"sotto-Organization di"@it . "in dataset" . "University of Oxford" . "Postdoctoral Research Assistant in Structural Biology" . . . "2B10" . "Pathology Support Building" . . . . . . . _:N4768b2c39a2842dbb151dfab9057088c . _:N04ac5d5ed8274fca9f7dbd92bf5613b0 . "street address"@en . . . "primary Site"@en . . . . . . "University of Oxford" . . "label" . "Mrs Marina Katash" . . "Oxford, University of" . "Research Grade 7: £38,674 – £46,913 per annum" . "Agent" . "Pathology EPA Building" . . "based near" . . . . . . "2025-05-30T12:00:00+01:00"^^ . "Pathology Support Building" . . . _:N4768b2c39a2842dbb151dfab9057088c . . . "Sir William Dunn School of Pathology" . . . . . . . "BV" . . . "homepage" . . . . "account" . . . _:N04ac5d5ed8274fca9f7dbd92bf5613b0 "Oxford" . . . . _:N95fc616111594fe4b834db95463fcccc . . _:N3318db49c6f7428ea10d9d80da4a9b50 . . "Is Part Of"@en . _:N95fc616111594fe4b834db95463fcccc "South Parks Road " . "Oxford Molecular Pathology Institute (OMPI)" . _:N04ac5d5ed8274fca9f7dbd92bf5613b0 . . . "tiene sede en"@es . . "sede principale"@it . . . "email"@en . . "false"^^ . . _:Ne651ef963d5d47a2a013b6b2415cf313 "+44-1865-270708" . "Voice"@en . "type" . . . "occupies" . . "address"@en . . "page" . . . "2025-05-06T09:00:00+01:00"^^ . "OxPoints"@en . _:N3318db49c6f7428ea10d9d80da4a9b50 "+44-1865-270000" . . "extended address"@en . _:N95fc616111594fe4b834db95463fcccc "Sir William Dunn School of Pathology " . . . . . "Sir William Dunn School of Pathology" . . . . . "has primary place" . "OUCS code" . . . . . . . . . . . . . . . """

This is an exciting opportunity for an enthusiastic and self-motivated scientist to join the lab of Dr Katerina Toropova. The project aims to elucidate the molecular mechanisms of dynein-2 transport in cilia.

 

Transport within cilia, the cell’s signalling and sensory antennae, is central to human biology. It enables these cell-surface organelles to assemble and dynamically change their proteome in response to stimuli, allowing them to transduce signals to the cell interior. Dynein-2 lies at the heart of these processes, as it is the molecular motor responsible for all retrograde transport from the tip of cilia to the cell body. Its mutation causes severe developmental and degenerative conditions. Despite its central role, how dynein-2 utilizes the energy from ATP hydrolysis to power retrograde transport remains poorly understood. It is also unclear how the conformational landscape of dynein-2 is affected by diseases mutations.

 

This project involves using a multi-scale structural biology approach, involving cryo-EM, cryo-ET, FIB milling, and biochemical methods to understand mechanisms of dynein-2 transport, building on recent advances in the group (NSMB 2017 PMID 28394326; NSMB 2019 PMID: 31451806; Cell 2022, PMID: 36462505). The research will be conducted in a friendly and supportive atmosphere with access to outstanding facilities and within a vibrant postdoc community.

 

The applicant should hold, or be close to completion of, a PhD/DPhil in Structural Biology, Biochemistry, or Molecular/Cell Biology. Experience in protein expression and purification are required for this position. Experience in cryo-EM, cryo-ET, or FIB milling would be an advantage, but is not essential as training can be provided.  

 

The post-holder will be responsible for managing their own academic research, establishing and optimising protocols, designing and accurately executing experiments, and contributing conceptually to the overall research programme. Good organisational and communication skills and the ability to work as part of a team are essential.  

 

This is a full-time position available for 3 years in the first instance, with a possibility of extension. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. The supporting statement should describe how you fit the criteria for the role, including your motivation and curiosity about the research project.

 

Informal enquiries about this post can be addressed to Dr Katerina Toropova: katerina.toropova@path.ox.ac.uk . 

 

The closing date for applications is 12.00 midday on the 30 May 2025.  Interviews will be held as soon as possible thereafter.

