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Wellcome Trust Centre Clinical Vaccinology and Tropical Medicine
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Department of Paediatrics, Sanders Research Group, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford
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179295 Full Stack Software developer Job Description Paediatrics
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Description of Full Stack Software Developer
About the role We have an exciting opportunity to join the Rare Genetic Disorders Research Group led by Prof. Stephan Sanders in the Department of Paediatrics at the University of Oxford as a Full Stack Software Developer. The group aims to identify, understand, and develop therapies for rare genetic disorders. The group is primarily computational but partners with multiple international labs (including Harvard, Yale, UC San Francisco [UCSF], and the New York Genome Center) to co-design experiments and generate novel datasets, including exome/genome sequencing of hundreds of thousands of individuals, large-scale single-cell data from primary human tissues, spatial transcriptomic data, and experimental genomic screens. As a Software Developer, you will be responsible for designing, implementing, and maintaining software systems to support these research projects. This includes building data pipelines, developing algorithms, and ensuring that data is stored efficiently and is accessible to all team members and external collaborators. You will be working in a highly collaborative environment, contributing directly to research outputs, and ensuring that the group’s software resources are functioning optimally. The Software Developer will be part of an interdisciplinary team working across sites at both Oxford and UCSF. The role offers a unique opportunity to contribute to world-class research in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in neurological diseases, drug development, haematology, and immunology, neuroimaging. The group led by Prof. Stephan Sanders is based in the recently formed Institute of Developmental and Regenerative Medicine (IDRM) in a brand-new building at the Old Road Churchill Campus. This position is offered full-time on a fixed-term contract initially until 31 December 2026 with the possibility to extend provided further external funding is available. This role meets the criteria for a UK Skilled Worker visa. About the department The Department of Paediatrics has been honoured with the Athena Swan Gold award, a national gender equality charter, recognising the Department's innovative policies and practices. We are committed to the professional development of our staff by providing up to ten paid days annually for skill enhancement and allowing applications for additional training funding. By joining us, you will have the opportunity to contribute to a forward-thinking department. We welcome new staff with ideas who are willing to shape the future of the department that thinks about its staff and wellbeing. In addition to the University of Oxford wellbeing resources, the Department of Paediatrics sponsors weekly exercise classes such as yoga and bootcamp sessions as well as a choir. For staff on work visas, we also offer financial assistance towards visa renewal fees. These activities are designed to promote physical and mental wellbeing among staff members. Please visit our website to find out more about the Department. About you This position would suit a highly motivated individual with strong programming skills and a passion for developing software that facilitates world-leading research. You will need to have experience in designing, developing, and maintaining software systems, particularly those supporting data management and computational workflows in a research setting. Applicants should hold a relevant Bachelor’s degree (or equivalent) in computer science, software engineering, or a related field, with proven experience in software development. Proficiency in programming languages such as Python is essential, and experience working with high-performance computing or cloud-based environments is desirable. Experience with data management and analysis in a scientific context will be an advantage. Application Process You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please Stephan Sanders, the group leader using the contact details below Only online applications received before 12.00 midday on 6th June 2025 will be considered. Interviews will be held as soon as possible thereafter. The Department of Paediatrics offers an Interview Expense Reimbursement Policy in its efforts towards equality, diversity and inclusion. Should you be invited to interview, we will share further information about the policy at that stage.
