. "Department of Physiology Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3QU" . . "telephone"@en . _:Nd02fdece9a7741978cd0da16e47dc181 "United Kingdom" . "locality"@en . . . "2024-04-29T12:00:00+01:00"^^ . . . . "2024-05-22T12:00:00+01:00"^^ . "subOrganization of"@en . . . "in dataset" . . . "logo" . . "preferred label"@en . . . . . . "Past vacancies at the University of Oxford" . . . . . . . "Associate Professor (Tf-University): Combined University and College salary: £52,815 - £70,918 per annum, plus substantial additional benefits including a College housing allowance of £10,420 p.a. and a research allowance of £1,800 p.a." . "value" . _:N881026a8e8754afa9719eab2b00b1c21 . . . _:N881026a8e8754afa9719eab2b00b1c21 . "172434"^^ . . . . . "Department of Physiology, Anatomy and Genetics (DPAG)" . "label" . . "primary Site"@en . . "169811 JD APTF Neuroscience" . . "Old Observatory" . "Physiology, Anatomy and Genetics" . "alternative label"@en . . """

Full-time, Fixed term for 1 year

We are seeking to appoint a motivated and forward-thinking Lab Manager to join Prof Molly Stevens’ dynamic and multidisciplinary team at the Kavli Institute for Nanoscience Discovery (www.stevensgroup.org). As Lab Technician, you will provide technical and administrative support to ensure the smooth running of Prof Molly Stevens’s lab at the Kavli Institute for Nanoscience Discovery. The Stevens Group is based at the Department of Physiology Anatomy and Genetics and is also part of the Institute of Biomedical Engineering. The role will include assisting with the daily lab organisation and management of the general lab area, assisting with the laboratory inductions for new laboratory users, placing purchase orders, preparing sample aliquots and other reagents, processing the lab inventory, and will also provide support for instrumentation maintenance and training. The lab technician will assist with the Risk Assessments and liaise with the Departmental H&S officers. The successful candidate will perform key supporting tasks toward the development of existing experimental projects. This will involve performing basic experimental procedures for example cell and tissue culture and isolation, biochemical assays, immunostaining, gene expression analysis (e.g. RNA and DNA extraction, PCR, etc.) and molecular cloning (e.g. bacterial transformation, plasmid purification, etc.). Full training will be provided but basic knowledge of biology- and chemical-based techniques and Health & Safety procedures is an advantage. The post holder will form part of the Stevens Group professional services team and they will work closely with representatives from the Departmental and Divisional professional services teams.

The post holder will have excellent communication skills and a collaborative approach to working with all staff and students. The post holder will be a confident self-starter and collaborative member of the team and will display impeccable work ethics.

 

The Role

The post is available from June 2024. This is a full-time position, initially fixed-term for 12 months in the first instance. Part-time appointments can be considered. The successful candidate will be based at the Department of Physiology Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, located at the Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3QU.

 

Next Steps

To apply for this position, please submit your application by midday on Wednesday 22nd May. Your application should include a cover letter, curriculum vitae (CV), and contact information for references.

 

Shortlisted candidates will be invited for interviews, which are likely to be held two weeks after the closing date.

 

Enquiries can be directed to the DPAG HR Team – hr@dpag.ox.ac.uk.

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.  

 

While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. 

