Condensed Matter Physics
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Research Grade 7: £38,674 -£46,913 per annum
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Postdoctoral Research Assistant in single-molecule biophysics of DNA damage-induced transcription stress
comment: We are looking to hire an outstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that has as its goals to understand the response of RNA polymerase to DNA damage-induced transcription stress. This post is fixed term for 3 years. What are you going to do? In this fully-funded project, you will: • employ advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study RNA polymerase and its response to DNA damage-induced transcription stress; • develop an interdisciplinary skillset by acquiring a practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies; • interact with biochemist and structural biology collaborators based at Oxford and in the Netherlands (Erasmus MC and Netherlands Cancer institute) in the context of collaborative projects; • come up with suggestions to expand the interdisciplinary skillset as necessary for the benefit of the project; • employ simulations and data analysis routines to analyze your data; • help to establish a scientifically outstanding and warmly communicative interdisciplinary team at the University of Oxford; • publish your results together with collaborators; • have the opportunity to obtain teaching experience and improve your leadership skills while guiding undergraduate and graduate students; About the project Unperturbed gene expression is vital for correct functioning of cells. RNA polymerase II is the enzyme that transcribes genes into mRNA, enabling subsequent protein synthesis. Its transcriptional activity is continuously challenged by the occurrence of DNA damage, resulting from exposure of DNA to cellular metabolites and environmental agents. Bulky and helix-distorting DNA damage physically blocks the forward movement of transcribing RNA polymerase II. Such DNA damage-induced transcription stress can lead to severe cellular dysfunction, death and senescence, and is believed to…
comment: We are looking to hire an outstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that has as its goals to understand the response of RNA polymerase to DNA damage-induced transcription stress. This post is fixed term for 3 years. **What are you going to do?** In this fully-funded project, you will: • employ advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study RNA polymerase and its response to DNA damage-induced transcription stress; • develop an interdisciplinary skillset by acquiring a practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies; • interact with biochemist and structural biology collaborators based at Oxford and in the Netherlands (Erasmus MC and Netherlands Cancer institute) in the context of collaborative projects; • come up with suggestions to expand the interdisciplinary skillset as necessary for the benefit of the project; • employ simulations and data analysis routines to analyze your data; • help to establish a scientifically outstanding and warmly communicative interdisciplinary team at the University of Oxford; • publish your results together with collaborators; • have the opportunity to obtain teaching experience and improve your leadership skills while guiding undergraduate and graduate students; **About the project** Unperturbed gene expression is vital for correct functioning of cells. RNA polymerase II is the enzyme that transcribes genes into mRNA, enabling subsequent protein synthesis. Its transcriptional activity is continuously challenged by the occurrence of DNA damage, resulting from exposure of DNA to cellular metabolites and environmental agents. Bulky and helix-distorting DNA damage physically blocks the forward movement of transcribing RNA polymerase II. Such DNA damage-induced transcription stress can lead to severe cellular dysfunction, death and senescence, and is bel…
contact: HR Team
subject: research
application closing date: 2025-06-16T12:00:00+01:00
notation: 179382
formal organization: University of Oxford
application opening date: 2025-05-02T09:00:00+01:00
salary: Research Grade 7: £38,674 -£46,913 per annum
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type: Vacancy
spatial: Condensed Matter Physics, Department of Physics, Clarendon Laboratory Building and Kavli Institute, Oxford, OX1
based near: Clarendon Laboratory
organization part: Condensed Matter Physics

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Current vacancies at the University of Oxford