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_________________________________________________________________________ Job description and selection criteria Job title Full Stack Software Developer Division Medical Sciences Department Paediatrics Location Department of Paediatrics, Sanders Research Group, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford Grade and salary Grade 7: £38,674- £46,913 per annum (with a discretionary range to £51,059 per annum) Hours Full-time Contract type Fixed-term until 31 December 2026 Reporting to Dani Breitinger-Blatt, Programme Manager Vacancy reference 179295 Additional information Applications are to be made online, please see the advert for the closing date. This role meets the criteria for a UK Skilled Worker visa Principal Investigator Stephan Sanders / supervisor Project team Sanders Group Project web site https://www.idrm.ox.ac.uk/research/neurology/neurology-researchgroups/sanders-group Funding partner The funds supporting this research project are provided by Simons Foundation Autism Research Initiative and National Institutes of Health USA The role The Sanders Group, led by Prof. Stephan Sanders, is dedicated to understanding rare genetic disorders and developing genetic therapies through computational and genomics research. The group is based in the University of Oxford and includes colleagues at the University of California, San Francisco (UCSF). The lab works closely with the MRC Centre of Research Excellence (CoRE) in Therapeutic Genomics, directed by Prof. Sanders. Research activities include: • Identifying the genes underlying neurodevelopmental delay and autism • Assessing the role of noncoding genetic variants to genetic disorders • Understanding the neurobiology and sex-bias of neurodevelopmental disorders • Improving the clinical diagnosis of genetic disorders • Developing therapies for genetic disorders, including antisense oligonucleotides (ASOs) and CRISPR-based approaches We work with large-scale (multiple Terabytes) genomic datasets primarily via cloud-based computing (mostly AWS, some Google Cloud). The software developer will work closely with a data manager in the group. The group is primarily bioinformatics focused with close collaborations with wet labs at Oxford and internationally. We are seeking a Full Stack Software Developer to design and develop web-based tools for visualizing and sharing genomic data and research results generated from Python- and R-based analysis scripts. This role will involve close collaboration with researchers, ensuring that genomic results can be accessed, interpreted, and shared efficiently. The successful candidate will contribute to the development and deployment of intuitive, high-performance web applications. Flexible working This role is based in person at the Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus. Hybrid working may be possible. Responsibilities • • • • • • • • • • Develop web-based applications to visualize and share genomic data outputs from Python-based analysis scripts. Design, implement, and maintain a secure and scalable full-stack architecture, incorporating both front-end and back-end components. Work closely with researchers to translate genomic data outputs into interactive web tools. Optimize application performance for large-scale genomic datasets. Develop APIs to facilitate data sharing across different computational environments (e.g., cloud-based services such as AWS and Google Cloud). Ensure proper authentication, authorization, and security best practices for genomic data access. Deploy, monitor, and maintain web applications in cloud or university-hosted environments. Work in managed computational research environments (e.g., Genomics England Research Portal, DNA Nexus) and help guide other members of the laboratory and collaborators in using these environments. Write clear documentation and provide training or guidance to lab members on using developed tools. Participate in troubleshooting and debugging issues in the web-based platforms. Department of Paediatrics,179295, Full Stack Software Developer – Job Description 2 • • Manage own administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. Contribute to research publications by developing and maintaining reproducible, welldocumented software tools. Selection criteria Essential • • • • • • • • • • A relevant Bachelor’s degree (e.g., Computer Science, Bioinformatics, Software Engineering) or equivalent substantial professional experience. Experience developing full-stack web applications using frameworks such as Django, Flask, or FastAPI (backend) and React, Vue.js, or Angular (frontend). Proficiency in Python (including packaging and testing) and JavaScript/TypeScript. Knowledge of DevOps practices for infrastructure as code (IaC), automated deployment and CI/CD (Continuous Integration/Continuous Deployment) pipelines. Familiarity with RESTful API development and integration. Experience with cloud computing platforms (AWS, Google Cloud, or Azure) and deploying web applications. Strong knowledge of authentication and security best practices for web applications. Experience using version control systems (e.g., Git, GitHub/GitLab). Excellent problem-solving skills and the ability to work independently. Strong communication skills and ability to collaborate effectively with researchers. Desirable • • • • • • • Experience with genomic or biomedical data visualization tools (e.g., D3.js, Plotly, BioJS). Familiarity with handling and visualizing large-scale genomic datasets (e.g., VCF, BAM/CRAM, or h5 single-cell RNA-seq data). Experience with containerization technologies (Docker, Kubernetes). Strong experience with database design and management (e.g., PostgreSQL, MySQL, MongoDB). Experience contributing to open-source projects. Experience of actively collaborating in the development of research articles for publication. Familiarity with biological data, including genetics, neuroscience, or therapeutics. