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Research Grade 8: 48,235 - 57,255 with a discretionary range to £64,228 per annum (pro-rata)
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179212 Postdoctoral Research Associate (Rinaldi Lab) Job Description
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About the role A position is available for a highly motivated Postdoctoral Research Associate to join the research group led by Prof Carlo Rinaldi at the University of Oxford. The group explores genetic causes of neurological disorders and aim to develop therapies for such conditions with a high complementary approach, ranging from stem cell modelling to functional genomic. Enhancers play a pivotal role in governing gene expression, and their disruption is increasingly recognized as a key driver of diseases. This is an exciting opportunity for a postdoctoral scientist to help lead a project focusing on interrogating enhancer function in the context of rare neurological diseases, with the goal to precisely modulate enhancer activity to fine-tune gene expression patterns and offer treatment opportunities for these diseases. The project will use a wide variety of data processing, data analysis, and statistical techniques to functional genomic data (ChIP-seq, RNA-seq, ATAC-seq, co-accessibility). Analysis will be performed on collaborative cloud computing environments using the extensive computing infrastructure developed by the Sanders Lab. You will be involved with all aspects of the data analysis including design, conduct, and dissemination. The post holder will work at the newly built Institute of Developmental and Regenerative Medicine (IDRM) at the Old Road Campus of University of Oxford in the laboratories of Prof Carlo Rinaldi. You will be well supported by the existing joint team, currently consisting of postdocs, bioinformaticians, PhD candidates, and research assistants. The post holder will be able to receive training in collaborating labs in order to benefit from interaction with researchers in diverse environments. You will be encouraged to attend training and research skill courses provided by the University of Oxford. There will be opportunities for contributing to and leading grant applications if appropriate, as well as being encouraged to submit work for presentation at national and international conferences. In addition, experience gained by supervision and mentoring of junior members in the lab will be useful for career development. The successful applicant will be expected to provide guidance and assistance to other researchers in the group and students, help in the preparation of scientific publications, and represent the group at public engagement events. This position is offered full-time on a fixed-term contract initially for one year or until 30 September 2026, whichever is sooner, with the possibility to extend provided further external funding is available. This role meets the criteria for a UK Skilled Worker visa. About the department The Department of Paediatrics holds the Athena Swan Gold award (a national gender equality charter) acknowledging the innovative policies and practices developed across the department. We encourage staff to develop their skills by offering all staff ten paid days of professional development each year and have a policy where staff can apply to receive funding for further training. In addition to the University of Oxford wellbeing resources, the Department of Paediatrics sponsors weekly exercise classes such as yoga and bootcamp sessions as well as a choir. For staff on work visas, we also offer financial assistance towards visa renewal fees. These activities are designed to promote physical and mental wellbeing among staff members. Please visit our website to find out more about the Department. About you This is a highly collaborative position, so excellent communication and interpersonal skills are essential. Applicants will need to hold a PhD, or be near completion, in Translational research, Neuroscience, Genetics, or a related subject. You will need to have demonstrated proficiency in stem cell culture, human genetics, translational research, and/or bioinformatics leading to impactful publications and experiencing in clinical research. Application Process You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Carlo Rinaldi, Professor of Molecular and Translational Neuroscience, using the contact details below. Only online applications received before 12.00 midday on Tuesday 29 April 2025 will be considered. Interviews will be held as soon as possible thereafter. The Department of Paediatrics offers an Interview Expense Reimbursement Policy in its efforts towards equality, diversity and inclusion. Should you be invited to interview, we will share further information about the policy at that stage.
