has site
primary Site
The Wellcome Trust Centre for Human Genetics
Source
The Oxford-GSK Institute of Molecular & Computational Medicine has a new and exciting opportunity for a Postdoctoral Researcher, specialising in Neuronal Dysfunction in Alzheimer’s Disease, to join the Institute. The Institute is built around Fellows and Oxford-GSK project teams located across different departments within the Medical Sciences Division. Projects will initially focus on neurodegeneration and the central nervous system, specifically Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis but it is anticipated the range of activities will expand into other research areas in future. Based within the group of Dr Hugo Fernandes at the Department of Physiology, Anatomy and Genetics, you will be responsible for designing, validating, troubleshooting, and performing relevant assays to interrogate dysregulation induced in iPS-neurons by exposure to material from Alzheimer’s brains. You will develop an iPS-neuronal-microglial co-culture screening platform that can assess synaptic function and synaptic loss, and keep meticulous, detailed records of your work and commit to engaging with cloud-based analyses on the IMCM data platform. Other duties will include collaborating with peer scientists from cross-functional teams to analyse and interpret large complex datasets and communicate findings, and promoting the Oxford-GSK IMCM locally and nationally and disseminating research outcomes to advance knowledge in the specialist area. It is essential that you hold a PhD/DPhil (or close to completion) in biochemistry, molecular biology, neuroscience or a related field, and have experience in cell culture, preferably human pluripotent stem cells. You will have knowledge of neurodegenerative diseases, such as Alzheimer’s Disease, and of differentiation of iPSCs into neuronal and glial cultures. Experience in molecular biology methodologies, following and adapting protocols and setting up cellular assays including image-based is essential for this role, and knowledge of neuroinflammation would be highly desirable. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. This position is offered full time on a fixed term contract until 30 September 2027 and is funded by GSK. Interviews will be held on 4 June 2025. Only applications received before 12 midday on 22 May 2025 will be considered. Please quote **179348** on all correspondence.
locality
preferred label
Research Grade 7: Research Grade 7: Salary in range £38,674 - £46,913 per annum.
extended address
The Oxford-GSK Institute of Molecular & Computational Medicine has a new and exciting opportunity for a Postdoctoral Researcher, specialising in Neuronal Dysfunction in Alzheimer’s Disease, to join the Institute. The Institute is built around Fellows and Oxford-GSK project teams located across different departments within the Medical Sciences Division. Projects will initially focus on neurodegeneration and the central nervous system, specifically Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis but it is anticipated the range of activities will expand into other research areas in future. Based within the group of Dr Hugo Fernandes at the Department of Physiology, Anatomy and Genetics, you will be responsible for designing, validating, troubleshooting, and performing relevant assays to interrogate dysregulation induced in iPS-neurons by exposure to material from Alzheimer’s brains. You will develop an iPS-neuronal-microglial co-culture screening platform that can assess synaptic function and synaptic loss, and keep meticulous, detailed records of your work and commit to engaging with cloud-based analyses on the IMCM data platform. Other duties will include collaborating with peer scientists from cross-functional teams to analyse and interpret large complex datasets and communicate findings, and promoting the Oxford-GSK IMCM locally and nationally and disseminating research outcomes to advance knowledge in the specialist area. It is essential that you hold a PhD/DPhil (or close to completion) in biochemistry, molecular biology, neuroscience or a related field, and have experience in cell culture, preferably human pluripotent stem cells. You will have knowledge of neurodegenerative diseases, such as Alzheimer’s Disease, and of differentiation of iPSCs into neuronal and glial cultures. Experience in molecular biology methodologies, following and adapting protocols and setting up cellular assays including image-based is essential for this role, and knowledge of neuroinflammation would be highly desirable. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. This position is offered full time on a fixed term contract until 30 September 2027 and is funded by GSK. Interviews will be held on 4 June 2025. Only applications received before 12 midday on 22 May 2025 will be considered. Please quote 179348 on all correspondence.
Postdoctoral Researcher in Neuronal Dysfunction in Alzheimer’s Disease, Oxford-GSK Institute of Molecular and Computational Medicine
Job title Postdoctoral Researcher in Neuronal Dysfunction in Alzheimer’s Disease, Oxford-GSK Institute of Molecular and Computational Medicine Division Medical Sciences Department Nuffield Department of Medicine Location Department of Physiology, Anatomy and Genetics, Dorothy Crowfoot Hodgkin Building, Sherrington Road, Oxford, OX1 3QU On occasion, the Centre for Human Genetics, Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford, OX3 7BN Grade and salary Research Grade 7: Salary in range £38,674 - £46,913 per annum. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year Hours Full time Contract type Fixed-term contract until 30 September 2027 Funding is provided by GSK Reporting to Dr Hugo Fernandes, Alzheimer’s Society Dementia Research Leader Fellow, with oversight from Dr Georgina Kerr, Senior Programme Manager Vacancy reference 179348 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation. About us What we offer • • • University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.chg.ox.ac.uk/ / www.imcm.ox.ac.uk / https://www.dpag.ox.ac.uk/ https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community The role This post provides an exciting opportunity to join the newly established multidisciplinary Oxford-GSK Institute of Molecular & Computational Medicine (IMCM) operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN), Sir William Dunn School of Pathology, Department of Psychiatry, and Department of Physiology, Anatomy and Genetics (DPAG). The Institute brings together the very best scientific, clinical, technological and computational expertise from Oxford University and GSK forming a unique industry/academic partnership. The aim of the Institute is to improve tools in, and knowledge from, genetics, genomics, molecular and single cell biology, spatial imaging, machine learning and novel methods of data handling to study the pattern of diseases in new ways. The Institute will develop disease agnostic platforms to change the clinical practise of pathology, helping to identify and validate early potential drug targets, and biomarkers to predict disease progression. The Institute is built around Fellows and Oxford-GSK project teams located across different departments within the Medical Sciences Division. Projects will initially focus on neurodegeneration and the central nervous system, specifically Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis but it is anticipated the range of activities will expand into other research areas in future. You will be a member of the group of Dr. Hugo Fernandes, an Alzheimer’s Society Dementia Research Leader Fellow and a Group Leader at the Department of Physiology, Anatomy and Genetics and the Kavli Institute for Nanoscience Discovery. The Fernandes group has vast experience in neurodegenerative disease in vitro modelling using human Induced Pluripotent Stem Cells (iPSC) and has advanced our understanding of molecular mechanism of neuronal dysfunction in Parkinson’s and Alzheimer’s disease. The group has developed and optimized methods for differentiation of diverse iPSC-neuronal subtypes and has contributed to the understanding of metabolic regulation of neuronal function in health using genetic CRISPR screens, organellar functional assays and single-cell multiomics profiling. In this postdoctoral role, you will work with iPSC-neurons to characterize neuronal dysfunction and establish co-culture models with iPSC-microglia to define mechanisms underlying neuroinflammation. These cell models will be challenged with material isolated from post-mortem brains donated by a large cohort of Alzheimer’s patients to the Oxford Brain Bank in collaboration with Professor Laura Parkkinen (Nuffield Department of Clinical Neuroscience). Neuronal dysfunction will be assessed through a range of cell-based assays and multi-omics approaches, in collaboration with Dr Sally Cowley (Sir William Dunn School of Pathology), working closely with a PDRA in her team. Responsibilities You will: • • • Culture and manipulate human induced Pluripotent Stem Cell lines and undertake their differentiation into neurons and microglia. Design, validate, troubleshoot, and perform relevant assays to interrogate dysregulation induced in iPS-neurons by exposure to material from Alzheimer’s brains. This will require standard cell and molecular biology methodologies, including qPCR, Western Blot, FACs, pharmacological and CRISPR-mediated genetic manipulation of intracellular signalling/trafficking pathways, organelle specific functional assays, high content imaging (Opera Phenix) and automated image analysis. It will also involve processing of samples for multi-omics analyses inlcuding transcriptomics, proteomics and lipidomics. Develop an iPS-neuronal-microglial co-culture screening platform that can assess synaptic function and synaptic loss. 1 • • • • • • • • • • • Keep meticulous, detailed records of your work and commit to engaging with cloud-based analyses on the IMCM data platform. Organise and prioritise your work efficiently and work to the highest standard to meet agreed deadlines. Communicate effectively with colleagues at all levels both within Oxford and at GSK to identify needs, risks and develop appropriate solutions, escalating where appropriate. Be flexible and responsive to the changing needs of individual projects. Collaborate with peer scientists from cross-functional teams to analyse and interpret large complex datasets and communicate findings. Prepare manuscripts for publication and contribute to written and oral presentations/reports as required. Promote the Oxford-GSK IMCM locally and nationally and disseminate research outcomes to advance knowledge in the specialist area. Represent the Oxford-GSK IMCM at external meetings/seminars. Perform other relevant duties as required to support the group’s activities. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Job descriptions can never be comprehensive and you may be required to undertake other similar tasks and responsibilities. Selection criteria Essential • • • • • • • • • Hold a PhD/DPhil (or close to completion) in biochemistry, molecular biology, neuroscience or a related field. Experience in cell culture, preferably human pluripotent stem cells. Knowledge of neurodegenerative diseases, such as Alzheimer’s Disease. Knowledge of differentiation of iPSCs into neuronal and glial cultures. Experience in molecular biology methodologies, following and adapting protocols and setting up cellular assays including image-based. Excellent communication skills, including the ability to write for publication, present results, and represent the research group at meetings. Be highly motivated, organised, keep meticulous records and have the capacity to think creatively. Ability to manage own research and administrative activities. Commitment to engage with, and promote awareness of, equality, diversity and inclusion and embedding these into your work. Desirable • • • • • Experience of working with iPSC-neuronal cultures. Experience of working productively in a multi-disciplinary team. Experience of integrative analyses with other data modalities. Knowledge of neuroinflammation. Experience with preparation of samples for multi-omics analysis (single-cell and bulk) and analysis of large omics-datasets. 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • • Regular manual handling Working with blood, human products and human tissues Work with any substance which has any of the following pictograms on their MSDS: 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy 4 Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN
country name
Job title Cellular Imaging Core Facility Assistant Manager Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN Grade and salary Standard Grade 8: £48,235 - £57,255 with a discretionary range to £62,407 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year. Hours Full time Contract type Fixed-term contract for 2 years in the first instance Funding is provided by the Department Reporting to James Bancroft, Cellular Imaging Core Facility Head Vacancy reference 179269 About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.chg.ox.ac.uk/ The role The Cellular Imaging Core Facility at the Centre for Human Genetics works with users from the Centre, the wider University and industry to provide a range of imaging methodologies along with experimental support and training. You will report to the Cellular Imaging Core Facility Head and be responsible for the day to day running of the facility. You will work with users of the Cellular Imaging Core Facility to provide training in a range of microscopy techniques at the appropriate level for the user and their project requirements. You will also advise on sample preparation and experimental strategy. You will take a leading role in the development of bespoke analysis pipelines and train users in the independent use of analysis platforms. You will work with the Cellular Imaging Core Facility Head and other team member and collaborators to help develop and implement new methods and techniques to address specific biological questions. You will contribute towards publications, by establishing and maintaining key collaborations with research groups. You will have an active role in the training and development of junior members of staff and supervise students within the facility. Responsibilities You will: • • • • • • • • • • • • • Agree clear objectives with the Core Facility Head. Provide light microscopy training for CHG and external users. Oversee the use of microscopes within the Core, carry out system performance tests and contact engineers and/or company representatives in case of malfunction or underperformance. Assist in experimental design and project planning with research groups. Develop advanced analysis workflows, and work with facility users and collaborators to generate quantitative data from imaging datasets. Take part in organisation and delivery of microscopy and analysis teaching. Work on the production of research articles in collaboration with users for submission to peer reviewed journals. Support the day to day running and administration of the Core, assisting with the booking system and calculating user recharges. Work with the Facility Head and other team members to generate new user training and reference materials. Supervise students and junior members of staff, working on projects with the facility. Participate in and support public engagement activities on behalf of the Centre for Human Genetics. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Job descriptions can never be comprehensive and you may be required to undertake other similar tasks and responsibilities. 1 Selection criteria Essential • • • • • • • • • • • Hold a PhD/DPhil (or close to completion) in biological sciences, biophysics, or any other suitable discipline relevant to the role. Significant knowledge and experience of light microscopy (confocal, widefield, Airyscan, SIM etc). Experience in live cell imaging. Familiarity with the existing literature pertaining to optical microscopy techniques. Experience in publishing microscopy and image analysis data. Experience teaching fundamental principles of microscopy to a varied audience. Experience in image data analysis with commercial and open-source image analysis packages. Excellent communication skills. Experience in training others in the use of complex microscope systems. Tissue culture and microscopy sample preparation experience. Clear enthusiasm for working in a Core Facility to support and enable the varied work of research groups throughout the centre. Desirable • • • • • • Experience in working within a microscopy facility. Prior development of bespoke analysis pipelines for a range of biological questions. Experience in molecular biology and labelling proteins with fluorescent proteins. Experience in culturing different cell lines and transfecting cells. Experience in advanced microscopy techniques such as STORM/SMLM, FRET, FLIM, FCS and FRAP. Management experience. 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • • • • • Night working (11pm-6am) Lone Working Driving on University business Regular manual handling Working with infectious pathogens (hazard group 2/3) - Hazard Group 3 pathogens Work with any substance which has any of the following pictograms on their MSDS: 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy 4 Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
Subject
tiene sede principal en
street address
a un site
Calling all microscopists! We are looking to a recruit an enthusiastic Assistant Manager to the growing Cellular Imaging Core Facility at the Centre for Human Genetics. This role will centre around cutting-edge light microscopy. Once in post, you will provide support to users of the Cellular Imaging Core Facility, training them in a range of microscopy techniques at the appropriate level for the user and their project requirements. The Cellular Imaging Core Facility takes a holistic approach to microscopy training and education, as such you will have the knowledge and experience to advise on sample preparation, imaging modalities and settings, data processing, as well as image analysis and data presentation. You will lead in the development of bespoke analysis pipelines and train users in the independent use of analysis platforms with a focus on ZEISS arivis Pro. In addition to overseeing the use of microscopes within the Core, you will carry out system performance tests and liaise proactively with service engineers and/or company representatives in case of malfunction or underperformance. You will support the day to day running and administration of the Core, generating training materials, assisting with the instrument booking system and facility finances (including user recharges). It is essential that you hold a PhD/DPhil (or close to completion) in biological sciences, biophysics, or any other suitable discipline relevant to the role, and have significant knowledge and experience of light microscopy (confocal, widefield, Airyscan, SIM etc). You will have experience in live cell imaging and be familiar with the principles underlying a diverse range of optical microscopy techniques. It is essential you have experience teaching fundamental principles of microscopy to a varied audience, and experience in image data analysis with commercial and open-source image analysis packages. This is an exciting opportunity with the potential to collaborate on projects across a wide range of biological research themes utilising some of the most advanced microscopy equipment in the University of Oxford. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. This position is offered full time on a fixed term contract for 2 years and is funded by the Department. Only applications received before 12 midday on 1 May 2025 will be considered. Please quote **179269** on all correspondence. For informal enquiries relating to this role please contact the Cellular Imaging Core Facility Head (Dr James Bancroft) at james.bancroft@well.ox.ac.uk.