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion
"""^^ . _:Nc087a40d3da147c7acd866c7a4941524 . "department" . . "University of Oxford" . "01865282167" . """St Hilda’s College Job Description and Selection Criteria Post Associate Professorship of Neuroscience and Tutorial Fellowship in Preclinical Medicine at St Hilda’s College Department/Faculty Department of Physiology, Anatomy and Genetics (DPAG), Parks Road, Oxford, OX1 3PT Division Medical Sciences Division College St Hilda’s College, Cowley Place, Oxford, OX4 1DY Contract type Permanent upon completion of a successful review. The review is conducted during the first 5 years. Salary Combined University and College salary: £52,815 - £70,918 per annum, plus substantial additional benefits including a College housing allowance of £10,420 p.a. and a research allowance of £1,800. An allowance of £3,078 p.a. would be made upon award of the title of Full Professor. Overview of the post The Department of Physiology, Anatomy and Genetics (DPAG), and St Hilda’s College are seeking to appoint a full-time Associate Professor of Neuroscience, to commence employment as soon as possible. This is a joint appointment: the successful candidate will be a member of DPAG as well as a Tutorial Fellow at St Hilda’s College. The role will involve undertaking independent research, undergraduate and graduate teaching, and graduate supervision. It will also encompass administrative and pastoral duties for the department and college. The department is seeking to recruit in the field of Neuroscience with a particular focus on the neurobiology of degeneration to complement existing research in the Department and across the University in the fields of Parkinson’s disease, Alzheimer’s disease and motor neuron disease. The research interests of the successful candidate will complement existing research underway at the Kavli Institute for Nanoscience Discovery (https://kavlinano.ox.ac.uk). While we do not wish to limit the candidates that we attract to a particular subject area within the field of the neurobiology of degeneration or related research, the fit of candidates to the research profile of the Department and the opportunities for such synergies will be an important selection criterion. We therefore anticipate that the new appointment will be in an area of molecular and cellular neuroscience of disease, which is the focus of several current research groups in DPAG (Wade-Martins, Cragg), in the Kavli Institute (Carlyle, Fernandes, Lang, Ryan, Salman), and in adjacent Departments (Magill, Talbot, Becker). Understanding the molecular basis of neurological and neurodegenerative diseases are currently among the major research challenges recognised by both the Medical Research Council and several major research charities (Parkinson’s UK, Alzheimer’s Research UK, Alzheimer’s Society, Motor Neuron Disease Association amongst others). The successful candidate will have a track record in attracting significant competitive peer reviewed external grants commensurate with working in a world leading department. The successful candidate will occupy high quality space within the Department, working closely with groups in the Kavli Institute. They will receive financial assistance in setting up new research activities and be encouraged to bid for University research support funds. The department has a research administration team to help in identifying and applying for grants. St Hilda’s College is a vibrant, diverse, inclusive community with a strong commitment to excellence in research and teaching, and an exceptional record of academic success. 2 Duties of the post The main duties of the post are as follows: For the Department of Physiology, Anatomy and Genetics  to engage in high level original and independent research in an area complementary to the Department’s research strategy in the neurobiology of degeneration aimed at providing mechanistic insight into brain function and disease pathophysiology;  to secure significant external funding and to engage in the supervision of research projects;  to disseminate research through publication in scholarly journals, participation in international conferences and seminars, and through other media;  to contribute to the department’s teaching of neuroscience to the pre-clinical students studying for the First BM and Final Honour School (FHS) in Medical Sciences, and of students studying for the fouryear M.Biomed.Sci programme and three-year BA in course in Human Sciences. Candidates should note that all staff are expected to be able to contribute to teaching beyond their specific area of expertise. The Department teaching load for the Associate Professor may amount to 15-20 lectures and 6-10 three-hour practical classes a year. These would include both basic teaching in first- and second-year courses, and more research-related teaching for the FHS course. The Department has a policy of reducing the teaching load for newly appointed Associate Professors, especially externally appointed candidates who are establishing a new laboratory;  to train and supervise graduate students in research;  to take part in the formal University examining of undergraduates throughout their courses (although this requirement would be reduced during the early part of the appointment);  to participate in the administration of the department as and when requested by the Head of Department, and to take an active role in departmental life. For St Hilda’s College In addition to duties relating to the Departmental side of the post, the appointee will be required to perform the College duties outlined below:        to undertake for the College six weighted hours per week of tuition per week, averaged over the three teams (24 weeks) over the academic year; to engage in advanced study and research and to contribute to the intellectual life and academic activities of the College; to share with the other Medicine Tutors responsibility for the organisation, oversight and teaching of Medicine at St Hilda’s College, which includes arranging teaching and termly college exams for undergraduate studying Medicine, monitoring students’ progress, and writing termly reports on their work; to provide pastoral care for St Hilda’s College undergraduate students reading Medicine; to take responsibility, with the other Medicine Tutors, for all student admissions to the subject, which for undergraduates will include interviewing in the December admissions period (training is required and will be provided) and involvement in outreach and recruitment activities including Open Days; to act as College Adviser to the College’s graduate students in the relevant subjects; to participate in the governance of the College, as a Trustee of the College as a Charity, which includes attendance at Governing Body meetings (three per term) and taking an appropriate share in the other committee and administrative work of the College. 3 The role of Associate Professor at Oxford Associate Professor is the main academic career grade at Oxford with a focus on research and teaching, spanning the full range of professor grades in the USA. Associate Professors are appointed jointly by a University department/faculty and an Oxford college, and you will have a contract with both. Associate Professors are full members of University departments/faculties and college governing bodies playing a role in the democratic governance of the University and their college. You will join a lively, intellectually stimulating and multi-disciplinary community which performs to the highest international levels in research and teaching, with extraordinary levels of innovation, creativity and entrepreneurship. There is considerable flexibility in the organisation of duties, with three 8-week undergraduate teaching terms and generous sabbatical leave to balance teaching and research (please see the Benefits, Terms and Conditions section for further details of sabbatical leave). There is the potential for temporary changes to the balance of duties between College and University to enable a focus on different aspects of work at different stages in your career. Oxford offers many opportunities for professional development in research and teaching. Associate Professors may apply for the title of full Professor in annual exercises. If the title is conferred, you will also have access to professorial merit pay opportunities. In exceptional cases, the title of full Professor may be awarded on appointment. Appointments are confirmed as permanent on successful completion of a review during the first five years. The vast majority of Associate Professors successfully complete this initial review. 4 Selection criteria Your application will be judged only against the criteria which are set out below. You should ensure that your application shows clearly how your skills and experience meet these criteria. The University is committed to fairness, consistency and transparency in selection decisions. Members of selection committees will be aware of the principles of equality of opportunity, fair selection and the risks of bias. There will be both female and male committee members wherever possible. If, for any reason, you have taken a career break or have had an atypical career and wish to disclose this in your application, the selection committee will take this into account, recognising that the quantity of your research may be reduced as a result. The successful candidate will demonstrate the following, taking account of the stage reached in the candidate’s career: Essential          A higher degree (DPhil/PhD) in a relevant area of research; A proven high standard of teaching, with the ability to provide excellent tutorial and small-group teaching to high-achieving undergraduate and graduate students in relevant subjects; Evidence of substantial research accomplishment and a strong publication record commensurate with working in a world leading department; Evidence of a substantial and realisable research plan, which will complement the Department’s research strategy in the neurobiology of degeneration; Independent research funding and a proven track record of success in the award of peer-reviewed research grants; Excellent interpersonal skills necessary for undertaking teaching in the tutorial context and the pastoral care of students; Ability and willingness to undertake the full range of administrative duties within the department and college; Demonstrable communication, interpersonal, time management and organisational skills necessary to undertake pastoral responsibilities, with a willingness to participate in and assist in College life and governance; Commitment to promoting awareness and understanding of equality, diversity, and inclusion, and embedding these principles among staff and students. Desirable     A record of research prizes and honours; Ability to collaborate with other researchers and to manage staff with empathy; Experience of relevant teaching of cellular neuroscience at an advanced level; Evidence of inclusive leadership through the promotion and endorsement of equality, diversity and inclusion policies, projects, and the active advancement of equality of opportunity. The University of Oxford is a proud signatory to the San Francisco Declaration on Research Assessment (DORA), which means all hiring, tenure and promotion decisions will evaluate applicants on the quality of their work, not the impact factor of the journal where it is published. 