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Postdoctoral Research Associate
further particulars: 179895 LMH_PG7_jd-and-person-spec-physics-OF-2.pdf
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formal organization: University of Oxford
subject: research
type: Vacancy
contact: HR Team
organization part: Condensed Matter Physics
application opening date: 2025-05-27T09:00:00+01:00
spatial: Condensed Matter Physics, Department of Physics, Clarendon Laboratory Building, Parks Road, Oxford, OX1 3PU
application closing date: 2025-07-01T12:00:00+01:00
based near: Clarendon Laboratory
comment: Applications are invited for a Postdoctoral Research Associate with expertise in advanced spectroscopic techniques applied to next-generation semiconductors for light-harvesting applications. The position is available for a fixed term of 36 months from time of appointment. This project is associated with a new EPSRC/UKRI-funded project entitled “Mastering charge-lattice interactions in novel semiconductors for renewable energy generation”. This collaborative project will tackle the complex array of exciting fundamental science arising in “soft” inorganic and hybrid semiconductors, seeking to develop new understanding to bridge the gap between existing models for well-established hard and soft semiconductors. The resulting discoveries will provide a blueprint for light-harvesting materials, guiding and accelerating the development of next-generation inorganic and hybrid crystalline semiconductors for the net-zero carbon transition. Materials explored will expand from an initial selection of semiconducting metal halides, chalcohalides and metal chalcogenides. The unusual properties displayed by many of these materials, including structural flexibility, strongly anharmonic lattice potentials, ionic migration, nanoscale assembly, or complex charge-screening processes are still poorly understood despite their critical impact on electronic properties and device performance. The project will provide a paradigm shift in our fundamental understanding of the charge-lattice interactions that govern such effects. This PDRA role will utilize several state-of-the-art spectroscopic techniques, such as transient photoluminescence, absorption & photoconductivity experiments and structural probes, to reveal new understanding of light harvesting materials with intermediate lattice softness. Through a powerful combination of advanced spectroscopic and structural techniques, this postdoctoral project will establish clear correlations and mechanisms linking core properties critical to ef…
notation: 179895
comment: Applications are invited for a Postdoctoral Research Associate with expertise in advanced spectroscopic techniques applied to next-generation semiconductors for light-harvesting applications. The position is available for a fixed term of 36 months from time of appointment. This project is associated with a new EPSRC/UKRI-funded project **entitled “Mastering charge-lattice interactions in novel semiconductors for renewable energy generation”**. This collaborative project will tackle the complex array of exciting fundamental science arising in “soft” inorganic and hybrid semiconductors, seeking to develop new understanding to bridge the gap between existing models for well-established hard and soft semiconductors. The resulting discoveries will provide a blueprint for light-harvesting materials, guiding and accelerating the development of next-generation inorganic and hybrid crystalline semiconductors for the net-zero carbon transition. Materials explored will expand from an initial selection of semiconducting metal halides, chalcohalides and metal chalcogenides. The unusual properties displayed by many of these materials, including structural flexibility, strongly anharmonic lattice potentials, ionic migration, nanoscale assembly, or complex charge-screening processes are still poorly understood despite their critical impact on electronic properties and device performance. The project will provide a paradigm shift in our fundamental understanding of the charge-lattice interactions that govern such effects. This PDRA role will utilize several state-of-the-art spectroscopic techniques, such as transient photoluminescence, absorption & photoconductivity experiments and structural probes, to reveal new understanding of light harvesting materials with intermediate lattice softness. Through a powerful combination of advanced spectroscopic and structural techniques, this postdoctoral project will establish clear correlations and mechanisms linking core properties critical t…
salary: Research Grade 7: £38,674 - £46,913 p.a.