Current vacancies at the University of Oxford
Standard Grade 9: Standard Grade 9: £55,636 - £64,228 with a discretionary range to £70,029 p.a. (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata)
178283 - Postdoctoral Research Assistant - JD
Unit price specification
Calling all microscopists! We are looking to a recruit an enthusiastic Assistant Manager to the growing Cellular Imaging Core Facility at the Centre for Human Genetics. This role will centre around cutting-edge light microscopy. Once in post, you will provide support to users of the Cellular Imaging Core Facility, training them in a range of microscopy techniques at the appropriate level for the user and their project requirements. The Cellular Imaging Core Facility takes a holistic approach to microscopy training and education, as such you will have the knowledge and experience to advise on sample preparation, imaging modalities and settings, data processing, as well as image analysis and data presentation. You will lead in the development of bespoke analysis pipelines and train users in the independent use of analysis platforms with a focus on ZEISS arivis Pro. In addition to overseeing the use of microscopes within the Core, you will carry out system performance tests and liaise proactively with service engineers and/or company representatives in case of malfunction or underperformance. You will support the day to day running and administration of the Core, generating training materials, assisting with the instrument booking system and facility finances (including user recharges). It is essential that you hold a PhD/DPhil (or close to completion) in biological sciences, biophysics, or any other suitable discipline relevant to the role, and have significant knowledge and experience of light microscopy (confocal, widefield, Airyscan, SIM etc). You will have experience in live cell imaging and be familiar with the principles underlying a diverse range of optical microscopy techniques. It is essential you have experience teaching fundamental principles of microscopy to a varied audience, and experience in image data analysis with commercial and open-source image analysis packages. This is an exciting opportunity with the potential to collaborate on projects across a wide range of biological research themes utilising some of the most advanced microscopy equipment in the University of Oxford. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. This position is offered full time on a fixed term contract for 2 years and is funded by the Department. Only applications received before 12 midday on 1 May 2025 will be considered. Please quote 179269 on all correspondence. For informal enquiries relating to this role please contact the Cellular Imaging Core Facility Head (Dr James Bancroft) at james.bancroft@well.ox.ac.uk.
Title
sede principale
valid through (0..1)
OxPoints
Research Grade 7: Research Grade 7: salary in range £38,674 - £43,171 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year
site principal
Nuffield Department of Clinical Medicine
alternative label
Job title Postdoctoral Research Assistant in the Interpretation Transcriptomics and Proteomics for Colorectal Cancer Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN Grade and salary Research Grade 7: salary in range £38,674 - £43,171 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year Hours Full time Contract type of Spatial Fixed-term contract until 31 December 2027 Funding is provided by GSK Reporting to Eoghan Mulholland, Spatial Biology Informatics Team Leader Vacancy reference 178278 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic Spatial Analysis and Interpretation of Spatial Transcriptomics for Colorectal Cancer Principal Investigator / supervisor PIs: Simon Leedham / Helen Byrne Co-Supervisors: Joshua Bull / Eoghan Mulholland Project team GO-PRECISE team Project web site https://www.chg.ox.ac.uk/people/simon-leedham https://www.maths.ox.ac.uk/people/helen.byrne University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.chg.ox.ac.uk/ Funding partner The funds supporting this research project are provided by GSK Recent publications EJM Mulholland et al (2024), bioRxiv 2024. 04.28.591245 JA Bull et al (2024), bioRxiv 2024.12.06.627195 JA Bull et al (2024), bioRxiv 2024.06.02.597010 BJ Stolz et al (2024). Bull Math Biol 86(11): 128. JA Bull et al (2024). Biological Imaging 4, e2. The role We invite applications for a Postdoctoral Research Assistant to work within the multidisciplinary GOPRECISE colorectal precancer team. This is a fixed term position until 31 December 2027, funded by GlaxoSmithKline (GSK). The work will be jointly supervised by Professor Simon Leedham (NDM), Professor Helen Byrne (Mathematical Institute, MI), Dr Joshua Bull (MI) and Dr Eoghan Mulholland (NDM). GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre-Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is directed by Professor Sarah Blagden. Within Oxford, the alliance spans multiple departments and brings together expertise in basic science (including spatial biology), immunology (including machine learning, bioinformatics, preclinical validation) and clinical development (including trial design, delivery and regulatory approval) as well as community engagement. This truly multi-disciplinary initiative aims to transform cancer by actively preventing its development, initially in people at highest risk of the disease and later in the wider population. This post is within the colorectal precancer theme which is jointly led by Simon Leedham and David Church. You will work as part of the Applied Spatial Biology Oxford group, a large multidisciplinary team in which experimentalists and clinicians work closely with mathematicians and computational biologists to identify key features of spatial datasets. You will work in collaboration with the research groups of Leedham and Byrne and the GO-PRECISE team. You will be responsible for the identification of novel spatial biomarkers in spatial transcriptomics data, providing insight into the biological mechanisms identified by data analysis methods in collaboration with quantitative researchers. Your work will establish new antigen markers of cancer that could be targeted with cancer vaccines. The generation of spatial data in biology has been transformed by multiplex imaging and spatial-omics technologies, such as single cell spatial transcriptomics. These approaches permit detailed mapping of phenotypic information about individual cells and their spatial locations within tissue sections. You will use MuSpAn, a Python toolbox for multiscale analysis of spatial data created by our group, to develop pipelines for high-throughput data analysis of spatial transcriptomics images (www.muspan.co.uk). This work will be supported in collaboration with Prof Byrne’s group at the Wolfson Centre for Mathematical Biology and other researchers in the Applied Spatial Biology Oxford group. 1 Responsibilities You will: • • • • • • • • • Manage your own academic research and administrative activities. Adapt existing and develop new research methodologies and materials. Analyse quantitative data from a variety of sources, particularly from Spatial Transcriptomics and Spatial Proteomics platforms. Collaborate with colleagues from the Mathematical Institute, Centre for Human Genetics, and the GO-PRECISE Alliance. Collaborate on the preparation of scientific reports and journal articles, present papers and posters at conferences/workshops. Contribute to community activities such as seminars and networking events. Develop skills in many areas of computational biological research via independent study and training courses. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Selection criteria Essential • • • • • • • Hold a PhD/DPhil (or close to completion) in experimental or theoretical biology, bioinformatics, clinical medicine, or a related discipline. Demonstrated ability to analyse and interpret complex multidimensional data. Experience of working with biomedical datasets, such as cancer data and/or spatial data. Excellent communication skills, including the ability to communicate effectively with researchers from outside your discipline, write for publication and present research proposals and results, and represent the research group at meetings. Experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms. The ability to work independently and to pursue research as part of an interdisciplinary team. A good publication record, for your career stage. Desirable • • • Background and/or interest in mathematics or computer science. Demonstrated enthusiasm for working across disciplinary boundaries with quantitative researchers (mathematicians, computer scientists, physicists, statisticians etc.). Good organisational skills. 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • • Lone Working Regular manual handling Travel outside of Europe or North America on University Business 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy 4 Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
178278 - Postdoctoral Research Assistant - JD
Fax
Centre for Human Genetics, seconded to Department of Physiology, Anatomy and Genetics, Dorothy Crowfoot Hodgkin Building, Sherrington Road, Oxford, OX1 3QU
Voice
We have an exciting opportunity for a Postdoctoral Research Assistant in the Interpretation of Spatial Transcriptomics and Proteomics for Colorectal Cancer. You will join the GO-PRECISE team at the Nuffield Department of Medicine, University of Oxford. GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre-Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is led by Professor Sarah Blagden. You will be responsible for managing your own academic research and administrative activities and adapting existing and developing new research methodologies and materials. You will analyse quantitative data from a variety of sources, particularly from Spatial Transcriptomics and Spatial Proteomics platforms, and collaborate with colleagues from the Mathematical Institute, Centre for Human Genetics, and the GO-PRECISE Alliance. Other duties will include contributing to community activities such as seminars and networking events and developing skills in many areas of computational biological research via independent study and training courses. It is essential that you hold a PhD/DPhil (or close to completion) in experimental or theoretical biology, bioinformatics, clinical medicine, or a related discipline and have demonstrated ability to analyse and interpret complex multidimensional data. You will have experience of working with biomedical datasets, such as cancer data and/or spatial data, and experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms. A background and/or interest in mathematics or computer science would be highly desirable. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV, and 2 referees as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GlaxoSmithKline. Only applications received before 12 midday on 12 May 2025 will be considered. Please quote 178278 on all correspondence.
