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Research Assistant in Functional Genomics of Sepsis
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Previous applicants need not re-apply. Applications are invited for a Research Assistant in Functional Genomics of Sepsis to join Professor Julian Knight’s research group, an established team with a track record of innovation and high impact research in functional genomics, sepsis and susceptibility to multi-factorial disease. This is an exciting new position funded through a collaboration with the Danaher corporation and its subsidiary Cepheid. This research is part of the Beacon programme ‘Development and prospective evaluation of point-of-need test for sepsis subtyping based on gene expression using the Cepheid GeneXpert platform’. The programme seeks to advance precision medicine for patients with sepsis by developing a point-of-care test to stratify patients based on their immune response profiles. We aim to use an integrated approach which leverages the host transcriptome, immune profiling, and electronic health records, in combination with the GeneXpert system for mRNA quantification. Our goal is to deliver a precision medicine approach for managing patients with severe infections. The work is highly collaborative with clinical teams, company partners, and expert investigators across the UK, the US, and Sweden. You will facilitate exciting new collaborative links with Danaher, which may involve travel to Sweden (Cepheid) and the United States (Danaher). You will have a degree in biology, genetics, immunology, biochemistry, molecular biology or related field and relevant research experience of patient blood or tissue sample processing in the laboratory and management of sample collections. You will be motivated by a stimulating and ambitious research environment with a desire to deliver high quality cutting-edge science and work in a laboratory offering the opportunity for career development and acquiring new expertise. This position is offered full time on a fixed term contract until 30 September 2027 and is funded by the Danaher Corporation. The anticipated start date is 1 September 2025. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. Only applications received before 12 midday on 23 June 2025 can be considered. Please quote 179416 on all correspondence.
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Wellcome Trust Centre for Human Genetics
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Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN
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Research Grade 6: Research Grade 6: Salary in range £34,982 - £40,855 per annum
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Job title Research Assistant in Functional Genomics of Sepsis Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN Grade and salary Research Grade 6: Salary in range £34,982 - £40,855 per annum (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata). Hours Full time Contract type Fixed-term contract until 30 September 2027 Funding is provided by the Danaher Corporation Additional information Anticipated start date 1 September 2025 Reporting to Professor Julian Knight, Group Head/Principal Investigator Vacancy reference 179416 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic Severe infectious disease – Genomics of Sepsis Principal Investigator / supervisor Professor Julian Knight University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.chg.ox.ac.uk/ Project web site https://www.chg.ox.ac.uk/research/research-groups/julian-knight-group Kwok AJ, Allcock A, Ferreira RC, Cano-Gamez E, Smee M, Burnham KL, Zurke Y-X, Emergency Medicine Research Oxford (EMROx), McKechnie S, Mentzer AJ, Monaco C, Udalova I, Hinds CJ, Davenport EE, Todd JA, Knight JC (2023). Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis. Nature Immunology 24, 767-779 Recent publications Cano-Gamez E, Burnham KL, Goh C, Malick ZH, Kwok A, Smith DA, Peters-Sengers H, Antcliffe D, Investigators G, McKechnie S, Scicluna BP, van der Poll T, Gordon AC, Hinds CJ, Davenport EE and Knight JC (2022). An immune dysfunction score for stratification of patients with acute infection based on whole blood gene expression. Science Translational Medicine 14, eabq4433 The role Applications are invited for a Research Assistant in the Genomics of Sepsis at the University of Oxford. You will be based at the Centre for Human Genetics (CHG) within the group of Professor Julian Knight, joining an established team with a track record of innovation and high impact research in functional genomics, sepsis and susceptibility to multi-factorial disease. You will have the opportunity to join a programme of research that is being further advanced through a collaboration with the Danaher corporation and its subsidiary Cepheid. This research is part of the Beacon programme ‘Development and prospective evaluation of point-of-need test for sepsis subtyping based on gene expression using the Cepheid GeneXpert platform’. The programme seeks to advance precision medicine for patients with sepsis by developing a point-of-care test to stratify patients based on their immune response profiles. We aim to use an integrated approach which leverages the host transcriptome, immune profiling, and electronic