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. If you have previously worked for the University we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Department of Paediatrics,179295, Full Stack Software Developer – Job Description 3 Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Lone Working due to hybrid working Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory basic Disclosure and Barring Service check due to the nature of this position working with highly sensitive data. • University security screening (e.g. identity checks) About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Paediatrics The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in drug development, gastroenterology, haematology, HIV, immunology, neuroimaging, neuromuscular diseases and vaccinology. Our work spans from early proof-of concept fundamental science, all the way up to its application in clinical settings. We continue to shape the landscape of medical science through positively impacting the lives of millions of children from our global research programmes, academic resources, and commitment to success. Our broad research base positions the department in a pivotal role and subsequently Department of Paediatrics,179295, Full Stack Software Developer – Job Description 4 a world leader in child health. With research facilitates in the UK and abroad, we work on a global scale, building a paediatric network in the medical science community. We are committed to inform and inspire external audiences worldwide through our public engagement and outreach activities. In 2021, we successfully administered a grant value of £130,895,28 obtained through 168 projects. Our strong relationship with funding bodies have also been a contributor to the successes and milestones in children’s health research. With strong support from the Wellcome Trust, NIH, Cancer Research UK, UKRI, MDUK, Bill & Melinda Gates Foundation, Academy of Medical Sciences and the NIHR, we have employed 360+ staff, researchers, and students. These figures continue to grow as we expand our activities to overcome the multitude of challenges within children’s research health. For more information please visit: http://www.paediatrics.ox.ac.uk/ The Department of Paediatrics holds a Gold Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division We are an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.medsci.ox.ac.uk/ How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two/three referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: Department of Paediatrics,179295, Full Stack Software Developer – Job Description 5 • • as part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting https://staff.web.ox.ac.uk/recruitment-support-faqs advice is available at: Non-technical questions about this job should be addressed to the recruiting department directly at recruitment@paediatrics.ox.ac.uk or using the contact details in the online advertisement. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our e-recruitment system to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. Department of Paediatrics,179295, Full Stack Software Developer – Job Description 6 There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. Department of Paediatrics,179295, Full Stack Software Developer – Job Description 7 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts including salary sacrifice schemes for bicycles and electric cars and other discounts. Staff can access a huge range of personal and professional development opportunities. See https://hr.admin.ox.ac.uk/staff-benefits. Employee Assistance Programme As part of our wellbeing offering staff get free access to Health Assured, a confidential employee assistance programme, available 24/7 for 365 days a year. Find out more https://staff.admin.ox.ac.uk/health-assured-eap. University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/. There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme. Family-friendly benefits We are a family-friendly employer with one of the most generous family leave schemes in the Higher Education sector (see https://hr.web.ox.ac.uk/family-leave). Our Childcare Services team provides guidance and support on childcare provision, and offers a range of high-quality childcare options at affordable prices for staff. In addition to 5 University nurseries, we partner with a number of local providers to offer in excess of 450 full time nursery places to our staff. Eligible parents are able to pay for childcare through salary sacrifice, further reducing costs. See https://childcare.admin.ox.ac.uk/. Supporting disability and health-related issues (inc menopause) We are committed to supporting members of staff with disabilities or long-term health conditions, including those experiencing negative effects of menopause. Information about the University’s Staff Disability Advisor, is at https://edu.admin.ox.ac.uk/disability-support. For information about how we support those going through menopause see https://hr.admin.ox.ac.uk/menopauseguidance. Staff networks The University has a number of staff networks including for research staff, BME staff, LGBT+ staff, disabled staff network and those going through menopause. Find out more at https://edu.admin.ox.ac.uk/networks. Department of Paediatrics,179295, Full Stack Software Developer – Job Description 8 The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Research staff The Researcher Hub supports all researchers on fixed-term contracts. They aim to help you settle in comfortably, make connections, grow as a person, extend your research expertise and approach your next career step with confidence. Find out more https://www.ox.ac.uk/research/support-researchers/researcher-hub. Oxford’s Research Staff Society is a collective voice for our researchers. They also organise social and professional networking activities for researchers. Find out more https://www.ox.ac.uk/research/support-researchers/connecting-other-researchers/oxfordresearch-staff-society. Department of Paediatrics,179295, Full Stack Software Developer – Job Description 9