 

At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers.
"""^^ . . "Mrs Marina Katash" . _:Ne651ef963d5d47a2a013b6b2415cf313 . . """

We are looking to recruit two enthusiastic and motivated Postdoctoral Research Assistants to join the group of Professor Ervin Fodor in the Sir William Dunn School of Pathology at the University of Oxford. The aim of the project is to gain in-depth molecular insights into how influenza viruses replicate, helping us better understand the molecular factors that determine host range and virulence — and ultimately contributing to the development of new antiviral approaches. The project takes a cross-disciplinary approach, combining biochemical, biophysical, cell biological, and virological methods, including reverse genetics for generating recombinant influenza viruses, proximity labelling, and cross-linking mass spectrometry.

 

The positions would suit enthusiastic and highly organised postdoctoral scientists with an interest in viral RNA-dependent RNA polymerases and its role in transcribing and replicating the viral RNA genome, as well as on the molecular mechanisms involved in the nuclear import, export, cytoplasmic trafficking, and assembly of the viral genome. There will also be an opportunity for the postholders to pursue their own ideas within the broader theme of understanding viral molecular mechanisms, including projects that could support future fellowship or independent position applications.

 

Applicants should hold, or be close to completion of, a PhD/DPhil in biochemistry, molecular biology, structural biology, virology, or a related field. Experience with molecular cloning and cell culture is essential. Experience with any of the other methods mentioned would be an advantage, but is not essential, as training will be provided.

 

The positions are funded by the UKRI-MRC and are for a fixed term until 30 September 2028. Informal inquiries about the positions can be sent to Professor Ervin Fodor: ervin.fodor@path.ox.ac.uk.

 

If you are interested in the positions, and have the skills and experience we are looking for, please apply online. You will need to upload a CV and a supporting statement. The statement should outline how you meet the criteria for the role, and include a brief account of your motivation and curiosity about the research project.  

 

The closing date for applications is 12.00 midday on Friday 30 May 2025. Interviews will be held as soon as possible thereafter.

 

