. "AV" . "165716"^^ . . . . . . . . """

Are you a dynamic and experienced HR professional looking for a new challenge?

 

We have an exciting opportunity for a Deputy HR Manager (maternity cover) to join our team at the Department of Physiology, Anatomy and Genetics. As the Deputy HR Manager, you will play a crucial role in managing the day-to-day operations of our HR function, ensuring the efficient delivery of services to our department. Your duties will include:


  • Supervising and developing a team of three HR and Payroll Assistants to deliver an effective HR service for the department;

  • Supporting managers in managing change and in handling individual employee cases, ensuring compliance with University policy, working with central HR where necessary;

  • Advising and supporting employees and managers through the end of fixed-term contract process ensuring consistent application of University HR policy and procedure;

  • Attending Divisional working groups or committees to build relationships and share best practice, and deputising for the HR Manager when required;

  • Managing the administration of recruitment exercises, including academic recruitment;

  • Monitoring the sick leave absence records, annual leave records, end of probationary periods and annual appraisal dates to advise managers as necessary;

  • Working closely with the rest of HR team, maintaining oversight of monthly payroll changes, ensuring that the correct funds are utilised, highlighting any funding issues, and adhering to the University’s deadlines.


The successful candidate will have demonstrable experience of working in an HR team/role and managing HR processes; they will be qualified or working toward CIPD graduate level, or have equivalent experience, show evidence of experience of operating HR information systems and producing management information reports, and excellent demonstrable skills in organisation and prioritisation of a busy workload, whilst maintaining a high level of accuracy.

 

The post is offered as a maternity cover for up to 12 months, and is available from 31st July 2023. You will be based in the Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Road, Oxford OX1 3PT.

 

The closing date for applications is midday on Wednesday 21st June. Interviews are likely to be held in the week commencing 26th June 2023.

 

Applications for internal secondment opportunities are also encouraged.

 

While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally.
"""^^ . . . . . . "Standard Grade 6: £31,502 - £37,386" . "University of Oxford" . . . . "Le Gros Clark Building" . "Title"@en . "Tinsley Building" . . . . . "2023-06-12T12:00:00+01:00"^^ . _:N8272771d10e14cb0b6aae86181e41492 "OX1 3PT" . "sotto-Organization di"@it . . . """

Research Assistant: Transgenic models of Parkinson’s disease

Fixed-term for 3 years

 

Applications are invited for a Research Assistant to work on a highly collaborative and interdisciplinary project to develop transgenic rodent models of Parkinson’s disease. The work will support projects seeking to use rodent models of disease to understand the earliest stage of neurodegeneration at a point in which neuronal dysfunction precedes neuronal loss, offering an early therapeutic window for therapy. The post will be based in the Laboratory of Molecular Neurodegeneration in the Department of Physiology, Anatomy and Genetics, and is supported by an international consortium funded by an Aligning Science Across Parkinson’s (ASAP) grant, and by the Wellcome Trust.

 

Duties include colony management, breeding and maintenance of lines of transgenic rodents; collection of brain tissue for gene expression analysis; general laboratory management, preparation of data for publication; contributions to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have a good working knowledge of molecular and cellular biology, excellent practical experience of working with animal models and an interest in pre-clinical in vivo models of neurological disease. Previous experience of the management and maintenance of transgenic rodent lines would be an advantage. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential.

 

Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and will have excellent practical experience of working with animal models.

 

The fixed-term post is available immediately for 3 years. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT.

 

Informal enquiries may be directed to Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).

 

Closing date for applications is midday on Monday 19th June 2023. Interviews are likely to be held in the week commencing 26th June 2023. 

