Postdoctoral Research Associate in Mechanisms of Cell Signalling
further particulars: 179455 Research Associate Gr 7 JD - Ranes.pdf
spatial: Dorothy Crowfoot Hodgkin Building, Biochemistry Department, South Parks Road, Oxford, OX1 3QU
salary: Research Grade 7: £41,997 - £46,913 per annum
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comment: **Pay Scale:** STANDARD RESEARCH GRADE 7 **Salary ( £)**: £41,997 - £46,913 per annum **Location:** Department of Biochemistry, South Parks Road, Oxford **Contract type:** Fixed Term Contract for up to 3 years **Hours:** Full Time (37.5 hours per week) **About the role** The Ranes lab are seeking a talented Postdoctoral Research Associate to investigate the molecular mechanisms driving the Wnt/beta-catenin signalling pathway at the plasma membrane. The lab undertakes a multidisciplinary approach spanning biochemistry/biophysics, cell biology and structural biology to address our research questions. In this role you will build on our previous success in the biochemical reconstitution of beta-catenin destruction complex, to investigate the mechanisms underpinning Wnt pathway activation and termination at the plasma membrane using both _in vitro_ and cell-based approaches. In this endeavour the position is for a Postdoc with expertise in cell signalling pathways, protein biochemistry and _in vitro_ cell biology. You will be responsible for studying the regulation and recruitment of cytoplasmic signal transduction proteins to the Wnt receptor complexes using state-of-the art tools and resources, such as _in vitro_ protein reconstitution to dissect discreet transduction steps, CRISPR approaches and super-resolution microscopy. This full-time fixed-term post is funded by the Wellcome Trust for up to 3 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. **What We Offer** Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel lo…
comment: Pay Scale: STANDARD RESEARCH GRADE 7 Salary (£): £41,997 - £46,913 per annum Location: Department of Biochemistry, South Parks Road, Oxford Contract type: Fixed Term Contract for up to 3 years Hours: Full Time (37.5 hours per week) About the role The Ranes lab are seeking a talented Postdoctoral Research Associate to investigate the molecular mechanisms driving the Wnt/beta-catenin signalling pathway at the plasma membrane. The lab undertakes a multidisciplinary approach spanning biochemistry/biophysics, cell biology and structural biology to address our research questions. In this role you will build on our previous success in the biochemical reconstitution of beta-catenin destruction complex, to investigate the mechanisms underpinning Wnt pathway activation and termination at the plasma membrane using both in vitro and cell-based approaches. In this endeavour the position is for a Postdoc with expertise in cell signalling pathways, protein biochemistry and in vitro cell biology. You will be responsible for studying the regulation and recruitment of cytoplasmic signal transduction proteins to the Wnt receptor complexes using state-of-the art tools and resources, such as in vitro protein reconstitution to dissect discreet transduction steps, CRISPR approaches and super-resolution microscopy. This full-time fixed-term post is funded by the Wellcome Trust for up to 3 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. What We Offer Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel loans The University also runs an eno…
based near: Dorothy Crowfoot Hodgkin Building
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application closing date: 2025-06-02T12:00:00+01:00
notation: 179455
application opening date: 2025-05-07T09:00:00+01:00

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179455 Research Associate Gr 7 JD - Ranes.pdf
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value: ____________________________________________________________________________ DEPARTMENT OF BIOCHEMISTRY Job Description Job title Postdoctoral Research Associate in Mechanisms of Cell Signalling Division Medical Sciences Department Biochemistry Location New Biochemistry, South Parks Road, Oxford, OX1 3QU Grade and salary Grade 7: £41,997 - £46,913 per annum Hours Full time (37.5 hours per week) Contract type Fixed term contract for up to 3 years in the first instance, with a possibility of further extension. Reporting to Dr Michael Ranes Vacancy reference 179455 Additional information You are required to submit a CV and a supporting statement with your application, outlining how you meet each of the selection criteria for the role (see below for details). Your application will not be processed if you do not include both documents. Research topic Molecular mechanisms in Wnt signal transduction Principal Investigator / supervisor Dr Michael Ranes Project team Ranes Lab Project web site www.bioch.ox.ac.uk/research/ranes Funding partner Recent publications The funds supporting this research project are provided by the Wellcome Trust Ranes, M., Zaleska, M., Sakalas, S., Knight, R. & Guettler, S. “Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.” Mol Cell 81, 3246-3261 (2021). The role The Ranes Lab is seeking a talented Postdoctoral Research Associate to investigate the molecular mechanisms driving the Wnt/beta-catenin signalling pathway at the plasma membrane. The lab undertakes a multidisciplinary approach spanning biochemistry/biophysics, cell biology and structural biology to address our research questions. The successful candidate will build on our previous success in the biochemical reconstitution of beta-catenin destruction complex, to investigate the mechanisms underpinning Wnt pathway activation and termination at the plasma membrane using both in vitro and cellbased appro…
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