5 Further Information Queries about the post should be addressed to the Head of the Department of Physiology, Anatomy and Genetics, Professor David Paterson, david.paterson@dpag.ox.ac.uk or Professor Richard Wade-Martins, richard.wade-martins@dpag.ox.ac.uk, Professor of Molecular Neuroscience and Head of the Laboratory of Molecular Neurodegeneration in the Kavli Institute. Candidates may also contact the Senior Tutor at S Hilda’s College, Dr Sarah Norman, senior.tutor@sthildas.ox.ac.uk. All enquiries will be treated in strict confidence; they will not form part of the selection decision. Hazard-specific / Safety-critical duties This job may include the following hazards or safety-critical activities, which will require successful preemployment health screening through our Occupational Health Service before the successful candidate will be allowed to start work:  Lone Working  Working with Ionising Radiation  Working with category 3b or 4 lasers (laser safety class)  Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens  Working with blood, human products, and human tissues  Work with allergens, e.g. laboratory animals, pollen, dust, fish or insects etc.  Work with any substance which has any of the following pictograms on their MSDS:  Travel outside of Europe or North America on University business. Additional security pre-employment checks This job will require the University Enhanced Level Screening check, and additional University security preemployment checks (e.g. identity checks). 6 How to apply To apply, visit https://my.corehr.com/pls/uoxrecruit/erq_jobspec_details_form.jobspec?p_id=169811, then click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please refer to the “Terms of Use” in the left-hand menu bar for information about privacy and data protection. Please provide details of three referees and indicate whether the University may contact them now. You will also be asked to upload a CV, the completed CV Summary Form, a supporting statement (listing publications, teaching experience and research grants held) and a 1–2-page research statement. The supporting statement should explain how you meet the selection criteria for the post using examples of your skills and experience. This may include experience gained in education or employment. The University and colleges welcome applications from candidates who have a disability or long-term health condition and is committed to providing long term support. The University’s disability advisor can provide support to applicants with a disability, please see https://edu.admin.ox.ac.uk/disability-support for details. Please let us know if you need any adjustments to the recruitment process, including the provision of these documents in large print, audio or other formats. If we invite you for interviews, we will ask whether you require any particular arrangements at the interview. The University Access Guide gives details of physical access to University buildings https://www.accessguide.ox.ac.uk/. Teaching commitments are mainly concentrated into Oxford’s three 8-week undergraduate teaching terms, making it easier to balance teaching and research. There is considerable flexibility in the organisation of duties, and generous sabbatical leave. Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by 12.00 noon on the closing date stated in the online advertisement. Should you experience any difficulties using the online application system, please email recruitment.support@admin.ox.ac.uk. Further help and support is available from https://hrsystems.admin.ox.ac.uk/recruitment-support. To return to the online application at any stage, please log back in and click the “My applications” button on the left-hand side of the page Please note that you will be notified of the progress of your application by automatic emails from our erecruitment system. Please check your spam/junk mail regularly to ensure that you receive all emails. Interviews for shortlisted candidates are anticipated to be held on the 13th & 14th June 2024. All shortlisted candidates will be interviewed and will be asked to give a presentation and conduct a teaching tutorial as part of the interview. 7 The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022 and 2023. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past three years. Please see annual report file:///C:/Users/dpaterson/Downloads/202122DPAGAnnualReportweb.pdf Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are four named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), and the Krebs Chair in Physiological Metabolism (vacant). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci, FRS; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. 8 Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). Also closely associated with the Department are The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA, RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, 9 selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk About St Hilda’s College St Hilda's is one of the constituent Colleges of Oxford University, founded in 1893. The college has equal numbers of men and women students, and maintains a commitment to equality of opportunity with a diversity community at all levels of students and fellows. The College has an academic staff of over 100 Fellows and Lecturers. There are at present approximately 400 undergraduates and 240 graduate students, who study most of the subjects offered by the University. Spectacularly set in four acres of gardens on the 10 banks of the Cherwell at Magdalen Bridge, the College promotes a thriving culture of research and intellectual engagement. Weekday lunches provide a popular time for Fellows to talk to colleagues in their own and other disciplines. During term-time, College Guest Nights are pleasant occasions to which Fellows may bring guests, and at which they may meet a wide range of interesting people. They may also enjoy the amenities of the Jacqueline du Pré Music Building, and the musical events that take place there, including free term-time concerts organised by the Director of College Music. The College has a very generous group of alumnae who are donors to development projects within the College. Many of them attend various College Societies and other events, and have funded studentships and similar initiatives for students and the College. Research clusters are supported by the College’s Research Support Scheme which provides seed funding for innovative interdisciplinary research and research events held by Fellows. The College Library has extensive holdings in the sciences, which boasts seven reading rooms over three floors, with seating for 158 readers. The galleried main reading room, dating from 1935, looks out over the River Cherwell and the 'dreaming spires' of central Oxford. The Library also has an unusually large collection of autobiographies, diaries and memoirs, and excellent holdings in both medicine journals and books. The Principal of St Hilda’s is Professor Dame Sarah Springman CBE FREng. The College has a Vice Principal, and a full-time Senior Tutor, who is also Tutor for Admissions (Undergraduate and Postgraduate). The Tutor for Graduates is responsible for postgraduates already on course, with the help of the College Advisors assigned to each student. Medicine and related fields at St Hilda's College The successful candidate will build upon existing strengths in related subjects that St Hilda's has a long and proud history of developing. Medicine is a successful subject area at St Hilda's. The appointee will share responsibility for the Medicine students with Professor Charlotte Stagg. Professor Stagg and the appointee will be ably supported by College Lecturers and external tutors. St Hilda’s admits 6 undergraduates in Medicine per year. There are also several graduate students studying related graduate degrees. In addition to regular subject events, the college is able to enhance the experience of Medicine students through generous travel grants, excellent library resources. Additional material about the College, including the research interests of Fellows and Lecturers, can be found at the St Hilda's web site: www.st-hildas.ox.ac.uk. For further details about the college side of the post please contact the Senior Tutor, Dr Sarah Norman (sarah.norman@st-hildas.ox.ac.uk). For further details of these Fellows and their research interests, please see http://www.st-hildas.ox.ac.uk/content/academic-staff. About the University of Oxford Oxford’s departments and colleges aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. Oxford’s self-governing community of international scholars includes Professors, Associate Professors, other college tutors, senior and junior research fellows and over 2,500 other University research staff. Research at Oxford combines disciplinary depth with an increasing focus on inter-disciplinary and multi-disciplinary activities addressing a rich and diverse range of issues. Oxford’s strengths lie both in empowering individuals and teams to address fundamental questions of global significance, and in providing all staff with a welcoming and inclusive workplace that supports everyone to develop and do their best work. Recognising that diversity is a great strength, and vital for innovation and 11 creativity, Oxford aspires to build a truly inclusive community which values and respects every individual’s unique contribution. While Oxford has long traditions of scholarship, it is also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities. It consistently has the highest external research income of any university in the UK (the most recent figures are available at www.ox.ac.uk/about/organisation/finance-and-funding), and is ranked first in the UK for university spinouts, with more than 130 spin-off companies created to date. Oxford is also recognised as a leading supporter of social enterprise. Oxford admits undergraduate students with the intellectual potential to benefit fully from the small group learning to which Oxford is deeply committed. Meeting in small groups with their tutor, undergraduates are exposed to rigorous scholarly challenge and learn to develop their critical thinking, their ability to articulate their views with clarity, and their personal and intellectual confidence. They receive a high level of personal attention from leading academics. Oxford has a strong postgraduate student body which now numbers over 10,000. Postgraduates are attracted to Oxford by the international standing of the faculty, by the rigorous intellectual training on offer, by the excellent research and laboratory facilities available, and by the resources of the museums and libraries, including one of the world’s greatest libraries, the Bodleian. For more information please visit www.ox.ac.uk/about/organisation 12 University Benefits, Terms and Conditions Salary The University component of the salary will be on the scale for Associate Professors, (£44,296 to £59,479 per annum). The combined College and University salary will be on a scale up to £70,918 per annum. An allowance of £3,078 p.a. would be made upon award of the title of Full Professor. Those appointed below the top of this salary range will receive annual increments until they reach the top point. There is also an annual ‘cost-of-living’ review. In exceptional cases, the Department/Faculty board may propose the awarding of additional increments within the substantive scale to an Associate Professor at any time during their appointment. Associate professors who are awarded the title of full professor receive an additional allowance (unless they already receive additional recruitment or retention payments at that level or above) see Recognition of Distinction | HR Support (ox.ac.uk); and they will be eligible for consideration in subsequent regular exercises for professorial merit pay (unless they already receive additional recruitment or retention payments