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion.
"""^^ . . . . . . "Henry Wellcome Building of Gene Function" . _:N8272771d10e14cb0b6aae86181e41492 . . . . . . . "HR & Payroll Assistant" . "2023-06-21T12:00:00+01:00"^^ . "2023-06-19T12:00:00+01:00"^^ . . . . . . . . "Medical Sciences Division" . . "Sophia Evans" . . "2023-06-21T12:00:00+01:00"^^ . "2B27" . . . . . "2023-06-23T12:00:00+01:00"^^ . . . . . . "DPAG" . . "type" . "address"@en . "Standard Grade 6: £31,502 - £37,386" . . . . . . . "Standard Grade 4: £24,715 - £28,131" . "primary Site"@en . "2023-06-30T12:00:00+01:00"^^ . "Old Observatory" . "Sherrington Building" . _:N1d6324b0c536402ba5122ad1d18c6d11 . . . "es suborganización de"@es . . . . "Fax"@en . "label" . . . . "2023-06-23T12:00:00+01:00"^^ . "Job Description" . "Voice"@en . . . . "true"^^ . . """**_Are you a dynamic and experienced HR professional looking for a new challenge?_** We have an exciting opportunity for a Deputy HR Manager (maternity cover) to join our team at the Department of Physiology, Anatomy and Genetics. As the Deputy HR Manager, you will play a crucial role in managing the day-to-day operations of our HR function, ensuring the efficient delivery of services to our department. Your duties will include: * Supervising and developing a team of three HR and Payroll Assistants to deliver an effective HR service for the department; * Supporting managers in managing change and in handling individual employee cases, ensuring compliance with University policy, working with central HR where necessary; * Advising and supporting employees and managers through the end of fixed-term contract process ensuring consistent application of University HR policy and procedure; * Attending Divisional working groups or committees to build relationships and share best practice, and deputising for the HR Manager when required; * Managing the administration of recruitment exercises, including academic recruitment; * Monitoring the sick leave absence records, annual leave records, end of probationary periods and annual appraisal dates to advise managers as necessary; * Working closely with the rest of HR team, maintaining oversight of monthly payroll changes, ensuring that the correct funds are utilised, highlighting any funding issues, and adhering to the University’s deadlines. The successful candidate will have demonstrable experience of working in an HR team/role and managing HR processes; they will be qualified or working toward CIPD graduate level, or have equivalent experience, show evidence of experience of operating HR information systems and producing management information reports, and excellent demonstrable skills in organisation and prioritisation of a busy workload, whilst maintaining a high level of accuracy. The post is offered as a maternity cover for up to 12 months, and is available from 31st July 2023. You will be based in the Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Road, Oxford OX1 3PT. The closing date for applications is midday on Wednesday 21st June. Interviews are likely to be held in the week commencing 26th June 2023. **_Applications for internal secondment opportunities are also encouraged._** **_While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements._** **_Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford._** We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. """ . . "University of Oxford" . . "alternative label"@en . _:N6de77d59d7be4074b3f105191dd5c75f . . "Old Observatory" . "email"@en . . . . . "department" . . "Department of Physiology, Anatomy & Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT" . . . "Physiology, Anatomy and Genetics, Department of (DPAG)" . _:Nf099bb0d550647918b403b537ab0ceb8 . "tiene sede principal en"@es . _:N4579afc32f5543269bd52cf14e4876eb "United Kingdom" . . . . "Le Gros Clark Building" . "Department of Physiology, Anatomy and Genetics, Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT" . . "165489"^^ . "Medical Sciences Division" . . "Deputy HR Manager job description" . "2023-05-22T09:00:00+01:00"^^ . "Source"@en . . . . . "Research Assistant" . _:N8272771d10e14cb0b6aae86181e41492 "Sherrington Building, Sherrington Road" . . . . . "telephone"@en . . . . "false"^^ . "Job Description" . . . . . . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job description and Selection Criteria Job title Research Assistant: Transgenic models of Parkinson’s disease Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT Grade and salary Grade 6: £31,502 - £37,386 per annum Hours Full time Contract type Fixed-term for 3 years Reporting to Professor Richard Wade-Martins Vacancy reference (AV23020) HRIS: 165491 Research topic Transgenic models of Parkinson’s disease Principal Investigator / supervisor Professor Richard Wade-Martins Project team Project web site Funding partner Recent publications The Research Assistant will become part of the Laboratory of Molecular Neurodegeneration, a highly active research group consisting of approximately thirty research scientists, comprising a mix of research fellows, post-doctoral research scientists, DPhil students and research assistants. Group members come from a mix of scientific and medical backgrounds, creating an exciting environment for research. This highly collaborative project offers an exceptional research environment to undertake research into Parkinson’s disease. www.ox.ac.uk/ www.dpag.ox.ac.uk/opdc https://www.dpag.ox.ac.uk/research/wade-martins-group https://parkinsonsroadmap.org/ This Grade 6 post will work on collaborative projects funded by the Wellcome Trust and the Aligning Science Across Parkinson’s (ASAP) consortium. Ryan B, Bengoa-Vergniory N, Williamson M, Kirkiz E, Roberts R, Corda G, Sloan M, Saqlain S, Cherubini M, Poppinga J, Bogetofte H, Cioroch M, Hester S and Wade-Martins R. (2021) REST protects dopaminergic Technical Skills neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model. Journal of Neuroscience 41(16):3731-3746. Bengoa-Vergniory N, Faggiani E, Ramos-Gonzalez P, Kirkiz E, ConnorRobson N, Brown LV, Siddique I, Li Z, Vingill S, Cioroch M, Cavaliere F, Threlfell S, Roberts B, Schrader T, Klärner F-G, Cragg S, Dehay B, Bitan G, Matute C, Bezard E and Wade-Martins R. (2020) CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and mouse models of Parkinson’s. Nature Communications 11(1):4885. Roberts BM, Doig NM, Brimblecombe KR, Lopes EF, Siddorn RE, Threlfell S, Connor-Robson N, Bengoa-Vergniory N, Pasternack N, Wade-Martins R, Magill PJ and Cragg SJ (2020) GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in early parkinsonism. Nature Communications 11(1):4958. Hunn BMH, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig N, Bannerman DM, Cragg SJ and Wade-Martins R (2019) Impairment of macroautophagy in dopamine neurons has opposing effects on parkinsonian pathology and behavior. Cell Reports 29(4):920-931. Dodson PD, Dreyer JK, Jennings KA, Syed ECJ, Wade-Martins R, Cragg SJ, Bolam JP and Magill PJ (2016) Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. Proceedings of the National Academy of Sciences. 113(15):E2180-8. Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, WadeMartins R. (2016) LRRK2 BAC transgenic rats develop progressive, LDOPA-responsive motor impairment, and deficits in dopamine circuit function. Human Molecular Genetics 25(5):951-63. Janezic S, Threlfell S, Dodson PD, Dowie MJ, Taylor TN, Potgieter D, Parkkinen L, Senior SL, Anwar S, Ryan B, Deltheil T, Kosillo P, Cioroch M, Wagner, K, Ansorge O, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, and Wade-Martins R. (2013) Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson's model. Proceedings of the National Academy of Sciences 110(42):E4016-25.  Breeding and maintenance of transgenic rodent (mouse and rat) lines  Colony management and genotyping  Record keeping for Home Office returns  General laboratory management 2 The role Background Parkinson’s disease results from the loss of dopamine neurons from the substantia nigra pars compacta, although it is now recognized that early deficits in neuronal function precede neuronal death. The WadeMartins laboratory has extensive experience of generating and characterising highly physiological transgenic rodent models of Parkinson’s by “deep-phenotyping” through collaborative projects looking at molecular neuropathology, neuronal function, and behaviour. Bacterial artificial chromosome (BAC) transgenics retain temporal and spatial regulation of gene expression in vivo providing significant advantages over cDNA-based systems traditionally used to generate transgenic lines. Genes expressed from genomic DNA BAC inserts are expressed at physiologically-relevant levels from their native promoter under the control of flanking enhancer and silencer elements allowing the expression of the full range of transcriptional and splicing diversity. These approaches result in rodent models which capture key elements of age-related neurodegenerative disease and can model the early stages of Parkinson’s suitable for therapeutic interventions. Supervisors: Professor Richard Wade-Martins and Professor Stephanie Cragg The role of the Research Assistant (RA) position will be to provide technical support to researchers working on two consortium grants funded a Wellcome Trust Collaborator Award led by Professor Wade-Martins and by the Aligning Science Across Parkinson’s initiative (ASAP; https://parkinsonsroadmap.org/) led by Professor Stephanie Cragg (Department of Physiology, Anatomy and Genetics). Duties will include the management and genotyping of transgenic rodent lines to generate experimental cohorts for collaborating groups, maintaining accurate records for Home Office returns, performing analysis of gene expression in brain tissue and training other group members in relevant experimental techniques. The post-holder will also undertake general laboratory management and administration, such as stock-taking and placing orders. The successful candidate will be based at the Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, New Biochemistry, Phase 2, Parks Road, Oxford in the Laboratory of Molecular Neurodegeneration headed by Professor Wade-Martins. Responsibilities  Support the development of rodent models by undertaking genotyping, breeding and maintenance of transgenic mouse and rat lines to supply experimental cohorts to collaborating laboratories  Molecular biology and histology: Molecular analysis of gene expression in dissected brain tissue at the RNA and protein level  Maintaining accurate records and preparing Home Office returns  Training other group members in relevant experimental techniques  General laboratory management, including stock taking and ordering laboratory reagents within defined budgets  Contribute to wider project planning, including ideas for new research projects  Determine the most appropriate methodologies to test hypotheses, and identify suitable alternatives if technical problems arise  Select, follow, and adapt experimental protocols  Gather, analyse, and present scientific data from a variety of sources  Contribute to scientific reports and journal articles and the presentation of data/papers at conferences  Manage own research and administrative activities, within guidelines provided by senior colleagues  Collaborate effectively with other team members to achieve collective goals Other Duties  Participate in a regular Annual Review; 3     Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training; Comply with Health and safety regulations; Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff; Any other duties that may be required from time to time commensurate with the grade of the job. This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Selection criteria Essential         Hold, or be near to completion of BSc or MSc degree in molecular biology, neuroscience, cell biology, genetics, biochemistry or a related biological discipline Experience of working with mice and/or rats Must have laboratory experience of some of the experimental molecular biology techniques required, such as PCR, genotyping, tissue dissection, and perfusion Must have an interest in pre-clinical in vitro and in vivo models of neurological disease Must be strongly motivated with a keen enthusiastic approach to science with good organisational, verbal and interpersonal skills Hold, or be capable of obtaining, a UK Home Office personal licence with relevant authorities to conduct required procedures. NB: professional training will be provided if you do not already have a personal licence Must have excellent IT skills including word-processing and spreadsheet or scientific graphic packages Commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work Desirable  Experience of maintenance and management of transgenic mouse or rat colonies Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:  Lone Working  Regular manual handling  Work with allergens, Eg laboratory animals, pollen, dust, fish or insects etc.  Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so 4 that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks This job includes duties that will require additional security pre-employment checks:  A satisfactory enhanced Disclosure and Barring Service check  University security screening (eg identity checks) The Oxford Parkinson's Disease Centre The Oxford Parkinson's Disease Centre (OPDC; www.opdc.ox.ac.uk) headed by Professor Wade-Martins is an international research Centre for Parkinson's disease established in February 2010. We have exploited a unique interdisciplinary research environment bringing together scientists and clinicians to create a centre of excellence focused on understanding the earliest pathological pathways in PD. Internationally-recognised scientists with strengths in stem cell models, genetics and genomics, transgenic rodent models, the structure and function of brain cells and circuits affected in PD, magnetic resonance imaging (MRI), and analysis of protein biomarkers, are working closely with experts in epidemiology and clinical neurology to better understand the causes of PD. The first phase of our translational program focused on understanding the molecular pathways to Parkinson's. We have built a new multi-disciplinary research program across the translational space comprising the OPDC Discovery Cohort as one of the best-characterised clinical PD cohorts in the world, a new program in Parkinson's fMRI and laboratory biomarkers, a core expertise in molecular genetics and molecular neuropathology, the largest induced pluripotent stem-cell (iPSC) research program in PD in Europe, and a world-leading research hub for the generation and deep-phenotyping of transgenic rodent models of PD. The current phase of our translational research is aimed at changing clinical practice. Our new program now targets the molecular pathways to Parkinson's exploiting new tools (i) to stratify the progression of PD; (ii) to predict the onset of PD; (iii) to identify potential targets through generating mechanism-based rationale; and (iv) to validate new disease-modifying treatments to prevent the development of PD. For more information please visit: www.dpag.ox.ac.uk/opdc Laboratory of Molecular Neurodegeneration The Laboratory of Molecular Neurodegeneration led by Professor Wade-Martins at the Department of Physiology, Anatomy and Genetics (DPAG) studies the molecular mechanisms of a range of human neurological diseases with the ultimate aim of developing novel therapies. The Laboratory plays a leading role in the OPDC integrating studies in post-mortem human brain tissue, transgenic and knock-out mouse and rat models, and iPSC-derived neuronal models of Parkinson's disease. Our work is highly interdisciplinary in nature and our research program has thrived through many collaborations within DPAG and in the South Park Road science area, and through interaction with scientific and clinical colleagues across Oxford. Our laboratory is part of the Kavli Institute for Nanoscience Discovery, an exciting new interdisciplinary research building at the University of Oxford facilitating interactive collaborative opportunities across cellular, molecular and physical sciences. For further information on our work, see: https://www.dpag.ox.ac.uk/research/wade-martins-group 5 About the University of Oxford Oxford’s departments and colleges aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. Oxford’s self-governing community of international scholars includes Professors, Associate Professors, other college tutors, senior and junior research fellows and over 2,500 other University research staff. Research at Oxford combines disciplinary depth with an increasing focus on inter-disciplinary and multi-disciplinary activities addressing a rich and diverse range of issues. Oxford’s strengths lie both in empowering individuals and teams to address fundamental questions of global significance, and in providing all staff with a welcoming and inclusive workplace that supports everyone to develop and do their best work. Recognising that diversity is a great strength, and vital for innovation and creativity, Oxford aspires to build a truly inclusive community which values and respects every individual’s unique contribution. While Oxford has long traditions of scholarship, it is also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. It consistently has the highest external research income of any university in the UK (the most recent figures are available at www.ox.ac.uk/about/organisation/finance-and-funding), and is ranked first in the UK for university spinouts, with more than 130 spin-off companies created to date. Oxford is also recognised as a leading supporter of social enterprise. Oxford admits undergraduate students with the intellectual potential to benefit fully from the small group learning to which Oxford is deeply committed. Meeting in small groups with their tutor, undergraduates are exposed to rigorous scholarly challenge and learn to develop their critical thinking, their ability to articulate their views with clarity, and their personal and intellectual confidence. They receive a high level of personal attention from leading academics. Oxford has a strong postgraduate student body which now numbers over 10,000. Postgraduates are attracted to Oxford by the international standing of the faculty, by the rigorous intellectual training on offer, by the excellent research and laboratory facilities available, and by the resources of the museums and libraries, including one of the world’s greatest libraries, the Bodleian. For more information please visit www.ox.ac.uk/about/organisation The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022, 2023. 6 Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past three years. Please see annual report file:///C:/Users/dpaterson/Downloads/202122DPAGAnnualReportweb.pdf Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are five named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), the Krebs Chair in Physiological Metabolism (vacant) and the John Black Professor of Bionanoscience (Professor Molly Stevens, FREng, FRS). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. 