Postdoctoral Research Assistant in Quantitative Spatial Data Analysis for Colorectal Precancer
We have an exciting opportunity for a Postdoctoral Research Assistant in Quantitative Spatial Data Analysis for Colorectal Precancer to join the multidisciplinary GO-PRECISE colorectal precancer team based at the Nuffield Department of Medicine, University of Oxford. GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre-Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is directed by Professor Sarah Blagden. This post is within the colorectal precancer theme which is jointly led by Simon Leedham and David Church. You will be responsible for managing your own academic research and administrative activities, and adapting existing mathematical and statistical methods for analysis of high-dimensional imaging data, and developing new ones. Other responsibilities will include analysing quantitative imaging data from a variety of sources, including Spatial Transcriptomics and multiplex Spatial Proteomics platforms and developing skills in computational biology and mathematical spatial analysis via independent study and training courses. It is essential that you hold a PhD/DPhil (or close to completion) in mathematics, statistics, physics, engineering, data science or a related discipline, and have demonstrated ability to analyse and interpret complex multidimensional data. Experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms is essential for this role, along with a strong interest in interdisciplinary research in the biological and medical sciences. Experience of applying software engineering best practices and experience of working with biomedical datasets, particularly cancer data and/or spatial data would be highly desirable for this position. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV, and 2 referees as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GlaxoSmithKline. Only applications received before 12 midday on 12 May 2025 will be considered. Please quote 178283 on all correspondence.
Research Grade 6: Research Grade 6: Salary in range £34,982 - £40,855 per annum
Are you looking for a new and unique challenge? Do you have a strategically commercial mind with an interest in clinical research? Working in the University’s largest department, the role of Business Manager will take ownership of the provision of strategic leadership and relationship management for the Centre for Human Genetics, the Division of Structural Biology, as well as across the Nuffield Department of Medicine and wider University. Demonstrating strong leadership, influencing and commercial skills, the Business Manager has accountability for the co-ordination and delivery of high-quality teaching and research support within their assigned research unit. The successful candidate will be the interface between professional services and the academic community, and is responsible for ensuring the alignment of support to advance the academic strategy and vision. Working with the Directors and Finance and Operations and Professional Services Heads of Function, you will define strategic and operational priorities, drive improvements, and manage the escalation of issues through to resolution, ensuring academics receive a positive experience. You will come from a varied senior operational background, including management of a diverse range of administrative staff, ideally in a higher education, public sector or other large and complex organisation. The successful candidate will have a strong understanding of financial management and analysis as well as experience of people management and good HR practice. You will come armed with strong interpersonal skills, with the ability to communicate effectively with a wide range of people, and proven ability to lead, manage change and develop people. The ability to work under pressure with excellent prioritisation skills will be critical to this role, as well as excellent IT skills and expertise in the use of spreadsheets and databases. Applications for this vacancy should to be made online. You will need to upload a supporting statement and CV as part of your online application. Your supporting statement should explain how you meet each of the selection criteria for the post, giving examples of your skills and experience. Our position is offered on a permanent and full time basis. You can expect positive support for your continued professional development through our Personal Development Review process. The University also offers a wide range of staff benefits, including entry to the generous USS pension scheme. Only applications received before 12 midday on 6th May 2025 will be considered. Interviews will be held during week commencing 12th May 2025. Please quote 178753 on all correspondence.
sous-Organization de
Job title Business Manager – Centre for Human Genetics Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Old Road Campus, Headington, Oxford, OX3 7BN Grade and salary Standard Grade 9: £55,636 - £64,228 with a discretionary range to £70,029 p.a. (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata). Hours Full time Contract type Permanent Funding is provided by the Department Reporting to Operations Director Vacancy reference 178753 Hybrid working arrangements The successful person will need to work on site for a minimum of 3 days per week Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation, but eligibility will depend on the chosen candidate’s details so, if a visa is required, this will be determined once the selection has been completed. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - www.chg.ox.ac.uk The role The Centre for Human Genetics (CHG) and Division of Structural Biology (STRUBI) are world-leading research facilities in the fields of human genetics, geneomics and structural biology, housed in the Henry Wellcome Buildings, Headington. As one of the largest facilities in NDM, these units support 6.500sqm of laboratory and office space, with over 600 research and Professional Services staff, and students working in a dynamic interdisciplinary research environment. The CHG and STRUBI house a range of facilities and specialist equipment including cryo-electron microscopy, optical microscopy, high-performance research computing, and a Functional Genetics Facility (FGF). The units’ standard lab environments are biological containment level 2, while the FGF and OPIC facilities include a containment level 3 lab environments. The CHG also hosts a range of internal entities. The Centre for Personalised Medicine (CPM) is a collaborative endeavour with St Anne’s College, hosting a wide range of public and patient engagement activities. The GSK-Oxford Institute for Computational and Molecular Medicine (IMCM) is a industrial partnership between the University of Oxford and GSK, supporting ground-breaking research to deal with the world’s most signficant health challenges. The Business Manager will report to the Operations Director – UK with accountability for the provision of strategic leadership and relationship management across the Nuffield Department of Medicine. The Business Manager will be responsible for the co-ordination and delivery of high-quality research support, demonstrating strong leadership, influencing and diplomatic skills. This position will act as the interface between Professional Services and the academic community, ensuring the alignment of support to advance the academic strategy and vision, using their detailed knowledge of operational structures across NDM. Acting as a senior point of contact for the CHG and STRUBI Directors and Principal Investigators, the Business Manager will be responsible for all aspects of operations and administration and contribute significantly to the design of Professional Services to meet the financial requirements of the department and the challenges of academic endeavour. The postholder will be required to analyse a range of management information, highlighting any issues to Heads of Function and document the measurements of success. This will involve working with other senior leaders across the department to define strategic and operational priorities, drive improvements, and manage the escalation of issues through to resolution, ensuring academics receive a positive experience when engaging with NDM Professional Services. You will be involved in strategic planning, providing accurate management information in partnership with the NDM Shared Service teams to ensure that operational activities and new projects within the CHG and STRUBI are aligned to the department’s strategic objectives, and delivers the expected benefits. You will have responsibility for overseeing the work of Professional Services staff working in both units, directly line managing the CHG and STRUBI Deputy Business Managers, Director’s Executive Assistant, and Senior Scientific Officer in the CPM. Co-line management of the Senior Finance Manager, Senior Building and Facilities Manager and IT Manager will also be part of the personnel remit for the position. 