in excess of the level of award) see Professorial Merit Pay | HR Support (ox.ac.uk). These awards do not result in any change to the duties of the post-holder. Additional remuneration may be paid for graduate supervision, examining and some tutorial teaching. Those holding administrative appointments within the department/faculty may be eligible for additional payments. Pension The University offers generous pension provision. Associate Professors are usually offered membership of the Universities Superannuation Scheme. Details are available at https://finance.web.ox.ac.uk/uss Sabbatical leave You will be eligible for sabbatical leave to allow you to focus on your research. In general, one term of leave is available for each six terms worked. This leave may either be taken as one term of leave after 6 terms of service, or accumulated and taken as one year of leave after 6 years of service. Outside commitments You may apply to spend up to 30 working days in each year on projects outside your employment duties, such as consultancy, spin-out activity and membership of research councils and other bodies. There is no limit to earnings from these activities without deduction from salary. Details of the approval process may be found at https://hr.admin.ox.ac.uk/holding-outside-appointments. Guidance is also available on: ownership of intellectual property https://governance.admin.ox.ac.uk/legislation/council-regulations-7-of-2002 and managing conflicts of interest https://researchsupport.admin.ox.ac.uk/governance/integrity 13 Membership of Congregation Oxford’s community of scholars governs itself through Congregation which is its “parliament”. You will be a voting member of Congregation. See https://www.ox.ac.uk/about/organisation/governance and https://governance.admin.ox.ac.uk/legislation/statute-iv-congregation for further details. Family support The University offers generous family leave arrangements, such as maternity, adoption, paternity and shared parental leave. Details are available at https://hr.admin.ox.ac.uk/family-leave-for-academic-staff. You will have considerable flexibility in the day-to-day organisation of duties in the Associate Professor role. Requests for flexible working patterns will be accommodated as far as possible. You will be eligible to apply to use the University nurseries (subject to availability of places). For details of the nurseries and how to apply for places, please see https://childcare.admin.ox.ac.uk/home. The University subscribes to Work and Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, online support and informative webinars in addition to the ability to book emergency childcare through their online service Bubble. For more details, please see https://hr.admin.ox.ac.uk/my-family-care. The Oxford University Newcomers' Club is run by volunteers, whose aim is to help the newly-arrived partners of visiting scholars, of graduate students and of newly appointed academic and administrative members of the University to settle in and to give them opportunities to meet people in Oxford. Further information is available at https://www.newcomers.ox.ac.uk/. Welcome for International Staff One of Oxford’s great strengths is its truly international body of research and teaching staff from over 140 countries, and we welcome applications from academics across the world. We can help international staff and partners/families make the transition to Oxford. Information about relocation, living and working in the UK and Oxford is available at welcome.ox.ac.uk. If you require a visa, we have a dedicated Staff Immigration Team to support successful applicants through the immigration process (for Global Talent and Skilled Worker visas) from job offer through to arrival in the UK. This is subject to the eligibility criteria being met for the respective visa routes. Relocation Subject to UK tax regulations and the availability of funding, a relocation allowance may be available. Promoting diversity The University is committed to recruiting and retaining the best people, whoever they are, to ensure equality of opportunity. The Vice Chancellor’s Diversity Fund provides resources for innovative projects to promote diversity. The Equality and Diversity Unit promotes good practice across the University by developing policies and offering training, and runs a range of support networks for staff. It works closely with Colleges, the Oxford University Student Union and external campaign groups. Please see https://edu.admin.ox.ac.uk/home for details. 14 Other benefits and discounts for University employees The University has a range of facilities and benefits for its staff, including discounted health insurance, sustainable travel schemes, and discounts in local shops and restaurants. Details are available at: https://hr.admin.ox.ac.uk/staff-benefits https://hr.admin.ox.ac.uk/discounts Pre-employment screening Your appointment will be subject to the University’s standard pre-employment screening. This will include right-to-work, proof of identity, references, a pre-employment health declaration, and any other checks as applicable to the post. We advise you to read the notes for applicants at https://jobs.ox.ac.uk/preemployment-checks. Length of appointment Appointments to Associate Professorships at Oxford are confirmed as permanent on successful completion of a review during the first five years. The University operates an employer justified retirement age for academic posts. With effect from 1 October 2023 the retirement date will be 30 September immediately preceding the 70th birthday. The justification for this may be found at https://hr.admin.ox.ac.uk/the-ejra For existing employees, any employment beyond the retirement age is subject to approval through the EJRA procedures. Further details can be found at https://hr.admin.ox.ac.uk/the-ejra Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/dataprotection-policy College Benefits, Terms and Conditions The combined College and University salary will be on a scale up to £70,918 per annum. As a Tutorial Fellow of St Hilda’s College, the person appointed will receive the following additional benefits from St Hilda’s College:     Accommodation allowance: £10,420, per annum (effective August 2023); Research and travel allowance: up to £1,800 per annum; Student entertainment allowance: up to £400 per annum; Entitlement to lunch and dinner in College without charge when the kitchens are open (approx. value £1495 per annum);  Membership of the Senior Common Room  Use of the College gym. 15 Accommodation may be available within the College for single occupancy. For a non-residential Fellow, a teaching room will be provided in the College free of charge. Offer of employment Applications for this post will be considered by a selection committee containing representatives from both the Department of Physiology, Anatomy and Genetics and St Hilda’s College. The selection committee is responsible for conducting all aspects of the recruitment and selection process; it does not, however, have the authority to make the final decision as to who should be appointed. The final decision will be made by the Medical Sciences divisional board and the Governing Body of St Hilda’s College on the basis of a recommendation made by the selection committee. No offer of appointment will be valid, therefore, until and unless the recommendation has been approved by both the divisional board and the governing body, and a formal contractual offer has been made. 16 """^^ . . "Le Gros Clark Building" . "address"@en . "has site"@en . "2024-05-22T12:00:00+01:00"^^ . "Unit price specification"@en . "AV24025_PDRS_Job Description" . . "172565"^^ . . "169811"^^ . . . . . . "23232575"^^ . "License"@en . . . . . . . "site principal"@fr . . "occupies" . . . _:Nc087a40d3da147c7acd866c7a4941524 . . "dpag"^^ . "Dorothy Crowfoot Hodgkin Building" . "tiene sede principal en"@es . . . "00000000"^^ . . . _:N881026a8e8754afa9719eab2b00b1c21 "Oxford" . "DPAG" . . . "postal code"@en . "comment" . . . . . . _:N518ccf2b6530404d8c88b322a962c4e6 . . . . . . "false"^^ . "AV" . "Subject"@en . "a un site"@fr . "email"@en . . "Tinsley Building" . "HR Team" . . _:N881026a8e8754afa9719eab2b00b1c21 "Wellington Square" . . . "false"^^ . . . . . _:Nc087a40d3da147c7acd866c7a4941524 . _:Nc087a40d3da147c7acd866c7a4941524 . "valid through (0..1)"@en . . . . . . "Tinsley Building" . . "Standard Grade 5: 28759" . . "2024-05-22T12:00:00+01:00"^^ . . """The Department of Physiology, Anatomy and Genetics (DPAG), and St Hilda’s College are seeking to appoint a full-time Associate Professor of Neuroscience with a focus on the neurobiology of degeneration to complement existing research in the Department and across the University in the fields of Parkinson’s disease, Alzheimer’s disease and motor neuron disease (to commence employment as soon as possible). This is a joint appointment: you will be a member of DPAG as well as a Tutorial Fellow at St Hilda’s College. The role will involve undertaking independent research, undergraduate and graduate teaching, and graduate supervision. It will also encompass administrative and pastoral duties for the department and college. DPAG is part of the University’s Medical Sciences Division and holds a world leading position in the QS World University Rankings. As Associate Professor, you will be expected to carry out high level original and independent research in an area complementary to the department’s Research Centre for Neuroscience. The main duties of this post will be to undertake discovery science, secure external funding to prosecute an independent research programme and educate undergraduate and post graduate students. You will have an ability to contribute to the teaching and training of pre-clinical students studying for the degree of Bachelor of Medicine for the Department and College, and of non- medical students studying the Biomedical Sciences degree course. You should have a higher degree (DPhil/PhD) in a relevant area of research; show evidence of excellence in undergraduate and graduate teaching, supervision and research training, and have a commitment to the organisation and delivery of teaching. You will show evidence of substantial independent research accomplishment and a strong publication record, as well as evidence of a substantial and realisable research plan which will complement the department’s research strategy. You should also have the ability and willingness to undertake a proportionate share of administrative duties within the Department and the College, and a commitment to the academic and pastoral support of students. Applications for this vacancy are to be made online. To apply for this role and for further details, including the job description and selection criteria, please click on the ‘Apply’ link herein. The closing date for applications is **12.00 noon on** **Monday 29th April 2024.** Interviews for shortlisted candidates are anticipated to take place on **Thursday 13th and Friday 14th June 2024** **.** Applications are particularly welcome from women, black and minority ethnic candidates, who are underrepresented in academic posts in Oxford. **Committed to equality and valuing diversity** """ . . "false"^^ . . _:N518ccf2b6530404d8c88b322a962c4e6 "+44-1865-270000" . . . . . _:Nd02fdece9a7741978cd0da16e47dc181 "off Parks Road" . . . "2B27"^^ . "AV"^^ . . . . . "notation"@en . "Professor David Paterson" . . . "2024-04-24T09:00:00+01:00"^^ . "Department of Physiology, Anatomy and Genetics (DPAG), and St Hilda’s College" . "Sherrington Building" . "sous-Organization de"@fr . "account" . "based near" . . . . . . "University of Oxford" . . . . _:Nd02fdece9a7741978cd0da16e47dc181 "OX1 3PT" . . """