At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers.
"""^^ . . . . "finance code" . "Sir William Dunn School of Pathology, South Parks Road, Oxford" . . . "2025-04-28T09:00:00+01:00"^^ . . . "OxPoints"@en . "2025-05-30T12:00:00+01:00"^^ . . "department" . . . "BV"^^ . "path" . . . "telephone"@en . "Title"@en . . . _:N95fc616111594fe4b834db95463fcccc "Oxford" . . . . . . . "Source"@en . . _:N04ac5d5ed8274fca9f7dbd92bf5613b0 "OX1 2JD" . . . _:N95fc616111594fe4b834db95463fcccc . . . . . "false"^^ . "preferred label"@en . . "Sir William Dunn School of Pathology, South Parks Road, Oxford" . . "Pathology, Sir William Dunn School of " . . _:N3318db49c6f7428ea10d9d80da4a9b50 . . . "License"@en . "tiene sede principal en"@es . . . . . "Research Grade 7: £38,674 - £46,913 p.a." . . . . . . . "179480"^^ . . "Subject"@en . . . . . . "2B10"^^ . _:N04ac5d5ed8274fca9f7dbd92bf5613b0 "Wellington Square" . "179492"^^ . . . . . _:N95fc616111594fe4b834db95463fcccc "United Kingdom" . . "notation"@en . """We are looking to recruit two enthusiastic and motivated Postdoctoral Research Assistants to join the group of Professor Ervin Fodor in the Sir William Dunn School of Pathology at the University of Oxford. The aim of the project is to gain in-depth molecular insights into how influenza viruses replicate, helping us better understand the molecular factors that determine host range and virulence — and ultimately contributing to the development of new antiviral approaches. The project takes a cross-disciplinary approach, combining biochemical, biophysical, cell biological, and virological methods, including reverse genetics for generating recombinant influenza viruses, proximity labelling, and cross-linking mass spectrometry. The positions would suit enthusiastic and highly organised postdoctoral scientists with an interest in viral RNA-dependent RNA polymerases and its role in transcribing and replicating the viral RNA genome, as well as on the molecular mechanisms involved in the nuclear import, export, cytoplasmic trafficking, and assembly of the viral genome. There will also be an opportunity for the postholders to pursue their own ideas within the broader theme of understanding viral molecular mechanisms, including projects that could support future fellowship or independent position applications. Applicants should hold, or be close to completion of, a PhD/DPhil in biochemistry, molecular biology, structural biology, virology, or a related field. Experience with molecular cloning and cell culture is essential. Experience with any of the other methods mentioned would be an advantage, but is not essential, as training will be provided. The positions are funded by the UKRI-MRC and are for a fixed term until 30 September 2028. Informal inquiries about the positions can be sent to Professor Ervin Fodor: ervin.fodor@path.ox.ac.uk. If you are interested in the positions, and have the skills and experience we are looking for, please apply online. You will need to upload a CV and a supporting statement. The statement should outline how you meet the criteria for the role, and include a brief account of your motivation and curiosity about the research project. The closing date for applications is 12.00 midday on Friday 30 May 2025. Interviews will be held as soon as possible thereafter. _At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers._ """ . "locality"@en . . . . . . . "Medical Sciences Division" . . "Medical Sciences Division" . _:N95fc616111594fe4b834db95463fcccc "OX1 3RE" . . "name" . "postal code"@en . . . "es suborganización de"@es . "site principal"@fr . . . . "has exact match"@en . . . . "comment" . _:N04ac5d5ed8274fca9f7dbd92bf5613b0 "United Kingdom" . . "valid through (0..1)"@en . . "Oxford Molecular Pathology Institute (OMPI)" . "179492_Job description" . . "Pathology EPA Building" . "23232665"^^ . "ha sede"@it . . . "has site"@en . "Sir William Dunn School of Pathology" . . "logo" . _:N4768b2c39a2842dbb151dfab9057088c . . . . "subOrganization of"@en . "Fax"@en . . . "sous-Organization de"@fr . "Sir William Dunn School of Pathology" . "false"^^ . . . "value" . . "Unit price specification"@en . "2025-05-30T12:00:00+01:00"^^ . . _:N4768b2c39a2842dbb151dfab9057088c . . "a un site"@fr . . . "Postdoctoral Research Assistant in Molecular Virology (2 posts)" . . _:Ne651ef963d5d47a2a013b6b2415cf313 . "2025-05-30T12:00:00+01:00"^^ . . _:N04ac5d5ed8274fca9f7dbd92bf5613b0 "University of Oxford" . "00000000"^^ . . . . "path"^^ . . "179480_Job description.doc" . "Address"@en . . "university" . . "country name"@en . "Current vacancies at the University of Oxford" . . . "true"^^ . . """This is an exciting opportunity for an enthusiastic and self-motivated scientist to join the lab of Dr Katerina Toropova. The project aims to elucidate the molecular mechanisms of dynein-2 transport in cilia. Transport within cilia, the cell’s signalling and sensory antennae, is central to human biology. It enables these cell-surface organelles to assemble and dynamically change their proteome in response to stimuli, allowing them to transduce signals to the cell interior. Dynein-2 lies at the heart of these processes, as it is the molecular motor responsible for all retrograde transport from the tip of cilia to the cell body. Its mutation causes severe developmental and degenerative conditions. Despite its central role, how dynein-2 utilizes the energy from ATP hydrolysis to power retrograde transport remains poorly understood. It is also unclear how the conformational landscape of dynein-2 is affected by diseases mutations. This project involves using a multi-scale structural biology approach, involving cryo-EM, cryo-ET, FIB milling, and biochemical methods to understand mechanisms of dynein-2 transport, building on recent advances in the group (NSMB 2017 PMID 28394326; NSMB 2019 PMID: 31451806; Cell 2022, PMID: 36462505). The research will be conducted in a friendly and supportive atmosphere with access to outstanding facilities and within a vibrant postdoc community. The applicant should hold, or be close to completion of, a PhD/DPhil in Structural Biology, Biochemistry, or Molecular/Cell Biology. Experience in protein expression and purification are required for this position. Experience in cryo-EM, cryo-ET, or FIB milling would be an advantage, but is not essential as training can be provided. The post-holder will be responsible for managing their own academic research, establishing and optimising protocols, designing and accurately executing experiments, and contributing conceptually to the overall research programme. Good organisational and communication skills and the ability to work as part of a team are essential. This is a full-time position available for 3 years in the first instance, with a possibility of extension. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. The supporting statement should describe how you fit the criteria for the role, including your motivation and curiosity about the research project. Informal enquiries about this post can be addressed to Dr Katerina Toropova: katerina.toropova@path.ox.ac.uk . The closing date for applications is 12.00 midday on the 30 May 2025. Interviews will be held as soon as possible thereafter. _At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers._ """ . . . . .