7 We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk The Kavli Institute for Nanoscience Discovery (Kavli INsD) “Where the physical sciences are brought into the cell” Leading scientific discovery into the most basic unit of life - the cell - the Kavli Institute for Nanoscience Discovery (Kavli INsD) is located at the heart of Oxford University’s science area and was inaugurated in March 2021. With over 30 faculty and 450 research staff and graduate students, world leading teams collaborate from multiple departments (biochemistry, cell biology, chemistry, physics, physiology, psychiatry, clinical neurosciences and engineering) to contribute to global health. By bringing multiple disciplines together under the same roof to advance scientific research the Kavli INsD creates an environment that encourages the cross-pollination of ideas and inter-disciplinary cooperation. The Institute comes together to work on global health challenges and benefits from the close proximity of the scientific departments as well as advanced imaging facilities and state-of-the-art-instrumentation. As the first Director of Kavli INsD Professor Dame Carol Robinson and the research teams are creating a culture that is both bold and respectful. The University of Oxford’s, Kavli Institute for Nanoscience Discovery is the U.S based Kavli Foundation’s 20th institute. The foundation, established in the year 2000 by Fred Kavli, has a mission “to advance science for the benefit of humanity”. Research institutes in the fields of nanoscience, astrophysics, neuroscience, and theoretical physics have been endowed by the foundation which also supports programs that strengthen the connection between science and society. Learn more at kavlifoundation.org Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster 8 printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. 9 How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of two referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Should you experience any difficulties using the online application system, and the FAQs do not answer your question, please email recruitment.support@admin.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 10 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 11 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 12 """^^ . . . . . . . . . . "01865 282167" . . "notation"@en . . . "Department of Physiology, Anatomy and Genetics, Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford" . . . """**Fixed-term, Full-time for 3 years** Applications are invited for a Research Assistant neuronal cell and molecular biologist to work on a new project to develop a novel gene therapy for Parkinson’s in-patient stem cell-derived neuronal models. The project in collaboration with Kaleibe Therapeutics represents an exciting opportunity to undertake translational work into biological therapeutics at the interface between academic and industrial research in an exceptional setting. This work will develop novel gene therapies for Parkinson’s by expression of complete genomic DNA transgenes from HSV1 viral vectors to correct cellular phenotypes in induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s patients. Duties will include the design, generation and delivery of HSV1 gene expression vectors in cellular models of Parkinson’s to study phenotypic correction; undertaking laboratory experiments; interpretation of data; imaging analysis; maintenance and differentiation of iPSC-derived neurons and cell lines; preparation of data for publication; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of neuronal cell cultures and DNA gene expression plasmid vectors, and a good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential. Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and have experience in cellular neuroscience or molecular cell biology relevant to analysis of neuronal phenotypes. The post is available for three years to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford. Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk). Closing date for applications is **midday on Friday 30th June 2023.** Interviews are likely to be held on **the week beginning 10th July 2023.** Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion """ . . "occupies" . . "Department of Physiology, Anatomy and Genetics (DPAG)" . . . "false"^^ . "License"@en . . . . "ha sede"@it . "Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT" . . "2023-06-27T12:00:00+01:00"^^ . . . "165491"^^ . . . . . . . "value" . . . . "Past vacancies at the University of Oxford" . _:N1d6324b0c536402ba5122ad1d18c6d11 "+44-1865-270708" . . _:N4579afc32f5543269bd52cf14e4876eb . . . "Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT" . "locality"@en . "Physiology, Anatomy and Genetics" . . "sous-Organization de"@fr . _:N4579afc32f5543269bd52cf14e4876eb . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job description and Selection Criteria Job title Deputy HR Manager Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Sherrington Building, Parks Road, Oxford, OX1 3PT Grade and salary Grade 6: £31,502 - £37,386 per annum Hours Full time (Part time requests will be considered) Contract type Maternity leave cover (fixed-term) Reporting to HR Manager Vacancy reference 165489 Additional information While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. We also encourage applications for internal secondments. The role You will be responsible for managing the day-to-day operation of the HR function, including the supervision of three HR staff, to ensure delivery of an efficient service to the Department of Physiology, Anatomy and Genetics, reporting to the HR Manager. This post is to cover the absence of the substantive postholder, who is taking a period of maternity leave. The post is available until 30th July 2024 or the actual return of the substantive postholder, or the resignation of the substantive postholder and employment of a new postholder, whichever is the earliest. Responsibilities Support • Supervise and develop a team of three HR and Payroll Assistants to deliver an effective HR service for the department; • • • • • • Confidently advise line managers and staff members, using appropriate methods of communication tailored to the audience, answering straightforward questions or researching employment law, interpreting procedures to answer more complex questions; Support managers in managing change and in handling straightforward individual employee cases, ensuring compliance with University policy, working with central HR where necessary Advise managers on staffing requirements, taking into account the department’s business, strategy and manpower planning; Work with managers to design effective job advertisements and job descriptions to ensure that they comply with University guidance and best practice, and have oversight of the recruitment process; Carry out induction sessions for new staff and deliver briefings on a range of HR topics within the department; Advise and support employees and managers through the end of fixed-term contract process ensuring consistent application of University HR policy and procedure. Development • • • • Planning, updating, and implementing new departmental HR policy, ensuring policies are in place for induction, probation, visitors, absence management, leavers etc; Communicate key HR policy changes to the department and update staff on new regulations within the University, providing briefing sessions for staff as required; Provide reports to the Senior Management Group to include updates on staffing, legislation changes and key developments in HR; Attend Divisional working groups or committees to build relationships and share best practice, and deputising for the HR Manager when required. Transactional • • • Manage the administration of recruitment exercises, including academic recruitment, which will include; working with managers to understand their staffing requirements, designing effective job advertisements and job descriptions ensuring that they comply with University guidance and best practice, placing advertisements, gathering information for visa applications where necessary, generating letters to applicants, and preparing short listing packs; Act as a panel member for interviews as part of the recruitment and selection process where appropriate; Prepare standard letters of appointment, contracts, and visitor agreements, ensuring that relevant right to work documentation, Occupational Health and ID checks are completed, and HMRC IR 35 rules are applied for consultants. Compliance • • • • Monitor the sick leave absence records, annual leave records, end of probationary periods and annual appraisal dates to advise managers as necessary and ensure that processes are in place for their correct storage and maintenance; Working closely with the rest of HR team, maintain oversight of monthly payroll changes, ensuring that the correct funds are utilised, highlighting any funding issues, and adhering to the University’s deadlines; Ensure compliance with payroll procedures awareness of statutory pay, and monitor working hours Attend appropriate training on employment law, University HR policies and procedures, and their effective implementation at departmental level. Other Duties • Participate in a regular Annual Review 2 • • • • Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training Comply with Health and safety regulations Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff Any other duties that may be required from time to time commensurate with the grade of the job. This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Selection criteria Essential selection criteria • • • • • • • • • • • Demonstrable experience of working in an HR team/role and managing HR processes Qualified or working toward CIPD graduate level, or have equivalent experience Evidence of sound knowledge and experience of the application of UK employment law and Home Office regulations for Visas Evidence of experience of operating HR information systems and producing management information reports Proven ability to clearly and accurately communicate processes and procedures verbally and in writing Proven ability to deal accurately and confidently with numbers Evidence of excellent organisational skills and ability to use initiative to prioritise a busy working whilst maintaining a high level of accuracy Proven ability to handle confidential information appropriately with awareness of General Data Protection Regulations Proven ability to develop professional and effective working relationships with key stakeholders Demonstrable experience of providing a high level of customer service Willingness to undertake professional development and training Desirable selection criteria • • • Previous experience of supervising staff HR experience within the University of Oxford or other higher education institutions Graduate member of the CIPD. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: 3 • A satisfactory enhanced Disclosure and Barring Service check due to regulated activity involving children OR regulated activity involving ‘at risk’ adults. About the University of Oxford Oxford’s departments and colleges aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. Oxford’s self-governing community of international scholars includes Professors, Associate Professors, other college tutors, senior and junior research fellows and over 2,500 other University research staff. Research at Oxford combines disciplinary depth with an increasing focus on inter-disciplinary and multi-disciplinary activities addressing a rich and diverse range of issues. Oxford’s strengths lie both in empowering individuals and teams to address fundamental questions of global significance, and in providing all staff with a welcoming and inclusive workplace that supports everyone to develop and do their best work. Recognising that diversity is a great strength, and vital for innovation and creativity, Oxford aspires to build a truly inclusive community which values and respects every individual’s unique contribution. While Oxford has long traditions of scholarship, it is also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. It consistently has the highest external research income of any university in the UK (the most recent figures are available at www.ox.ac.uk/about/organisation/finance-and-funding), and is ranked first in the UK for university spinouts, with more than 130 spin-off companies created to date. Oxford is also recognised as a leading supporter of social enterprise. Oxford admits undergraduate students with the intellectual potential to benefit fully from the small group learning to which Oxford is deeply committed. Meeting in small groups with their tutor, undergraduates are exposed to rigorous scholarly challenge and learn to develop their critical thinking, their ability to articulate their views with clarity, and their personal and intellectual confidence. They receive a high level of personal attention from leading academics. Oxford has a strong postgraduate student body which now numbers over 10,000. Postgraduates are attracted to Oxford by the international standing of the faculty, by the rigorous intellectual training on offer, by the excellent research and laboratory facilities available, and by the resources of the museums and libraries, including one of the world’s greatest libraries, the Bodleian. For more information please visit www.ox.ac.uk/about/organisation The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk 4 The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022, 2023. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past three years. Please see annual report file:///C:/Users/dpaterson/Downloads/202122DPAGAnnualReportweb.pdf Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are five named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), the Krebs Chair in Physiological Metabolism (vacant) and the John Black Professor of Bionanoscience (Professor Molly Stevens, FREng, FRS). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate 5 students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical 6 Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of three referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. 7 Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Should you experience any difficulties using the online application system, and the FAQs do not answer your question, please email recruitment.support@admin.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 8 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 9 """^^ . "has site"@en . "sede principale"@it . . "2023-06-19T12:00:00+01:00"^^ . "has primary place" . . . . . . . "Current vacancies at the University of Oxford" . "Sherrington Building" . "2023-05-15T09:00:00+01:00"^^ . "Sophia Evans" . "in dataset" . "Henry Wellcome Building of Gene Function" . . "OxPoints"@en . . "country name"@en . . . . . """**Full-time, Fixed term until 31 January 2025** Applications are invited for a Research Assistant neuronal cell biologist to work on a research project at the Oxford Parkinson's Disease Centre (OPDC) to functionally identify new genes underlying Parkinson’s disease. This is an exciting opportunity to support CRISPRi functional screening in induced pluripotent stem cell (iPSC)-derived dopamine neurons. This project will undertake functional analysis of GWAS loci to identify new genes underlying the cellular pathology of Parkinson’s, focused on the endolysosomal system to better understand the molecular mechanisms of the disease. Duties include differentiation and analysis of iPSC-derived neurons and cell lines; use of CRISPRi technology; high-content imaging analysis; design and implementation of experiments; interpretation of data; preparation of data for publication; contributions to wider project planning and determine the most appropriate methodologies to test hypotheses as well as performing general laboratory management. You will have excellent practical experience of working with cell cultures, preferably using iPSC models or neurons, and knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a BSc or MSc in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes. The fixed-term post is available from September 1st 2023 until January 31st 2025. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT. Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk). Closing date for applications is **midday on Tuesday 27 June 2023.** Interviews are likely to be held the **week beginning 03 July 2023**. Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion. """ . "a un site"@fr . "HR Team" . "Standard Grade 6: £31,502 - £37,386" . "2023-06-27T12:00:00+01:00"^^ . . . . . . . _:N4579afc32f5543269bd52cf14e4876eb "Oxford" . . . . . _:N8272771d10e14cb0b6aae86181e41492 "off Parks Road" . "2023-05-23T12:00:00+01:00"^^ . . . . _:Nf099bb0d550647918b403b537ab0ceb8 . "preferred label"@en . "false"^^ . _:N8272771d10e14cb0b6aae86181e41492 "United Kingdom" . . _:N6de77d59d7be4074b3f105191dd5c75f . . . """**Laboratory Technician in Cell Biology and Genetics** **Regulation and activities of amyloidogenic APP and TGFBI in physiological and pathological protein aggregation** Full-time/Fixed Term until 31 March 2025 (in the first instance) Applications are invited for a Laboratory Technician position to work on a project to determine the mechanisms regulating protein aggregation and amyloidogenesis, using a new live-cell model developed in the fruit fly, _Drosophila melanogaster_. Amyloid accumulation is associated with several major human diseases, most notably neurodegenerative disorders. The post- holder will join Professor Clive Wilson’s group, which has recently shown that homologues of two human proteins implicated in pathological amyloidogenesis, Amyloid Precursor Protein (APP; Alzheimer’s Disease) and Transforming Growth Factor-Beta-Induced (TGFBI; corneal dystrophies) have normal roles in protein aggregation. They will support research to understand how normal protein aggregation is controlled and how it differs from pathological amyloid formation, and undertake experiments to find new genes controlling these two processes. Duties of the role include assisting with planning and undertaking experiments, processing samples and specimens and writing up experimental results. The post-holder will ensure smooth day-to-day running of the laboratory, assist with fly stock maintenance, and maintain databases of equipment, consumables and/or fly stocks. They will assist with inductions and be a point of reference for less experienced team members. To apply, they must have laboratory experience, knowledge of safety regulations and an enthusiasm for research. They must also be educated to at least A-level or equivalent qualification in science, and have good interpersonal and communication skills. The post is available from 1 September 2023. It is jointly funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC), and will be based in The Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Rd, Oxford OX1 3PT. Informal enquiries may be directed to the DPAG HR Team (hr@dpag.ox.ac.uk) or to Professor Clive Wilson (clive.wilson@dpag.ox.ac.uk). Closing date for applications is **midday on Monday 12 June.** Interviews are likely to be held **in the week beginning 26 June**. Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. While this is a full-time role, we welcome applications from individuals who seek flexible working arrangements. We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion """ . "Standard Grade 6: £31,502 - £37,386 per annum" . . . "01865282167" . "Job Description" . . . . . . . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021 and 2022 Job description and Selection Criteria Job title Research Assistant (Neuronal cell and molecular biologist: “High-capacity genomic DNA expression vectors for therapeutic gene delivery in Parkinson’s disease”) Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford Grade and salary Grade 6: £31,502 - £37,386 per annum Hours Full time Contract type Fixed-term for 3 years Reporting to Professor Richard Wade-Martins Vacancy reference (AV23023) HRIS: 165696 Additional information This Grade 6 post is available immediately as part of a collaborative project with Kaleibe Therapeutics and Replay: https://replay.bio Research topic High-capacity genomic DNA expression vectors for therapeutic gene delivery in Parkinson’s disease Principal Investigator / supervisor Professor Richard Wade-Martins Project team Project web site Funding partner The Research Assistant will become part of the Laboratory of Molecular Neurodegeneration, a highly active research group consisting of approximately thirty research scientists, comprising a mix of Research Fellows, Post-Doctoral scientists, DPhil students and Research Assistants. Group members come from a mix of scientific and medical backgrounds, creating an exciting environment for research. The project will develop novel high-capacity therapeutic viral gene therapy vectors for Parkinson’s using patient iPSC-derived dopamine neurons. www.opdc.ox.ac.uk https://www.dpag.ox.ac.uk/research/wade-martins-group The funds supporting this research project are provided by Kaleibe Therapeutics and Replay: https://replay.bio Recent publications Technical skills Wade-Martins, R., Smith, E.R., Tyminski, E., Chiocca, E.A. and Saeki, Y. (2001) An infectious transfer and expression system for genomic DNA loci in human and mouse cells. Nature Biotechnology 19: 1067-1070. Wade-Martins, R., White, R.E., Kimura, H., Cook, P. and James, M.R. (2000) Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene. Nature Biotechnology 18: 1311-1314. Peruzzi, P.P. Lawler, S., Senior, S.L., Dmitrieva, N., Edser, P.A.H., Gianni, D., Chiocca, E.A. and Wade-Martins, R. (2009) Physiological gene regulation and functional complementation of a neurological disease gene deficiency in neurons Molecular Therapy 17(9):1517-26. Malpartida AB, Williamson M, Narendra DP, Wade-Martins R and Ryan BJ. (2020) Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy. Trends Biochem Sci. 46:329-343. Lang C, Campbell K, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C and WadeMartins R (2019) Single cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes. Cell Stem Cell 24:93-106. Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA and Wade-Martins R (2019) Cellular αsynuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons. Human Molecular Genetics 28:2001-2013. Fernandes HJR, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA and Wade-Martins R (2016) ER stress and autophagic perturbations lead to elevated extracellular α-synuclein in GBA-N370S Parkinson's iPSCderived dopamine neurons. Stem Cell Reports 6(3):342-56.  Design, construction, packaging and delivery of HSV1 viral gene expression vectors in Parkinson’s neuronal models in vitro  Differentiation of human iPSC lines into dopamine neurons  Analysis of neuronal phenotypes in Parkinson’s cellular models by molecular and cell biology and cell imaging The role Supervisors: Prof Richard Wade-Martins (DPAG) The project will design, construct and deliver high-capacity genomic DNA herpes simplex virus type 1 (HSV1) gene expression vectors carrying wild-type versions of familial Parkinson’s disease genes to patient iPSCderived dopamine neurons to test for therapeutic correction in vitro. High-capacity HSV1 vectors have many advantages for delivery and expression of neurological disease genes. The delivery of the whole genomic DNA locus of a gene provides the context for expression comparable to that from the endogenous site of the same gene. This is due to the presence of all the regulatory regions, including introns and noncoding flanking DNA, which ensures the right chromatin conformation of the locus is achieved and allows expression to be regulated at physiological levels and with tissue and time specificity. HSV1 vectors expressing genomic loci of interest will be delivered to iPSC-derived cellular models of Parkinson’s for therapeutic correction of cellular phenotypes and restore neuronal function. This is an exciting opportunity to contribute to the discovery of a novel therapeutic approach for Parkinson’s, developing new biological therapies at the interface between academic research and industry. Kaleibe 2 Therapeutics is a new company with Professor Wade-Martins as a scientific co-founder launched by the genome writing company Replay (https://replay.bio) to develop gene therapy disease-modifying therapeutics to restore neuronal function in Parkinson’s disease. The work will undertake cutting edge academic research in neuronal cell biology with a focus on translating biological findings into novel therapies. The successful candidate will be based at the Department of Physiology, Anatomy and Genetics, and the Kavli Institute for Nanoscience Discovery in the New Biochemistry Building on South Parks Road in the Laboratory of Molecular Neurodegeneration headed by Professor Wade-Martins. Responsibilities The post-holder will undertake:  Design and construction of DNA plasmid vectors for gene expression  Packaging and delivery of high-capacity HSV1 viral vectors to Parkinson’s iPSC-derived dopamine neurons in vitro  Apply cellular and molecular biology techniques and imaging to assay neuronal phenotypes in iPSC-derived neurons from Parkinson’s patients  Undertake maintenance culture and neuronal differentiation of iPSC lines and differentiation into dopamine neurons  Contribute to wider project planning, including ideas for new research projects  Determine the most appropriate methodologies to test hypotheses, and identify suitable alternatives if technical problems arise  Select, follow, and adapt experimental protocols  Gather, analyse, and present scientific data from a variety of sources  Contribute to scientific reports and journal articles and the presentation of data/papers at conferences  Manage own research and administrative activities, within guidelines provided by senior colleagues  Collaborate effectively with other team members to achieve collective goals Other Duties  Participate in a regular Annual Review;  Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training;  Comply with Health and safety regulations;  Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff;  Any other duties that may be required from time to time commensurate with the grade of the job. This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Selection criteria Essential      Hold or be near to completion of BSc or MSc degree in neuroscience or cell/molecular biology or equivalent. Experience in DNA plasmid cloning to generate gene expression vectors Experience in neuronal/glial cell culture, preferably in primary rodent cultures and/or human pluripotent stem cells Experience in setting up cellular assays: molecular and cell biology and imaging. The candidate will be highly motivated, with the capacity to think creatively and work across teams 3  Commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work Desirable  Experience in design, construction, packaging and delivery of viral vectors  Knowledge of neurodegenerative diseases, such as Parkinson’s  Knowledge of herpes simplex virus type 1 (HSV1) vector systems Hazard-specific / Safety-critical duties This job includes the following hazard-specific or safety-critical duties which will require successful preemployment health screening through our Occupational Health Department before the successful candidate will be allowed to start work:  Lone Working  Regular manual handling  Work with allergens, e.g. laboratory animals, pollen, dust, fish or insects etc.  Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks This job will require additional security pre-employment checks:  A satisfactory enhanced Disclosure and Barring Service check  University security screening (eg identity checks) About the University of Oxford Oxford’s departments and colleges aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. Oxford’s self-governing community of international scholars includes Professors, Associate Professors, other college tutors, senior and junior research fellows and over 2,500 other University research staff. Research at Oxford combines disciplinary depth with an increasing focus on inter-disciplinary and multi-disciplinary activities addressing a rich and diverse range of issues. Oxford’s strengths lie both in empowering individuals and teams to address fundamental questions of global significance, and in providing all staff with a welcoming and inclusive workplace that supports everyone to develop and do their best work. Recognising that diversity is a great strength, and vital for innovation and creativity, Oxford aspires to build a truly inclusive community which values and respects every individual’s unique contribution. 4 While Oxford has long traditions of scholarship, it is also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. It consistently has the highest external research income of any university in the UK (the most recent figures are available at www.ox.ac.uk/about/organisation/finance-and-funding), and is ranked first in the UK for university spinouts, with more than 130 spin-off companies created to date. Oxford is also recognised as a leading supporter of social enterprise. Oxford admits undergraduate students with the intellectual potential to benefit fully from the small group learning to which Oxford is deeply committed. Meeting in small groups with their tutor, undergraduates are exposed to rigorous scholarly challenge and learn to develop their critical thinking, their ability to articulate their views with clarity, and their personal and intellectual confidence. They receive a high level of personal attention from leading academics. Oxford has a strong postgraduate student body which now numbers over 10,000. Postgraduates are attracted to Oxford by the international standing of the faculty, by the rigorous intellectual training on offer, by the excellent research and laboratory facilities available, and by the resources of the museums and libraries, including one of the world’s greatest libraries, the Bodleian. For more information please visit www.ox.ac.uk/about/organisation The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk 5 The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past three years. Please see annual report file:///C:/Users/dpaterson/Downloads/202122DPAGAnnualReportweb.pdf Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are four named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), and the Krebs Chair in Physiological Metabolism (vacant). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. 6 Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk The Kavli Institute for Nanoscience Discovery (Kavli INsD) “Where the physical sciences are brought into the cell” Leading scientific discovery into the most basic unit of life - the cell - the Kavli Institute for Nanoscience Discovery (Kavli INsD) is located at the heart of Oxford University’s science area and was inaugurated in March 2021. With over 30 faculty and 450 research staff and graduate students, world leading teams collaborate from multiple departments (biochemistry, cell biology, chemistry, physics, physiology, psychiatry, clinical neurosciences and engineering) to contribute to global health. By bringing multiple disciplines together under the same roof to advance scientific research the Kavli INsD creates an environment that encourages the cross-pollination of ideas and inter-disciplinary cooperation. The Institute comes together to work on global health challenges and benefits from the close proximity of the scientific departments as well as advanced imaging facilities and state-of-the-art-instrumentation. As the first Director of Kavli INsD Professor Dame Carol Robinson and the research teams are creating a culture that is both bold and respectful. The University of Oxford’s, Kavli Institute for Nanoscience Discovery is the U.S based Kavli Foundation’s 20th institute. The foundation, established in the year 2000 by Fred Kavli, has a mission “to advance science for the benefit of humanity”. Research institutes in the fields of nanoscience, astrophysics, neuroscience, and theoretical physics have been endowed by the foundation which also supports programs that strengthen the connection between science and society. Learn more at kavlifoundation.org Laboratory of Molecular Neurodegeneration The Laboratory of Molecular Neurodegeneration led by Professor Wade-Martins at the Department of Physiology, Anatomy and Genetics (DPAG) studies the molecular mechanisms of a range of human neurological diseases including Parkinson’s disease and Alzheimer’s disease with the ultimate aim of developing novel therapies. The Laboratory plays a leading role in the OPDC integrating studies in iPSC- 7 derived neuronal models of Parkinson's disease, post-mortem human brain tissue and transgenic and knockout mouse and rat models. The laboratory is equipped with an Opera Phenix high content imager with robotic automation; automated liquid handling; ECHO 550 Nanodrop dispenser with Access robotics, BMG Pherastar high-throughput plate reader; FlexStation calcium analysis; Seahorse Flux Analyser; and two electrophysiology rigs, to undertake high-throughput stem cell characterisation and high-content imaging screens for drug and target discovery. The group is a mix of Research Fellows, Post-Doctoral scientists, Research Assistants and DPhil students working to develop a range of novel small molecule and biological therapeutics for Parkinson’s. Our work is highly interdisciplinary in nature and our research program has thrived through many collaborations within DPAG and in the South Park Road science area, and through interaction with scientific and clinical colleagues across Oxford. Our laboratory is part of the Kavli Institute for Nanoscience Discovery, an exciting new interdisciplinary research building at the University of Oxford facilitating interactive collaborative opportunities across cellular, molecular and physical sciences. For more information please visit: https://www.dpag.ox.ac.uk/research/wade-martins-group Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. 8 Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. Laboratory of Molecular Neurodegeneration The Laboratory of Molecular Neurodegeneration led by Professor Wade-Martins at the Department of Physiology, Anatomy and Genetics (DPAG) studies the molecular mechanisms of a range of human neurological diseases including Parkinson’s disease and Alzheimer’s disease with the ultimate aim of developing novel therapies. The Laboratory plays a leading role in the OPDC integrating studies in iPSCderived neuronal models of Parkinson's disease, post-mortem human brain tissue and transgenic and knockout mouse and rat models. The laboratory is equipped with an Opera Phenix high content imager with robotic automation; automated liquid handling; ECHO 550 Nanodrop dispenser with Access robotics, BMG Pherastar high-throughput plate reader; FlexStation calcium analysis; Seahorse Flux Analyser; and two electrophysiology rigs, to undertake high-throughput stem cell characterisation and high-content imaging screens for drug and target discovery. The group is a mix of Research Fellows, Post-Doctoral scientists, Research Assistants and DPhil students working to develop a range of novel small molecule and biological therapeutics for Parkinson’s. Our work is highly interdisciplinary in nature and our research program has thrived through many collaborations within DPAG and in the South Park Road science area, and through interaction with scientific and clinical colleagues across Oxford. Our laboratory is part of the Kavli Institute for Nanoscience Discovery, an exciting new interdisciplinary research building at the University of Oxford facilitating interactive collaborative opportunities across cellular, molecular and physical sciences. For more information please visit: https://www.dpag.ox.ac.uk/research/wade-martins-group 9 How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of two referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Should you experience any difficulties using the online application system, and the FAQs do not answer your question, please email recruitment.support@admin.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 10 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 11 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 12 """^^ . . . . """**_Join our dynamic Human Resources team and experience an exciting journey as an HR & Payroll Assistant within our vibrant, fast-paced Department._** We're seeking a dedicated individual with exceptional organisational skills, well-developed IT skills, and the ability to communicate effectively, both orally and in writing, with a diverse audience. As a member of our team, you'll play a crucial role in delivering an efficient and professional HR service to our department. At DPAG, you'll have the opportunity to foster strong working relationships with key stakeholders across the University, such as the Payroll, Staff Immigration, and Reward teams, as well as line managers, employees, and the public, ensuring smooth collaboration and effective communication. Your ability to handle confidential information with discretion and adhere to data protection and information security guidelines will be paramount. We value attention to detail and the ability to work methodically, following and interpreting procedures accurately. The ideal candidate for this position will have previous recruitment experience in a fast-paced environment, coupled with exposure to various HR tasks. You'll receive comprehensive training in recruitment and payroll functions, gaining a thorough understanding of human resource administration. Every day will present new challenges, requiring resilience, adaptability, and strong time management skills to handle your varied workload. Reporting directly to the HR Manager and working closely with the Deputy HR Manager, you'll have the guidance and support needed to excel in your role. To apply for this position, please submit your CV and a covering letter; your covering letter should showcase how you meet each of the selection criteria for the position, providing examples of your skills and experiences throughout your employment history, education, or any career breaks you may have taken. This permanent position is available immediately. The closing date for applications is midday on Friday 23rd June. Interviews are likely to be held in the week commencing 10th July 2023. **_While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements._** **_Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford._** We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. """ . . . . . . . . . _:N8272771d10e14cb0b6aae86181e41492 . "HR team" . "dpag" . "valid through (0..1)"@en . "Unit price specification"@en . "subOrganization of"@en . . . . _:N6de77d59d7be4074b3f105191dd5c75f . """