Fixed-term for 13 months/Full-time

 

The researcher will join a collaborative effort between DPAG and WRH, funded by an award from the Research Innovation Fund of Pancreatic Cancer UK.

 

To expand, pancreatic cancer cells must first adapt to the acidic conditions in tumours by implementing adaptations involving ‘survival genes’, which also represent vulnerabilities for new therapies to target. We propose to derail cancer progression using DNA-binding molecules, called triplex-forming oligonucleotides (TFOs), that inactivate these survival genes in the most metabolically active and acid-resistant cells responsible for driving aggressive disease.

 

The successful applicant will lead on pioneering research efforts to bring the latest therapeutic cargo delivery and TFO technology to eliminate pancreatic cancer cells. Work at this innovation stage is entirely in vitro. The project, funded by PCUK’s Research Innovation Fund, is a first step towards delivering precision medicine to target a metabolic vulnerability in cancer.

 

The successful applicant will have experience in working with nucleic acids, in delivering constructs to cells, and in performing assays; demonstrable skills in cell culture are essential; experience in developing therapy is desirable, although training will be provided, if necessary. Applicants must hold, or be close to completion of, a PhD/DPhil in a relevant field, such as biochemistry, molecular biology, oncology, or chemistry

 

The fixed term post is available from 01 July 2024. The post will be based in The Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Rd, Oxford OX1 3PT

 

Informal enquiries may be directed to the DPAG HR Team – hr@dpag.ox.ac.uk  

 

Closing date for applications is midday on 22 May 2024

 

Interviews are likely to be held on the week commencing 03 June 2024

 

 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion
"""^^ . "university" . "HR Team" . "Current vacancies at the University of Oxford" . . . . . "Agent" . . . . . . . . . "has exact match"@en . . . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job description and Selection Criteria Job title Laboratory Technician Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3QU Grade and salary Grade 5: £28,131 per annum Hours Full time Contract type Fixed-term (12 months) Reporting to Professor Molly Stevens Vacancy reference (AV24026) HRIS: 172565 Additional information While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. The role We are seeking to appoint an experienced member of the team to provide technical and administrative support to ensure the smooth running of Prof Molly Stevens’s lab at the Kavli Institute for Nanoscience Discovery. The Stevens Group is based at the Department of Physiology Anatomy and Genetics and is also part of the Institute of Biomedical Engineering. The role will include assisting with the daily lab organisation and management of the general lab area, assisting with the laboratory inductions for new laboratory users, placing purchase orders, preparing sample aliquots and other reagents, processing the lab inventory, and will also provide support for instrumentation maintenance and training. The lab technician will assist with the Risk Assessments and liaise with the Departmental H&S officers. The successful candidate will perform key supporting tasks toward the development of existing experimental projects. This will involve performing basic experimental procedures for example cell and tissue culture and isolation, biochemical assays, immunostaining, gene expression analysis (e.g. RNA and DNA extraction, PCR, etc.) and molecular cloning (e.g. bacterial transformation, plasmid purification, etc.). Full training will be provided but basic knowledge of biology- and chemical-based techniques and Health & Safety procedures is an advantage. The post holder will form part of the Stevens Group professional services team and they will work closely with representatives from the Departmental and Divisional professional services teams. The post holder will have excellent communication skills and a collaborative approach to working with all staff and students. The post holder will be a confident self-starter and collaborative member of the team and will display impeccable work ethics. Responsibilities                   Responsible for managing a scientific process Manage and organise key processes in support of ongoing experimental projects. Manage and organise the general lab space and resources, overseeing the preparation, storage, and inventory control of laboratory equipment and supplies. Liaise with research staff and PhD students to support the group’s activities to ensure continuity in the laboratory work. Contribute to research programmes by performing technical support as appropriate. Oversee the repairs and maintenance of laboratory equipment by arranging for on or off-site repairs. Maintain equipment, including washing, sterilisation and disposal, perform quality checks and contribute to the general cleanliness and upkeep of the laboratory space. Dispose lab waste, including chemical and biological waste, in alignment with H&S regulations. Deliver lab inductions and training of lab users and visitors. Organise lab checkouts for researchers leaving the team and ensure that the research materials and samples are redeployed, stored, catalogued, or archived, as appropriate. Monitor and order stock as necessary taking responsibility for organising resources in support of research and lab management. Raise purchase orders for laboratory supplies and equipment and liaise with administrative staff for laboratory budget guidelines, monitoring and management. Liaise with providers and assist in arranging service contracts. Write and review basic operating procedures and risk assessments, and ensure that these processes are carried out properly and kept up to date. Work with all members of the team to enhance lab safety and take initiatives to champion and introduce good H&S practices. Engage with the Kavli Institute and DPAG Health and Safety committees. Collaborate with senior team members in the response to incidents, investigation and subsequent follow up for identified actions to ensure they are completed and implemented, communicating with stakeholders throughout. Maintain accurate and complete records of lab operations. Assess, prioritise and monitor requests and tasks, communicating in a timely manner with relevant parties about progress to resolution. 2  Provide a point of reference for less experienced team members, and provide guidance to staff and students. Other Duties  Participate in a regular Annual Review;  Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training;  Comply with Health and safety regulations;  Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff;  Any other duties that may be required from time to time commensurate with the grade of the job. This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Selection criteria Essential selection criteria                Educated to at least A-level or equivalent qualification in science Experience of working laboratory environment Ability to troubleshoot problems with experiments and arrive at an appropriate solution Ability to write up experimental results Practical experience in chemistry (e.g. analytical chemistry, chemical synthesis, etc.) and/or biology (e.g. cell culture, isolation, biochemical assays, immunostaining, etc.) laboratory techniques. Practical experience in general wet lab techniques Experience managing and auditing laboratory inventories. Strong attention to detail, with the ability to organise samples and record results in a clear and organised fashion Knowledge of current health and safety regulations in a scientific laboratory environment. Good IT skills including Office, Teams, SharePoint, ELN, inventory software, and hardware (e.g. data storage, ancillary IT equipment). Ability to organise own work load and take initiative as appropriate Knowledge of health and safety regulations in a laboratory environment A proactive approach to work and the ability to support colleagues. Excellent verbal and written communication skills. Commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work. Desirable selection criteria    Degree in a scientific or technical subject or equivalent work experience. Experience working with safety-critical duties e.g. handling of hazardous chemicals, biological materials, cryogenics, and/or laser sources, etc. Knowledge of relevant research regulations e.g. the Human Tissue Act, Department of Health Research Governance Framework, GCP requirements, ISO standards, etc. 3 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows:  Lone Working  Work in hot or cold environments  Driving on University business  Working with Ionising Radiation  Regular manual handling  Working with category 3b or 4 lasers (laser safety class)  Work with any substance which has any of the following pictograms on their MSDS: Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks:  A satisfactory basic Disclosure and Barring Service check  University security screening (eg identity checks). About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spinouts, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. 4 Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022, 2023. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department of Physiology, Anatomy and Genetics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past four years. Please see the 2022/2023 annual report: https://www.dpag.ox.ac.uk/news/annual-report-2022-2023 Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are five named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), the Krebs Chair in Physiological Metabolism (vacant) and the John Black Professor of 5 Bionanoscience (Professor Dame Molly Stevens, FREng, FRS). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk The Kavli Institute for Nanoscience Discovery (Kavli INsD) “Where the physical sciences are brought into the cell” Leading scientific discovery into the most basic unit of life - the cell - the Kavli Institute for Nanoscience Discovery (Kavli INsD) is located at the heart of Oxford University’s science area and was inaugurated in March 2021. With over 30 faculty and 450 research staff and graduate students, world leading teams collaborate from multiple departments (biochemistry, cell biology, chemistry, physics, physiology, psychiatry, clinical neurosciences and engineering) to contribute to global health. By bringing multiple disciplines together under the same roof to advance scientific research the Kavli INsD creates an environment that encourages the cross-pollination of ideas and inter-disciplinary cooperation. The Institute comes together to work on global health challenges and benefits from the close proximity of the scientific departments as well as advanced imaging facilities and state-of-the-art-instrumentation. As the first Director of Kavli INsD Professor Dame Carol Robinson and the research teams are creating a culture that is both bold and respectful. The University of Oxford’s, Kavli Institute for Nanoscience Discovery is the U.S based Kavli Foundation’s 20th institute. The foundation, established in the year 2000 by Fred Kavli, has a mission “to advance science for the benefit of humanity”. Research institutes in the fields of nanoscience, astrophysics, neuroscience, and theoretical physics have been endowed by the foundation which also supports programs that strengthen the connection between science and society. Learn more at kavlifoundation.org 6 Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. 7 Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs Non-technical questions about this job should be addressed to the recruiting department directly at hr@dpag.ox.ac.uk. 8 To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. aspect of EDI in DPAG. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 9 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependants. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. Oxford Research Staff Society (OxRSS) A society run by and for Oxford University research staff. It offers researchers a range of social and professional networking opportunities. Membership is free, and all researchers employed by Oxford University are welcome to join. Subscribe at researchstaff-subscribe@maillist.ox.ac.uk to join the mailing list to find out about upcoming events and other information for researchers, or contact the committee on committee@oxrss.ox.ac.uk. For more information, see www.ox.ac.uk/oxrss, Twitter @ResStaffOxford, and Facebook www.facebook.com/oxrss. 10 """^^ . . . . "sede principale"@it . . "dpag" . "Department of Physiology, Anatomy and Genetics (DPAG)" . . . "Is Part Of"@en . . "Sherrington Building" . "2B27" . . . _:N881026a8e8754afa9719eab2b00b1c21 "University of Oxford" . . . "01865 282167" . . . "Henry Wellcome Building of Gene Function" . . . "OxPoints"@en . "OxPoints"@en . . . "2024-04-17T15:00:00+01:00"^^ . "2024-05-22T12:00:00+01:00"^^ . _:Nc087a40d3da147c7acd866c7a4941524 . "page" . . . . "Postdoctoral Research Scientist" . . . _:Nd02fdece9a7741978cd0da16e47dc181 . _:Nd76de89a6b3d4e0299637d580512a24e . "2024-04-29T12:00:00+01:00"^^ . . _:Nd02fdece9a7741978cd0da16e47dc181 . . "23233659"^^ . . "Oxford, University of" . . . . "Source"@en . . . "Title"@en . "Laboratory Technician" . . "Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT" . "finance code" . . "ha sede"@it . . . . """**Fixed-term for 13 months/Full-time** The researcher will join a collaborative effort between DPAG and WRH, funded by an award from the Research Innovation Fund of Pancreatic Cancer UK. To expand, pancreatic cancer cells must first adapt to the acidic conditions in tumours by implementing adaptations involving ‘survival genes’, which also represent vulnerabilities for new therapies to target. We propose to derail cancer progression using DNA-binding molecules, called triplex-forming oligonucleotides (TFOs), that inactivate these survival genes in the most metabolically active and acid-resistant cells responsible for driving aggressive disease. The successful applicant will lead on pioneering research efforts to bring the latest therapeutic cargo delivery and TFO technology to eliminate pancreatic cancer cells. Work at this innovation stage is entirely in vitro. The project, funded by PCUK’s Research Innovation Fund, is a first step towards delivering precision medicine to target a metabolic vulnerability in cancer. The successful applicant will have experience in working with nucleic acids, in delivering constructs to cells, and in performing assays; demonstrable skills in cell culture are essential; experience in developing therapy is desirable, although training will be provided, if necessary. Applicants must hold, or be close to completion of, a PhD/DPhil in a relevant field, such as biochemistry, molecular biology, oncology, or chemistry The fixed term post is **available from 01 July 2024**. The post will be based in The Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Rd, Oxford OX1 3PT Informal enquiries may be directed to the DPAG HR Team – hr@dpag.ox.ac.uk Closing date for applications is **midday on 22 May 2024** Interviews are likely to be held on the **week commencing 03 June 2024** Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion """ . "Voice"@en . "Physiology, Anatomy and Genetics, Department of (DPAG)" . "Address"@en . "Le Gros Clark Building" . . _:Nd02fdece9a7741978cd0da16e47dc181 "Sherrington Building, Sherrington Road" . . "name" . . "sotto-Organization di"@it . . . "2024-02-12T09:00:00+00:00"^^ . "has primary place" . . . . . . _:N518ccf2b6530404d8c88b322a962c4e6 . . "street address"@en . "Level 1 Meeting Room" . . . "Level 1 Meeting Room" . . . _:N881026a8e8754afa9719eab2b00b1c21 "United Kingdom" . . "extended address"@en . "Fax"@en . . . . _:Nd76de89a6b3d4e0299637d580512a24e "+44-1865-270708" . . _:Nd02fdece9a7741978cd0da16e47dc181 "Oxford" . "country name"@en . _:N881026a8e8754afa9719eab2b00b1c21 "OX1 2JD" . . "true"^^ . . . """**Full-time, Fixed term for 1 year** We are seeking to appoint a motivated and forward-thinking Lab Manager to join Prof Molly Stevens’ dynamic and multidisciplinary team at the Kavli Institute for Nanoscience Discovery (www.stevensgroup.org). As Lab Technician, you will provide technical and administrative support to ensure the smooth running of Prof Molly Stevens’s lab at the Kavli Institute for Nanoscience Discovery. The Stevens Group is based at the Department of Physiology Anatomy and Genetics and is also part of the Institute of Biomedical Engineering. The role will include assisting with the daily lab organisation and management of the general lab area, assisting with the laboratory inductions for new laboratory users, placing purchase orders, preparing sample aliquots and other reagents, processing the lab inventory, and will also provide support for instrumentation maintenance and training. The lab technician will assist with the Risk Assessments and liaise with the Departmental H&S officers. The successful candidate will perform key supporting tasks toward the development of existing experimental projects. This will involve performing basic experimental procedures for example cell and tissue culture and isolation, biochemical assays, immunostaining, gene expression analysis (e.g. RNA and DNA extraction, PCR, etc.) and molecular cloning (e.g. bacterial transformation, plasmid purification, etc.). Full training will be provided but basic knowledge of biology- and chemical-based techniques and Health & Safety procedures is an advantage. The post holder will form part of the Stevens Group professional services team and they will work closely with representatives from the Departmental and Divisional professional services teams. The post holder will have excellent communication skills and a collaborative approach to working with all staff and students. The post holder will be a confident self-starter and collaborative member of the team and will display impeccable work ethics. **The Role** The post is available from June 2024. This is a full-time position, initially fixed-term for 12 months in the first instance. Part-time appointments can be considered. The successful candidate will be based at the Department of Physiology Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, located at the Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3QU. **Next Steps** To apply for this position, please submit your application by **midday on Wednesday 22nd May**. Your application should include a cover letter, curriculum vitae (CV), and contact information for references. Shortlisted candidates will be invited for interviews, which are likely to be held two weeks after the closing date. Enquiries can be directed to the DPAG HR Team – hr@dpag.ox.ac.uk. Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion """ . . . "Associate Professor of Neuroscience" . . . "homepage" . . . . . "Medical Sciences Division" . "Henry Wellcome Building of Gene Function" . "es suborganización de"@es . "Job Description" . . . . . "false"^^ . . . """

