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application closing date: 2025-04-16T12:00:00+01:00
salary: Research Grade 7: £38,674 - £46,913
further particulars: FINAL - job-description-and-selection-criteria-template-Mar 2025_NNRCO (1).pdf
comment: About the role Applications are invited for a Postdoctoral Research Associate in Medicinal Chemistry to work under the supervision of Professor Angela Russell for a period of up to 2 years. The project involves the discovery of medicinal chemistry optimisation of small molecule modulators of metabolic function and new target discovery using human cellular models. The post is funded by NovoNordisk. Find out more about the russell research and group at: russell group About you Applicants must hold a PhD in Chemistry, Medicinal Chemistry, Chemical Biology or a relevant subject area, (or be close to completion) prior to taking up the appointment. The research requires experience in synthetic organic chemistry, medicinal chemistry (including but not limited to compound optimisation for in vivo proof of concept studies) and de novo drug design/ development as well as at least two of asymmetric synthesis, chemical biology, amnio acid chemistry, nucleotide chemistry, sugar/amino sugar chemistry. Expertise in modern organic synthesis and a strong working knowledge of medicinal mhemistry. You will be expected to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will test hypotheses and analyses scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. The post will be based in the Department of Chemistry, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1, 3TA and is available as soon as possible. Application Process Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your application. In your supporting statement (<5 pages), please explain how you meet each of the selection criteria found in the job description. Certificates, references and research papers should not be provided at this stage. The closing date for application…
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comment: **About the role** Applications are invited for a Postdoctoral Research Associate in Medicinal Chemistry to work under the supervision of Professor Angela Russell for a period of up to 2 years. The project involves the discovery of medicinal chemistry optimisation of small molecule modulators of metabolic function and new target discovery using human cellular models. The post is funded by NovoNordisk. _Find out more about the russell research and group at:_ russell group **About you** Applicants must hold a PhD in Chemistry, Medicinal Chemistry, Chemical Biology or a relevant subject area, ( **or be close to completion** ) prior to taking up the appointment. The research requires experience in synthetic organic chemistry, medicinal chemistry (including but not limited to compound optimisation for in vivo proof of concept studies) and de novo drug design/ development as well as at least two of asymmetric synthesis, chemical biology, amnio acid chemistry, nucleotide chemistry, sugar/amino sugar chemistry. Expertise in modern organic synthesis and a strong working knowledge of medicinal mhemistry. You will be expected to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will test hypotheses and analyses scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. The post will be based in the Department of Chemistry, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1, 3TA and is available as soon as possible. **Application Process** Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your application. In your supporting statement **( <5 pages)**, please explain how you meet each of the selection criteria found in the job description. **Certificates, references and research papers should not be provided at this stage.** The…
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FINAL - job-description-and-selection-criteria-template-Mar 2025_NNRCO (1).pdf
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value: Job Description DEPARTMENT OF CHEMISTRY Summary Job title Postdoctoral Research Associate in Medicinal Chemistry Division Mathematical, Physical and Life Sciences Department Department of Chemistry Location Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA Grade and salary Grade 7: £38,674 - £46,913 per annum (inclusive of Oxford University Weighting) Hours Full time Contract type Fixed-term (24 months) Reporting to Professor Angela Russell Vacancy reference 178576 Additional information Research topic Small molecule modulation of metabolic function and new target discovery in human cellular models Principal Investigator / supervisor Professor Angela Russell Project team Russell Group Project web site https://russellchem.web.ox.ac.uk/ Funding partner The funds supporting this research project are provided by NovoNordisk. The role The post, funded by Novo Nordisk, is available immediately, or as soon as possible thereafter for 24 months, with the possibility of further extension. The successful applicant will join an established team of medicinal chemists working under the direct supervision Professor Angela Russell, on a collaborative project with scientists at the Novo Nordisk Research Centre Oxford (NNRCO). The project involves the discovery and medicinal chemistry optimisation of small molecule modulators of metabolic function and new target discovery using human cellular models. We have already performed a phenotypic screen using these models which has yielded several small molecule hit series. The successful candidate’s role will be to optimise the chemistry around these hits in close collaboration with colleagues at NNCRO, with the objective of progressing to a robust lead molecule for proof of concept efficacy studies and to enable concomitant target deconvolution studies. This is an exciting opportunity to work in an industry-academia collaboration with world leading researchers and contribute to the development of innovative new therapeutic …

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