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Current vacancies at the University of Oxford
Postdoctoral Research Associate in Mechanisms of ubiquitin signalling within inflammation and cell death
Summary Job title Postdoctoral Research Associate in Mechanisms of ubiquitin signalling within inflammation and cell death Division Medical Sciences Department Department of Biochemistry Location Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford Grade and salary Grade 7: £41,997 to £46,913 per annum Hours Full time (37.5 hours per week) Contract type Fixed-term for up to 3 years in the first instance Reporting to Dr Paul Elliott Vacancy reference 179922 Additional information You are required to submit a CV and a supporting statement with your application, outlining how you meet each of the selection criteria for the role (see below for details). Your application will not be processed if you do not include both documents. Research topic Structural understanding of ubiquitin signalling Principal Investigator / supervisor Dr Paul Elliott Project team Project web site https://elliottlab.web.ox.ac.uk Funding partner The funds supporting this research project are provided by BBSRC & CRUK Recent publications Dietz L, Ellison CJ, Riechmann C, Cassidy CK, Felfoldi FD, Pinto-Fernandez A, Kessler BM, Elliott PR. (2023) Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science. 379 (6637) The role We are seeking to appoint a Postdoctoral Research Associate with experience of structural biology techniques to join the group of Dr Paul Elliott to investigate the mechanisms of ubiquitin signalling within inflammation and cell death. The Elliott group is embedded within the Department of Biochemistry and is at the forefront of the ubiquitin signalling field. The group employs a multifaceted approach including biochemical, biophysical and structural biology techniques (NMR, protein crystallography and cryo-EM) combined with in cellulo studies to address fundamental questions around ubiquitin regulation and function. The post-holder will have access to state of the art facilities located within the thriving Department and will employ structural biology methods to address the group’s research questions. This is a full-time fixed term post funded by the BBSRC and Cancer Research UK for up to 3 years in the first instance. Responsibilities         Use structural biology techniques (X-ray, cryoEM and NMR) combined with biochemical and biophysical assays to investigate how ubiquitin controls the balance between cell survival and cell death. Work independently and manage their own research and the overall project to meet deadlines. Contribute to day-to-day running of the laboratory. Supervise and train junior members of the group (4th year undergraduate Master’s and DPhil students). Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques. Lead preparation of journal articles for publication. Present their research at national and international conferences. Embed the principles of mutual respect, equality, diversity, inclusivity and sustainability in all aspects of your work; undertake training as and when asked to do so. Selection criteria Essential selection criteria 1. Hold a PhD/DPhil or be nearing completion of a PhD/DPhil in Biochemistry or Structural Biology. 2. Experience of molecular biology cloning methods and protein expression and purification techniques. 3. Experience of using structural biology methods. 4. Demonstrated detailed record keeping and data archiving. 5. Demonstrated ability to communicate their research effectively (e.g. in peer-reviewed publications) with a strong understanding of the relevant field. 6. Demonstrated ability to work effectively in a team. 7. Ability to work independently and independent thinking. Desirable selection criteria 1. 2. 3. 4. Experience of biophysical methods. Experience of cryoEM sample preparation, data acquisition and analysis. Knowledge of the ubiquitination system. Experience of insect or mammalian protein expression systems. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we 179922 Research Associate Gr 7 - Elliott 2 will contact the referees you have nominated. If you have previously worked for the University we will also verify key information such as your dates of employment and reason for leaving your previous role with the department/unit where you worked. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:  Lone Working  Work in hot or cold environments  Work with any substance which has any of the following pictograms on their MSDS: 179922 Research Associate Gr 7 - Elliott 3 About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spin-outs, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. Department of Biochemistry The Department of Biochemistry in Oxford was established in 1920 and is now one of the largest in Europe. Situated in an attractive area close to the University Parks and River Cherwell, the Department is housed in the University Science Area and is currently undergoing a major expansion programme centred on the recently completed and award-winning New Biochemistry Building. The Science Area includes the Radcliffe Science Library and the Natural History Museum, and is conveniently located for easy access to the town centre and colleges. The department includes research laboratories working in the areas of Cell Biology, Development and Genetics; Chromosomal and RNA Biology; Infection and Disease Processes; Microbiology and Systems Biology; and Structural Biology and Molecular Biophysics. It is particularly well equipped with an extensive computer network, all the basic hardware essential in today's research, together with an excellent range of state-of-the-art specialist equipment. For more information please visit: http://www.bioch.ox.ac.uk/ The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Bronze Athena SWAN award. The Department of Biochemistry is strongly committed to equality and valuing diversity and we operate a flexible working policy for all staff. The Department holds a departmental Silver Athena SWAN award to recognise advancement of gender equality: representation, progression and success for all. Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching, and the largest academic division in the University of Oxford. It includes 15 clinical departments and 5 non-clinical departments. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: http://www.ox.ac.uk/divisions/medical_sciences.html 179922 Research Associate Gr 7 - Elliott 4 How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs Non-technical questions about this job should be addressed to the recruiting department directly, please email recruitment@bioch.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 179922 Research Associate Gr 7 - Elliott 5 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82 of 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. The University’s Policy on Information Security Awareness The information security awareness training is compulsory for all University staff; and as part of our responsibility as a Department, ALL employees of the Department will be required to complete the online information security awareness module, which provides a combination of information, case studies and links to additional resources relating to information security. You will be expected to complete this course as part of your induction process, on your first day working in the Department of Biochemistry. This training will also need to be completed in order to successfully complete your probationary period. In order to ensure that we are compliant and up-to-date with the information security awareness training, we need to ensure that all staff members have completed the latest course, which may be accessed from the Information Security’s website by using the following link: https://www.infosec.ox.ac.uk/guidance-policy/training-and-awareness You will also be required to undertake this course on an annual basis, in order to satisfy the security awareness training requirements of the University’s Information Security Policy. 179922 Research Associate Gr 7 - Elliott 6 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, flexible working options, travel discounts including salary sacrifice schemes for bicycles and electric cars and other discounts. Staff can access a huge range of personal and professional development opportunities. See https://hr.admin.ox.ac.uk/staff-benefits Employee Assistance Programme As part of our wellbeing offering staff get free access to Health Assured, a confidential employee assistance programme, available 24/7 for 365 days a year. Find out more https://staff.admin.ox.ac.uk/health-assuredeap University Club and sports facilities Membership of the University Club is free for University staff. It offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits We are a family-friendly employer with one of the most generous family leave schemes in the Higher Education sector. Our Childcare Services team provides guidance and support on childcare provision, and offers a range of high quality childcare options at affordable prices for staff. In addition to 5 University nurseries, we partner with a number of local providers to offer in excess of 450 full time nursery places to our staff. Eligible parents are able to pay for childcare through salary sacrifice, further reducing costs. See https://childcare.admin.ox.ac.uk/. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities for dependants of all types. See https://hr.admin.ox.ac.uk/my-family-care Supporting disability and health-related issues (inc menopause) We are committed to supporting members of staff with disabilities or long-term health conditions, including those experiencing negative effects of menopause. Information about the University’s Staff Disability Advisor, is at https://edu.admin.ox.ac.uk/disability-support. For information about how we support those going through menopause see https://hr.admin.ox.ac.uk/menopause-guidance Staff networks The University has a number of staff networks including for research staff, BME staff, LGBT+ staff, disabled staff network and those going through menopause. Find out more at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Research staff The Researcher Hub supports all researchers on fixed-term contracts. They aim to help you settle in comfortably, make connections, grow as a person, extend your research expertise and approach your next career step with confidence. Find out more https://www.ox.ac.uk/research/supportresearchers/researcher-hub Oxford’s Research Staff Society is a collective voice for our researchers. They also organise social and professional networking activities for researchers. Find out more https://www.ox.ac.uk/research/supportresearchers/connecting-other-researchers/oxford-research-staff-society 179922 Research Associate Gr 7 - Elliott 7
NTriples description of Postdoctoral Research Associate in Mechanisms of ubiquitin signalling within inflammation and cell death