Fixed-term, Full-time for 3 years

 

Applications are invited for a Research Assistant neuronal cell and molecular biologist to work on a new project to develop a novel gene therapy for Parkinson’s in-patient stem cell-derived neuronal models. The project in collaboration with Kaleibe Therapeutics represents an exciting opportunity to undertake translational work into biological therapeutics at the interface between academic and industrial research in an exceptional setting. This work will develop novel gene therapies for Parkinson’s by expression of complete genomic DNA transgenes from HSV1 viral vectors to correct cellular phenotypes in induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s patients.

 

Duties will include the design, generation and delivery of HSV1 gene expression vectors in cellular models of Parkinson’s to study phenotypic correction; undertaking laboratory experiments; interpretation of data; imaging analysis; maintenance and differentiation of iPSC-derived neurons and cell lines; preparation of data for publication; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of neuronal cell cultures and DNA gene expression plasmid vectors, and a good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential.

 

Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and have experience in cellular neuroscience or molecular cell biology relevant to analysis of neuronal phenotypes.

 

The post is available for three years to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford.

 

Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).

 

Closing date for applications is midday on Friday 30th June 2023.

 

Interviews are likely to be held on the week beginning 10th July 2023.

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.  

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion
"""^^ . . "2023-05-30T09:00:00+01:00"^^ . "Research Assistant" . . "Department of Physiology, Anatomy and Genetics (DPAG)" . . "2023-06-01T09:00:00+01:00"^^ . "Subject"@en . "2023-06-12T12:00:00+01:00"^^ . "Standard Grade 5: £28,131 - £33,348" . . . "extended address"@en . "university" . "HR Team" . "false"^^ . . _:N8272771d10e14cb0b6aae86181e41492 "Oxford" . . "false"^^ . _:Nf099bb0d550647918b403b537ab0ceb8 "+44-1865-270000" . . . "165726"^^ . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job description and Selection Criteria Job title Research Assistant: Functional CRISPRi screening of Parkinson’s genes in human iPSC neurons Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT Grade and salary Grade 6: £31,502 - £37,386 per annum Hours Full time Contract type Fixed-term until 31 January 2025 Reporting to Professor Richard Wade-Martins Vacancy reference (AV23022) HRIS:165716 Research topic Functional CRISPRi screening of Parkinson’s genes in human iPSC neurons Principal Investigator / supervisor Professor Richard Wade-Martins Project team Project web site The Research Assistant will become part of the Laboratory of Molecular Neurodegeneration, a highly active research group consisting of approximately thirty research scientists, comprising a mix of research fellows, post-doctoral research scientists, DPhil students and research assistants. Group members come from a mix of scientific and medical backgrounds, creating an exciting environment for research. This highly collaborative project offers an exceptional research environment to undertake research into Parkinson’s disease. The project will use CRISPRi technologies to screen for candidate genes in Parkinson’s disease using patient induced-pluripotent stem cellderived neurons. www.ox.ac.uk/ www.dpag.ox.ac.uk/opdc https://www.dpag.ox.ac.uk/research/wade-martins-group Funding partner Recent publications Technical Skills This post will work on a collaborative project funded by GSK through a functional genomics initiative with the University of Oxford. Bogetofte H, Ryan BJ, et al (2023). Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBAN370S dopamine neurons. Cell Rep. 42(3):112180. Agarwal D et al. (2020) A human single cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disorders. Nature Communications 11(1):4183. Bengoa-Vergniory N et al (2020) CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and mouse models of Parkinson’s. Nature Communications 11(1):4885. Lang C, Campbell K et al (2019) Single cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes. Cell Stem Cell 24:93-106. Zambon F et al (2019) Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons. Human Molecular Genetics 28(12):2001-2013. Connor-Robson N (2019) An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Neurobiology of Disease 127:512-526. Wallings R, Humble SW, Ward ME and Wade-Martins R (2019) Lysosomal dysfunction at the centre of Parkinson’s Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis. Trends in Neuroscience; 42(12):899-912. Sandor C et al (2017). Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson’s disease. Human Molecular Genetics, 26(3):552-566. Fernandes HJR et al (2016) ER stress and autophagic perturbations lead to elevated extracellular α-synuclein in GBA-N370S Parkinson's iPSCderived dopamine neurons. Stem Cell Reports 6(3):342-56. • Differentiation of human iPSC lines into dopamine neurons • Generation and use of CRISPRi vector systems for screening • Analysis of neuronal phenotypes • Molecular and cell biology, protein biochemistry and cell imaging The role Study background: Genome-wide association studies (GWAS) in Parkinson’s disease have made tremendous advances in the last decade with many robust and highly reproducible associated regions. The latest metaanalysis (Nalls et al Lancet Neurology 2019) identified 90 independent genome-wide significant association signals which together explain up to 36% of the heritable risk of Parkinson’s disease. Our own recent human transcriptome analysis (Agarwal et al., 2020) has associated genetic risk for PD with dopaminergic neuron specific gene expression, with no association in astrocytes or microglia. Study design: Although the follow-up approach is often taken to focus on a single gene at the peak of the GWAS interval, that may not necessarily identify the causal variant or the relevant gene. Functional biology offers opportunities to screen through genes within GWAS regions agnostically to move from SNP to responsible gene at scale. We will undertake a functional CRISPRi screen in iPSC-derived dopamine neurons 2 to dissect Parkinson’s GWAS regions by screening ~1000 ORFs across 90 recently identified loci to identify genes focussed on those with function in the disease-relevant endolysosomal pathway. Supervisor: Prof Richard Wade-Martins (DPAG) and Dr Brent Ryan This is an exciting opportunity to contribute to the identification of novel genes underlying Parkinson’s, a major age-related neurodegenerative disease, using state-of-the-art CRISPRi techniques in human stem cellderived neuronal models. The successful candidate will be based at the Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, New Biochemistry, Phase 2, Parks Road, Oxford in the Laboratory of Molecular Neurodegeneration headed by Professor Wade-Martins and will undertake cutting edge translational academic research in neuronal cell biology of neurodegenerative disease. Responsibilities              Differentiation of iPSC-derived dopamine neurons from Parkinson’s patients and controls Apply CRIPSRi techniques in iPSC-derived dopamine neurons from Parkinson’s patients and controls Undertake high-throughput biological assays of neuronal function using high content imaging and related approaches Validate potential novel Parkinson’s disease targets discovered using in depth functional assays of endolysosomal biology and disease pathology Training other group members in relevant experimental techniques General laboratory management, including stock taking and ordering laboratory reagents within defined budgets Contribute to wider project planning, including ideas for new research projects Determine the most appropriate methodologies to test hypotheses, and identify suitable alternatives if technical problems arise Select, follow, and adapt experimental protocols Gather, analyse, and present scientific data from a variety of sources Contribute to scientific reports and journal articles and the presentation of data/papers at conferences Manage own research and administrative activities, within guidelines provided by senior colleagues Collaborate effectively with other team members to achieve collective goals Other Duties  Participate in a regular Annual Review;  Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training;  Comply with Health and safety regulations;  Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff;  Any other duties that may be required from time to time commensurate with the grade of the job. This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Selection criteria Essential selection criteria   Hold, or be near to completion of BSc or MSc degree in molecular biology, neuroscience, cell biology, genetics, biochemistry or a related biological discipline Experience in cell culture, preferably in neuronal cell culture or human induced pluripotent stem cell (iPSC)-derived models 3    Experience in molecular and cell biology, protein biochemistry and running cellular assays Must have excellent IT skills including word-processing and spreadsheet or scientific graphic packages Commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work Desirable selection criteria     Knowledge of neurodegenerative diseases, such as Parkinson’s or related disorders Knowledge of the endolysosomal system in health and disease Knowledge of CRISPRi technology Experience of plasmid manipulation, vector generation, viral packaging and transduction Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:  Lone Working  Regular manual handling  Work with allergens, Eg laboratory animals, pollen, dust, fish or insects etc.  Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks:  A satisfactory enhanced Disclosure and Barring Service check  University security screening (eg identity checks) The Oxford Parkinson's Disease Centre The Oxford Parkinson's Disease Centre (OPDC; www.opdc.ox.ac.uk) headed by Professor Wade-Martins is an international research Centre for Parkinson's disease established in February 2010. We have exploited a unique interdisciplinary research environment bringing together scientists and clinicians to create a centre of excellence focused on understanding the earliest pathological pathways in PD. Internationally-recognised scientists with strengths in stem cell models, genetics and genomics, transgenic rodent models, the structure and function of brain cells and circuits affected in PD, magnetic resonance imaging (MRI), and analysis of protein biomarkers, are working closely with experts in epidemiology and clinical neurology to better understand the causes of PD. 4 The first phase of our translational program focused on understanding the molecular pathways to Parkinson's. We have built a new multi-disciplinary research program across the translational space comprising the OPDC Discovery Cohort as one of the best-characterised clinical PD cohorts in the world, a new program in Parkinson's fMRI and laboratory biomarkers, a core expertise in molecular genetics and molecular neuropathology, the largest induced pluripotent stem-cell (iPSC) research program in PD in Europe, and a world-leading research hub for the generation and deep-phenotyping of transgenic rodent models of PD. The current phase of our translational research is aimed at changing clinical practice. Our new program now targets the molecular pathways to Parkinson's exploiting new tools (i) to stratify the progression of PD; (ii) to predict the onset of PD; (iii) to identify potential targets through generating mechanism-based rationale; and (iv) to validate new disease-modifying treatments to prevent the development of PD. For more information please visit: www.dpag.ox.ac.uk/opdc Laboratory of Molecular Neurodegeneration The Laboratory of Molecular Neurodegeneration led by Professor Wade-Martins at the Department of Physiology, Anatomy and Genetics (DPAG) studies the molecular mechanisms of a range of human neurological diseases with the ultimate aim of developing novel therapies. The Laboratory plays a leading role in the OPDC integrating studies in post-mortem human brain tissue, transgenic and knock-out mouse and rat models, and iPSC-derived neuronal models of Parkinson's disease. Our work is highly interdisciplinary in nature and our research program has thrived through many collaborations within DPAG and in the South Park Road science area, and through interaction with scientific and clinical colleagues across Oxford. Our laboratory is part of the Kavli Institute for Nanoscience Discovery, an exciting new interdisciplinary research building at the University of Oxford facilitating interactive collaborative opportunities across cellular, molecular and physical sciences. For further information on our work, see: https://www.dpag.ox.ac.uk/research/wade-martins-group About the University of Oxford Oxford’s departments and colleges aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. Oxford’s self-governing community of international scholars includes Professors, Associate Professors, other college tutors, senior and junior research fellows and over 2,500 other University research staff. Research at Oxford combines disciplinary depth with an increasing focus on inter-disciplinary and multi-disciplinary activities addressing a rich and diverse range of issues. Oxford’s strengths lie both in empowering individuals and teams to address fundamental questions of global significance, and in providing all staff with a welcoming and inclusive workplace that supports everyone to develop and do their best work. Recognising that diversity is a great strength, and vital for innovation and creativity, Oxford aspires to build a truly inclusive community which values and respects every individual’s unique contribution. While Oxford has long traditions of scholarship, it is also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. It consistently has the highest external research income of any university in the UK (the most recent figures are available at 5 www.ox.ac.uk/about/organisation/finance-and-funding), and is ranked first in the UK for university spinouts, with more than 130 spin-off companies created to date. Oxford is also recognised as a leading supporter of social enterprise. Oxford admits undergraduate students with the intellectual potential to benefit fully from the small group learning to which Oxford is deeply committed. Meeting in small groups with their tutor, undergraduates are exposed to rigorous scholarly challenge and learn to develop their critical thinking, their ability to articulate their views with clarity, and their personal and intellectual confidence. They receive a high level of personal attention from leading academics. Oxford has a strong postgraduate student body which now numbers over 10,000. Postgraduates are attracted to Oxford by the international standing of the faculty, by the rigorous intellectual training on offer, by the excellent research and laboratory facilities available, and by the resources of the museums and libraries, including one of the world’s greatest libraries, the Bodleian. For more information please visit www.ox.ac.uk/about/organisation The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk 6 The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022, 2023. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past three years. Please see annual report file:///C:/Users/dpaterson/Downloads/202122DPAGAnnualReportweb.pdf Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are five named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), the Krebs Chair in Physiological Metabolism (vacant) and the John Black Professor of Bionanoscience (Professor Molly Stevens, FREng, FRS). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. 7 Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk The Kavli Institute for Nanoscience Discovery (Kavli INsD) “Where the physical sciences are brought into the cell” Leading scientific discovery into the most basic unit of life - the cell - the Kavli Institute for Nanoscience Discovery (Kavli INsD) is located at the heart of Oxford University’s science area and was inaugurated in March 2021. With over 30 faculty and 450 research staff and graduate students, world leading teams collaborate from multiple departments (biochemistry, cell biology, chemistry, physics, physiology, psychiatry, clinical neurosciences and engineering) to contribute to global health. By bringing multiple disciplines together under the same roof to advance scientific research the Kavli INsD creates an environment that encourages the cross-pollination of ideas and inter-disciplinary cooperation. The Institute comes together to work on global health challenges and benefits from the close proximity of the scientific departments as well as advanced imaging facilities and state-of-the-art-instrumentation. As the first Director of Kavli INsD Professor Dame Carol Robinson and the research teams are creating a culture that is both bold and respectful. The University of Oxford’s, Kavli Institute for Nanoscience Discovery is the U.S based Kavli Foundation’s 20th institute. The foundation, established in the year 2000 by Fred Kavli, has a mission “to advance science for the benefit of humanity”. Research institutes in the fields of nanoscience, astrophysics, neuroscience, and theoretical physics have been endowed by the foundation which also supports programs that strengthen the connection between science and society. Learn more at kavlifoundation.org 8 Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. 9 To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of two referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Should you experience any difficulties using the online application system, and the FAQs do not answer your question, please email recruitment.support@admin.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. 10 Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 11 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 12 """^^ . "2023-06-30T12:00:00+01:00"^^ . . . "165696"^^ . . . . . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job description and Selection Criteria Job title Laboratory Technician Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Sherrington Building Parks Road, Oxford, OX1 3PT Grade and salary Grade 5: £28,131 - £33,348 per annum Hours Full time Contract type Fixed-term until 31/03/2025 Reporting to Professor Clive Wilson Vacancy reference (AV23018) HRIS: 165249 Additional information While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. Research topic Regulation and activities of amyloidogenic APP and TGFBI in physiological and pathological protein aggregation Principal Investigator / supervisor Professor Clive Wilson Project team Wilson Group Project web site https://www.dpag.ox.ac.uk/research/wilson-group Funding partner Recent publications The funds supporting this research project are provided by Biotechnology and Biological Sciences Research Council (BBSRC) 1. Redhai S, et al. (2016) Regulation of dense-core granule replenishment by autocrine BMP signalling in Drosophila secondary cells. PLoS Genet. 12:e1006366. 2. Selkoe DJ, Hardy J. (2016) The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 8:595-608.. 3. Han KE, et al. (2016) Pathogenesis and treatments of TGFBI corneal dystrophies. Prog Retin Eye Res. 50:67-88. The role The individual appointed will work on a project focused on using genetic approaches in the fruit fly, Drosophila melanogaster, to work out how processes in which proteins assemble into large aggregates are controlled and how these processes might be blocked. Such aggregation events are observed normally in certain cell types, but are also seen in several neurodegenerative disorders, such as Alzheimer’s Disease and Parkinson’s Disease, where they are involved in degeneration. This position is linked to a UK Research and Innovation- (UKRI-) funded project grant, primarily supported by the Biotechnology and Biological Sciences Research Council (BBSRC), but also with Medical Research Council (MRC) input. The appointee will report to Professor Clive Wilson, as Principal Investigator, and will join a team of researchers studying the mechanisms by which cells package and secrete complex signals to regulate cell-cell communication events. The Wilson group has characterised a cell model in flies, the secondary cell of the male accessory gland, in which signals are packaged into extremely large storage granules, called dense-core granules, through rapid aggregation, and these granules then dissipate when released into the lumen of the gland1. Recently, in unpublished work, they have shown that this aggregation process is controlled by the homologues of two human proteins that are involved in protein aggregation diseases, the Amyloid Precursor Protein (APP; Alzheimer’s Disease)2 and Transforming Growth Factor-Beta-Induced (TGFBI; corneal dystrophy)3. These diseases are characterised by pathological protein assembly into insoluble material called amyloid. Expressing the human amyloid-inducing alleles in secondary cells blocks normal aggregation. In the project, the successful applicant will play an important role in searching for genes that differentially affect normal and pathological protein aggregation in these cells, because this should highlight new ways of treating amyloid diseases. The appointee will be a member of our research team, have previous laboratory experience, and will provide research, technical and administrative support to ensure progression and smooth running of the project. In addition to playing roles in maintaining the flies that are housed in the laboratory and ensuring that the project’s objectives are fulfilled, they will work closely with a postdoctoral researcher employed on the same grant and undertake a specific genetic screen, involving fly genetics, microdissection and imaging to identify new regulators of the protein aggregation process. The genes identified will subsequently be studied in other model systems through translational collaborations with colleagues in Oxford and beyond. The advertised position therefore provides an excellent opportunity for further career development and exposure to multidisciplinary research focused on the study of a major biomedical question using a range of different experimental systems. The post-holder, who will be located in the Department of Physiology, Anatomy and Genetics, will work with other researchers who have strong interests in driving Drosophila studies towards clinical applications. They will also be expected to provide guidance and training to less experienced members of the research team. Responsibilities          Assist with planning experiments, undertake specific genetic experiments associated with the project, and support other project-related studies; Process samples and specimens, monitor results to spot discrepancies and propose refinements and re-run experiments where necessary Write up experimental results which would occasionally contribute to sections (text, methodology, tables, figures) of publications; Attend and participate in relevant meetings; Maintain part of the Drosophila stock collection in the group, receive new stocks arriving in the laboratory and oversee the distribution of fly stocks within the group and externally; When required, make fly food and produce vials and bottles for fly husbandry and experiments; Be responsible for managing scientific processes in the group and maintaining quality control; Write and review basic operating procedures; Maintain databases of equipment, lab consumables and/or fly stocks, run reports and interpret results; 2       Ensure the smooth day-to-day running of the laboratory, e.g. by ensuring equipment is functioning, and monitoring and ordering stock as necessary; Liaise with providers and assist in arranging service contracts; Contribute to the general cleanliness and upkeep of the laboratory space and the maintenance of laboratory equipment; Assist with inductions and training of colleagues or students; Provide a point of reference for less experienced team members; Keep up to date with and advise on matters relating to Good Laboratory Practice (GLP), Health and Safety, COSHH sheets and other regulations relevant to the post. Other Duties  Participate in a regular Annual Review;  Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training;  Comply with Health and safety regulations;  Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff;  Any other duties that may be required from time to time commensurate with the grade of the job. This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Selection criteria Essential         Experience of working in a laboratory environment and with hazardous chemicals; Enthusiasm about research and interest in participating in experiments with ability to organise own work load and take initiative as appropriate; Educated to at least A-level or equivalent qualification in science; Strong attention to detail, with the ability to organise samples and record results in a clear and organised fashion, and to troubleshoot problems with experiments and arrive at an appropriate solution Very good organisational, verbal and interpersonal skills; IT skills including a knowledge of Word, Excel (i.e. data basing) and PowerPoint programmes; Knowledge of health and safety regulations in a laboratory environment; Commitment to engaging with, and being receptive to, equality, diversity and inclusion in the workplace Desirable  Experience working with Drosophila;  A BSc or equivalent qualification in science;  Supervisory experience Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:  Lone Working  Work with allergens, Eg Drosophila melanogaster (fruit flies) 3 Additional security pre-employment checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks This job includes duties that will require additional security pre-employment checks:  A satisfactory enhanced Disclosure and Barring Service check  University security screening (eg identity checks) About the University of Oxford Oxford’s departments and colleges aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. Oxford’s self-governing community of international scholars includes Professors, Associate Professors, other college tutors, senior and junior research fellows and over 2,500 other University research staff. Research at Oxford combines disciplinary depth with an increasing focus on inter-disciplinary and multi-disciplinary activities addressing a rich and diverse range of issues. Oxford’s strengths lie both in empowering individuals and teams to address fundamental questions of global significance, and in providing all staff with a welcoming and inclusive workplace that supports everyone to develop and do their best work. Recognising that diversity is a great strength, and vital for innovation and creativity, Oxford aspires to build a truly inclusive community which values and respects every individual’s unique contribution. While Oxford has long traditions of scholarship, it is also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. It consistently has the highest external research income of any university in the UK (the most recent figures are available at www.ox.ac.uk/about/organisation/finance-and-funding), and is ranked first in the UK for university spinouts, with more than 130 spin-off companies created to date. Oxford is also recognised as a leading supporter of social enterprise. Oxford admits undergraduate students with the intellectual potential to benefit fully from the small group learning to which Oxford is deeply committed. Meeting in small groups with their tutor, undergraduates are exposed to rigorous scholarly challenge and learn to develop their critical thinking, their ability to articulate their views with clarity, and their personal and intellectual confidence. They receive a high level of personal attention from leading academics. Oxford has a strong postgraduate student body which now numbers over 10,000. Postgraduates are attracted to Oxford by the international standing of the faculty, by the rigorous intellectual training on offer, by the excellent research and laboratory facilities available, and by the resources of the museums and libraries, including one of the world’s greatest libraries, the Bodleian. For more information please visit www.ox.ac.uk/about/organisation 4 The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022, 2023. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked 5 number one in the QS World University Rankings for the past three years. Please see annual report file:///C:/Users/dpaterson/Downloads/202122DPAGAnnualReportweb.pdf Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are five named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), the Krebs Chair in Physiological Metabolism (vacant) and the John Black Professor of Bionanoscience (Professor Molly Stevens, FREng, FRS). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. 6 Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. 7 How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of two referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Should you experience any difficulties using the online application system, and the FAQs do not answer your question, please email recruitment.support@admin.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, 8 please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 9 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 10 """^^ . "postal code"@en . "2023-05-31T12:00:00+01:00"^^ . . . "Tinsley Building" . . . "OUCS code" . _:N1d6324b0c536402ba5122ad1d18c6d11 . . . . "Oxford, University of" . "Address"@en . _:N4579afc32f5543269bd52cf14e4876eb "University of Oxford" . """**Research Assistant: Transgenic models of Parkinson’s disease** **Fixed-term for 3 years** Applications are invited for a Research Assistant to work on a highly collaborative and interdisciplinary project to develop transgenic rodent models of Parkinson’s disease. The work will support projects seeking to use rodent models of disease to understand the earliest stage of neurodegeneration at a point in which neuronal dysfunction precedes neuronal loss, offering an early therapeutic window for therapy. The post will be based in the Laboratory of Molecular Neurodegeneration in the Department of Physiology, Anatomy and Genetics, and is supported by an international consortium funded by an Aligning Science Across Parkinson’s (ASAP) grant, and by the Wellcome Trust. Duties include colony management, breeding and maintenance of lines of transgenic rodents; collection of brain tissue for gene expression analysis; general laboratory management, preparation of data for publication; contributions to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have a good working knowledge of molecular and cellular biology, excellent practical experience of working with animal models and an interest in pre-clinical _in vivo_ models of neurological disease. Previous experience of the management and maintenance of transgenic rodent lines would be an advantage. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and will have excellent practical experience of working with animal models. The fixed-term post is available immediately for 3 years. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT. Informal enquiries may be directed to Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk). Closing date for applications is **midday on Monday 19th June** **2023.** Interviews are likely to be **held in the week commencing 26th June 2023**. Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion. """ . """