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Old Road Campus Research Building, Roosevelt Drive
Standard Grade 7: 38,674 - 46,913 with a discretionary range to £51,059 per annum (pro-rata)
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**About the role** We have an exciting opportunity to join the Rare Genetic Disorders Research Group led by Prof. Stephan Sanders in the Department of Paediatrics at the University of Oxford as a Full Stack Software Developer. The group aims to identify, understand, and develop therapies for rare genetic disorders. The group is primarily computational but partners with multiple international labs (including Harvard, Yale, UC San Francisco [UCSF], and the New York Genome Center) to co-design experiments and generate novel datasets, including exome/genome sequencing of hundreds of thousands of individuals, large-scale single-cell data from primary human tissues, spatial transcriptomic data, and experimental genomic screens. As a Software Developer, you will be responsible for designing, implementing, and maintaining software systems to support these research projects. This includes building data pipelines, developing algorithms, and ensuring that data is stored efficiently and is accessible to all team members and external collaborators. You will be working in a highly collaborative environment, contributing directly to research outputs, and ensuring that the group’s software resources are functioning optimally. The Software Developer will be part of an interdisciplinary team working across sites at both Oxford and UCSF. The role offers a unique opportunity to contribute to world-class research in a growing department within the Medical Sciences Division. The Department of Paediatrics is a world leader in child health research and hosts internationally renowned research programmes in neurological diseases, drug development, haematology, and immunology, neuroimaging. The group led by Prof. Stephan Sanders is based in the recently formed Institute of Developmental and Regenerative Medicine (IDRM) in a brand- new building at the Old Road Churchill Campus. This position is offered full-time on a fixed-term contract initially until 31 December 2026 with the possibility to extend provided further external funding is available. This role meets the criteria for a UK Skilled Worker visa. **About the department** The Department of Paediatrics has been honoured with the Athena Swan Gold award, a national gender equality charter, recognising the Department's innovative policies and practices. We are committed to the professional development of our staff by providing up to ten paid days annually for skill enhancement and allowing applications for additional training funding. By joining us, you will have the opportunity to contribute to a forward-thinking department. We welcome new staff with ideas who are willing to shape the future of the department that thinks about its staff and wellbeing. In addition to the University of Oxford wellbeing resources, the Department of Paediatrics sponsors weekly exercise classes such as yoga and bootcamp sessions as well as a choir. For staff on work visas, we also offer financial assistance towards visa renewal fees. These activities are designed to promote physical and mental wellbeing among staff members. Please visit our website to find out more about the Department. **About you** This position would suit a highly motivated individual with strong programming skills and a passion for developing software that facilitates world-leading research. You will need to have experience in designing, developing, and maintaining software systems, particularly those supporting data management and computational workflows in a research setting. Applicants should hold a relevant Bachelor’s degree (or equivalent) in computer science, software engineering, or a related field, with proven experience in software development. Proficiency in programming languages such as Python is essential, and experience working with high-performance computing or cloud-based environments is desirable. Experience with data management and analysis in a scientific context will be an advantage. **Application Process** You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement. To discuss the post in more detail, please Stephan Sanders, the group leader using the contact details below **Only online applications received before 12.00 midday on 6th June 2025 will be considered. Interviews will be held as soon as possible thereafter.** The Department of Paediatrics offers an Interview Expense Reimbursement Policy in its efforts towards equality, diversity and inclusion. Should you be invited to interview, we will share further information about the policy at that stage.
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