health records, in combination with the GeneXpert system for mRNA quantification. Our goal is to deliver a precision medicine approach for managing patients with severe infections. The work is highly collaborative with clinical teams, company partners, and expert investigators across the UK, the US, and Sweden. You will facilitate exciting new collaborative links with Danaher, which may involve travel to Sweden (Cepheid) and the United States (Danaher). We seek to develop a point-of-care test and associated algorithms which could distinguish between individuals at different levels of immune dysfunction. We also aim to identify decision points along the patient journey where this test could be most useful upon deployment. You will be responsible for managing on-going sample collection from recruited patients with sepsis. Key tasks include sample processing and extraction, maintaining the sample biobank and associated databases, liaison with research nurse teams and researchers at Cepheid, running, supporting and validating the GeneXpert test, performing functional genomic assays including RNA-sequencing, and other work as required, including immunological assays. You will have relevant research experience in cell purification and tissue culture, immunology, molecular biology and genomics. Experience of management of sample collections will also be part of your skills set. You will be motivated by a stimulating and ambitious research environment with a desire to deliver high quality cutting-edge science and work in a laboratory offering the opportunity for career development and acquiring new expertise. You will be part of a dynamic research team lead by Professor Julian Knight who has extensive experience in the functional genomics of immunity and sepsis. The team includes postdoctoral scientists with significant expertise in both wet lab and functional genomic analysis. 1 Responsibilities You will: • • • • • • • • • • • • • • • • Manage sample collection from recruited individuals through excellent team communication and record keeping skills. Maintain and manage the project sample database. Support clinical phenotyping and related data management. Perform cell and tissue culture including isolation of primary human cells and nucleic acids. Prepare and analyse blood samples for GeneXpert assay and relevant immunological, molecular biology and -omic assays. Work closely with the research nurse team and our collaborators in Danaher and Cepheid to ensure samples and data is shared in a timely and appropriate manner, and project milestones are met. Plan and monitor project deadlines. Multi-task and prioritise your own workload. Work with other members of the laboratory on related projects. Help in the education and training of staff and students as necessary and appropriate. Keep detailed, accurate and comprehensible records of experimental plans and work, aid in writing of reports and contribute to the publication of research findings in high quality journals. Attend appropriate scientific seminars and meetings and to remain up to date with developments in the relevant fields. Work as part of an interdisciplinary team, contribute fully to laboratory meetings and discussion of the aims and objectives of the group’s work. Participate and support public engagement activities on behalf of the Centre, working with the Centre’s Public Engagement and Communications Officer. This is anticipated to be around 2 days per year. Work closely with the group head and keep him up-to-date with progress and difficulties in the research project. Undertake such other duties as may be required from time to time that are commensurate with the grade and responsibilities of this post. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Job descriptions can never be comprehensive and you may be required to undertake other similar tasks and responsibilities. Selection criteria Essential • • • • • • A degree in biology, genetics, immunology, biochemistry, molecular biology or related field. A demonstrable interest in the research described here. Experience of patient blood or tissue sample processing in the laboratory and management of sample collections. Demonstrable high level of communication skills both written and oral. Ability to organize and prioritise work efficiently delivering results to required standard and to an agreed schedule. Evidence of working with accuracy, self-motivation and integrity. 2 • • Evidence of sound decision-making, problem-solving, planning and organisation. Ability to work within a team effectively. Desirable • • • • • Experience in tissue culture and working with primary human cells. Experience of standard molecular biology techniques. Experience of maintaining databases for study sample collections and phenotyping data. Experience of functional genomic protocols. Knowledge of the principles and application of bioinformatics, statistical genetics and/or high throughput sequencing data analysis. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • Working with blood, human products and human tissues Work with any substance which has any of the following pictograms on their MSDS: 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy 4 Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
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