Join our dynamic Human Resources team and experience an exciting journey as an HR & Payroll Assistant within our vibrant, fast-paced Department.

 

We're seeking a dedicated individual with exceptional organisational skills, well-developed IT skills, and the ability to communicate effectively, both orally and in writing, with a diverse audience. As a member of our team, you'll play a crucial role in delivering an efficient and professional HR service to our department.

 

At DPAG, you'll have the opportunity to foster strong working relationships with key stakeholders across the University, such as the Payroll, Staff Immigration, and Reward teams, as well as line managers, employees, and the public, ensuring smooth collaboration and effective communication. Your ability to handle confidential information with discretion and adhere to data protection and information security guidelines will be paramount. We value attention to detail and the ability to work methodically, following and interpreting procedures accurately.

 

The ideal candidate for this position will have previous recruitment experience in a fast-paced environment, coupled with exposure to various HR tasks. You'll receive comprehensive training in recruitment and payroll functions, gaining a thorough understanding of human resource administration. Every day will present new challenges, requiring resilience, adaptability, and strong time management skills to handle your varied workload. Reporting directly to the HR Manager and working closely with the Deputy HR Manager, you'll have the guidance and support needed to excel in your role.

 

To apply for this position, please submit your CV and a covering letter; your covering letter should showcase how you meet each of the selection criteria for the position, providing examples of your skills and experiences throughout your employment history, education, or any career breaks you may have taken.

 

This permanent position is available immediately. The closing date for applications is midday on Friday 23rd June. Interviews are likely to be held in the week commencing 10th July 2023.

 

While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally.
"""^^ . . "HR & Payroll Assistant JD" . . _:N4579afc32f5543269bd52cf14e4876eb "Wellington Square" . _:N6de77d59d7be4074b3f105191dd5c75f . "finance code" . . . "Deputy HR Manager (maternity cover)" . """

Full-time, Fixed term until 31 January 2025

 

Applications are invited for a Research Assistant neuronal cell biologist to work on a research project at the Oxford Parkinson's Disease Centre (OPDC) to functionally identify new genes underlying Parkinson’s disease.

 

This is an exciting opportunity to support CRISPRi functional screening in induced pluripotent stem cell (iPSC)-derived dopamine neurons. This project will undertake functional analysis of GWAS loci to identify new genes underlying the cellular pathology of Parkinson’s, focused on the endolysosomal system to better understand the molecular mechanisms of the disease. 

 

Duties include differentiation and analysis of iPSC-derived neurons and cell lines; use of CRISPRi technology; high-content imaging analysis; design and implementation of experiments; interpretation of data; preparation of data for publication; contributions to wider project planning and determine the most appropriate methodologies to test hypotheses as well as performing general laboratory management.

 

You will have excellent practical experience of working with cell cultures, preferably using iPSC models or neurons, and knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a BSc or MSc in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes.

 

The fixed-term post is available from September 1st 2023 until January 31st 2025. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT. Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk). 

 

Closing date for applications is midday on Tuesday 27 June 2023. 

 

Interviews are likely to be held the week beginning 03 July 2023.  

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion.
"""^^ . . "Is Part Of"@en . . "Department of Physiology, Anatomy & Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT" . _:N4579afc32f5543269bd52cf14e4876eb "OX1 2JD" . . . "OxPoints"@en . . "HR Team" . "false"^^ . """

Laboratory Technician in Cell Biology and Genetics

Regulation and activities of amyloidogenic APP and TGFBI in physiological and pathological protein aggregation

 

Full-time/Fixed Term until 31 March 2025 (in the first instance)

 

Applications are invited for a Laboratory Technician position to work on a project to determine the mechanisms regulating protein aggregation and amyloidogenesis, using a new live-cell model developed in the fruit fly, Drosophila melanogaster. Amyloid accumulation is associated with several major human diseases, most notably neurodegenerative disorders. The post-holder will join Professor Clive Wilson’s group, which has recently shown that homologues of two human proteins implicated in pathological amyloidogenesis, Amyloid Precursor Protein (APP; Alzheimer’s Disease) and Transforming Growth Factor-Beta-Induced (TGFBI; corneal dystrophies) have normal roles in protein aggregation. They will support research to understand how normal protein aggregation is controlled and how it differs from pathological amyloid formation, and undertake experiments to find new genes controlling these two processes.