The Department of Physiology, Anatomy and Genetics (DPAG), and St Hilda’s College are seeking to appoint a full-time Associate Professor of Neuroscience with a focus on the neurobiology of degeneration to complement existing research in the Department and across the University in the fields of Parkinson’s disease, Alzheimer’s disease and motor neuron disease (to commence employment as soon as possible). This is a joint appointment: you will be a member of DPAG as well as a Tutorial Fellow at St Hilda’s College. The role will involve undertaking independent research, undergraduate and graduate teaching, and graduate supervision. It will also encompass administrative and pastoral duties for the department and college.

 

DPAG is part of the University’s Medical Sciences Division and holds a world leading position in the QS World University Rankings. As Associate Professor, you will be expected to carry out high level original and independent research in an area complementary to the department’s Research Centre for Neuroscience. The main duties of this post will be to undertake discovery science, secure external funding to prosecute an independent research programme and educate undergraduate and post graduate students. You will have an ability to contribute to the teaching and training of pre-clinical students studying for the degree of Bachelor of Medicine for the Department and College, and of non-medical students studying the Biomedical Sciences degree course.

 

You should have a higher degree (DPhil/PhD) in a relevant area of research; show evidence of excellence in undergraduate and graduate teaching, supervision and research training, and have a commitment to the organisation and delivery of teaching. You will show evidence of substantial independent research accomplishment and a strong publication record, as well as evidence of a substantial and realisable research plan which will complement the department’s research strategy. You should also have the ability and willingness to undertake a proportionate share of administrative duties within the Department and the College, and a commitment to the academic and pastoral support of students.

 

Applications for this vacancy are to be made online. To apply for this role and for further details, including the job description and selection criteria, please click on the ‘Apply’ link herein.

 

The closing date for applications is 12.00 noon on Monday 29th April 2024. Interviews for shortlisted candidates are anticipated to take place on Thursday 13th and Friday 14th June 2024.

 

Applications are particularly welcome from women, black and minority ethnic candidates, who are underrepresented in academic posts in Oxford.