1 Organogram Operations Director - UK G10 Business Manager G9 Head of Facilities and Capital Projects G9 Director of Digital Information G10 Deputy Director of Finance G9 Senior Finance Manager Deputy Business Manager - CHG G8 Deputy Business Manager - STRUBI G8 Executive Assitant to the Director CHG G6 Senior Scientific Officer G8 Senior Building and Facilities Manager G9 IT Manager CHG Administration Team STRUBI Administration Team CHG PA Team CPM Administration Team HWB Facilities Team CHG IT Team Responsibilities Service Delivery & Business Relationship Management • • • • • • • • Build and sustain strategic relationships, fostering a successful Professional Services environment that maintains a focus on supporting world-leading teaching and research through alignment with the academic mission. Lead the CHG and STRUBI Professional Services teams to engage with the academic community, promoting a greater understanding of research priorities, evolving operational needs, and a ‘one team’ approach for delivering services. Undertake regular reviews with Unit Directors, PIs and Heads of Function to assess levels of service performance/satisfaction, identify potential issues, and collaborate with Operations Director to develop sustainable, fit-for-purpose resolutions, unpinned by a solution-focussed approach to problem solving. Working closely with Professional Services teams across NDM, and other internal/external sources of best practice, to ensure that units’ operational activities take place in compliance with legislation, funding terms and conditions and University policy. Work across NDM to assess, manage and communicate risks that could impact the academic mission, research priorities, or operations. Support Heads of Function and Operations Directors to proactively manage the expectations of the academic community, identifying the drivers of change and raising awareness of operational opportunities and dependencies that influence levels and quality of service delivery. In collaboration with the Heads of Function to define Service Level Agreements, KPIs, and performance measurements. Where appropriate, jointly plan and implement continual improvements to service delivery. Sponsor and lead strategic projects in CHG and STRUBI to deliver service improvement initiatives, contributing to and aligning with the NDM Professional Services strategy. 2 Strategic Development and Planning • • • • • • • Provide senior leadership support and strategic advice to the CHG and STRUBI Directors, with oversight of financial and administrative operations, supporting the research priorities of the units. Sit on all strategic committees for the units, and support the Directors in the implementation of an effective governance structure to manage unit operations and plan strategic direction. Contribute to strategic discussions and the development of plans within the units, and at a departmental or divisional level as required. Responsibility for the preparation and implementation of detailed financial, operational and space plans required to support research and teaching within the unit. Assess changes to the University’s policies and procedures, analysing their impact on the unit and ensuring they are understood and effectively communicated. In collaboration with the Heads of Function, the post holder will identify trends which could have an impact on unit activity, recommending approaches to address these and implement solutions. Supported by NDM’s functional teams, you will produce timely and accurate management information to support Unit strategic planning and decision-making and take the lead in the effective implementation of the Head of Unit's strategic research and staffing priorities. Human Resources • • • • • • • • Work in partnership with the NDM HR Centres for Excellence to ensure a professional HR service is delivered across CHG and STRUBI. Maintain a good working knowledge of employment law, seeking guidance as appropriate. Ensure that all information regarding employment contracts, including pay changes, are communicated clearly and in a timely manner to HR for action, in accordance with the set process. Be responsible for ensuring contracts of employment and associated paperwork is signed-off with due care/diligence and in accordance with the prevailing statutory rules and policies of the University. Working effectively with Deputy Business Managers to conduct monthly payroll verification checks against the requests provided to HR and for investigating queries arising. Provide monthly reviews of staff contractual status, ensuring requests for extensions, changes to contract type or notice are notified to the HR team in accordance with the process. Support the Unit Directors and PIs in development of career pathways for academic colleagues, and provide expert advice on the financial and contractual commitments made to support research applications and letters or support. Support the Department’s Athena SWAN and EDI programmes, ensuring the Unit level actions plans are taken forward, in consultation with the NDM EDI Facilitator, Athena SWAN Co-ordinator and NDM HR Director. Financial Management and Forecasting • • • • • Have dual line management of the Unit’s Finance Manager. The post holder will provide line management for unit operations whilst the NDM Deputy Head of Finance will provide professional development and support with detailed accounting issues. Management of recruitment, PDRs, annual leave and employee relation matters will be undertaken jointly. Be required to maintain a good working knowledge of best financial practice and a good understanding of University financial regulations, policies and processes. The post holder will work closely with the NDM Finance Team to ensure appropriate levels of service delivery. Responsibility for setting the units’ budgets, and monitoring progress against it, taking remedial action where necessary, including validation of monthly pay and research overhead income to minimise costs passing to the department, development of strategies to minimise variances and ensure general ledger accounts do not generate deficits, and optimisation of use of trust funds and restricted donations. Support with the development and scrutiny of business plans for Small Research Facilities and other initiatives, working with the SRF Operations Manager, and SRF Leads to maximise financial performance and build sustainability and growth. Challenge high value purchase orders, expenses and journals not in line with budget or forecasts. Oversee the generation and circulation of monthly reports to PI’s & budget holders to allow them to 3 • • • • • validate transactions and raise queries. Hold and participate in regular financial reviews with stakeholders. Within specified deadlines, you will produce unit I&E budgets and forecasts including detailed analysis for pay and research, with opportunities & risks clearly identified, including asset replacement planning. Ensure the unit maintains an up to date delegation of authority, promoting the use of preferred suppliers, value for money and budgetary controls. Lead tendering processes and approval of new suppliers in conjunction with key staff involved in the process. Ensure that the units maintain a contracts register to monitor contractual commitments and supplier performance. Review all service and procurement contracts to ensure compliance with University terms and conditions wherever possible, identifying any areas of contractual risk and liaising with central Procurement and NDM compliance teams appropriately to implement suitable mitigation. Grant Management • • • • Maintain a strategic overview of the units’ grant portfolios and their impact on business operating income and expenditure. Work with the Head of Grant Management to identify and mitigate risks by influencing behaviours to ensure best practice grant application and management. Identify new funding opportunities, working with the Head of Grant Management and Director of Research Delivery to ensure that the terms and conditions are acceptable to the Department. Accountability for the financial management of the units’ research grants and contracts, with oversight for ensuring funds are expended on their designated purpose and comply with regulations or procedures of the relevant funding body, seeking and acting on advice from the NDM GMT, Research Services and Research Accounts as appropriate. Governance & Compliance • • • • • • • Working in partnership with the NDM Head of Health and Safety, you will support the Unit Directors to ensure all Health and Safety responsibilities are allocated appropriately, with support from the NDM Health and Safety Team, the Medical Sciences Division Safety Office and OU Safety Office. Be fully accountable to ensure that the H&S standards in their area are met and that training of staff and students is recorded and up-to-date. You will ensure that all documentation related to the H&S Management of their area are readily available and stored adequately. Have a broad understanding of activity in shared building space, including associated Health and Safety Risk Assessments and the impact of new activity taking place or being re-located. Be responsible and accountable for the implementation, review and update of IT, Information Security and Governance systems, processes and procedures to ensure compliance with University, Divisional and Departmental policies. Have overall supervision and implementation of all regulatory processes in their area with the support of relevant NDM, Divisional and OU staff. This includes, but is not limited to H&S, HTA and Environmental regulations. Maintain and review the Units’ strategic risk register, taking accountability and ownership of mitigations and action plans within CHG and STRUBI, including the safeguarding of assets and adequate insurance cover. Act as the principle point of contact for all operational audits related to the unit. The postholder will be responsible for ensuring effective management plans are in place to address audit findings, control changes are embedded within normal operating practice and actions are addressed in line with agreed delivery dates. Estates & Facilities • Have dual line management of the HWB Senior Building and Facilities Manager. The post holder will provide line management for unit operations whilst the NDM Head of Space and Capital Projects will provide professional development and support with strategic projects and issues cutting across the Department. Management of recruitment, PDRs, annual leave and employee relation matters will be undertaken jointly. 