX3 9DU Web: www.ndcn.ox.ac.uk | Tel: +44(0)1865 234702 | Email: recruitment@ndcn.ox.ac.uk Job title Postdoctoral Research Associate: Neurophysiologist Division Medical Sciences Division Department Nuffield Department of Clinical Neurosciences (NDCN) Location Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU Lab based work onsite, but hybrid working possible Research Grade 7: £38,674 – £45,628 per annum Grade and salary A less experienced candidate may be appointed at Research Grade 6 (£34,982 to £40,855) per annum, with a commensurate adjustment in either the essential criteria, responsibilities or duties. Hours Full time Contract type Fixed-term until 31st December 2028 Reporting to Prof Stuart Peirson and Prof Mark Hankins Vacancy reference 178406 Additional information Flexible working hours are possible given the nature of the project Research topic Visual neuroscience Principal Investigator / supervisor Prof Stuart Peirson and Prof Mark Hankins Project team Circadian and Visual Neuroscience Group www.ox.ac.uk/ Project web site https://www.ndcn.ox.ac.uk/news/a-multidisciplinary-team-ofscientists-aims-to-solve-the-mystery-of-magnetoreception https://www.ndcn.ox.ac.uk/research/circadian-and-visualneuroscience-peirson https://www.ndcn.ox.ac.uk/research/retinal-neurobiologyoptogenetics-group Funding partner The funds supporting this research project are provided by a Wellcome Discovery award. https://pubmed.ncbi.nlm.nih.gov/36630957/ Recent publications https://pubmed.ncbi.nlm.nih.gov/39825567/ https://pubmed.ncbi.nlm.nih.gov/36813962/ The role We are seeking a neuroscientist with a strong background in visual and/or circadian biology to work as part of the Sleep and Circadian Neuroscience Institute (SCNi) within the Nuffield Department of Clinical Neurosciences (NDCN). The successful candidate will be responsible for leading a specific research project entitled ‘Investigating the multiple role…
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