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_________________________________________________________________________ Job description and selection criteria Job title Postdoctoral Research Associate Division Medical Sciences Department Paediatrics Location Institute of Developmental & Regenerative Medicine (IDRM) University of Oxford Grade and salary Research Grade 8: £48,235 - £57,255 per annum (with a discretionary range to £64,228 per annum) Hours Full-time Contract type Fixed-term (12 months) or until 30 September 2026, whichever is sooner Reporting to Prof Carlo Rinaldi, Professor of Molecular and Translational Neuroscience Vacancy reference 179212 Additional information Research topic Applications are to be made online, please see the advert for the closing date. This role meets the criteria for a UK Skilled Worker visa Therapy development for rare neurological diseases Principal Investigator Prof Carlo Rinaldi / supervisor Project team Rinaldi Lab Project web site https://www.idrm.ox.ac.uk/research/neurology Funding partner The funds supporting this research project are provided by a gift agreement The role Reporting to Dr. Carlo Rinaldi, who is based at the IDRM, the post holder will be a member of the Rinaldi lab, with responsibility for carrying out research to understand the genetics and neurobiology underlying neurological and neurodevelopmental disorders, with the ultimate goal to develop treatments for these conditions. The post holder will also work as a member of a multidisciplinary team and provide guidance to other members of the research group, including other postdocs, research assistants, technicians, and PhD and project students. The Rinaldi lab (https://www.rinaldi-lab.com/) has access to unique disease modelling systems (e.g. stem cells-derived neurons and organoids on a chip) and numerous datasets of varying scales on university computer clusters and cloud-based services (AWS and Google). This post offers a uniquely rich opportunity to manage data assets and deploy data processing and analysis pipelines on the genomic data as part of the research projects with direct relevance to human diseases. Flexible working Hybrid working may be possible in agreement with the line manager. Responsibilities • Generate, maintain and differentiate induced pluripotent stem cells from affected and unaffected individuals into neurons (i.e. cortical and motor neurons). • Conduct detailed analysis of datasets in collaboration with colleagues in partner institutions and research groups. • Harness knowledge on the regulatory mechanisms of gene expression to develop therapies for rare neurological diseases with unmet clinical need. • Act as a source of information and advice to other members of the group on data access and methodologies, techniques, and protocols and to document these in the laboratory codebase and information base. • Liaising with other project teams, external sites, and data repositories to receive, share, and/or deposit data. • Write research articles. Present papers at national conferences, and lead seminars to disseminate research finding. • Attend scientific seminars, meetings, and training, as appropriate, and represent the research group at external meetings/seminars, either with other members of the group or alone. • Develop ideas for generating research income, and present detailed research proposals to senior researchers. Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 2 Selection criteria Essential • • • • • • • • • A PhD (or equivalent), or near completion, in Translational research, Neuroscience, Genetics, or a related subject. Experience with stem cell culture. Demonstrable experience, ability, and practical success in genetics, biostatistics, and/or bioinformatics, including experience of contributing to publications and presentations. Clear understanding of patient-centred and translational research. Ability to manage own academic research and associated activities. Ability to collaborate with colleagues and advise other researchers both in-person and remotely. Ability to contribute ideas for new research projects and research income generation. Demonstrable ability to organise and prioritise work efficiently whilst delivering results to the required standard and to an agreed schedule. Excellent communication skills, including the ability to write for publications, design and generate figures reflecting data analyses, present research proposals and results, and represent the research group at meetings. Desirable • • • • • Hold an MD degree. Experience in clinical trial and/or clinical research. Experience of independently managing a research project. Experience of research into the genetics of neurodevelopmental disorders. Experience with the analysis of genetic and/or functional genomic data. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. If you have previously worked for the University we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 3 Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory basic Disclosure and Barring Service check due to the nature of this position working with highly sensitive data • University security screening (e.g. identity checks) About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. The Rinaldi Lab The Rinaldi Group, led by Prof Carlo Rinaldi, works on understanding mechanism of disease for rare neurological condition, with the goal to develop gene therapy treatments for these conditions. Research activities include: • • • • Culture of iPS cells and differentiation into motor neurons and skeletal muscle Development of organoid systems to model the neuromuscular unit Assessing the role of enhancers to genetic disorders Developing therapies for genetic disorders, including antisense oligonucleotides (ASOs) and CRISPR-based approaches • Development of live imaging tools to assess transcription dynamics Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 4 immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. We are committed to inform and inspire external audiences worldwide through our public engagement and outreach activities. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a Gold Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 5 How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two/three referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • as part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting https://staff.web.ox.ac.uk/recruitment-support-faqs advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 6 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts including salary sacrifice schemes for bicycles and electric cars and other discounts. Staff can access a huge range of personal and professional development opportunities. See https://hr.admin.ox.ac.uk/staff-benefits. Employee Assistance Programme As part of our wellbeing offering staff get free access to Health Assured, a confidential employee assistance programme, available 24/7 for 365 days a year. Find out more https://staff.admin.ox.ac.uk/health-assured-eap. University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/. There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme. Family-friendly benefits We are a family-friendly employer with one of the most generous family leave schemes in the Higher Education sector (see https://hr.web.ox.ac.uk/family-leave). Our Childcare Services team provides guidance and support on childcare provision, and offers a range of high-quality childcare options at affordable prices for staff. In addition to 5 University nurseries, we partner with a number of local providers to offer in excess of 450 full time nursery places to our staff. Eligible parents are able to pay for childcare through salary sacrifice, further reducing costs. See https://childcare.admin.ox.ac.uk/. Supporting disability and health-related issues (inc menopause) We are committed to supporting members of staff with disabilities or long-term health conditions, including those experiencing negative effects of menopause. Information about the University’s Staff Disability Advisor, is at https://edu.admin.ox.ac.uk/disability-support. For information about how we support those going through menopause see https://hr.admin.ox.ac.uk/menopauseguidance. Staff networks The University has a number of staff networks including for research staff, BME staff, LGBT+ staff, disabled staff network and those going through menopause. Find out more at https://edu.admin.ox.ac.uk/networks. Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 8 The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Research staff The Researcher Hub supports all researchers on fixed-term contracts. They aim to help you settle in comfortably, make connections, grow as a person, extend your research expertise and approach your next career step with confidence. Find out more https://www.ox.ac.uk/research/support-researchers/researcher-hub. Oxford’s Research Staff Society is a collective voice for our researchers. They also organise social and professional networking activities for researchers. Find out more https://www.ox.ac.uk/research/support-researchers/connecting-other-researchers/oxfordresearch-staff-society. Department of Paediatrics, 179212, Postdoctoral Research Associate – Job Description 9
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**About the role** A position is available for a highly motivated Postdoctoral Research Associate to join the research group led by Prof Carlo Rinaldi at the University of Oxford. The group explores genetic causes of neurological disorders and aim to develop therapies for such conditions with a high complementary approach, ranging from stem cell modelling to functional genomic. Enhancers play a pivotal role in governing gene expression, and their disruption is increasingly recognized as a key driver of diseases. This is an exciting opportunity for a postdoctoral scientist to help lead a project focusing on interrogating enhancer function in the context of rare neurological diseases, with the goal to precisely modulate enhancer activity to fine-tune gene expression patterns and offer treatment opportunities for these diseases. The project will use a wide variety of data processing, data analysis, and statistical techniques to functional genomic data (ChIP-seq, RNA-seq, ATAC-seq, co-accessibility). Analysis will be performed on collaborative cloud computing environments using the extensive computing infrastructure developed by the Sanders Lab. You will be involved with all aspects of the data analysis including design, conduct, and dissemination. The post holder will work at the newly built Institute of Developmental and Regenerative Medicine (IDRM) at the Old Road Campus of University of Oxford in the laboratories of Prof Carlo Rinaldi. You will be well supported by the existing joint team, currently consisting of postdocs, bioinformaticians, PhD candidates, and research assistants. The post holder will be able to receive training in collaborating labs in order to benefit from interaction with researchers in diverse environments. You will be encouraged to attend training and research skill courses provided by the University of Oxford. There will be opportunities for contributing to and leading grant applications if appropriate, as well as being encouraged to submit work for presentation at national and international conferences. In addition, experience gained by supervision and mentoring of junior members in the lab will be useful for career development. The successful applicant will be expected to provide guidance and assistance to other researchers in the group and students, help in the preparation of scientific publications, and represent the group at public engagement events. This position is offered full-time on a fixed-term contract initially for one year or until 30 September 2026, whichever is sooner, with the possibility to extend provided further external funding is available. This role meets the criteria for a UK Skilled Worker visa. **About the department** The Department of Paediatrics holds the Athena Swan Gold award (a national gender equality charter) acknowledging the innovative policies and practices developed across the department. We encourage staff to develop their skills by offering all staff ten paid days of professional development each year and have a policy where staff can apply to receive funding for further training. In addition to the University of Oxford wellbeing resources, the Department of Paediatrics sponsors weekly exercise classes such as yoga and bootcamp sessions as well as a choir. For staff on work visas, we also offer financial assistance towards visa renewal fees. These activities are designed to promote physical and mental wellbeing among staff members. Please visit our website to find out more about the Department. **About you** This is a highly collaborative position, so excellent communication and interpersonal skills are essential. Applicants will need to hold a PhD, or be near completion, in Translational research, Neuroscience, Genetics, or a related subject. You will need to have demonstrated proficiency in stem cell culture, human genetics, translational research, and/or bioinformatics leading to impactful publications and experiencing in clinical research. **Application Process** You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please contact Carlo Rinaldi, Professor of Molecular and Translational Neuroscience, using the contact details below. **Only online applications received before 12.00 midday on Tuesday 29 April 2025 will be considered. Interviews will be held as soon as possible thereafter.** The Department of Paediatrics offers an Interview Expense Reimbursement Policy in its efforts towards equality, diversity and inclusion. Should you be invited to interview, we will share further information about the policy at that stage.
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