 

Committed to equality and valuing diversity
"""^^ . . . . _:Nd76de89a6b3d4e0299637d580512a24e . . "room" . . . "Old Observatory" . . . . . "tiene sede en"@es . . "OUCS code" . . . . . "Medical Sciences Division" . "Dorothy Crowfoot Hodgkin Building" . """Oxford Anatomy & Physiology ranked #1 in QS World Rankings by subject 2017, 2018, 2020, 2021, 2022 and 2023 Job description and Selection Criteria Job title Postdoctoral Research Scientist Division Medical Sciences Division Department Physiology, Anatomy & Genetics Location Sherrington Building, Parks Road, Oxford, OX1 3PT Grade and salary Grade 7: £36,024 - £41,732 per annum Hours Full time Contract type Fixed-term for 13 months Available from 01 July 2024 Reporting to Professor Pawel Swietach Vacancy reference AV24025 / HRIS: 172434 Additional information This work will be undertaken in collaboration with Prof Helen Townley at the Nuffield Department of Women’s and Reproductive Health (WRH) Research topic Innovative methods to target pancreatic cancer metabolism Principal Investigator / supervisor PI: Pawel Swietach Co applicant: Helen Townley Project team Swietach Group (DPAG) in collaboration with Townley Group (Women’s and Reproductive Health) Project web site www.ox.ac.uk/ Funding partner Recent publications The funds supporting this research project are provided by Pancreatic Cancer UK (PCUK) 1. Michl J, White B, Monterisi S, Bodmer WF, Swietach P. Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance. Proc Natl Acad Sci U S A. 2024;121:e2319055121. doi: 10.1073/pnas.2319055121 2. Blaszczak W, White B, Monterisi S, Swietach P. Dynamic IL6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells. Cell Rep. 2024;43:113612. doi: 10.1016/j.celrep.2023.113612 3. Swietach P, Boedtkjer E, Pedersen SF. How protons pave the way to aggressive cancers. Nat Rev Cancer. 2023;23:825-841. doi: 10.1038/s41568-023-00628-9 4. Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P. Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2. Cell Rep. 2023;42:112601. doi: 10.1016/j.celrep.2023.112601 5. Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ. Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy. Cell Rep. 2022;39:110796. doi: 10.1016/j.celrep.2022.110796 6. Monterisi S, Michl J, Hulikova A, Koth J, Bridges EM, Hill AE, Abdullayeva G, Bodmer WF, Swietach P. Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes. Elife. 2022;11. doi: 10.7554/eLife.78425 7. Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P. CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH. Cell Rep. 2022;38:110493. doi: 10.1016/j.celrep.2022.110493 8. Blaszczak W, Williams H, Swietach P. Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production. Br J Cancer. 2022;127:1365-1377. doi: 10.1038/s41416-022-01910-7 The role The researcher will join a collaborative effort between DPAG and WRH, funded by an award from the Research Innovation Fund of Pancreatic Cancer UK. The researcher will be involved in developing a treatment and an appropriate delivery strategy to target a metabolic vulnerability in pancreatic ductal adenocarcinoma (PDAC). The aggressiveness and treatment-resistance in PDAC necessitates powerful interventions, but these carry the risk of damaging normal cells. The high metabolic rate required by PDAC for growth could be inhibited by drugs, but cancer cells may survive periods of quiescence, recover when treatment stops, or acquire resistance. Another approach is to inactivate genes that are essential for survival, but the right choice of target depends on knowing the adversities that cancer cell must overcome. The clue is in appreciating the tissue from which PDAC develops. Pancreatic ducts secrete large quantities of bicarbonate to neutralize stomach acids. Expunging bicarbonate (an alkali) from the fluid surrounding pancreatic cells makes their environment acidic, which is not something most cells experience. PDAC cells can out-compete their neighbours by becoming acid-resistant. Since cancer metabolism produces acid, this trait is beneficial when PDAC develops into a solid tumour and metastasises. These adaptations present druggable vulnerabilities. In a recent article in Nature Reviews Cancer, we explain how acidity should be exploited in treatments. Acidresistance is somewhat analogous to drug resistance, the difference being that cells produce acid themselves. This sets up a vicious cycle, wherein acid-resistant cells produce more acid to amplify their survival advantage. Eliminating this feature would derail cancer progression, but only few attempts have been made. Therapies that neutralize tumour acidity have been trialled, but rather than inactivating the acid-adaptive process, they delay it. New ideas are needed, which is why we are applying to the PCUK research innovation fund. 2 Our proposed strategy is (1) to target acid-resistant cells and (2) inactivate a critical survival mechanism. This strategy is supported by mathematical modelling predictions and builds on our discoveries. We found that cells can only survive acidity if they can respire with oxygen. To do this, they need a gene called NDUFS1. Cancer cells also need a pathway called fermentation which produces lactic acid, but this is normally blocked in acidic conditions. Acid-adapted cells overcome this by degrading an acid-entry pathway into cells called SLC4A2. We also found that acid-adapted cells can be distinguished by a protein at their surface called CEACAM5. This provides a way of delivering therapies. But how will we inactivate NDUFS1 selectively in acid-resistant PDAC cells? We propose an innovative approach that uses a decades-old method called triplex-forming oligonucleotides (TFOs). These molecules can be engineered to inactivate NDUFS1 only in cells that are acidic inside. We will make cells acidic by blocking the pathway for removing lactic acid using drugs called monocarboxylate transport inhibitors (MCTi). To combine this, we will package MCTi and TFOs into particle called cubosomes which will be covered with antibodies that bind to CEACAM5. Our approach combines potency because TFOs kill cells by inactivating a “survival” gene, with high selectivity, in that acid-resistant PDAC cells meet the criteria for targeting. Compared to treatments, such as gemcitabine, 5-FU or other FOLFIRINOX components, our approach has a clear strategy to target the most aggressive cells. As a result, it may be possible to increase toxicity towards PDAC cells, without causing intolerable side-effects. Our team includes expertise in cubosome technology and is supported by a network of PDAC collaborators through two EU+UK-wide consortia. The project benefits from the wealth of information we have on PDAC lines, spanning a range of properties with respect to acidity. This proof-of-concept project will: 1. Refine ways of targeting MCTi and TFO-loaded cubosomes to CEACAM5-expressing PDAC cells using a panel of cell lines we have extensively characterised; 2. Generate TFOs that repress genes, including NDUFS1, in the acidic range only and benchmark performance against other gene inactivation methods that are not activated by cellular acidity; 3. Test the product for selective killing of the most acid-resistant cells under “petri dish” conditions. Responsibilities • • • • • • • • • Manage academic research activities and associated small-scale project management, co-ordinate multiple aspects of work to meet deadlines Receive training to innovate scientific techniques Use specialist scientific equipment in a laboratory environment Engage in the collaborative opportunity between the host departments Undertake the research plan on cell lines, with a view of seeking translational opportunities for future work. Contribute ideas for new research projects Collaborate in the preparation of scientific reports and journal articles and present papers and posters Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques Represent the research group at external meetings/seminars, either with other members of the group or alone Other Duties • Participate in an Annual Review; • Undertake any necessary training identified and continuing professional development in order to stay up-to-date professionally including annual Information Governance training; • Comply with Health and safety regulations; • Comply with the policies and procedures set out in the Handbook for University Support staff (or) Academic-Related staff; • Any other duties that may be required from time to time commensurate with the grade of the job. 3 This job description should be regarded only as a guide to the duties required and is not intended to be definitive. It may be reviewed in the light of a change in circumstances following consultation with the post holder. The job description does not form part of the contract. Selection criteria Essential selection criteria • • • • • • • • Hold, or be close to completion of, a PhD/DPhil in a relevant field, such as biochemistry, molecular biology, oncology, or chemistry Possess sufficient specialist knowledge in the area of DNA biology, and awareness of triplex forming oligonucleotide technology. Demonstrable experience in cell culture, including methods to deliver drugs or nucleotides Ability to manage own academic research and associated activities Previous experience of contributing to publications/presentations Ability to contribute ideas for new research projects and research income generation Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings Commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work Desirable selection criteria • Experience in the development of innovative therapies • Experience in delivery methods, such as those involving nanoparticles* *Training will be provided in the area of cellular physiology or specific aspects of nanoparticle development. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • Lone Working • Working with category 3b or 4 lasers (laser safety class) • Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens • Work with any substance which has any of the following pictograms on their MSDS: 4 Additional security pre-employment checks This job includes duties that require the following additional security pre-employment checks: • A satisfactory basic Disclosure and Barring Service check/Overseas Criminal Records check • University security screening (eg identity checks) About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe's most entrepreneurial universities and we rank first in the UK for university spinouts, and in recent years we have spun out 15-20 new companies every year. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information, please visit www.ox.ac.uk/about/organisation. 5 The Department of Physiology, Anatomy and Genetics Oxford Anatomy and Physiology ranked #1 in the QS World University Rankings by subject 2017, 2018, 2020 2021, 2022, 2023. Our mission is empowering discovery in the physiological sciences to improve health and educate the next generation of doctors and biomedical scientists. For more information, please visit www.dpag.ox.ac.uk The Department of Physiology, Anatomy and Genetics holds a silver Athena Swan award to recognise advancement of gender equality: representation, progression and success for all. The Department is a large pre-clinical department within the Medical Sciences Division, with ca. 500 staff and students. It has a world-class reputation in both its research and teaching. The Department was part of the University of Oxford’s Biological Sciences submission to the Research Excellence Framework 2021 that was rated top for its world-leading research. Moreover, Oxford’s Anatomy and Physiology has been ranked number one in the QS World University Rankings for the past four years. Please see the 2022/2023 annual report: https://www.dpag.ox.ac.uk/news/annual-report-2022-2023 Information about faculty in the Department Professor David Paterson FRSNZ is the Head of Department. There are five named Professors: the Dr Lee’s Professor of Anatomy (vacant) the Waynflete Professor of Physiology (Professor Gero Miesenböck, FRS FMedSci), the BHF Professor of Regenerative Medicine, Development and Reproduction (Professor Paul Riley, FMedSci), the Krebs Chair in Physiological Metabolism (vacant) and the John Black Professor of Bionanoscience (Professor Molly Stevens, FREng, FRS). Other appointments include four Research Professors (Professor Dame Frances Ashcroft, FRS; Emeritus Professor Dame Kay Davies CBE, FRS FMedSci; Professor Scott Waddell FMedSci; Professor Anant Parekh FMedSc FRS), one Wellcome Trust Principal Research Fellow (Professor Andrew King, FMedSci FRS), 13 further full professors and 15 associate professors. There are approximately 175 academic-related research staff supported by external grants and over 100 graduate 6 students registered for higher degrees in the Department. The teaching and the research activities of the department are supported by teams of professional services and technical staff. Research Centres/Institutes and research themes The Department has a distinctive, forward-looking, and integrative biomedical research programme organised into four research Centres with a presence in two research institutes https://www.dpag.ox.ac.uk/. We also have strong cross-cutting themes in cardiac sciences, cell physiology, development and cell biology, functional genomics, metabolism and endocrinology, and neuroscience, which map on to the research centres. These include the Centre for Integrative Neuroscience (Director: Professor A King FRS), Centre for Neural Circuits and Behaviour (Director: Professor G Miesenboeck FRS), Centre for Cellular & Molecular Neurobiology (Emeritus Professor Dame Kay Davies FRS and Professor Dame Frances Ashcroft FRS), Centre for Integrative Physiology (Professor A Parekh FRS)/the Burdon Sanderson Cardiac Science Centre (Director: Professor Manuela Zaccolo FRSB). The Institute for Developmental and Regenerative Medicine (IDRM: Director Professor Paul Riley FMedsci) and the new Kavli Institute for Nanoscience Discovery, which is directly opposite the Sherrington building. https://kavlifoundation.org/news/meet-new-kavli-institute-nanoscience-discovery-university-oxford The Research Centres and thematic areas bring together researchers who address a range of fundamental issues in the biosciences at molecular, cellular, tissue and systems levels of organisation. https://www.dpag.ox.ac.uk/centres For more information, please visit www.dpag.ox.ac.uk Research support facilities The Department has shared state-of-the-art facilities for a wide range of applications, such as a histology service, DNA/RNA services (rapid and supportive access to microRNA,RNASeq, CHIPSeq, etc.), confocal and other high resolution imaging equipment as well as a Transmission Electron Microscope. Proteomics facilities include MALDI-TOF/TOF and Ion Trap LCMS/MS systems, and there are extensive magnetic resonance spectroscopy (MRS) and imaging (MRI) facilities for in vivo rodent and clinical investigations, including hyperpolarised technologies. The Department also provides central support in photography, digital imaging, and poster printing as well as a high-quality mechanical workshop. A dedicated research support team helps with grant applications and awards, and data storage and computation facilities. The department is supported by a dedicated IT team. Teaching The main teaching responsibility of the Department is for pre-clinical Medicine students and those reading Biomedical Sciences. There are also contributions to teaching in Biochemistry, Biological Sciences, Human Sciences, Physics, and a graduate Neuroscience MSc programme. In Oxford, Medicine students take a three-year preclinical course before proceeding to clinical training (a further three years). The first five terms of the three-year pre-clinical course provide broad training in all aspects of medical science (leading to the 1st BM qualification). Both pre-clinical 7 Medicine and Biomedical Sciences students spend the last four terms of their course studying for a BA degree, selecting two Advanced Options from a choice of ten, ranging from systems physiology and neuroscience to cellular and molecular science. Both cohorts also undertake an experimental project, which forms one paper in their final examination; these projects are supervised by members of the academic staff. The Department also contributes some preclinical teaching to the first part of the Graduate entry Medicine course. Equality, Diversity and Inclusion in DPAG The Department of Physiology, Anatomy and Genetics (DPAG) is committed to promoting a diverse and inclusive community. We have an active Equality, Diversity, and Inclusion (EDI) committee and are pro-active in promoting race equality. We hold an Athena SWAN silver award in recognition of our efforts to introduce organisational and cultural practices, which promote gender equality and create a better working environment for all. The Department promotes family-friendly policies and supports flexible working arrangements where possible. The University offers 450 nursery places for staff and students at five dedicated University nurseries and a network of local community nurseries. We will be happy to provide you with information about nurseries and schools in Oxford upon request. We encourage applications from suitably qualified, experienced, and eligible candidates regardless of sex, race, disability, age, sexual orientation, transgender status, religion or belief, marital status, or pregnancy and maternity. We embrace our differences, and you are very welcome at DPAG, without the need to hide any part of who you are. Applications are particularly welcome from women and black and minority ethnic heritage candidates, who are under-represented in academic posts in Oxford. To learn more about EDI in DPAG, visit our website: https://www.dpag.ox.ac.uk/work-with-us/equalitydiversity-inclusion For more information about the University’s family friendly benefits, please also see https://hr.admin.ox.ac.uk/information-for-parents-and-carers Potential applicants may email heidi.de-wet@dpag.ox.ac.uk and/or sally.vine@dpag.ox.ac.uk to discuss any aspect of EDI in DPAG. The Medical Sciences Division The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford. World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care. For more information please visit: www.medsci.ox.ac.uk 8 How to apply Applications are made through our online recruitment portal. Information about how to apply is available on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants) Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday UK time on the closing date stated in the online advertisement Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Should you experience any difficulties using the online application system, and the FAQs do not answer your question, please email recruitment.support@admin.ox.ac.uk. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/jobapplicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. 9 The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/theejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 10 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See https://hr.admin.ox.ac.uk/staff-benefits University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and https://www.sport.ox.ac.uk/. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See https://welcome.ox.ac.uk/ There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See https://staffimmigration.admin.ox.ac.uk/visa-loan-scheme Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to the Work+Family Space, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See https://hr.admin.ox.ac.uk/my-family-care Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see https://childcare.admin.ox.ac.uk/ Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see https://edu.admin.ox.ac.uk/disability-support Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at https://edu.admin.ox.ac.uk/networks The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 11 """^^ . . . "type" . . "Standard Grade 7: £36,024 - £41,732" .