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Postdoctoral Research Assistant in single-molecule biophysics of DNA replication
formal organization: University of Oxford
notation: 179355
spatial: Condensed Matter Physics, Department of Physics, Clarendon Laboratory Building and Kavli Institute, Oxford OX1
subject: research
application closing date: 2025-06-16T12:00:00+01:00
application opening date: 2025-05-02T09:00:00+01:00
salary: Research Grade 7: £38,674 -£46,913 per annum
based near: Clarendon Laboratory
organization part: Condensed Matter Physics
comment: We are looking to hire an outstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that has as its goals to understand the dynamics of eukaryotic DNA replication. This post is fixed term for 3 years. **What are you going to do?** In this fully-funded project, you will: • develop and employ novel advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study DNA replication; • develop and employ simulations and data analysis routines to analyze your data; • develop an interdisciplinary skillset by acquiring a practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies; • come up with suggestions to expand the interdisciplinary skillset as necessary for the benefit of the project; • help to establish a scientifically outstanding and warmly communicative interdisciplinary team at the University of Oxford; • publish your results together with other biophysicists and biochemists on the team; • have the opportunity to obtain teaching experience and improve your leadership skills while guiding undergraduate and graduate students; **About the project** During our lifetimes, we copy approximately a lightyear’s worth of DNA, and how the different components of the molecular machinery (the replisome) work together to achieve this successfully is an area of highly active research. Here, you will take on the exciting challenge of **understanding the _dynamics_ of DNA replication** by studying the activity of eukaryotic replisome at the single-molecule level. You will examine replisome composition, replisome motion dynamics, and the interplay between these two quantities; and examine how these change in the context of chromatin or obstacles on the DNA. To do so, you will design and employ novel biophysical instrumentation (e.g. optical tweezers, single-molecule fluorescence, microfluidics, cryo-electron microscopy) and analyze the resul…
type: Vacancy
contact: HR Team
internal applications only: false
comment: We are looking to hire an outstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that has as its goals to understand the dynamics of eukaryotic DNA replication. This post is fixed term for 3 years. What are you going to do? In this fully-funded project, you will: • develop and employ novel advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study DNA replication; • develop and employ simulations and data analysis routines to analyze your data; • develop an interdisciplinary skillset by acquiring a practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies; • come up with suggestions to expand the interdisciplinary skillset as necessary for the benefit of the project; • help to establish a scientifically outstanding and warmly communicative interdisciplinary team at the University of Oxford; • publish your results together with other biophysicists and biochemists on the team; • have the opportunity to obtain teaching experience and improve your leadership skills while guiding undergraduate and graduate students; About the project During our lifetimes, we copy approximately a lightyear’s worth of DNA, and how the different components of the molecular machinery (the replisome) work together to achieve this successfully is an area of highly active research. Here, you will take on the exciting challenge of understanding the dynamics of DNA replication by studying the activity of eukaryotic replisome at the single-molecule level. You will examine replisome composition, replisome motion dynamics, and the interplay between these two quantities; and examine how these change in the context of chromatin or obstacles on the DNA. To do so, you will design and employ novel biophysical instrumentation (e.g. optical tweezers, single-molecule fluorescence, microfluidics, cryo-electron microscopy) and analyze the resulting datasets …

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179895 LMH_PG7_jd-and-person-spec-physics-OF-2.pdf
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value: _________________________________________________________________________ Job Description and Selection Criteria Job title Post-Doctoral Research Associate Division Condensed Matter Physics Department Physics Location Clarendon Laboratory, Oxford Grade and salary Grade 7: £38,674 - £46,913 per annum Hours Full time Contract type Fixed-term from time of appointment for 36 months Reporting to Prof Laura Herz Vacancy reference 179895 Closing date – midday on 1 July 2025 Additional information Research topic Advanced Device Concepts for Next-Generation Photovoltaics Principal Investigator / supervisor Supervisor: Prof Laura Herz Project team Professor Laura Herz (PI) Project web site https://www-herz.physics.ox.ac.uk Funding partner Recent publications The funds supporting this research project are provided by UKRI/ EPSRC, UK Advanced Functional Materials 34, 2315942 (2024), Advanced Materials 35, 2210834 (2023), Advanced Materials 35, 2305009 (2023) The role Applications are invited for a Postdoctoral Research Assistant who will work on an exciting new UKRI/EPSRC project entitled “Mastering charge-lattice interactions in novel semiconductors for renewable energy generation”. This collaborative project will tackle the complex array of exciting fundamental science arising in “soft” inorganic and hybrid semiconductors, seeking to develop new understanding to bridge the gap between existing models for well-established hard and soft semiconductors. The resulting discoveries will provide a blueprint for light-harvesting materials, guiding and accelerating the development of next-generation inorganic and hybrid crystalline semiconductors for the net-zero carbon transition. The unusual properties displayed by such materials, including structural flexibility, strongly anharmonic lattice potentials, ionic migration, nanoscale assembly, or complex charge-screening processes are still poorly understood despite their critical impact on electronic properties and hence device perform…

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