4 • • Represent the operational and financial interests of the units in all refurbishment and new build projects impacting them, working with the Head of Space and Capital Projects, Unit Directors and Project Boards to deliver projects on time and within budget. Coordinate and lead the capital replacement and refurbishment plan for their unit and ensure these plans are fed into NDM, working with appropropriate Heads of Function, Operations Directors and Unit Directors funding and prioritisation for capital replacement. Communications & Public Engagement • • • • Promote the units’ and NDM’s research and other announcements through a variety of communications channels, in partnership with the NDM Head of Communications. Support the NDM Head of Communications to ensure that internal communications are circulated, and actioned where required. Work with the Unit Directors to ensure that a clear and functional communications strategy is in place for the promotion of the unit’s activities, and effective circulation of key internal communication to all staff and students. In liaison with PI’s and research staff, you will be responsible for provision of support as appropriate to Public Engagement and Outreach Activities, working closely with the NDMS Head of Communications and other unit-based communications staff. Other duties • • • • • • Chair committees/groups and represent NDM Professional Services on a wide range of University, divisional, departmental committees and interdisciplinary networks. When required, provide operational support for Business Managers in other research units to ensure resilience for staffing and mission critical activities. Any other duties as required by the Operations Directors, NDM Chiel of Staff or NDM Chief Operating Officer, appropriate for the grade. Engage with stakeholders across the Medical Sciences Division, the University and wider HE/private sectors who have expertise in the continual improvement of Professional Service capabilities. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Selection criteria Essential • • • • • • • • • Be educated to degree level, or equivalent vocational qualification or experience. Senior managerial experience in a varied working environment, including management of a diverse range of administrative staff, in a relevant field. Advanced numeracy skills with experience and understanding of financial management, accounting and analysis. Experience of personnel management and good HR practice, with the ability to manage and resolve complex and stressful situations. Experience of research grant costing and grant accounting, including a thorough understanding of the accounting requirements of the major funding bodies. Demonstrable ability to communicate effectively, both verbally and in writing, with a wide range of people within and external to the organisation. Strong interpersonal skills, with a proven ability to lead, manage change, to maintain confidentiality as appropriate and to encourage team-based approach to tasks. Evidence of the ability to perform effectively under pressure, with excellent prioritisation, delegation and time management skills. High level of computer literacy with expertise in the use of spreadsheets and databases. 5 Desirable • • Experience in higher education sector. Experience in change management in complex organisations. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Additional security pre-employment checks This job includes duties that will require additional security pre-employment checks: • A satisfactory enhanced Disclosure and Barring Service check 6 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/professionalandmanagement/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates 7 Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 8
Applications are invited for a Research Assistant in Functional Genomics of Sepsis to join Professor Julian Knight’s research group, an established team with a track record of innovation and high impact research in functional genomics, sepsis and susceptibility to multi-factorial disease. This is an exciting new position funded through a collaboration with the Danaher corporation and its subsidiary Cepheid. This research is part of the Beacon programme ‘Development and prospective evaluation of point-of-need test for sepsis subtyping based on gene expression using the Cepheid GeneXpert platform’. The programme seeks to advance precision medicine for patients with sepsis by developing a point-of-care test to stratify patients based on their immune response profiles. We aim to use an integrated approach which leverages the host transcriptome, immune profiling, and electronic health records, in combination with the GeneXpert system for mRNA quantification. Our goal is to deliver a precision medicine approach for managing patients with severe infections. The work is highly collaborative with clinical teams, company partners, and expert investigators across the UK, the US, and Sweden. You will facilitate exciting new collaborative links with Danaher, which may involve travel to Sweden (Cepheid) and the United States (Danaher). You will have a degree in biology, genetics, immunology, biochemistry, molecular biology or related field and relevant research experience of patient blood or tissue sample processing in the laboratory and management of sample collections. You will be motivated by a stimulating and ambitious research environment with a desire to deliver high quality cutting-edge science and work in a laboratory offering the opportunity for career development and acquiring new expertise. This position is offered full time on a fixed term contract until 30 September 2027 and is funded by the Danaher Corporation. The anticipated start date is 1 September 2025. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. Only applications received before 12 midday on 8 May 2025 can be considered. Please quote 179416 on all correspondence.
es suborganización de
Cellular Imaging Core Facility Assistant Manager
subOrganization of
address
has exact match
Postdoctoral Research Assistant in the Interpretation of Spatial Transcriptomics and Proteomics for Colorectal Cancer
Research Assistant in Functional Genomics of Sepsis
Job title Research Assistant in Functional Genomics of Sepsis Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN Grade and salary Research Grade 6: Salary in range £34,982 - £40,855 per annum (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata). Hours Full time Contract type Fixed-term contract until 30 September 2027 Funding is provided by the Danaher Corporation Additional information Anticipated start date 1 September 2025 Reporting to Professor Julian Knight, Group Head/Principal Investigator Vacancy reference 179416 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic Severe infectious disease – Genomics of Sepsis Principal Investigator / supervisor Professor Julian Knight University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.chg.ox.ac.uk/ Project web site https://www.chg.ox.ac.uk/research/research-groups/julian-knight-group Kwok AJ, Allcock A, Ferreira RC, Cano-Gamez E, Smee M, Burnham KL, Zurke Y-X, Emergency Medicine Research Oxford (EMROx), McKechnie S, Mentzer AJ, Monaco C, Udalova I, Hinds CJ, Davenport EE, Todd JA, Knight JC (2023). Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis. Nature Immunology 24, 767-779 Recent publications Cano-Gamez E, Burnham KL, Goh C, Malick ZH, Kwok A, Smith DA, Peters-Sengers H, Antcliffe D, Investigators G, McKechnie S, Scicluna BP, van der Poll T, Gordon AC, Hinds CJ, Davenport EE and Knight JC (2022). An immune dysfunction score for stratification of patients with acute infection based on whole blood gene expression. Science Translational Medicine 14, eabq4433 The role Applications are invited for a Research Assistant in the Genomics of Sepsis at the University of Oxford. You will be based at the Centre for Human Genetics (CHG) within the group of Professor Julian Knight, joining an established team with a track record of innovation and high impact research in functional genomics, sepsis and susceptibility to multi-factorial disease. You will have the opportunity to join a programme of research that is being further advanced through a collaboration with the Danaher corporation and its subsidiary Cepheid. This research is part of the Beacon programme ‘Development and prospective evaluation of point-of-need test for sepsis subtyping based on gene expression using the Cepheid GeneXpert platform’. The programme seeks to advance precision medicine for patients with sepsis by developing a point-of-care test to stratify patients based on their immune response profiles. We aim to use an integrated approach which leverages the host transcriptome, immune profiling, and electronic health records, in combination with the GeneXpert system for mRNA quantification. Our goal is to deliver a precision medicine approach for managing patients with severe infections. The work is highly collaborative with clinical teams, company partners, and expert investigators across the UK, the US, and Sweden. You will facilitate exciting new collaborative links with Danaher, which may involve travel to Sweden (Cepheid) and the United States (Danaher). We seek to develop a point-of-care test and associated algorithms which could distinguish between individuals at different levels of immune dysfunction. We also aim to identify decision points along the patient journey where this test could be most useful upon deployment. You will be responsible for managing on-going sample collection from recruited patients with sepsis. Key tasks include sample processing and extraction, maintaining the sample biobank and associated databases, liaison with research nurse teams and researchers at Cepheid, running, supporting and validating the GeneXpert test, performing functional genomic assays including RNA-sequencing, and other work as required, including immunological assays. You will have relevant research experience in cell purification and tissue culture, immunology, molecular biology and genomics. Experience of management of sample collections will also be part of your skills set. You will be motivated by a stimulating and ambitious research environment with a desire to deliver high quality cutting-edge science and work in a laboratory offering the opportunity for career development and acquiring new expertise. You will be part of a dynamic research team lead by Professor Julian Knight who has extensive experience in the functional genomics of immunity and sepsis. The team includes postdoctoral scientists with significant expertise in both wet lab and functional genomic analysis. 