Henry Wellcome Building of Gene Function
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Description of Postdoctoral Research Scientist
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Department of Physiology, Anatomy and Genetics (DPAG)
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Postdoctoral Research Scientist
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based near: Sherrington Building
salary: Research Grade 7: £38,674 - £46,913
application closing date: 2025-05-02T12:00:00+01:00
application opening date: 2025-04-15T09:00:00+01:00
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comment: Contract & job type: Fixed-term, Full-time until 30 June 2028 About us: At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment. Overview of the role: We are seeking a Postdoctoral Research Scientist to join the research group of Professor Stephanie Cragg on a discovery project in the field of striatal neurobiology. The ideal candidate will hold a PhD in a relevant area of neurobiology and expertise in electrophysiological and/or photometry techniques alongside genetic tools ideally for application to investigate astrocyte biology in the central nervous system. In this role, you will be responsible for conducting high quality research using state-of-the-art tools to understand interactions between cholinergic interneurons, astrocytes, and other neuromodulator networks in the striatum, in health and in animal models of Parkinson’s disease. You will also help to train and supervise other members of the Group. This post is available until 30 June 2028. Key responsibilities: • Work with the grant holders to deliver high quality research with real-time electrophysiological and imaging techniques to record striatal neurons and astrocytes in brain slices, and manipulate cells and circuits using viral and other targeting methods. • Apply allied methods that include intracranial vector delivery using stereotaxic surgeries, systemic dosing, brain slice immunohistochemistry and microscopy, and molecular analyses of brain tissue. • Help to overseeing the management and genotyping of transgenic animal model colonies and parkinsonian models. Selection criteria: • The post hol…
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comment: **Contract & job type: Fixed-term, Full-time until 30 June 2028** **About us:** At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment. **Overview of the role:** We are seeking a Postdoctoral Research Scientist to join the research group of Professor Stephanie Cragg on a discovery project in the field of striatal neurobiology. The ideal candidate will hold a PhD in a relevant area of neurobiology and expertise in electrophysiological and/or photometry techniques alongside genetic tools ideally for application to investigate astrocyte biology in the central nervous system. In this role, you will be responsible for conducting high quality research using state-of-the-art tools to understand interactions between cholinergic interneurons, astrocytes, and other neuromodulator networks in the striatum, in health and in animal models of Parkinson’s disease. You will also help to train and supervise other members of the Group. This post is available until 30 June 2028. **Key responsibilities:** • Work with the grant holders to deliver high quality research with real-time electrophysiological and imaging techniques to record striatal neurons and astrocytes in brain slices, and manipulate cells and circuits using viral and other targeting methods. • Apply allied methods that include intracranial vector delivery using stereotaxic surgeries, systemic dosing, brain slice immunohistochemistry and microscopy, and molecular analyses of brain tissue. • Help to overseeing the management and genotyping of transgenic animal model colonies and parkinsonian models. **Selection criter…
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Research Grade 7: £38,674 - £46,913
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Job Description
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value: Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022, 2023, 2024 and 2025. Job description and Selection Criteria Job title Postdoctoral Research Scientist in striatal physiology Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Sherrington Building, Parks Road, Oxford, OX1 3PT Grade and salary Grade 7: £38, 674- £46, 913 per annum Hours Full time Contract type Fixed term post until 30 June 2028 Reporting to Professor Stephanie Cragg Vacancy reference AV25010 HRIS: 179317 Additional information The post is available from 1st of July 2025 Research topic Regulation of striatal cholinergic interneuron function in health and Parkinson’s disease Principal Investigator / supervisor Professor Stephanie Cragg Project team Cragg Group Project web site https://www.dpag.ox.ac.uk/research/cragg-group Funding partner The funds supporting this research project are provided by the UKRI Medical Research Council Recent publications Stedehouder et al 2024, Nature Communications, PMID: 39562551 The role We invite applications for a motivated and enthusiastic Postdoctoral Research Scientist to join the Cragg lab under the leadership of Professor Stephanie Cragg within the Department of Physiology, Anatomy, and Genetics (DPAG). The postholder will assist the team’s work on a project funded by the MRC that will be supervised by Professor Cragg and project co-lead Dr Simon Bossi and involve collaboration with other colleagues locally and internationally. This project will exploit state-of-the-art tools to understand interactions between astrocytes, glycine receptors and cholinergic interneurons in the striatum. Acetylcholine released from cholinergic interneurons (ChIs) is thought to strongly influence striatal function, shaping action selection in health and disease. Accumulating data are indicating that ACh transmission is disturbed in a range of psychomotor diseases such as Parkinson’s disease, giving ren…
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