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Pay Scale: STANDARD GRADE 7 Salary (£): £41,997 to £46,913 per annum Location: Department of Biochemistry, South Parks Road, Oxford Contract type: Fixed Term Hours: Full-time About the role We are seeking to appoint a Postdoctoral Research Associate with experience of structural biology techniques to join Dr Paul Elliott’s Lab to investigate the mechanisms of ubiquitin signalling within inflammation and cell death. The Elliott group is embedded within the Department of Biochemistry and is at the forefront of the ubiquitin signalling field. The group employs a multifaceted approach including biochemical, biophysical and structural biology techniques (NMR, protein crystallography and cryo-EM) to address fundamental questions around ubiquitin regulation and function. The post-holder will have access to state-of-the-art facilities located within the thriving Department and will employ structural biology methods to address the group’s research questions. This is a full-time fixed term post funded by the BBSRC and Cancer Research UK for up to 3 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. What We Offer Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel loans The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work. About you Applicants should hold a PhD/DPhil, or be near completion of a PhD/DPhil in structural biology, biochemistry or related area and have gained experience in a wide range of structural biology experimental techniques, including cryo-electron microscopy. You will be highly motivated with a proven ability to independently and effectively manage research projects, whilst also working within a team environment. Additionally, you will have excellent written communication skills and have demonstrated your ability to produce high quality research through publication in peer-reviewed journals. Application Process Applications for this vacancy are to be made online via www.recruit.ox.ac.uk and Vacancy ID 179922. You will be required to upload your curriculum vitae and a supporting statement, setting out how you meet the selection criteria for the post, using examples of your skills and experience. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now. For further details, please refer to the How to apply section of the job description. Any further enquires may be directed to recruitment@bioch.ox.ac.uk. The closing date for applications is 12.00 noon on Monday 23rd June 2025. Only applications received before this time can be considered. Interviews for shortlisted candidates to be held as soon as possible thereafter. Committed to equality and valuing diversity
Description of Postdoctoral Research Associate in Mechanisms of ubiquitin signalling within inflammation and cell death
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**Pay Scale:** STANDARD GRADE 7 **Salary ( £)**: £41,997 to £46,913 per annum **Location:** Department of Biochemistry, South Parks Road, Oxford **Contract type:** Fixed Term **Hours:** Full-time **About the role** We are seeking to appoint a Postdoctoral Research Associate with experience of structural biology techniques to join Dr Paul Elliott’s Lab to investigate the mechanisms of ubiquitin signalling within inflammation and cell death. The Elliott group is embedded within the Department of Biochemistry and is at the forefront of the ubiquitin signalling field. The group employs a multifaceted approach including biochemical, biophysical and structural biology techniques (NMR, protein crystallography and cryo-EM) to address fundamental questions around ubiquitin regulation and function. The post-holder will have access to state-of-the-art facilities located within the thriving Department and will employ structural biology methods to address the group’s research questions. This is a full-time fixed term post funded by the BBSRC and Cancer Research UK for up to 3 years in the first instance. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. **What We Offer** Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel loans The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work. **About you** Applicants should hold a PhD/DPhil, or be near completion of a PhD/DPhil in structural biology, biochemistry or related area and have gained experience in a wide range of structural biology experimental techniques, including cryo- electron microscopy. You will be highly motivated with a proven ability to independently and effectively manage research projects, whilst also working within a team environment. Additionally, you will have excellent written communication skills and have demonstrated your ability to produce high quality research through publication in peer-reviewed journals. **Application Process** Applications for this vacancy are to be made online via www.recruit.ox.ac.uk and Vacancy ID **179922**. You will be required to upload your curriculum vitae and a supporting statement, setting out how you meet the selection criteria for the post, using examples of your skills and experience. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now. For further details, please refer to the How to apply section of the job description. Any further enquires may be directed to recruitment@bioch.ox.ac.uk. The closing date for applications is **12.00 noon** on **Monday 23rd June 2025**. Only applications received before this time can be considered. Interviews for shortlisted candidates to be held as soon as possible thereafter. **Committed to equality and valuing diversity**
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Dorothy Crowfoot Hodgkin Building, Biochemistry Department, South Parks Road, Oxford, OX1 3QU
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Biochemistry Building, Dorothy Hodgkin Road
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Research Grade 7: £41,997 to £46,913 per annum