1 Responsibilities You will: • • • • • • • • • • • • • • • • Manage sample collection from recruited individuals through excellent team communication and record keeping skills. Maintain and manage the project sample database. Support clinical phenotyping and related data management. Perform cell and tissue culture including isolation of primary human cells and nucleic acids. Prepare and analyse blood samples for GeneXpert assay and relevant immunological, molecular biology and -omic assays. Work closely with the research nurse team and our collaborators in Danaher and Cepheid to ensure samples and data is shared in a timely and appropriate manner, and project milestones are met. Plan and monitor project deadlines. Multi-task and prioritise your own workload. Work with other members of the laboratory on related projects. Help in the education and training of staff and students as necessary and appropriate. Keep detailed, accurate and comprehensible records of experimental plans and work, aid in writing of reports and contribute to the publication of research findings in high quality journals. Attend appropriate scientific seminars and meetings and to remain up to date with developments in the relevant fields. Work as part of an interdisciplinary team, contribute fully to laboratory meetings and discussion of the aims and objectives of the group’s work. Participate and support public engagement activities on behalf of the Centre, working with the Centre’s Public Engagement and Communications Officer. This is anticipated to be around 2 days per year. Work closely with the group head and keep him up-to-date with progress and difficulties in the research project. Undertake such other duties as may be required from time to time that are commensurate with the grade and responsibilities of this post. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Job descriptions can never be comprehensive and you may be required to undertake other similar tasks and responsibilities. Selection criteria Essential • • • • • • A degree in biology, genetics, immunology, biochemistry, molecular biology or related field. A demonstrable interest in the research described here. Experience of patient blood or tissue sample processing in the laboratory and management of sample collections. Demonstrable high level of communication skills both written and oral. Ability to organize and prioritise work efficiently delivering results to required standard and to an agreed schedule. Evidence of working with accuracy, self-motivation and integrity. 2 • • Evidence of sound decision-making, problem-solving, planning and organisation. Ability to work within a team effectively. Desirable • • • • • Experience in tissue culture and working with primary human cells. Experience of standard molecular biology techniques. Experience of maintaining databases for study sample collections and phenotyping data. Experience of functional genomic protocols. Knowledge of the principles and application of bioinformatics, statistical genetics and/or high throughput sequencing data analysis. Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • Working with blood, human products and human tissues Work with any substance which has any of the following pictograms on their MSDS: 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy 4 Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
tiene sede en
Address
telephone
email
Are you looking for a new and unique challenge? Do you have a strategically commercial mind with an interest in clinical research? Working in the University’s largest department, the role of Business Manager will take ownership of the provision of strategic leadership and relationship management for the Centre for Human Genetics, the Division of Structural Biology, as well as across the Nuffield Department of Medicine and wider University. Demonstrating strong leadership, influencing and commercial skills, the Business Manager has accountability for the co-ordination and delivery of high-quality teaching and research support within their assigned research unit. The successful candidate will be the interface between professional services and the academic community, and is responsible for ensuring the alignment of support to advance the academic strategy and vision. Working with the Directors and Finance and Operations and Professional Services Heads of Function, you will define strategic and operational priorities, drive improvements, and manage the escalation of issues through to resolution, ensuring academics receive a positive experience. You will come from a varied senior operational background, including management of a diverse range of administrative staff, ideally in a higher education, public sector or other large and complex organisation. The successful candidate will have a strong understanding of financial management and analysis as well as experience of people management and good HR practice. You will come armed with strong interpersonal skills, with the ability to communicate effectively with a wide range of people, and proven ability to lead, manage change and develop people. The ability to work under pressure with excellent prioritisation skills will be critical to this role, as well as excellent IT skills and expertise in the use of spreadsheets and databases. Applications for this vacancy should to be made online. You will need to upload a supporting statement and CV as part of your online application. Your supporting statement should explain how you meet each of the selection criteria for the post, giving examples of your skills and experience. Our position is offered on a permanent and full time basis. You can expect positive support for your continued professional development through our Personal Development Review process. The University also offers a wide range of staff benefits, including entry to the generous USS pension scheme. Only applications received before 12 midday on **6th** ** May 2025** will be considered. Interviews will be held during week commencing 12th May 2025. Please quote 178753 on all correspondence.
We have an exciting opportunity for a Postdoctoral Research Assistant in the Interpretation of Spatial Transcriptomics and Proteomics for Colorectal Cancer. You will join the GO-PRECISE team at the Nuffield Department of Medicine, University of Oxford. GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre- Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is led by Professor Sarah Blagden. You will be responsible for managing your own academic research and administrative activities and adapting existing and developing new research methodologies and materials. You will analyse quantitative data from a variety of sources, particularly from Spatial Transcriptomics and Spatial Proteomics platforms, and collaborate with colleagues from the Mathematical Institute, Centre for Human Genetics, and the GO-PRECISE Alliance. Other duties will include contributing to community activities such as seminars and networking events and developing skills in many areas of computational biological research via independent study and training courses. It is essential that you hold a PhD/DPhil (or close to completion) in experimental or theoretical biology, bioinformatics, clinical medicine, or a related discipline and have demonstrated ability to analyse and interpret complex multidimensional data. You will have experience of working with biomedical datasets, such as cancer data and/or spatial data, and experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms. A background and/or interest in mathematics or computer science would be highly desirable. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV, and 2 referees as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GlaxoSmithKline. Only applications received before 12 midday on 12 May 2025 will be considered. Please quote **178278** on all correspondence.
sotto-Organization di
Research Grade 7: Research Grade 7: salary in range £38,674 - £46,913 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year
postal code
notation
Is Part Of
Wellcome Trust Centre for Human Genetics
179269 - Cellular Imaging Core Facility Assistant Manager - JD
We have an exciting opportunity for a Postdoctoral Research Assistant in Quantitative Spatial Data Analysis for Colorectal Precancer to join the multidisciplinary GO-PRECISE colorectal precancer team based at the Nuffield Department of Medicine, University of Oxford. GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre- Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is directed by Professor Sarah Blagden. This post is within the colorectal precancer theme which is jointly led by Simon Leedham and David Church. You will be responsible for managing your own academic research and administrative activities, and adapting existing mathematical and statistical methods for analysis of high-dimensional imaging data, and developing new ones. Other responsibilities will include analysing quantitative imaging data from a variety of sources, including Spatial Transcriptomics and multiplex Spatial Proteomics platforms and developing skills in computational biology and mathematical spatial analysis via independent study and training courses. It is essential that you hold a PhD/DPhil (or close to completion) in mathematics, statistics, physics, engineering, data science or a related discipline, and have demonstrated ability to analyse and interpret complex multidimensional data. Experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms is essential for this role, along with a strong interest in interdisciplinary research in the biological and medical sciences. Experience of applying software engineering best practices and experience of working with biomedical datasets, particularly cancer data and/or spatial data would be highly desirable for this position. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV, and 2 referees as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GlaxoSmithKline. Only applications received before 12 midday on 12 May 2025 will be considered. Please quote **178283** on all correspondence.