 

Duties of the role include assisting with planning and undertaking experiments, processing samples and specimens and writing up experimental results. The post-holder will ensure smooth day-to-day running of the laboratory, assist with fly stock maintenance, and maintain databases of equipment, consumables and/or fly stocks. They will assist with inductions and be a point of reference for less experienced team members.

 

To apply, they must have laboratory experience, knowledge of safety regulations and an enthusiasm for research. They must also be educated to at least A-level or equivalent qualification in science, and have good interpersonal and communication skills.

 

The post is available from 1 September 2023. It is jointly funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC), and will be based in The Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Rd, Oxford OX1 3PT.

 

Informal enquiries may be directed to the DPAG HR Team (hr@dpag.ox.ac.uk) or to Professor Clive Wilson (clive.wilson@dpag.ox.ac.uk).

 

Closing date for applications is midday on Monday 12 June. Interviews are likely to be held in the week beginning 26 June.

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. While this is a full-time role, we welcome applications from individuals who seek flexible working arrangements.

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion
"""^^ . . "Job Description" . "site principal"@fr . "Laboratory Technician" . . . . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job description and Selection Criteria Job title HR and Payroll Assistant Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Sherrington Building, Parks Road, Oxford Grade and salary Grade 4: £24,715 - £28,131 per annum Hours Full time Contract type Permanent Reporting to HR Manager Vacancy reference AV23024, HRIS: 165726 Additional information While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. The role This is an excellent opportunity for an HR & Payroll Assistant to join our busy Human Resources team within a complex and dynamic organisation. You will work as a member of the HR team providing an efficient and professional HR service to the Department. You will be the first point of contact for general advice on various HR policies and administrative matters, and will be responsible for managing the full recruitment life cycle, from the identification of a vacancy to the point of inducting a new employee. You will also support international recruitment and will be required to be fully conversant with the current UKBA immigration and visa regulations. Training will be provided in this complex area. You should have excellent organisational skills and well-developed IT skills, and the ability to communicate effectively with a diverse audience. You will be fully trained in the delivery of the recruitment and payroll functions, and will develop a thorough understanding of personnel administration. The actual duties you will undertake on a day-to-day basis will vary and so being able to manage your workload and time is essential. You will report directly to the HR Manager. Responsibilities Recruitment You will be responsible for the full recruitment life cycle, from the identification of the vacancy and advertising, through to preparing interview packs, issuing contracts for a number of vacancies at any one time and inducting new employees. Working to strict deadlines, you will ensure that the recruitment process operates in a smooth and timely manner. Attention to detail is imperative at each stage of the process. • Provide advice, guidance and support to line managers throughout the recruitment process. • Liaise with line managers to prepare job descriptions, selection criterion, adverts and agree recruitment deadlines, ensuring that all key elements are included to ensure that they comply with University guidance and best practice. • Ensure that all appropriate authorities have been obtained e.g. approved protocol requests, funding approval, etc. • Advertise all vacancies on the University website. Identify and utilise social media and other options for advertising as required. • Ensure adverts are printed and saved on the first day of advertising, in line with Departmental and University guidelines. Make sure that posts that could be eligible for sponsorship, comply with the necessary advertising requirements. • Keep recruitment spreadsheets up-to-date with all related information e.g. closing and interview dates. • Collate applications for shortlisting and arrange interviews with the interview panel in a timely manner, ensuring that the Recruitment Panel members are kept up-to-date with any changes. • Communicate with candidates regarding interviews and general enquires regarding vacancies. • Meet and greet candidates and take copies of their proof of Right to Work. • Keep up-to-date with changes on Right to Work and visa legislation, checking with the HR Manager or the Staff Immigration Team as required. • Ensure that all offers are in line with funding and Personnel guidelines. • Process all pre-employment checks for new staff members, in line with recruitment and selection policies and procedures, including right to work, references, occupational health, and security checks as required and in a timely manner. • Prepare standard letters of appointment and contracts, and set-up new starters/process transfers on PeopleXD accurately and in a timely manner, following departmental and university guidelines. • Induct new starters and ensure that line managers have the relevant information and paperwork to prepare for their new starter – e.g. IT access and university cards. • Book inductions for all new starters with the Departmental Safety Officer and IT Service Desk Manager to take place within the first week. • Set-up all new starters on TeamSeer and send induction/probation information to line mangers. • Ensure travel expenses are claimed correctly and inform candidates of the University’s benefits, polices and related information. • Help prepare information for work permits applications as required. Payroll • Provide first line support regarding payroll enquiries from staff and managers, and investigate any discrepancies. • Complete all monthly payroll changes, including new starts/leavers ensuring that the correct funds are utilised, adhering to the University’s deadlines and ensuring that all changes are authorised by the Head of Administration and Finance. Liaising with the Grants Administration or Finance team as appropriate. • Produce all associated paperwork for payroll changes. • Ensure all changes to payroll have been verified and checked against monthly reports, advising of any discrepancies and chasing any queries. • File all correspondence on individual Personnel files. 2 Personnel Administration • Act as first point of contact for enquiries from employees, line managers and the general public by telephone, email and face to face, answering straightforward questions or redirecting as appropriate. • Monitor the generic HR Team email box. • Assist the HR Manager with the end of fixed-term contract (FTC) process, to include the identification of all FTCs ending on a 6-month rolling basis. Arrange for all notifications to be sent to individuals and line managers in accordance with University and departmental policies; to arrange redeployment meetings and to advise on the priority candidate process within recruitment and to produce contract changes documentation as required. • Manage the probation and annual review process, ensuring that any concerns are flagged with the HR Manager and/or the Head of Administration and Finance. To produce the appropriate letter for all staff completing probation. • Ensure accurate maintenance of all confidential personnel files that you are working on. • Manage the archiving of recruitment filing and closing of vacancies on PeopleXD upon completion. • Run regular reports on fixed term employees, probation, permission to work in the UK and other relevant data. Run ad-hoc reports as and when required. General Responsibilities • Plan your workload, carry out work in an accurate and timely manner and ensure all deadlines are met. • Read and keep up-to-date with University changes to policy and procedures, updating the team and any related paperwork/templates as necessary (e.g. HRIS changes to university job description templates). • Be willing to learn new IT, advertising and social media, or software packages and put together user guides for the team and/or staff as required. • Participate in team meetings, projects and other University wide networking opportunities. • Take responsibility for your own work load organisation in conjunction with team priorities. • Work across the team and provide support to address workload peaks, cover for staff absence to ensure consistent delivery of professional and efficient HR support. The post-holder is not an authorised signatory for personnel matters. Other Duties • Participate in a regular Annual Review; • Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training; • Comply with Health and safety regulations; • Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff; • Any other duties that may be required from time to time commensurate with the grade of the job. This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Essential selection criteria • • Educated to GCSE (grade A-C) level English and Maths, or equivalent. Good customer care skills, including the ability to communicate professionally, confidently, tactfully, and effectively to a high standard with people at all levels both in writing and veritably and to deliver excellent service. 3 • • • • • • • • • • • Excellent organisational skills and the ability to use initiative to prioritise a busy workload and meet deadlines, while maintaining a high degree of accuracy and attention to detail. Ability to foster excellent working relationships with key individuals and departments across the University (e.g. Payroll, Staff Immigration Team, Reward team) line managers, employee and the public. Good attention to detail and ability to follow and interpret standard procedures and sources accurately. Ability to work effectively both independently and as a member of a team. The ability to handle confidential material appropriately, together with an awareness of data protection and information security guidelines. Able to demonstrate good numeracy skills. Proven IT skills with experience of working with databases (ideally PeopleXD) and entering data accurately. Demonstrable ability to prioritise workload and produce accurate, detailed work within deadlines. Experience of working in a personnel/recruitment environment. Ability to work independently and as part of a team. Commitment to engaging with, and being receptive to, equality, diversity and inclusion in the workplace. Desirable selection criteria • • • Previous experience of using the PeopleXD database. Have, or would be interested in, pursuing CIPD qualifications. Knowledge of current UKBA immigration and visa regulations, would be advantageous. However, full training will be provided. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory basic Disclosure and Barring Service check. About the University of Oxford Oxford’s departments and colleges aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. 4 Oxford’s self-governing community of international scholars includes Professors, Associate Professors, other college tutors, senior and junior research fellows and over 2,500 other University research staff. Research at Oxford combines disciplinary depth with an increasing focus on inter-disciplinary and multi-disciplinary activities addressing a rich and diverse range of issues. Oxford’s strengths lie both in empowering individuals and teams to address fundamental questions of global significance, and in providing all staff with a welcoming and inclusive workplace that supports everyone to develop and do their best work. Recognising that diversity is a great strength, and vital for innovation and creativity, Oxford aspires to build a truly inclusive community which values and respects every individual’s unique contribution. While Oxford has long traditions of scholarship, it is also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. It consistently has the highest external research income of any university in the UK (the most recent figures are available at www.ox.ac.uk/about/organisation/finance-and-funding), and is ranked first in the UK for university spinouts, with more than 130 spin-off companies created to date. Oxford is also recognised as a leading supporter of social enterprise. Oxford admits undergraduate students with the intellectual potential to benefit fully from the small group learning to which Oxford is deeply committed. Meeting in small groups with their tutor, undergraduates are exposed to rigorous scholarly challenge and learn to develop their critical thinking, their ability to articulate their views with clarity, and their personal and intellectual confidence. They receive a high level of personal attention from leading academics. Oxford has a strong postgraduate student body which now numbers over 10,000. Postgraduates are attracted to Oxford by the international standing of the faculty, by the rigorous intellectual training on offer, by the excellent research and laboratory facilities available, and by the resources of the museums and libraries, including one of the world’s greatest libraries, the Bodleian. For more information please visit www.ox.ac.uk/about/organisation The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022, 2023. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk 5 The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past three years. Please see annual report file:///C:/Users/dpaterson/Downloads/202122DPAGAnnualReportweb.pdf Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are five named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), the Krebs Chair in Physiological Metabolism (vacant) and the John Black Professor of Bionanoscience (Professor Molly Stevens, FREng, FRS). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, 6 functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG 7 The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of three referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. 8 Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Should you experience any difficulties using the online application system, and the FAQs do not answer your question, please email recruitment.support@admin.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 9 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as Universitysupported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 10 """^^ . "tiene sede en"@es . . "165249"^^ . "comment" . . . . "street address"@en . . . . "Research Assistant" . "has exact match"@en . . . . "false"^^ . . . .