Job title Postdoctoral Research Assistant in Quantitative Spatial Data Analysis for Colorectal Precancer Division Medical Sciences Department Nuffield Department of Medicine Location Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN Grade and salary Research Grade 7: salary in range £38,674 - £46,913 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year Hours Full time Contract type Fixed-term contract until 31 December 2027 Funding is provided by GSK Reporting to Eoghan Mulholland, Spatial Biology Informatics Team Leader Vacancy reference 178283 Additional information This role meets the eligibility requirements for a Skilled Worker Certificate of Sponsorship under UK Visas and Immigration legislation. About us • • • What we offer https://hr.admin.ox.ac.uk/staff-benefits • An excellent contributory pension scheme • 38 days annual leave • A pensionable Oxford University Weighting allowance of £1,500 per annum (pro rata) • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs • A welcoming and diverse community Research topic Spatial Analysis of Spatial Transcriptomics for Colorectal Precancer Principal Investigator / supervisor PIs: Simon Leedham / Helen Byrne Project team GO-PRECISE team University of Oxford - www.ox.ac.uk/about/organisation Nuffield Department of Medicine (NDM) - https://www.ndm.ox.ac.uk Unit - https://www.chg.ox.ac.uk/ Co-Supervisors: Joshua Bull / Eoghan Mulholland Project web site https://www.chg.ox.ac.uk/people/simon-leedham https://www.maths.ox.ac.uk/people/helen.byrne Funding partner The funds supporting this research project are provided by GSK Recent publications EJM Mulholland et al (2024), bioRxiv 2024. 04.28.591245 JA Bull et al (2024), bioRxiv 2024.12.06.627195 JA Bull et al (2024), bioRxiv 2024.06.02.597010 BJ Stolz et al (2024). Bull Math Biol 86(11): 128. JA Bull et al (2024). Biological Imaging 4, e2. The role We invite applications for a Postdoctoral Research Assistant to work within the multidisciplinary GOPRECISE colorectal precancer team. This is a fixed term position until 31 December 2027, funded by GlaxoSmithKline (GSK). The work will be jointly supervised by Professor Simon Leedham (NDM), Professor Helen Byrne (Mathematical Institute, MI), Dr Joshua Bull (MI) and Dr Eoghan Mulholland (NDM). GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre-Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is directed by Professor Sarah Blagden. Within Oxford, the alliance spans multiple departments and brings together expertise in basic science (including spatial biology), immunology (including machine learning, bioinformatics, preclinical validation) and clinical development (including trial design, delivery and regulatory approval) as well as community engagement. This truly multi-disciplinary initiative aims to transform cancer by actively preventing its development, initially in people at highest risk of the disease and later in the wider population. This post is within the colorectal precancer theme which is jointly led by Simon Leedham and David Church. You will work as part of the Applied Spatial Biology Oxford group, a large multidisciplinary team of mathematicians, computational biologists, experimentalists and clinicians, and in collaboration with the research groups of Leedham and Byrne and the GO-PRECISE team. You will be responsible for developing and using cutting-edge mathematical methods to describe the spatial characteristics and cellular interactions that characterise colorectal precancer, identifying novel spatial biomarkers from spatial transcriptomics data, and exploring neoantigens or therapeutic targets that could be used for novel interception strategies. The generation of spatial data in biology has been transformed by multiplex imaging and spatial-omics technologies, such as single cell spatial transcriptomics. These approaches permit detailed mapping of phenotypic information about individual cells and their spatial locations within tissue sections. To aid in mathematical analysis of spatial data, you will use MuSpAn, a Python toolbox for multiscale analysis of spatial data which includes techniques drawn from spatial statistics, topological data analysis and networks (www.muspan.co.uk), to develop pipelines for high-throughput data analysis of spatial transcriptomics imaging. Your research will involve the theoretical development and practical application of new mathematical methods which expand this toolbox, using a new precancer dataset. 1 Responsibilities You will: • • • • • • • • • • Manage your own academic research and administrative activities. Adapt existing mathematical and statistical methods for analysis of high-dimensional imaging data, and develop new ones. Analyse quantitative imaging data from a variety of sources, including Spatial Transcriptomics and multiplex Spatial Proteomics platforms. Develop skills in computational biology and mathematical spatial analysis via independent study and training courses. Collaborate with colleagues from the Mathematical Institute, Centre for Human Genetics, and the PRECISE Alliance. Collaborate on the preparation of scientific reports and journal articles, present papers and posters at conferences/workshops. Follow and promote best practices for research software engineering and reproducible research within the University of Oxford and the wider UK and international research community. Contribute to community activities such as seminars and networking events. Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year. Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements. Selection criteria Essential • • • • • • • • Hold a PhD/DPhil (or close to completion) in mathematics, statistics, physics, engineering, data science or a related discipline. Demonstrated ability to analyse and interpret complex multidimensional data. Experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms. Have a strong interest in interdisciplinary research in the biological and medical sciences. Excellent communication skills, including the ability to communicate effectively with biomedical researchers, write for publication and present research proposals and results, and represent the research group at meetings. Demonstrated enthusiasm for working across disciplinary boundaries. The ability to work independently and to pursue research as part of an interdisciplinary team. A good publication record, for your career stage. Desirable • • • • Experience of applying software engineering best practices (e.g. issue tracking, code review, testing, documentation and continuous integration) Experience of close collaboration with researchers in the biological or medical sciences. Experience of working with biomedical datasets, particularly cancer data and/or spatial data. Good organisational skills. 2 Pre-employment screening Standard checks If you are offered the post, the offer will be subject to standard pre-employment checks. You will be asked to provide: proof of your right-to-work in the UK; proof of your identity; and (if we haven’t done so already) we will contact the referees you have nominated. You will also be asked to complete a health declaration so that you can tell us about any health conditions or disabilities for which you may need us to make appropriate adjustments. Please read the candidate notes on the University’s pre-employment screening procedures at: https://www.jobs.ox.ac.uk/pre-employment-checks Hazard-specific / Safety-critical duties This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service, and the offer of employment will be subject a successful outcome of this assessment. The hazards or safety-critical duties involved are as follows: • • • Lone Working Regular manual handling Travel outside of Europe or North America on University Business 3 How to apply Applications are made through our e-recruitment system and you will find all the information you need about how to apply on our Jobs website https://www.jobs.ox.ac.uk/how-to-apply. If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the onscreen instructions to register as a new user or log-in if you have applied previously. As part of your application you will be asked to provide details of two referees and indicate whether we can contact them now. You will be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please upload all documents as PDF files with your name and the document type in the filename. Please note using a long file name may prevent you from uploading your documents. • http://www.ox.ac.uk/about_the_university/jobs/research/ All applications must be received by midday UK time on the closing date stated in the online advertisement. If you currently work for the University please note that: • • As part of the referencing process, we will contact your current department to confirm basic employment details including reason for leaving. Although employees may hold multiple part-time posts, they may not hold more than the equivalent of a full time post. If you are offered this post, and accepting it would take you over the equivalent of full-time hours, you will be expected to resign from, or reduce hours in, your other posts(s) before starting work in the new post. Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s). If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments). If you need help Application FAQs, including technical troubleshooting advice is available at: https://staff.web.ox.ac.uk/recruitment-support-faqs. Non-technical questions about this job should be addressed to the recruiting department directly recruitment@ndm.ox.ac.uk To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will receive an automated email from our online recruitment portal to confirm receipt of your application. Please check your spam/junk mail if you do not receive this email. Important information for candidates Data Privacy 4 Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: https://compliance.admin.ox.ac.uk/job-applicant-privacy-policy. The University’s Policy on Data Protection is available at: https://compliance.admin.ox.ac.uk/data-protection-policy. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for very senior research posts at grade RSIV/D35 and clinical equivalents E62 and E82, which with effect from 1 October 2023 will be 30 September before the 70th birthday. The justification for this is explained at: https://hr.admin.ox.ac.uk/the-ejra. For existing employees on these grades, any employment beyond the retirement age is subject to approval through the procedures: https://hr.admin.ox.ac.uk/the-ejra. There is no normal or fixed age at which staff in posts at other grades have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. 5
Business Manager - Centre for Human Genetics
License
Standard Grade 8: Standard Grade 8: £48,235 - £57,255 with a discretionary range to £62,407 p.a
Centre for Human Genetics, Old Road Campus, Headington, Oxford, OX3 7BN
Past vacancies at the University of Oxford
ha sede